Objective To investigate the effect of gender differences in distal femoral geometry on the clinical outcomes of total knee arthroplasty (TKA).Methods From March 2003 to October 2006,213 cases with 294 osteoarthritic ...Objective To investigate the effect of gender differences in distal femoral geometry on the clinical outcomes of total knee arthroplasty (TKA).Methods From March 2003 to October 2006,213 cases with 294 osteoarthritic knees who展开更多
In environmental risk assessments（ERA）, biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse ou...In environmental risk assessments（ERA）, biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes（e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function）. To mitigate these limitations, the concept of adverse outcome pathways（AOPs） was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event（MIE） to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo（a）pyrene（Ba P）, silver nanoparticles（Ag NPs）, and selenium（Se）. Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population levels.Also, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural environment.The development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem.展开更多
Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study...Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.展开更多
文摘Objective To investigate the effect of gender differences in distal femoral geometry on the clinical outcomes of total knee arthroplasty (TKA).Methods From March 2003 to October 2006,213 cases with 294 osteoarthritic knees who
基金a part of the project (20140342) titled " Development of techniques for assessment and management of hazardous chemicals in the marine environment " funded by the Ministry of Oceans and Fisheries, Korea to Jae-Seong Leesupported by the " Korea Polar Ocean Development: K-POD " grant (project no. PM14030) funded by the Ministry of Oceans and Fisheries, Korea
文摘In environmental risk assessments（ERA）, biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes（e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function）. To mitigate these limitations, the concept of adverse outcome pathways（AOPs） was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event（MIE） to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo（a）pyrene（Ba P）, silver nanoparticles（Ag NPs）, and selenium（Se）. Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population levels.Also, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural environment.The development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem.
文摘Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.
