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Secured-FL:Blockchain-Based Defense against Adversarial Attacks on Federated Learning Models
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作者 Bello Musa Yakubu Nor Shahida Mohd Jamail +1 位作者 Rabia Latif Seemab Latif 《Computers, Materials & Continua》 2026年第3期734-757,共24页
Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work pr... Federated Learning(FL)enables joint training over distributed devices without data exchange but is highly vulnerable to attacks by adversaries in the form of model poisoning and malicious update injection.This work proposes Secured-FL,a blockchain-based defensive framework that combines smart contract-based authentication,clustering-driven outlier elimination,and dynamic threshold adjustment to defend against adversarial attacks.The framework was implemented on a private Ethereum network with a Proof-of-Authority consensus algorithm to ensure tamper-resistant and auditable model updates.Large-scale simulation on the Cyber Data dataset,under up to 50%malicious client settings,demonstrates Secured-FL achieves 6%-12%higher accuracy,9%-15%lower latency,and approximately 14%less computational expense compared to the PPSS benchmark framework.Additional tests,including confusion matrices,ROC and Precision-Recall curves,and ablation tests,confirm the interpretability and robustness of the defense.Tests for scalability also show consistent performance up to 500 clients,affirming appropriateness to reasonably large deployments.These results make Secured-FL a feasible,adversarially resilient FL paradigm with promising potential for application in smart cities,medicine,and other mission-critical IoT deployments. 展开更多
关键词 Federated learning(FL) blockchain FL based privacy model defense FL model security ethereum smart contract
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Face-Pedestrian Joint Feature Modeling with Cross-Category Dynamic Matching for Occlusion-Robust Multi-Object Tracking
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作者 Qin Hu Hongshan Kong 《Computers, Materials & Continua》 2026年第1期870-900,共31页
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba... To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions. 展开更多
关键词 Cross-category dynamic binding joint feature modeling face-pedestrian association multi object tracking occlusion robustness
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Nash Bargaining Solution-Based Multi-Objective Model Predictive Control for Constrained Interactive Robots
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作者 Minglei Zhu Jun Qi 《IEEE/CAA Journal of Automatica Sinica》 2025年第7期1516-1518,共3页
Dear Editor,This letter proposes a novel Nash bargaining solution-based multiobjective model predictive control(MPC)scheme to deal with the interaction force control and the path-following problem of the constrained i... Dear Editor,This letter proposes a novel Nash bargaining solution-based multiobjective model predictive control(MPC)scheme to deal with the interaction force control and the path-following problem of the constrained interactive robot.Considering the elastic interaction force model,a mechanical trade-off always exists between the interaction force and position,which means that neither force nor path following can satisfy their desired demands completely.Based on this consideration,two irreconcilable control specifications,the force object function and the position track object function,are proposed,and a new multi-objective MPC scheme is then designed. 展开更多
关键词 constrained interactive robots constrained interactive robotconsidering force path following interaction force modela interaction force control Nash bargaining solution path following problem multi objective model predictive control
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Modeling Real Objects for Kansei-based Shape Retrieval 被引量:2
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作者 Yukihiro Koda Ichi Kanaya Kosuke Sato 《International Journal of Automation and computing》 EI 2007年第1期14-17,共4页
A large number of 3D models are created on computers and available for networks. Some content-based retrieval technologies are indispensable to find out particular data from such anonymous datasets. Though several sha... A large number of 3D models are created on computers and available for networks. Some content-based retrieval technologies are indispensable to find out particular data from such anonymous datasets. Though several shape retrieval technologies have been developed, little attention has been given to the points on human's sense and impression (as known as Kansei) in the conventional techniques, In this paper, the authors propose a novel method of shape retrieval based on shape impression of human's Kansei. The key to the method is the Gaussian curvature distribution from 3D models as features for shape retrieval. Then it classifies the 3D models by extracted feature and measures similarity among models in storage. 展开更多
关键词 Shape retrieval Kansei engineering modeling of real object.
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Human-Object Interaction Recognition Based on Modeling Context 被引量:1
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作者 Shuyang Li Wei Liang Qun Zhang 《Journal of Beijing Institute of Technology》 EI CAS 2017年第2期215-222,共8页
This paper proposes a method to recognize human-object interactions by modeling context between human actions and interacted objects.Human-object interaction recognition is a challenging task due to severe occlusion b... This paper proposes a method to recognize human-object interactions by modeling context between human actions and interacted objects.Human-object interaction recognition is a challenging task due to severe occlusion between human and objects during the interacting process.Since that human actions and interacted objects provide strong context information,i.e.some actions are usually related to some specific objects,the accuracy of recognition is significantly improved for both of them.Through the proposed method,both global and local temporal features from skeleton sequences are extracted to model human actions.In the meantime,kernel features are utilized to describe interacted objects.Finally,all possible solutions from actions and objects are optimized by modeling the context between them.The results of experiments demonstrate the effectiveness of our method. 展开更多
关键词 human-object interaction action recognition object recognition modeling context
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Using Agent-Based Modeling to Study the Adaptation and Evolution of Human Emotions and Cognition
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作者 Duan Qin Luo Siyang 《心理科学》 北大核心 2025年第6期1314-1332,共19页
This review explores the use of agent-based modeling(ABM)within the framework of study human emotion and cognition in the context of its ability to simulate complex social interactions,adaptive changes,and evolutionar... This review explores the use of agent-based modeling(ABM)within the framework of study human emotion and cognition in the context of its ability to simulate complex social interactions,adaptive changes,and evolutionary processes.By representing agents and their defined environments with probabilistic interactions,ABM allows the assessment of the effects of individual behavior at the micro level on the greater social phenomena at the macro level.The review looks into the applications of ABM in portraying some of the key components of emotions and cognition-empathy,cooperation,decision making,and emotional transmission-and analyzes the problems including scalability,empirical validation,and description of sensitive emotional states.The most important conclusion is that merging ABM with information neurobiological data and artificial intelligence(AI)techniques would allow for deepening the interactions within the system and enhancing its responsiveness to stimuli.This review highlights approaches that aim to exploit the ABM methodology more fully and integrates methods from biology,neuroscience,and engineering.This integration could contribute to our understanding of the human behavior evolution and adaptation within systems relevant to policymaking,healthcare,and education. 展开更多
关键词 agent-based modeling emotions evolution cognition evolution social interactions
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Three dimensional modeling and developing of tunnel based on objectarx technique 被引量:1
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作者 张和生 姬阳瑞 +1 位作者 温志勇 石秀伟 《Journal of Coal Science & Engineering(China)》 2006年第2期62-65,共4页
Studied the methods of 3D modeling in tunnel of underground and realized the3D visual expression of tunnel using language Object ARX CAD.
关键词 tunnel of underground 3D methodof model object ARX
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Modeling Method of Automotive Body CAN/LIN Nets Application Protocol Based on Object-oriented Colored Petri Net 被引量:8
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作者 FANG Hua HAN Jianghong and LIU Xiaoping 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2011年第6期999-1006,共8页
Recently automotive nets are adopted to solve increasing problems in automotive electronic systems.Technologies of automotive local area network from CAN and LIN can solve the problems of the increasing of wire bunch ... Recently automotive nets are adopted to solve increasing problems in automotive electronic systems.Technologies of automotive local area network from CAN and LIN can solve the problems of the increasing of wire bunch weight and lack in module installation space.However,the multilayer automotive nets software becomes more and more complex,and the development expense is difficult to predict and to keep in check.In this paper,the modeling method of hierarchical automotive nets and the substitution operation based on object-oriented colored Petri net(OOCPN) are proposed.The OOCPN model which analyzes the software structure and validates the collision mechanism of CAN/LIN bus can speed the automobile system development.First,the subsystems are divided and modeled by object-oriented Petri net(OOPN).According to the sets of message sharing relations,the message ports among them are set and the communication gate transitions are defined.Second,the OOPN model is substituted step by step until the inner objects in the automotive body control modules(BCM) are indivisible and colored by colored Petri net(CPN).And the color subsets mark the node messages for the collision mechanism.Third,the OOCPN model of the automotive body CAN/LIN nets is assembled,which keeps the message sets and the system can be expanded.The proposed model is used to analyze features of information sharing among the objects,and it is also used to describe each subsystem real-time behavior of processing messages and implemental device controllers operating,and puts forward a reasonable software framework for the automotive body control subsystem.The research can help to design the communication model in the automotive body system effectively and provide a convenient and rapid way for developing the logical hierarchy software. 展开更多
关键词 automotive body CAN/LIN bus information sharing object-oriented colored Petri net modeling
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Modelica-based Object-orient Modeling of Rotor System with Multi-Faults 被引量:1
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作者 LI Ming WANG Yu +2 位作者 LI Fucai LI Hongguang MENG Guang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第6期1169-1181,共13页
Modelica-based object-orient method is proved to be rapid, accurate and easy to modify, which is suitable for prototype modeling and simulation of rotor system, whose parameters need to be modified frequently. Classic... Modelica-based object-orient method is proved to be rapid, accurate and easy to modify, which is suitable for prototype modeling and simulation of rotor system, whose parameters need to be modified frequently. Classical non-object-orient method appears to be inefficient because the code is difficult to modify and reuse. An adequate library for object-orient modeling of rotor system with multi-faults is established, a comparison with non-object-orient method on Jeffcott rotor system and a case study on turbo expander with multi-faults are implemented. The relative tolerance between object-orient method and non-object-orient is less than 0.03%, which proves that these two methods are as accurate as each other. Object-orient modeling and simulation is implemented on turbo expander with crack, rub-impact, pedestal looseness and multi-faults simultaneously. It can be conclude from the case study that when acting on compress side of turbo expander separately, expand wheel is not influenced greatly by crack fault, the existence of rub-impact fault forces expand wheel into quasi-periodic motion and the orbit of expand wheel is deformed and enhanced almost 1.5 times due to pedestal looseness. When acting simultaneously, multi-faults cannot be totally decomposed but can be diagnosed from the feature of vibration. Object-orient method can enhance the efficiency of modeling and simulation of rotor system with multi-faults, which provides an efficient method on prototype modeling and simulation. 展开更多
关键词 rotor system multi-faults object-orient modeling modelICA
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3D Object Detection with Attention:Shell-Based Modeling
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作者 Xiaorui Zhang Ziquan Zhao +1 位作者 Wei Sun Qi Cui 《Computer Systems Science & Engineering》 SCIE EI 2023年第7期537-550,共14页
LIDAR point cloud-based 3D object detection aims to sense the surrounding environment by anchoring objects with the Bounding Box(BBox).However,under the three-dimensional space of autonomous driving scenes,the previou... LIDAR point cloud-based 3D object detection aims to sense the surrounding environment by anchoring objects with the Bounding Box(BBox).However,under the three-dimensional space of autonomous driving scenes,the previous object detection methods,due to the pre-processing of the original LIDAR point cloud into voxels or pillars,lose the coordinate information of the original point cloud,slow detection speed,and gain inaccurate bounding box positioning.To address the issues above,this study proposes a new two-stage network structure to extract point cloud features directly by PointNet++,which effectively preserves the original point cloud coordinate information.To improve the detection accuracy,a shell-based modeling method is proposed.It roughly determines which spherical shell the coordinates belong to.Then,the results are refined to ground truth,thereby narrowing the localization range and improving the detection accuracy.To improve the recall of 3D object detection with bounding boxes,this paper designs a self-attention module for 3D object detection with a skip connection structure.Some of these features are highlighted by weighting them on the feature dimensions.After training,it makes the feature weights that are favorable for object detection get larger.Thus,the extracted features are more adapted to the object detection task.Extensive comparison experiments and ablation experiments conducted on the KITTI dataset verify the effectiveness of our proposed method in improving recall and precision. 展开更多
关键词 3D object detection autonomous driving point cloud shell-based modeling self-attention mechanism
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Study on business process modeling based on object-oriented Petri Net
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作者 SHI Guo-ling LI Yi-jun MA Wei-zhong 《Chinese Business Review》 2008年第1期56-60,共5页
In the developing course of the information system, the modeling method of information system and model expressing problem are very important. This paper through discussing the facing object of Petri network, expatiat... In the developing course of the information system, the modeling method of information system and model expressing problem are very important. This paper through discussing the facing object of Petri network, expatiates the basic problem of how to set up the business procedure model on the basis of Petri network, and shows the expressing and storing methods of the model in computer way. 展开更多
关键词 facing object of Petri network modeling information system business procedure
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The Feature-Based a New Object Coding Approach for Prismatic Parts at the Part Modeling
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作者 Ismet Celik Ali Unuvar 《Modeling and Numerical Simulation of Material Science》 2013年第4期129-138,共10页
Use of features in order to achieve the integration of design and manufacture has been considered to be a key factor recent years. Features such as manufacturing properties form the workpiece. Features are structured ... Use of features in order to achieve the integration of design and manufacture has been considered to be a key factor recent years. Features such as manufacturing properties form the workpiece. Features are structured systematically through object oriented modeling. This article explains an object coding method developed for prismatic workpieces and the use of that method in process planning. Features have been determined and modeled as objects. Features have been coded according to their types and locations on the workpiece in this given method. Feature codings have been seen to be very advantageous in process planning. 展开更多
关键词 FEATURE Feature based modeling object Oriented modeling Process Planning
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A lightweight pure visual BEV perception method based on dual distillation of spatial-temporal knowledge
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作者 LIU Bingdong YU Ruihang +1 位作者 XIONG Zhiming WU Meiping 《Journal of Systems Engineering and Electronics》 2026年第1期36-44,共9页
Bird's-eye-view(BEV)perception is a core technology for autonomous driving systems.However,existing solutions face the dilemma of high costs associated with multimodal methods and limited performance of vision-onl... Bird's-eye-view(BEV)perception is a core technology for autonomous driving systems.However,existing solutions face the dilemma of high costs associated with multimodal methods and limited performance of vision-only approaches.To address this issue,this paper proposes a framework named“a lightweight pure visual BEV perception method based on dual distillation of spatial-temporal knowledge”.This framework innovatively designs a lightweight vision-only student model based on Res Net,which leverages a dual distillation mechanism to learn from a powerful teacher model that integrates temporal information from both image and light detection and ranging(LiDAR)modalities.Specifically,we distill efficient multi-modal feature extraction and spatial fusion capabilities from the BEVFusion model,and distill advanced temporal information fusion and spatiotemporal attention mechanisms from the BEVFormer model.This dual distillation strategy enables the student model to achieve perception performance close to that of multi-modal models without relying on Li DAR.Experimental results on the nu Scenes dataset demonstrate that the proposed model significantly outperforms classical vision-only algorithms,achieves comparable performance to current state-of-the-art vision-only methods on the nu Scenes detection leaderboard in terms of both mean average precision(mAP)and the nu Scenes detection score(NDS)metrics,and exhibits notable advantages in inference computational efficiency.Although the proposed dual-teacher paradigm incurs higher offline training costs compared to single-model approaches,it yields a streamlined and highly efficient student model suitable for resource-constrained real-time deployment.This provides an effective pathway toward low-cost,high-performance autonomous driving perception systems. 展开更多
关键词 3D object detection bird's-eye-view(BEV) knowledge distillation multimodal fusion lightweight model
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LLMKB:Large Language Models with Knowledge Base Augmentation for Conversational Recommendation
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作者 FANG Xiu QIU Sijia +1 位作者 SUN Guohao LU Jinhu 《Journal of Donghua University(English Edition)》 2026年第1期91-103,共13页
Conversational recommender systems(CRSs)focus on refining preferences and providing personalized recommendations through natural language interactions and dialogue history.Large language models(LLMs)have shown outstan... Conversational recommender systems(CRSs)focus on refining preferences and providing personalized recommendations through natural language interactions and dialogue history.Large language models(LLMs)have shown outstanding performance across various domains,thereby prompting researchers to investigate their applicability in recommendation systems.However,due to the lack of task-specific knowledge and an inefficient feature extraction process,LLMs still have suboptimal performance in recommendation tasks.Therefore,external knowledge sources,such as knowledge graphs(KGs)and knowledge bases(KBs),are often introduced to address the issue of data sparsity.Compared to KGs,KBs possess higher retrieval efficiency,making them more suitable for scenarios where LLMs serve as recommenders.To this end,we introduce a novel framework integrating LLMs with KBs for enhanced retrieval generation,namely LLMKB.LLMKB initially leverages structured knowledge to create mapping dictionaries,extracting entity-relation information from heterogeneous knowledge to construct KBs.Then,LLMKB achieves the embedding calibration between user information representations and documents in KBs through retrieval model fine-tuning.Finally,LLMKB employs retrievalaugmented generation to produce recommendations based on fused text inputs,followed by post-processing.Experiment results on two public CRS datasets demonstrate the effectiveness of our framework.Our code is publicly available at the link:https://anonymous.4open.science/r/LLMKB-6FD0. 展开更多
关键词 recommender system large language model(LLM) knowledge base(KB)
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Towards mechanism-based tau-targeted therapies
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作者 Lidia Bakota Roland Brandt 《Neural Regeneration Research》 2026年第2期687-688,共2页
Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta... Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,tau is not an easy target because it dynamically interacts with microtubules and other cellular components,which presents a challenge for tau-targeted drugs.New cellular models could aid the development of mechanism-based tau-targeted therapies. 展开更多
关键词 tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively
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Koopman-Based Robust Model Predictive Control With Online Identification for Nonlinear Dynamical Systems
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作者 Ruiqi Ke Jingchuan Tang +1 位作者 Zongyu Zuo Yan Shi 《IEEE/CAA Journal of Automatica Sinica》 2025年第9期1947-1949,共3页
Dear Editor,This letter presents a novel approach to the data-driven control of unknown nonlinear systems.By leveraging online sparse identification based on the Koopman operator,a high-dimensional linear system model... Dear Editor,This letter presents a novel approach to the data-driven control of unknown nonlinear systems.By leveraging online sparse identification based on the Koopman operator,a high-dimensional linear system model approximating the actual system is obtained online.The upper bound of the discrepancy between the identified model and the actual system is estimated using real-time prediction error,which is then utilized in the design of a tube-based robust model predictive controller.The effectiveness of the proposed approach is validated by numerical simulation. 展开更多
关键词 koopman operatora online identification tube based control real time prediction error online sparse identification identified model Koopman based control robust model predictive control
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Modeling of the Mechanical Properties of Blend Based Polymer Nanocomposites Considering the Effects of Janus Nanoparticles on Polymer/Polymer Interface 被引量:5
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作者 Esmail Sharifzadeh 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2019年第2期164-177,共14页
Blend based polymer nanocomposites, comprising Janus nanoparticles at their polymer/polymer interface, were analytically/experimentally evaluated. The modeling procedure was performed in two stages: first, modeling of... Blend based polymer nanocomposites, comprising Janus nanoparticles at their polymer/polymer interface, were analytically/experimentally evaluated. The modeling procedure was performed in two stages: first, modeling of polymer/polymer interface region comprising Janus nanoparticles and second, modeling of the entire systems as a function of the variation of the blend morphology.In the first stage, the modeling procedure was performed based on the development of the model proposed by Ji et al. and in the second stage, the fundamental of Kolarik's model was used in order to propose a developed and more practical model. It was shown that Janus nanoparticles may form dual polymer/particle interphase at polymer/polymer interface which can drastically affect the final mechanical properties of the system. Comparing the results of tensile tests imposed on different prepared samples with the predictions of the model proved its accuracy and reliability(error < 9%). 展开更多
关键词 BLEND based POLYMER nanocomposites JANUS NANOPARTICLES modeling of MECHANICAL properties
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A criterion for selecting the appropriate one from the trained models for model-based offline policy evaluation
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作者 Chongchong Li Yue Wang +1 位作者 Zhi-Ming Ma Yuting Liu 《CAAI Transactions on Intelligence Technology》 2025年第1期223-234,共12页
Offline policy evaluation,evaluating and selecting complex policies for decision-making by only using offline datasets is important in reinforcement learning.At present,the model-based offline policy evaluation(MBOPE)... Offline policy evaluation,evaluating and selecting complex policies for decision-making by only using offline datasets is important in reinforcement learning.At present,the model-based offline policy evaluation(MBOPE)is widely welcomed because of its easy to implement and good performance.MBOPE directly approximates the unknown value of a given policy using the Monte Carlo method given the estimated transition and reward functions of the environment.Usually,multiple models are trained,and then one of them is selected to be used.However,a challenge remains in selecting an appropriate model from those trained for further use.The authors first analyse the upper bound of the difference between the approximated value and the unknown true value.Theoretical results show that this difference is related to the trajectories generated by the given policy on the learnt model and the prediction error of the transition and reward functions at these generated data points.Based on the theoretical results,a new criterion is proposed to tell which trained model is better suited for evaluating the given policy.At last,the effectiveness of the proposed criterion is demonstrated on both benchmark and synthetic offline datasets. 展开更多
关键词 offline policy evaluation reinforcement learning model based
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Research on Real-Time Object Detection and Tracking for UAV Surveillance Based on Deep Learning
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作者 Fei Liu Lu Jia Sichuan 《Journal of Electronic Research and Application》 2025年第3期235-240,共6页
To address the challenges of low accuracy and insufficient real-time performance in dynamic object detection for UAV surveillance,this paper proposes a novel tracking framework that integrates a lightweight improved Y... To address the challenges of low accuracy and insufficient real-time performance in dynamic object detection for UAV surveillance,this paper proposes a novel tracking framework that integrates a lightweight improved YOLOv5s model with adaptive motion compensation.A UAV-view dynamic feature enhancement strategy is innovatively introduced,and a lightweight detection network combining attention mechanisms and multi-scale fusion is constructed.The robustness of tracking under motion blur scenarios is also optimized.Experimental results demonstrate that the proposed method achieves a mAP@0.5 of 68.2%on the VisDrone dataset and reaches an inference speed of 32 FPS on the NVIDIA Jetson TX2 platform.This significantly improves the balance between accuracy and efficiency in complex scenes,offering reliable technical support for real-time applications such as emergency response. 展开更多
关键词 UAV surveillance Real-time object detection Deep learning Lightweight model Motion compensation
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Preliminary Design and Application of a Longitudinal Trajectory Model for Prognosis of Intracerebral Hemorrhage Based on Blood Urea Nitrogen Characteristics
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作者 GUO Dong-bin QI Xiao-long HUANG Jun-long 《Chinese Journal of Biomedical Engineering(English Edition)》 2025年第3期118-124,共7页
Objective:To preliminarily construct and apply a longitudinal trajectory model for the prognosis of intracerebral hemorrhage(ICH)based on blood urea nitrogen(BUN)characteristics.Methods:Clinical data from 320 ICH pati... Objective:To preliminarily construct and apply a longitudinal trajectory model for the prognosis of intracerebral hemorrhage(ICH)based on blood urea nitrogen(BUN)characteristics.Methods:Clinical data from 320 ICH patients admitted to our hospital between 2020 and 2024 were collected,including demographic information,National Institutes of Health Stroke Scale(NIHSS)scores at admission,dynamic changes in BUN levels during treatment,and 30-day survival outcomes.A latent class growth model(LCGM)was first used for preliminary modeling,followed by a latent growth mixture modeling(GMM)approach to determine the final model.Three classes of BUN trajectories for ICH prognosis were identified,and latent classes were established.GMM modeling was then performed on these latent classes,considering linear,quadratic,and cubic polynomial forms;six GMM models were constructed and individuals were assigned to latent trajectory groups for validation.Results:LCGM analysis ultimately identified three dynamic BUN trajectory groups:Sustained low-level group(76 cases,23.8%):BUN remained stable between 3.1-9.0 mmol/L,with the highest 30-day survival rate(98.7%).Fluctuating-declining group(222 cases,69.4%):BUN initially increased and then slowly decreased(peak at day 3:15.2 mmol/L),with a 30-day mortality of 8.1%(18/222),higher than the sustained low-level group.Sustained high-level group(22 cases,6.9%):BUN mean>9.0 mmol/L,with a 30-day mortality of 41.7%(P=0.000).GMM model fitting showed that the cubic polynomial GMM model was optimal(AIC=6754.474,BIC=6852.450,Entropy=0.905).Incorporating gender,age,and BMI as covariates revealed significant effects for gender(Estimate=0.045,-0.011,P=0.000,0.000).The AUC for predicting 30-day mortality was 0.88(sensitivity 82.8%,specificity 77.9%),which increased to 0.89 when combined with admission NIHSS scores.Conclusion:The LCGM+GMM model based on dynamic BUN trajectories effectively distinguishes prognostic subgroups in ICH patients.Patients with persistently elevated or fluctuating-rising BUN levels have a significantly higher mortality risk compared to those with sustained low levels.This model provides a new quantitative tool for early identification of high-risk patients and poor prognoses. 展开更多
关键词 Blood urea nitrogen construct apply longitudinal trajectory model intracerebral hemorrhage ich based Longitudinal trajectory model Intracerebral hemorrhage Latent growth mixture modeling PROGNOSIS latent class growth model lcgm
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