Twenty-four hour (circadian) rhythmicity is an important component of biological variability associated with studies relating to biomarkers of aging. Chronobiological testing techniques must be utilized because (1) ma...Twenty-four hour (circadian) rhythmicity is an important component of biological variability associated with studies relating to biomarkers of aging. Chronobiological testing techniques must be utilized because (1) many variables that are related to the modulation of metabolic output vary dramatically at different times of the day; (2) various experimental variable and treatment groups must be synchronized with environmental cues that control circadian rhythms; and (3) multiple circadian variables may interact together to modulate the rate of aging. The rhythm for physiological factors such as whole animal metabolic output, body temperature, heart rate, urine flow, potassium, etc. were found to be dissociated or altered by the senescence process; behavioral variables such as spontaneous activity, wheel running, feeding and drinking, verbal performance, as well as sleep-wakefulness rhythms, seem to be accurate predictors of biological age. Circadian rhythms for a variety of enzymes of intermediary metabolism which are directly associated with energy metabolism have been well documented. These well-defined rhythms of enzyme activity have also been shown to degenerate with aging. Rhythms tend to lose amplitude as activity falls with age and as a general loss of regulation (especially time of day where maximal activity might be found) of activity across the 24-h span occurs. As with behavioral variables, changes in enzyme rhythms appear to accurately predict aging. Generally speaking, the loss of temporal organization with age, characterized by decreased circadian amplitude, loose internal synchronization, and poor response to external environmental time queues, is associated with poor health states and decreased longevity. Temporal rhythms for whole animal parameters are highly correlated with molecular events, such as regulation of cellular metabolism. DNA repair, and gene expression. Automated data acquisition and process control systems will be required for future Chronobiological studies to develop biomarkers of aging.展开更多
Converters with pulse width modulation are used for connections between the direct current （DC） and alternating current （AC） networks, e.g., in uninterrupted power supply systems, AC electromotor drives, for power...Converters with pulse width modulation are used for connections between the direct current （DC） and alternating current （AC） networks, e.g., in uninterrupted power supply systems, AC electromotor drives, for powering induction furnaces, in audio technique. Spectrum of signals sampled by pulse amplitude modulation and output voltage spectrum of the converter with pulse width modulation have similar properties. Spectrum of signals sampled by pulse amplitude modulation contains a harmonic of frequency equal to the frequency of the modulating signal and the harmonics of frequencies equal to the sum of frequency of the modulating signal and multiples of the sampling frequency. The output voltage spectrum of the converter with bipolar pulse width modulation contains harmonic of frequency equal to the frequency of the modulating signal and harmonics of frequencies equal to sum of the frequency of the modulating signal and multiples of the frequency of the carrier signal. It also contains harmonics of frequencies equal to the sum of the multiples of the frequency of the modulating signal and the multiples of the carrier signal. The comparison analysis was carried out for the harmonics of the output voltage of the converter with bipolar pulse width modulation in time domain. The dependency of the amplitudes and frequency spectrum on the wave forms of the carrier signal and modulating signal was shown. Similarity of the output voltage spectrum of the converter and signal spectrum sampled by the pulse width modulation was also shown. Key words： Output voltage converter with bipolar pulse width modulation, spectral analysis, Fourier series, carrier signal, reference signal.展开更多
Handedness-selective chiral transport is an intriguing phenomenon that not only holds signifcant importance for fundamental research but also carries application prospects in fields such as optical communications and ...Handedness-selective chiral transport is an intriguing phenomenon that not only holds signifcant importance for fundamental research but also carries application prospects in fields such as optical communications and sensing.Currently,on-chip chiral transport devices are static,unable to modulate the output modes based on the input modes.This limits both device functionality reconfiguration and information transmission capacity.Here,we propose to use the incident polarization diversity to control the Hamiltonian evolution path,achieving polarization-dependent chiral transport.By mapping the evolution path of TE and TM polarizations onto elaborately engineered double-coupled waveguides,we experimentally demonstrate that different polarizations yield controllable modal outputs.This work combines Multiple-lnput,Multiple-Output,and polarization diversity concepts with chiral transport and challenges the prevailing notion that the modal outputs are fixed to specific modes in chiral transport,thereby opening pathways for the development of on-chip reconfigurable and high-capacity handedness-selective devices.展开更多
An S band SLED-type pulse compressor has been manufactured by the Institute of High Energy Physics,Beijing, trying to reach 100 MW maximum input power, which means the output peak power is about 500 MW at the phase re...An S band SLED-type pulse compressor has been manufactured by the Institute of High Energy Physics,Beijing, trying to reach 100 MW maximum input power, which means the output peak power is about 500 MW at the phase reversal time. To improve the reliability at very high power, amplitude modulation and phase modulation with flat-top output are considered, and RF modulation studies on the S-band SLED are presented in this paper.Furthermore, a method is developed using the CST Microwave Studio transient solver to simulate the time response of the pulse compressor, which can verify the modulation theory. In addition, the experimental setup was constructed and the flat-top output obtained in low power tests. Both amplitude modulation and phase modulation methods can give flat-top output, and the average power gain for both methods is almost the same.展开更多
文摘Twenty-four hour (circadian) rhythmicity is an important component of biological variability associated with studies relating to biomarkers of aging. Chronobiological testing techniques must be utilized because (1) many variables that are related to the modulation of metabolic output vary dramatically at different times of the day; (2) various experimental variable and treatment groups must be synchronized with environmental cues that control circadian rhythms; and (3) multiple circadian variables may interact together to modulate the rate of aging. The rhythm for physiological factors such as whole animal metabolic output, body temperature, heart rate, urine flow, potassium, etc. were found to be dissociated or altered by the senescence process; behavioral variables such as spontaneous activity, wheel running, feeding and drinking, verbal performance, as well as sleep-wakefulness rhythms, seem to be accurate predictors of biological age. Circadian rhythms for a variety of enzymes of intermediary metabolism which are directly associated with energy metabolism have been well documented. These well-defined rhythms of enzyme activity have also been shown to degenerate with aging. Rhythms tend to lose amplitude as activity falls with age and as a general loss of regulation (especially time of day where maximal activity might be found) of activity across the 24-h span occurs. As with behavioral variables, changes in enzyme rhythms appear to accurately predict aging. Generally speaking, the loss of temporal organization with age, characterized by decreased circadian amplitude, loose internal synchronization, and poor response to external environmental time queues, is associated with poor health states and decreased longevity. Temporal rhythms for whole animal parameters are highly correlated with molecular events, such as regulation of cellular metabolism. DNA repair, and gene expression. Automated data acquisition and process control systems will be required for future Chronobiological studies to develop biomarkers of aging.
文摘Converters with pulse width modulation are used for connections between the direct current （DC） and alternating current （AC） networks, e.g., in uninterrupted power supply systems, AC electromotor drives, for powering induction furnaces, in audio technique. Spectrum of signals sampled by pulse amplitude modulation and output voltage spectrum of the converter with pulse width modulation have similar properties. Spectrum of signals sampled by pulse amplitude modulation contains a harmonic of frequency equal to the frequency of the modulating signal and the harmonics of frequencies equal to the sum of frequency of the modulating signal and multiples of the sampling frequency. The output voltage spectrum of the converter with bipolar pulse width modulation contains harmonic of frequency equal to the frequency of the modulating signal and harmonics of frequencies equal to sum of the frequency of the modulating signal and multiples of the frequency of the carrier signal. It also contains harmonics of frequencies equal to the sum of the multiples of the frequency of the modulating signal and the multiples of the carrier signal. The comparison analysis was carried out for the harmonics of the output voltage of the converter with bipolar pulse width modulation in time domain. The dependency of the amplitudes and frequency spectrum on the wave forms of the carrier signal and modulating signal was shown. Similarity of the output voltage spectrum of the converter and signal spectrum sampled by the pulse width modulation was also shown. Key words： Output voltage converter with bipolar pulse width modulation, spectral analysis, Fourier series, carrier signal, reference signal.
基金National Natural Science Foundation of China(Grant No.12474382)National Key Research and Development Project of China(Grant No.2024YFA1209302)+1 种基金Science,Technology and Innovation Commission of Shenzhen Municipality(Grant No.JCYJ20220530161010023)Key Laboratory of High-Temperature Electromagnetic Materials and Structure of MOE,Wuhan University of Science and Technology(GrantNo.KB202501).
文摘Handedness-selective chiral transport is an intriguing phenomenon that not only holds signifcant importance for fundamental research but also carries application prospects in fields such as optical communications and sensing.Currently,on-chip chiral transport devices are static,unable to modulate the output modes based on the input modes.This limits both device functionality reconfiguration and information transmission capacity.Here,we propose to use the incident polarization diversity to control the Hamiltonian evolution path,achieving polarization-dependent chiral transport.By mapping the evolution path of TE and TM polarizations onto elaborately engineered double-coupled waveguides,we experimentally demonstrate that different polarizations yield controllable modal outputs.This work combines Multiple-lnput,Multiple-Output,and polarization diversity concepts with chiral transport and challenges the prevailing notion that the modal outputs are fixed to specific modes in chiral transport,thereby opening pathways for the development of on-chip reconfigurable and high-capacity handedness-selective devices.
基金Supported by National Natural Science Foundation of China(11475201)
文摘An S band SLED-type pulse compressor has been manufactured by the Institute of High Energy Physics,Beijing, trying to reach 100 MW maximum input power, which means the output peak power is about 500 MW at the phase reversal time. To improve the reliability at very high power, amplitude modulation and phase modulation with flat-top output are considered, and RF modulation studies on the S-band SLED are presented in this paper.Furthermore, a method is developed using the CST Microwave Studio transient solver to simulate the time response of the pulse compressor, which can verify the modulation theory. In addition, the experimental setup was constructed and the flat-top output obtained in low power tests. Both amplitude modulation and phase modulation methods can give flat-top output, and the average power gain for both methods is almost the same.
