目的:观察穴位针刺联合三伏贴治疗老年膝骨关节炎(knee osteoarthritis,KOA)的临床疗效及对患者血清骨代谢与Lequesnse指数的影响。方法:选取2022年7月至2023年7月江西中医药大学第二附属医院诊治的KOA患者100例,按照随机数字表法分为...目的:观察穴位针刺联合三伏贴治疗老年膝骨关节炎(knee osteoarthritis,KOA)的临床疗效及对患者血清骨代谢与Lequesnse指数的影响。方法:选取2022年7月至2023年7月江西中医药大学第二附属医院诊治的KOA患者100例,按照随机数字表法分为对照组和联合组,每组50例。两组患者均进行基础康复训练,对照组另给予三伏贴贴敷治疗,联合组在对照组治疗的基础上给予穴位针刺治疗。观察两组患者临床疗效、不良反应发生率、中医证候评分、Lysholm功能评分、Lequesnse指数,检测两组患者治疗前后血清骨钙素(bone glaprotein,BGP)、骨保护素(osteoprotegerin,OPG)、I型胶原C端肽(C-telopeptide of type I collagen,CTX-Ⅰ)、白细胞介素(interleukin,IL)-1、基质金属蛋白酶(matrix metalloproteinase,MMP)-3、肿瘤坏死因子(tumor necrosis factor,TNF)-α水平。结果:两组KOA患者治疗后中医证候评分、Lequesnse指数降低、Lysholm功能评分均优于治疗前(P<0.05),且联合组治疗后中医证候评分和Lequesnse指数低于对照组,Lysholm功能评分高于对照组,差异有统计学意义(P<0.05);联合组治疗后BGP、OPG水平高于对照组,CTX-I水平低于对照组,差异有统计学意义(P<0.05);联合组治疗后IL-1、MMP-3、TNF-α水平低于对照组,差异有统计学意义(P<0.05);联合组有效率为92.00%,对照组有效率为76.00%,联合组有效率高于对照组,差异有统计学意义(P<0.05);对照组不良反应发生率为8%,联合组不良反应发生率为4%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:穴位针刺联合三伏贴治疗老年KOA,可调节血清炎症因子水平与骨代谢指标,降低Lequesnse指数,改善患者骨关节功能,提高患者生活质量,且不良反应发生率较低。展开更多
Habitat quality is an important indicator for evaluating the quality of ecosystem.The Qinghai Province section of the Yellow River Basin plays an important role in the ecological protection of the upper reaches of the...Habitat quality is an important indicator for evaluating the quality of ecosystem.The Qinghai Province section of the Yellow River Basin plays an important role in the ecological protection of the upper reaches of the Yellow River Basin.To comprehensively analysis the alterations of habitat quality in the Qinghai Province section of the Yellow River Basin,this study utilized the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST)model to calculate the habitat quality index and analyze the spatio-temporal variation characteristics of habitat quality in the study area from 2000 to 2022,and calculated seven landscape pattern indices(number of patches,patch density,largest patch index(LPI),landscape shape index(LSI),contagion index(CONTAG),Shannon diversity index,and Shannon evenness index)to research the variation of landscape pattern in the study area.The results showed that the number of patches,patch density,LPI,LSI,Shannon diversity index,and Shannon evenness index increased from 2000 to 2022,while the CONTAG decreased,indicating that the landscape pattern in the Qinghai Province section of the Yellow River Basin changed in the direction of distribution fragmentation,shape complexity,and heterogeneity.The average value of the habitat quality index in the Qinghai Province section of the Yellow River Basin from 2000 to 2022 was 0.90.Based on the value of habitat quality index,we divided the level of habitat quality into five categories:lower(0.00-0.20),low(0.20-0.40),moderate(0.40-0.60),high(0.60-0.80),and higher(0.80-1.00).Most areas were at the higher habitat quality level.The lower habitat quality patches were mainly distributed in Longyang Gorge and Yellow River-Huangshui River Valley.From 2000 to 2022,the habitat quality in most areas was stable;the increase areas were mainly distributed in Guinan County,while the decrease areas were mainly distributed in Xining City,Maqen County,Xinghai County,Qumarleb County,and Darlag County.To show the extent of habitat quality variation,we calculated Sen index.The results showed that the higher habitat quality area had a decrease trending,while other categories had an increasing tendency,and the decreasing was faster than increasing.The research results provide scientific guidance for promoting ecological protection and high-quality development in the Qinghai Province section of the Yellow River Basin.展开更多
文摘目的:观察穴位针刺联合三伏贴治疗老年膝骨关节炎(knee osteoarthritis,KOA)的临床疗效及对患者血清骨代谢与Lequesnse指数的影响。方法:选取2022年7月至2023年7月江西中医药大学第二附属医院诊治的KOA患者100例,按照随机数字表法分为对照组和联合组,每组50例。两组患者均进行基础康复训练,对照组另给予三伏贴贴敷治疗,联合组在对照组治疗的基础上给予穴位针刺治疗。观察两组患者临床疗效、不良反应发生率、中医证候评分、Lysholm功能评分、Lequesnse指数,检测两组患者治疗前后血清骨钙素(bone glaprotein,BGP)、骨保护素(osteoprotegerin,OPG)、I型胶原C端肽(C-telopeptide of type I collagen,CTX-Ⅰ)、白细胞介素(interleukin,IL)-1、基质金属蛋白酶(matrix metalloproteinase,MMP)-3、肿瘤坏死因子(tumor necrosis factor,TNF)-α水平。结果:两组KOA患者治疗后中医证候评分、Lequesnse指数降低、Lysholm功能评分均优于治疗前(P<0.05),且联合组治疗后中医证候评分和Lequesnse指数低于对照组,Lysholm功能评分高于对照组,差异有统计学意义(P<0.05);联合组治疗后BGP、OPG水平高于对照组,CTX-I水平低于对照组,差异有统计学意义(P<0.05);联合组治疗后IL-1、MMP-3、TNF-α水平低于对照组,差异有统计学意义(P<0.05);联合组有效率为92.00%,对照组有效率为76.00%,联合组有效率高于对照组,差异有统计学意义(P<0.05);对照组不良反应发生率为8%,联合组不良反应发生率为4%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:穴位针刺联合三伏贴治疗老年KOA,可调节血清炎症因子水平与骨代谢指标,降低Lequesnse指数,改善患者骨关节功能,提高患者生活质量,且不良反应发生率较低。
基金supported by the Demonstration Project of Integrated Ecological Rehabilitation Technology for Key Soil and Water Erosion Areas in the Yellow River Valley(2021-SF-134).
文摘Habitat quality is an important indicator for evaluating the quality of ecosystem.The Qinghai Province section of the Yellow River Basin plays an important role in the ecological protection of the upper reaches of the Yellow River Basin.To comprehensively analysis the alterations of habitat quality in the Qinghai Province section of the Yellow River Basin,this study utilized the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST)model to calculate the habitat quality index and analyze the spatio-temporal variation characteristics of habitat quality in the study area from 2000 to 2022,and calculated seven landscape pattern indices(number of patches,patch density,largest patch index(LPI),landscape shape index(LSI),contagion index(CONTAG),Shannon diversity index,and Shannon evenness index)to research the variation of landscape pattern in the study area.The results showed that the number of patches,patch density,LPI,LSI,Shannon diversity index,and Shannon evenness index increased from 2000 to 2022,while the CONTAG decreased,indicating that the landscape pattern in the Qinghai Province section of the Yellow River Basin changed in the direction of distribution fragmentation,shape complexity,and heterogeneity.The average value of the habitat quality index in the Qinghai Province section of the Yellow River Basin from 2000 to 2022 was 0.90.Based on the value of habitat quality index,we divided the level of habitat quality into five categories:lower(0.00-0.20),low(0.20-0.40),moderate(0.40-0.60),high(0.60-0.80),and higher(0.80-1.00).Most areas were at the higher habitat quality level.The lower habitat quality patches were mainly distributed in Longyang Gorge and Yellow River-Huangshui River Valley.From 2000 to 2022,the habitat quality in most areas was stable;the increase areas were mainly distributed in Guinan County,while the decrease areas were mainly distributed in Xining City,Maqen County,Xinghai County,Qumarleb County,and Darlag County.To show the extent of habitat quality variation,we calculated Sen index.The results showed that the higher habitat quality area had a decrease trending,while other categories had an increasing tendency,and the decreasing was faster than increasing.The research results provide scientific guidance for promoting ecological protection and high-quality development in the Qinghai Province section of the Yellow River Basin.
