Based on Kunming statistical yearbook and field survey data of agricultural non-point source pollution in counties or districts in the Dianchi Lake basin,previous and current situation of agricultural production and a...Based on Kunming statistical yearbook and field survey data of agricultural non-point source pollution in counties or districts in the Dianchi Lake basin,previous and current situation of agricultural production and agricultural non-point source pollution control in the Dianchi Lake basin were studied,and countermeasures and suggestions of comprehensive control of agricultural non-point source pollution in the basin were proposed.展开更多
Lung squamous cell carcinoma （LUSC） causes approximately 400 000 deaths each year worldwide. The occurrence of LUSC is attributed to exposure to cigarette smoke, which induces the development of numerous genomic abn...Lung squamous cell carcinoma （LUSC） causes approximately 400 000 deaths each year worldwide. The occurrence of LUSC is attributed to exposure to cigarette smoke, which induces the development of numerous genomic abnormalities. However, few studies have investigated the genomic variations that occur only in normal tissues that have been similarly exposed to tobacco smoke as tumor tissues. In this study, we sequenced the whole genomes of three normal lung tissue samples and their paired adjacent squamous cell carcinomas. We then called genomic variations specific to the normal lung tissues through filtering the genomic sequence of the normal lung tissues against that of the paired tumors, the reference human genome, the dbSNP138 common germline variants, and the variations derived from sequencing artifacts. To expand these observations, the whole exome sequences of 478 counterpart normal controls （CNCs） and paired LUSCs of The Cancer Genome Atlas （TCGA） dataset were analyzed. Sixteen genomic variations were called in the three normal lung tissues. These variations were confirmed by Sanger capillary sequencing. A mean of 0.5661 exonic variations/Mb and 7.7887 altered genes per sample were identified in the CNC genome sequences of TCGA. In these CNCs, C：G→T：A transitions, which are the genomic signatures of tobacco carcinogen N-methyl-N-nitro-N-nitrosoguanidine, were the predominant nucleotide changes. Twenty five genes in CNCs had a variation rate that exceeded 2%, including ARSD （18.62%）, MUC4 （8.79%）, and RBMX（7.11%）. CNC variations in CTAGE5 and USP17L7were associated with the poor prognosis of patients with LUSC. Our results uncovered previously unreported genomic variations in CNCs, rather than LUSCs, that may be involved in the develooment of LUSC.展开更多
In this paper, a discussion is devoted to the theory and method of a reversed-frame normalization design to robust flight control system. The robust stability theory of the normal transfer function matrix with the sam...In this paper, a discussion is devoted to the theory and method of a reversed-frame normalization design to robust flight control system. The robust stability theory of the normal transfer function matrix with the same characteristic gain loci is proved. An example of flight control system design shows the application and advantage of this method.展开更多
Hyperimmune sera (HIS), raised against crude giardia antigen, on in vitro interaction, caused more agglutination of Giardia lamblia trophozoites. Heat inactivated HIS possessed a comparable agglutinating activity as t...Hyperimmune sera (HIS), raised against crude giardia antigen, on in vitro interaction, caused more agglutination of Giardia lamblia trophozoites. Heat inactivated HIS possessed a comparable agglutinating activity as the non-inactivated controls. Non-inactivated normal (unimmunized) serum caused immobilization of Giardia trophozoite, which was checked on heat inactivation. Antibodies in immune sera are mainly responsible for agglutination, whereas the heat labile non-immune components control the mobility of the intestinal parasite.展开更多
New coronavirus pneumonia spread rapidly all over the world in the first half of 2020, which is a new respiratory disease with strong infectiousness. At present, the epidemic situation in China has been effectively co...New coronavirus pneumonia spread rapidly all over the world in the first half of 2020, which is a new respiratory disease with strong infectiousness. At present, the epidemic situation in China has been effectively controlled, but the global epidemic situation remains grim, and the National Health Commission has instructed that the prevention and control of new coronavirus pneumonia should become normalized. As outposts for surveillance of public health events, hospitals are an important front in the fight against the epidemic. Therefore, it is very crucial to construct infection prevention and control system actively to contain the outbreak. This paper analyzes and summarizes the normal prevention and control management strategy of Infection Control Branch Management (hereinafter referred to as Hospital Infection-Control Dept) in a certain designated comprehensive third-grade hospital in Guangdong Province and transforms the prevention and control means in emergency state into measures for sustainable development, which also provides basis and reference for Hospital Infection-Control Dept of medical institutions to formulate prevention and control guidelines.展开更多
For a class of nonlinear systems with dynamic uncertainties, robust adaptive stabilization problem is considered in this paper. Firstly, by introducing an observer, an augmented system is obtained. Based on the system...For a class of nonlinear systems with dynamic uncertainties, robust adaptive stabilization problem is considered in this paper. Firstly, by introducing an observer, an augmented system is obtained. Based on the system, we construct an exp-ISpS Lyapunov function for the unmodeled dynamics, prove that the unmodeled dynamics is exp-ISpS, and then obtain a dynamic normalizing signal to counteract the dynamic disturbances. By the backstepping technique, an adaptive controller is given, it is proved that all the signals in the adaptive control system are globally uniformly ultimately bounded, and the output can be regulated to the origin with any prescribed accuracy. A simulation example further demonstrates the efficiency of the control scheme.展开更多
The time delay-induced instability in an Internet congestion control model is investigated. The star topology is considered, and the link bandwidth ratio and the control gain are selected as the tunable parameters for...The time delay-induced instability in an Internet congestion control model is investigated. The star topology is considered, and the link bandwidth ratio and the control gain are selected as the tunable parameters for congestion suppression. The stability switch boundary is obtained by the eigenvalue analysis for the linearized system around the equilibrium. To investigate the oscillatory congestion when the equilibrium becomes unstable, the center manifold reduction and the normal form theory are used to study the periodic oscillation induced by the delay. The theoretical analysis and numerical simulation show that the ratio between bandwidths of the trunk link and the regular link,rather than these bandwidths themselves, is crucial for the stability of the congestion control system. The present results demonstrate that it is not always effective to increase the link bandwidth ratio for stabilizing the system, and for some certain delays, adjusting the control gain is more efficient.展开更多
Relative radiometric normalization (RRN) minimizes radiometric differences among images caused by inconsistencies of acquisition conditions rather than changes in surface. Scale invariant feature transform (SIFT) has ...Relative radiometric normalization (RRN) minimizes radiometric differences among images caused by inconsistencies of acquisition conditions rather than changes in surface. Scale invariant feature transform (SIFT) has the ability to automatically extract control points (CPs) and is commonly used for remote sensing images. However, its results are mostly inaccurate and sometimes contain incorrect matching caused by generating a small number of false CP pairs. These CP pairs have high false alarm matching. This paper presents a modified method to improve the performance of SIFT CPs matching by applying sum of absolute difference (SAD) in a different manner for the new optical satellite generation called near-equatorial orbit satellite and multi-sensor images. The proposed method, which has a significantly high rate of correct matches, improves CP matching. The data in this study were obtained from the RazakSAT satellite a new near equatorial satellite system. The proposed method involves six steps: 1) data reduction, 2) applying the SIFT to automatically extract CPs, 3) refining CPs matching by using SAD algorithm with empirical threshold, and 4) calculation of true CPs intensity values over all image’ bands, 5) preforming a linear regression model between the intensity values of CPs locate in reverence and sensed image’ bands, 6) Relative radiometric normalization conducting using regression transformation functions. Different thresholds have experimentally tested and used in conducting this study (50 and 70), by followed the proposed method, and it removed the false extracted SIFT CPs to be from 775, 1125, 883, 804, 883 and 681 false pairs to 342, 424, 547, 706, 547, and 469 corrected and matched pairs, respectively.展开更多
The wash-out filter （WF） technique is used to control the flutter of a two dimensional airfoil with cubic non-linearity in incompressible flow. Firstly, Hopf bifurcation theory is used to determine the point at whic...The wash-out filter （WF） technique is used to control the flutter of a two dimensional airfoil with cubic non-linearity in incompressible flow. Firstly, Hopf bifurcation theory is used to determine the point at which the nonlinear controller is introduced. The system is then transformed into Jordan canonical form, based on analysis of linearized eigenvalues of the system. Secondly, for the introduced WF controller, the linear control gain is determined according to Hopf bifurcation condition. The sym- bolic computing program of normal form direct method （NFDM） is also used to obtain the normal form of the controlled system. The non-linear control gain can be determined based on the relation of the type of bifurcation and the parameters of the normal form, to transform sub-critical Hopf bifurcation to be su- per-critical one. Lastly, numerical simulations are used to certify the validity of theoretical analysis, in which the amplitude of flutter or limit cycle of the controlled system is reduced greatly, comparing to the original system.展开更多
基金Supported by Research on the Comprehensive Control Measures of Agricultural Non-point Source Pollution in the Dianchi Lake Basin Funded by Kunming Agricultural Bureau(2016JC01)Project of Yunnan Engineering Research Center for Urban Characteristic Agriculture(TSNY0201)+7 种基金Scientific Research Foundation of Yunnan Department of Education(2014Y390)Application Base Research Project for Young Scholars of Yunnan Province(2013FD040)Talent Introduction Project of Kunming University(YJL14005)Talent Introduction Foundation of Kunming University(YJL12010)Key Foundation of Kunming University(XJL12020)Scientific Research Project for Undergraduates of Kunming University(XJD16081)Research on the Ecology and Rational Distribution of Main Cultivars in Producing Areas of Raw Materials of China Tobacco in Yunnan ProvinceProject of Construction of the Dominant Key Subject(Ecology)in Universities and Colleges in Yunnan Province(05000511311)
文摘Based on Kunming statistical yearbook and field survey data of agricultural non-point source pollution in counties or districts in the Dianchi Lake basin,previous and current situation of agricultural production and agricultural non-point source pollution control in the Dianchi Lake basin were studied,and countermeasures and suggestions of comprehensive control of agricultural non-point source pollution in the basin were proposed.
基金This work was supported by the National Natural Science Funds of China for Distinguished Young Scholar （No. 81425025）, the National Key Research and Development Program of China （No. 2016YFC0905500）, the National Natural Science Foundation of China （No. 81672765）, the Strategic Priority Research Program of the Chinese Academy of Sciences （No. XDA 12010307）, and grants from the State Key Laboratory of Membrane Biology. The funders had no role in the design, data collection, and analysis of the study or in the preparation of and the decision to publish the manuscript. The results shown here are partly based on the data generated by The Cancer Genome Atlas, which is managed by the NCI and NHGRI. Information about TCGA can be found at http：//cancergenome.nih. gov. The dbGaP accession number is phs000178.v9.p8.
文摘Lung squamous cell carcinoma （LUSC） causes approximately 400 000 deaths each year worldwide. The occurrence of LUSC is attributed to exposure to cigarette smoke, which induces the development of numerous genomic abnormalities. However, few studies have investigated the genomic variations that occur only in normal tissues that have been similarly exposed to tobacco smoke as tumor tissues. In this study, we sequenced the whole genomes of three normal lung tissue samples and their paired adjacent squamous cell carcinomas. We then called genomic variations specific to the normal lung tissues through filtering the genomic sequence of the normal lung tissues against that of the paired tumors, the reference human genome, the dbSNP138 common germline variants, and the variations derived from sequencing artifacts. To expand these observations, the whole exome sequences of 478 counterpart normal controls （CNCs） and paired LUSCs of The Cancer Genome Atlas （TCGA） dataset were analyzed. Sixteen genomic variations were called in the three normal lung tissues. These variations were confirmed by Sanger capillary sequencing. A mean of 0.5661 exonic variations/Mb and 7.7887 altered genes per sample were identified in the CNC genome sequences of TCGA. In these CNCs, C：G→T：A transitions, which are the genomic signatures of tobacco carcinogen N-methyl-N-nitro-N-nitrosoguanidine, were the predominant nucleotide changes. Twenty five genes in CNCs had a variation rate that exceeded 2%, including ARSD （18.62%）, MUC4 （8.79%）, and RBMX（7.11%）. CNC variations in CTAGE5 and USP17L7were associated with the poor prognosis of patients with LUSC. Our results uncovered previously unreported genomic variations in CNCs, rather than LUSCs, that may be involved in the develooment of LUSC.
基金This paper has been supported by the National Natural Science Foundation of Chaina.
文摘In this paper, a discussion is devoted to the theory and method of a reversed-frame normalization design to robust flight control system. The robust stability theory of the normal transfer function matrix with the same characteristic gain loci is proved. An example of flight control system design shows the application and advantage of this method.
文摘Hyperimmune sera (HIS), raised against crude giardia antigen, on in vitro interaction, caused more agglutination of Giardia lamblia trophozoites. Heat inactivated HIS possessed a comparable agglutinating activity as the non-inactivated controls. Non-inactivated normal (unimmunized) serum caused immobilization of Giardia trophozoite, which was checked on heat inactivation. Antibodies in immune sera are mainly responsible for agglutination, whereas the heat labile non-immune components control the mobility of the intestinal parasite.
文摘New coronavirus pneumonia spread rapidly all over the world in the first half of 2020, which is a new respiratory disease with strong infectiousness. At present, the epidemic situation in China has been effectively controlled, but the global epidemic situation remains grim, and the National Health Commission has instructed that the prevention and control of new coronavirus pneumonia should become normalized. As outposts for surveillance of public health events, hospitals are an important front in the fight against the epidemic. Therefore, it is very crucial to construct infection prevention and control system actively to contain the outbreak. This paper analyzes and summarizes the normal prevention and control management strategy of Infection Control Branch Management (hereinafter referred to as Hospital Infection-Control Dept) in a certain designated comprehensive third-grade hospital in Guangdong Province and transforms the prevention and control means in emergency state into measures for sustainable development, which also provides basis and reference for Hospital Infection-Control Dept of medical institutions to formulate prevention and control guidelines.
基金Supported-by Program for New Century Excellent Talents in Universities of China （NCET-05-0607）, National Natural Science Foundation of China （60774010）, and Program for Fundamental Research of Natural Sciences in Universities of Jiangsu Province （07KJB510114）
基金Supported by Program for New Century Excellent Talents in Universities of China （NCET-05-0607）, National Natural Science Foundation of China （60774010）, and Project for Fundamental Research of Natural Sciences in Universities of Jiangsu Province （07KJB510114）
基金This work was supported by the National Natural Science Foundation of China (No. 60304003)Program for New Century Excellent Talents in University (No. NCET-05-0607).
文摘For a class of nonlinear systems with dynamic uncertainties, robust adaptive stabilization problem is considered in this paper. Firstly, by introducing an observer, an augmented system is obtained. Based on the system, we construct an exp-ISpS Lyapunov function for the unmodeled dynamics, prove that the unmodeled dynamics is exp-ISpS, and then obtain a dynamic normalizing signal to counteract the dynamic disturbances. By the backstepping technique, an adaptive controller is given, it is proved that all the signals in the adaptive control system are globally uniformly ultimately bounded, and the output can be regulated to the origin with any prescribed accuracy. A simulation example further demonstrates the efficiency of the control scheme.
基金Project supported by the National Natural Science Foundation of China(Nos.11572224,11502168,11772229,and 11872277)
文摘The time delay-induced instability in an Internet congestion control model is investigated. The star topology is considered, and the link bandwidth ratio and the control gain are selected as the tunable parameters for congestion suppression. The stability switch boundary is obtained by the eigenvalue analysis for the linearized system around the equilibrium. To investigate the oscillatory congestion when the equilibrium becomes unstable, the center manifold reduction and the normal form theory are used to study the periodic oscillation induced by the delay. The theoretical analysis and numerical simulation show that the ratio between bandwidths of the trunk link and the regular link,rather than these bandwidths themselves, is crucial for the stability of the congestion control system. The present results demonstrate that it is not always effective to increase the link bandwidth ratio for stabilizing the system, and for some certain delays, adjusting the control gain is more efficient.
文摘Relative radiometric normalization (RRN) minimizes radiometric differences among images caused by inconsistencies of acquisition conditions rather than changes in surface. Scale invariant feature transform (SIFT) has the ability to automatically extract control points (CPs) and is commonly used for remote sensing images. However, its results are mostly inaccurate and sometimes contain incorrect matching caused by generating a small number of false CP pairs. These CP pairs have high false alarm matching. This paper presents a modified method to improve the performance of SIFT CPs matching by applying sum of absolute difference (SAD) in a different manner for the new optical satellite generation called near-equatorial orbit satellite and multi-sensor images. The proposed method, which has a significantly high rate of correct matches, improves CP matching. The data in this study were obtained from the RazakSAT satellite a new near equatorial satellite system. The proposed method involves six steps: 1) data reduction, 2) applying the SIFT to automatically extract CPs, 3) refining CPs matching by using SAD algorithm with empirical threshold, and 4) calculation of true CPs intensity values over all image’ bands, 5) preforming a linear regression model between the intensity values of CPs locate in reverence and sensed image’ bands, 6) Relative radiometric normalization conducting using regression transformation functions. Different thresholds have experimentally tested and used in conducting this study (50 and 70), by followed the proposed method, and it removed the false extracted SIFT CPs to be from 775, 1125, 883, 804, 883 and 681 false pairs to 342, 424, 547, 706, 547, and 469 corrected and matched pairs, respectively.
文摘The wash-out filter （WF） technique is used to control the flutter of a two dimensional airfoil with cubic non-linearity in incompressible flow. Firstly, Hopf bifurcation theory is used to determine the point at which the nonlinear controller is introduced. The system is then transformed into Jordan canonical form, based on analysis of linearized eigenvalues of the system. Secondly, for the introduced WF controller, the linear control gain is determined according to Hopf bifurcation condition. The sym- bolic computing program of normal form direct method （NFDM） is also used to obtain the normal form of the controlled system. The non-linear control gain can be determined based on the relation of the type of bifurcation and the parameters of the normal form, to transform sub-critical Hopf bifurcation to be su- per-critical one. Lastly, numerical simulations are used to certify the validity of theoretical analysis, in which the amplitude of flutter or limit cycle of the controlled system is reduced greatly, comparing to the original system.
