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mTORC1 and mTORC2 synergy in human neural development, disease, and regeneration 被引量:1
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作者 Navroop K.Dhaliwal Julien Muffat Yun Li 《Neural Regeneration Research》 2026年第4期1552-1553,共2页
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul... The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health. 展开更多
关键词 m tor neural development mtorc central nervous system cns mtor neurodevelopmental disorders neurodegenerative conditions
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Ecosystem management and agricultural green development in subtropical regions
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作者 Jinshui Wu Tony G.O’Donnell +4 位作者 Andrew Macrae Hongsong Chen Weiguo Cheng Zhihong Xu Zhengmiao Deng 《Journal of Integrative Agriculture》 2026年第2期399-401,共3页
The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to ... The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America. 展开更多
关键词 ecosystem management developing countries subtropical regions sustainable development goal agricultural green development zero hunger sustainable development goal sdg population growth
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Innovation and Development Policy(中文名:《创新与发展政策(英文)》)征稿启事
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《科研管理》 北大核心 2026年第1期F0004-F0004,共1页
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊... Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。 展开更多
关键词 创新与发展政策 Innovation and development Policy
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Innovation and Development Policy(中文名:《创新与发展政策(英文)》)征稿启事
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《科研管理》 北大核心 2026年第3期F0004-F0004,共1页
Innovation and Development Policy简称“IDP”,中文名《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。... Innovation and Development Policy简称“IDP”,中文名《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版四期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。 展开更多
关键词 Innovation and development Policy
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Guiding the younger generation to explore new scenarios for participating in standards development and application
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作者 Li Zhiping 《China Standardization》 2026年第1期43-44,共2页
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You... Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization. 展开更多
关键词 standards development sustainable development application standards international partnerships high quality development consolidates global consensus younger generation common language
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New Year Message for 2026 from Petroleum Exploration and Development
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作者 Editorial Office of Petroleum Exploration and Development 《Petroleum Exploration and Development》 2026年第1期F0002-F0002,共1页
Time flows with no stop,and seasons change in swift succession.As we bid farewell to 2025 and welcome the Spring Festival of 2026,the Editorial Office of Petroleum Exploration and Development extends our most heartfel... Time flows with no stop,and seasons change in swift succession.As we bid farewell to 2025 and welcome the Spring Festival of 2026,the Editorial Office of Petroleum Exploration and Development extends our most heartfelt gratitude and sincerest New Year wishes to our editorial board members,experts,authors,readers,and friends from all sectors. 展开更多
关键词 development new year message seasons change editorial office editorial board members petroleum exploration experts petroleum exploration development
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Standards lead the high-quality development of intelligent construction in China
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作者 Cheng Zhijun 《China Standardization》 2026年第1期49-49,共1页
To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction fou... To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial). 展开更多
关键词 STandARDS technical guidelines high quality development Ministry Housing Urban Rural development intelligent constructionstandards replicable experience intelligent construction
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Health-related physical fitness in children and adolescents and the United Nations Sustainable Development Goals:Signals of convergence
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作者 Diego Augusto Santos Silva Mark S.Tremblay 《Journal of Sport and Health Science》 2026年第3期6-12,共7页
1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconn... 1.Background The United Nations(UN)2030 Agenda for Sustainable Development,adopted in 2015,established the Sustainable Development Goals(SDGs)as a comprehensive framework to address global challenges through interconnected social,economic,and environmental targets. 展开更多
关键词 sustainable development goals sdgs sustainable developmentadopted AGENDA children adolescents address global challenges united nations sustainable development goals
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International Comparison and China's Path on the Protection of Agricultural Intangible Cultural Heritage and Origins
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作者 Zhang Xue Tadesse Kenea Amentae 《科技与法律(中英文)》 2026年第2期137-148,共12页
Agricultural Intangible Cultural Heritage(AICH)embodies collective,intergenerational knowledge sys⁃tems that are increasingly exposed to risks of misappropriation and inequitable commercialization under contemporary i... Agricultural Intangible Cultural Heritage(AICH)embodies collective,intergenerational knowledge sys⁃tems that are increasingly exposed to risks of misappropriation and inequitable commercialization under contemporary intellectual property(IP)regimes.This study investigates the"cost of inaction"in protecting AICH and geographical origins through a qualitative comparative case study approach,drawing on selected cases from Africa,Asia,and Latin America,alongside Chinese practices.By combining narrative analysis and thematic synthesis,the study identi⁃fies two dominant patterns:external misappropriation driven by institutional gaps-manifested in biopiracy,trademark squatting,and exploitation of information asymmetry-and internal inequities arising from commercialization processes that marginalize indigenous communities in benefit-sharing.The findings reveal that existing international IP frame⁃works,including TRIPs and the CBD,provide fragmented and insufficient protection for collective knowledge sys⁃tems.Comparative analysis of national responses highlights three distinct governance models:defensive protection(In⁃dia),rights-based sui generis legislation(Peru),and market-oriented geographical indication systems(European Union),each with inherent limitations.In contrast,Chinese practices demonstrate strong capacity in market integra⁃tion and industrial upgrading but remain constrained by weak recognition of community rights and limited institutional⁃ization of benefit-sharing mechanisms.This study contributes to the literature by proposing a composite institutional framework that integrates existing IP regimes with a sui generis system centered on collective rights recognition,prior informed consent,and mandatory benefit-sharing.The framework also emphasizes the need for embedded integration with patent,trademark,and geographical indication systems,as well as institutional adaptation in the context of the digital economy.The findings offer theoretical insights and policy implications for developing countries seeking to bal⁃ance cultural preservation,economic development,and equitable governance of traditional knowledge. 展开更多
关键词 agricultural intangible cultural heritage traditional knowledge origins geographical indications benefitsharing collective rights
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Intersection of mitochondrial dysfunction and myelination:An overlooked aspect in neurodevelopmental disorders
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作者 Ariel Nir Sade Gal Wiener Boaz Barak 《Neural Regeneration Research》 2026年第2期659-660,共2页
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th... Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs. 展开更多
关键词 neurodevelopmental disorders ndds rokach white matter developing brain MYELINATION neurodevelopmental processes mitochondrial dysfunction white matter wm known developing braina
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Study on the development,applications,and standardization status of environmental DNA(eDNA)technology in China
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作者 Li Xiawei Duan Bin +3 位作者 Lu Jing Li Xueling Wang Min Yang Yongqi 《China Standardization》 2026年第1期54-59,共6页
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i... Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology. 展开更多
关键词 environmental DNA development application standardization status
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Africa’s Economic Development Amidst Profound Changes:Characteristics,Challenges and Prospects
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作者 Tian Feng 《Contemporary World》 2026年第1期32-38,共7页
After the end of World War II,African countries successively gained independence and ushered in a golden age of economic development.Through the strategies of primary product exports,transitional economic policies and... After the end of World War II,African countries successively gained independence and ushered in a golden age of economic development.Through the strategies of primary product exports,transitional economic policies and import substitution development,their economic growth accelerated significantly.However,due to the limitations of these strategies,the structural problem of Africa being an exporter of cheap industrial raw materials and an importer of manufactured goods remained unresolved. 展开更多
关键词 import substitution developmenttheir import substitution development primary product exports manufactured goods economic development transitional economic policies African countries economic developmentthrough
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Current Situation of Application and Development Prospects of the Statistical Analysis of Big Data
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作者 Zhuoran LI 《Meteorological and Environmental Research》 2026年第1期45-47,共3页
With the advent of the big data era,modern statistics has enjoyed unprecedented development opportunities and also faced numerous new challenges.Traditional statistical computing methods are often limited by issues su... With the advent of the big data era,modern statistics has enjoyed unprecedented development opportunities and also faced numerous new challenges.Traditional statistical computing methods are often limited by issues such as computer memory capacity and distributed storage of data across different locations,and are unable to directly apply to large-scale data sets.Therefore,in the context of big data,designing efficient and theoretically guaranteed statistical learning and inference algorithms has become a key issue that the current field of statistics urgently needs to address.In this paper,the application status of statistical analysis methods in the big data environment was systematically reviewed,and its future development directions were analyzed to provide reference and support for the further development of theory and methods of the statistical analysis of big data. 展开更多
关键词 Big data Statistical analysis Current status development prospects
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New Plan,New Opportunities:Debates and decisions made at the Two Sessions on policies and market access could benefit Africa’s development
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作者 CHARLES ONUNAIJU 《ChinAfrica》 2026年第4期18-19,共2页
Avery significant event in China’s political calendar took place in Beijing in early March,and,as usual,it was more than optics.The fourth sessions of the 14th National People’s Congress(NPC)and the 14th National Co... Avery significant event in China’s political calendar took place in Beijing in early March,and,as usual,it was more than optics.The fourth sessions of the 14th National People’s Congress(NPC)and the 14th National Committee of the Chinese People’s Political Consultative Conference(CPPCC),the country’s top legislative and advisory bodies,are expected to set the course for China’s direction over the year and beyond. 展开更多
关键词 two sessions CPPCC development policy China market access NPC Africa
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National development requires the younger generation to cultivate the standardization consciousness and mindset
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作者 Zhang Xiaogang 《China Standardization》 2026年第1期42-42,共1页
The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
关键词 collective efforts youth competition national development improvement standardization consciousness
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The role of m^(6)A in plant development,stress response,and agricultural practices
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作者 Jin Qi Shaoxia Li +3 位作者 Jun Su Yushi Lu Wenjin Yu Changxia Li 《Horticultural Plant Journal》 2026年第1期19-35,共17页
N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While... N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance. 展开更多
关键词 N6-methyladenosine Epitranscriptomics Plant development STRESS Agricultural production
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Earth’s New Horizon:Innovations in Ecological Development and Environmental Preservation
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作者 Haitao Wang Xuan Zhang Zhaojun Wu 《Journal of Environmental & Earth Sciences》 2026年第1期298-323,共26页
The environment and its preservation are becoming more and more dependent on ecological development in an age of accelerating climate risk,biodiversity loss,and pressures of pollution.This review summarizes the fronti... The environment and its preservation are becoming more and more dependent on ecological development in an age of accelerating climate risk,biodiversity loss,and pressures of pollution.This review summarizes the frontiers of innovation that are capable of enhancing integration of human development and ecological integrity,and how the interaction between technical,ecological,and institutional innovations can produce real-world results.We initially discuss developing ecological innovations that offer new opportunities to urban development,such as low-impact cities,ecological infrastructure,clean energy transitions,and biodiversity-informed siting,and digital decision-support systems enhancing planning and resource efficiency.Then,we evaluate progress in the field of preservation and restoration,with a particular focus on nature-based solutions,a process-based approach to restoration science,connectivity conservation,and a watershed-scale and seascape-scale approach to restore resilience and help recover biodiversity.In these spheres,we discover measurement,monitoring,and verification(MRV),one of the main pillars of scale alongside remote sensing,automated field monitoring,environmental Deoxyribonucleic Acid(DNA),and Artificial Intelligence(AI)-enabled analytics,increasing the range of trackable and manageable indices as well as creating new issues with baselines,uncertainty,and data ethics.Lastly,we compare governance,finance,and equity as key conversion processes that can turn innovations into sustainable dividends with authenticity principles,however,of additionality,permanence,and leakage avoidance,and with rightsbased and redistributive mechanisms and approaches that reinforce legitimacy.We end by providing a portfolio roadmap of prioritization of the interventions that have high co-benefits and the identification of critical research and institutional gaps to provide net-positive ecological results. 展开更多
关键词 Ecological development Environmental Preservation Nature-Based Solutions MRV Circular Economy
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Hide-in-Bird Pond:A new pathway to synergize biodiversity conservation and sustainable development in China
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作者 Lin He Dao Yan +3 位作者 Ming Liu Yuanfang Hu Shunyu Yao Fei Wu 《Avian Research》 2026年第1期183-191,共9页
Reconciling biodiversity conservation with economic advancement represents a defining challenge of the Anthropocene epoch.Although ecotourism is widely promoted as a strategy capable of delivering both environmental a... Reconciling biodiversity conservation with economic advancement represents a defining challenge of the Anthropocene epoch.Although ecotourism is widely promoted as a strategy capable of delivering both environmental and developmental benefits,empirical evidence regarding its ecological and socioeconomic impacts remains limited.This study critically examined the Hide-in-Bird Pond(HIBP)model,a rapidly expanding,community-based avitourism framework in China that integrates targeted wildlife provisioning with concealed infrastructure for bird observation,simultaneously establishing a novel income source for economically marginalized rural regions through ecotourism.Semi-structured online interviews were conducted with 98 HIBP operators,and thematic analysis was applied to evaluate current developmental patterns,spatial distribution,and conservation outcomes.A total of 251 HIBP sites were identified across China,predominantly located in biodiversity-rich but economically marginalized regions.These sites collectively supported 524 bird species—36%of China's avifauna—including 148 species classified as nationally protected or threatened(38%of nationally listed bird taxa).These findings suggest that HIBP can serve as an integrative socio-ecological platform that aligns conservation objectives with sustainable rural development.However,the absence of standardized governance frameworks and ecological safeguards poses significant risks to biodiversity an d long-term sustainability.Implementation of science-based adaptive management systems,incorporating systematic biodiversity monitoring,inclusive stakeholder coordination,and certified sustainable tourism protocols,is critical to ensure ecological integrity and sectoral resilience.These findings offer novel insights into aligning conservation objectives with economic development across regions characterized by high biodiversity and persistent economic disadvantage. 展开更多
关键词 Avitourism BIRD-WATCHING Biological resource use Biodiversity conservation ECOTOURISM Sustainable development
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A Governance Quality Lens on the Influence of Chinese Outward Investment on Human Development in Belt and Road Initiative Countries
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作者 YANG Bo EBN JALAL Md Jahid +5 位作者 SARKAR Md Abdur Rouf ALAM Mohammad Jahangir DING Shijun BEGUM Ismat Ara RAHMAN Md.Naimur LO Kevin 《Chinese Geographical Science》 2026年第1期64-81,共18页
In the evolving global economy,China’s Outward Foreign Direct Investment(OFDI)holds increasing significance,specially within the context of the Belt and Road Initiative(BRI).Despite earlier studies have acknowledged ... In the evolving global economy,China’s Outward Foreign Direct Investment(OFDI)holds increasing significance,specially within the context of the Belt and Road Initiative(BRI).Despite earlier studies have acknowledged the role of governance quality in at-tracting Chinese OFDI,their explanatory capacity regarding human development has not received sufficient attention.This study ad-dresses this gap,investigating the relationship between Chinese OFDI and human development,emphasizing the governance quality’s moderating role.Using data from 122 BRI countries from 2004 to 2021,we employed the Panel Corrected Standard Error model through Prais-Winsten regression,complimented by robustness check via the Spatial Durbin Model.Our analysis revealed a significant positive relationship between Chinese OFDI and human development in BRI countries,indicating that Chinese investments act as cata-lysts for improved well-being.More importantly,governance quality plays a vital role in shaping this relationship,revealing that effect-ive governance enhanced the human development outcomes of OFDI.Post-hoc analysis of governance indicators,both as a composite index and individual dimensions,supported this finding.Regional heterogeneity analysis further showed that Chinese OFDI has stronger effects on Human Development Index(HDI)in Asia and Africa compared to Europe,Latin America,and Oceania.However,the moder-ating effect of governance quality seemed more prominent in Oceania and Latin America,indicating its role in fostering the benefits of Chinese investments in these regions.These findings hold implications for academia and policy,emphasizing the need for transparent,accountable,and effective governance to drive sustainable and inclusive human development within the BRI framework. 展开更多
关键词 overseas investment human development governance quality moderating effect China
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Parental exposure to ocean acidification impacts the larval development and transcriptome of the Pacific oyster Crassostrea gigas
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作者 Hailun FU Wen TENG +3 位作者 Shoudu ZHANG Zhangjie PENG Jiulin CHAN Linlin ZHANG 《Journal of Oceanology and Limnology》 2026年第1期433-444,共12页
Atmospheric carbon dioxide(CO_(2))levels are escalating at an unprecedented rate,leading to the phenomenon of ocean acidification(OA).Parental exposure to acidification has the potential to enhance offspring resilienc... Atmospheric carbon dioxide(CO_(2))levels are escalating at an unprecedented rate,leading to the phenomenon of ocean acidification(OA).Parental exposure to acidification has the potential to enhance offspring resilience through cross-generation plasticity.In this study,we analyzed larval growth and transcriptomic profiles in the Pacific oyster,Crassostrea gigas,a species of significant ecological relevance,under both control and elevated CO_(2)conditions experienced by their parental generation.Our findings indicate that the oyster populations exposed to OA exhibited a higher incidence of abnormalities during the D-shaped larval stage,followed by accelerated growth at the eyed stage.Through a comparative transcriptomic investigation of eyed larvae(25 d after fertilization),we observed that parental exposure to OA substantially influenced the gene expression in the offspring.Genes associated with lipid catabolism and shell formation were notably upregulated in oysters with parental OA exposure,potentially playing a role in cross-generational conditioning and conferring resilience to OA stressors.These results underscore the profound impact of OA on oyster larval development via cross-generational mechanisms and shed light on the molecular underpinnings of cross-generation plasticity. 展开更多
关键词 cross-generation plasticity OYSTER ocean acidification(OA) larval development TRANSCRIPTOME
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