期刊文献+
共找到1,101,056篇文章
< 1 2 250 >
每页显示 20 50 100
Nonlinear Dynamic Analysis of Temperature Characteristics in Oscillating Heat Pipes Under Radial Rotations
1
作者 Ning Qian Fan Jiang +4 位作者 Marco Bernagozzi Jiajia Chen Marco Marengo Yucan Fu Jiuhua Xu 《Chinese Journal of Mechanical Engineering》 2025年第6期548-561,共14页
Radial rotating oscillating heat pipes(R-OHPs)have excellent thermal performance and great potential for application in the thermal management of rotatory machinery.However,the heat transport behavior and temperature ... Radial rotating oscillating heat pipes(R-OHPs)have excellent thermal performance and great potential for application in the thermal management of rotatory machinery.However,the heat transport behavior and temperature characteristics of R-OHPs are complex,and their understanding is still limited,hence necessitating further research.In this study,thanks to an experimental investigation involving a copper R-OHP running with acetone and water,its thermal performance is evaluated,and then the temperature characteristics are analyzed by nonlinear dynamic analysis.The study reveals that the effective heat transfer coefficient of R-OHPs undergoes a notable increase with rising rotational speed,exhibiting a peak at a threshold speed value.Such a peak is present irrespectively of the working fluid,and,after exceeding the threshold,higher rotational speeds lead to a lower thermal performance.Based on nonlinear dynamic analysis,the power spectrum density of the evaporator temperature indicates a lack of dominant frequency in temperature signals,suggesting a complex behavior characterized by random oscillations of vapor slugs and liquid plugs.In order to better understand how strong the chaotic behavior is,an autocorrelation analysis was carried out,the OHP at static state has a stronger chaos than R-OHPs.The correlation dimension analysis of the evaporator temperature provides values ranging from 1.2 to 1.6,which together with the Lyapunov exponent calculations,further support an evident chaotic nature of R-OHPs. 展开更多
关键词 Temperature characteristics Oscillating heat pipe nonlinear dynamics analysis Radial rotations
在线阅读 下载PDF
Nonlinear stress analysis of aero-engine pipeline based on semi-analytical method
2
作者 Weijiao CHEN Xiaochi QU +3 位作者 Ruixin ZHANG Xumin GUO Hui MA Bangchun WEN 《Applied Mathematics and Mechanics(English Edition)》 2025年第3期521-538,共18页
Fatigue failure caused by vibration is the most common type of pipeline failure.The core of this research is to obtain the nonlinear dynamic stress of a pipeline system accurately and efficiently,a topic that needs to... Fatigue failure caused by vibration is the most common type of pipeline failure.The core of this research is to obtain the nonlinear dynamic stress of a pipeline system accurately and efficiently,a topic that needs to be explored in the existing literature.The shell theory can better simulate the circumferential stress distribution,and thus the Mindlin-Reissner shell theory is used to model the pipeline.In this paper,the continuous pipeline system is combined with clamps through modal expansion for the first time,which realizes the coupling problem between a shell and a clamp.While the Bouc-Wen model is used to simulate the nonlinear external force generated by a clamp,the nonlinear coupling characteristics of the system are effectively captured.Then,the dynamic equation of the clamp-pipeline system is established according to the Lagrange energy equation.Based on the resonance frequency and stress amplitude obtained from the experiment,the nonlinear parameters of the clamp are identified with the semi-analytical method(SAM)and particle swarm optimization(PSO)algorithm.This study provides a theoretical basis for the clamp-pipeline system and an efficient and universal solution for stress prediction and analysis of pipelines in engineering. 展开更多
关键词 pipeline modeling stress analysis nonlinear-clamp support nonlinear vibration
在线阅读 下载PDF
Nonlinear effect analysis and compensation based on improved friction observer for torque rotating stage
3
作者 Yingjie Jia Bo Liu +1 位作者 Hui Tang Yuzhang Wei 《Nanotechnology and Precision Engineering》 2025年第3期138-148,共11页
In semiconductor precision packaging and other applications involving alignment of automated equipment,the nonlinear motion caused by structural characteristics and friction effects on torque-type rotating motion stag... In semiconductor precision packaging and other applications involving alignment of automated equipment,the nonlinear motion caused by structural characteristics and friction effects on torque-type rotating motion stages seriously affects output accuracy and stability.To solve this problem,the motion characteristics of a rotating stage and the mechanism by which friction nonlinearity influences accuracy are analyzed in detail.In addition,a compound control strategy based on a kinematic model and the Stribeck friction model is designed.A friction disturbance observer based on output position feedback is improved for simple parameter tuning.Finally,an experimental system is constructed to carry out validation tests,including identification of nonlinear characteristics and performance comparisons.The experimental results show that the linear tracking error of the torque-type rotating stage is less than 1.47µm after adoption of the proposed model-based composite control strategy,and the corresponding rotary angle deviation is less than 0.0153°.The linearity of output motion is increased to 97.59%and the error compensation effect is improved by 51.6%compared with the PID control method.The experimental results confirm that the analysis method adopted here and the proposed compensation strategy can effectively reduce frictional nonlinearity and improve motion accuracy.The proposed method can also be applied to other precision electromechanical systems. 展开更多
关键词 Rotating stage Mechanical analysis Frictional nonlinear effect Disturbance observation
在线阅读 下载PDF
Nonlinear frequency prediction and uncertainty analysis for fully clamped laminates by using a self-developed multi-scale neural networks system
4
作者 Yuan LIU Xuan ZHANG +6 位作者 Xibin CAO Jinsheng GUO Zhongxi SHAO Qingyang DENG Pengbo FU Yaodong HOU Haipeng CHEN 《Chinese Journal of Aeronautics》 2025年第9期225-250,共26页
To improve design accuracy and reliability of structures,this study solves the uncertain natural frequencies with consideration for geometric nonlinearity and structural uncertainty.Frequencies of the laminated plate ... To improve design accuracy and reliability of structures,this study solves the uncertain natural frequencies with consideration for geometric nonlinearity and structural uncertainty.Frequencies of the laminated plate with all four edges clamped(CCCC)are derived based on Navier's method and Galerkin's method.The novelty of the current work is that the number of unknowns in the displacement field model of a CCCC plate with free midsurface(CCCC-2 plate)is only three compared with four or five in cases of other exposed methods.The present analytical method is proved to be accurate and reliable by comparing linear natural frequencies and nonlinear natural frequencies with other models available in the open literature.Furthermore,a novel method for analyzing effects of mean values and tolerance zones of uncertain structural parameters on random frequencies is proposed based on a self-developed Multiscale Feature Extraction and Fusion Network(MFEFN)system.Compared with a direct Monte Carlo Simulation(MCS),the MFEFNbased procedure significantly reduces the calculation burden with a guarantee of accuracy.Our research provides a method to calculate nonlinear natural frequencies under two boundary conditions and presentes a surrogate model to predict frequencies for accuracy analysis and optimization design. 展开更多
关键词 Geometric nonlinearity LAMINATES Multiscale feature extraction and fusion networks(MFEFN) Natural frequency Uncertainty analysis
原文传递
Theoretical and Experimental Analysis of Nonlinear Large Tensile Deformation of Superelastic SMA-Based Honeycomb Structures
5
作者 Yahao Wang Wenjiong Chen +1 位作者 Renjing Gao Shutian Liu 《Acta Mechanica Solida Sinica》 2025年第1期45-64,共20页
Honeycomb structures of shape memory alloy(SMA)have become one of the most promising materials for flexible skins of morphing aircraft due to their excellent mechanical properties.However,due to the nonlinear material... Honeycomb structures of shape memory alloy(SMA)have become one of the most promising materials for flexible skins of morphing aircraft due to their excellent mechanical properties.However,due to the nonlinear material and geometric large deformation,the SMA honeycomb exhibits significant and complex nonlinearity in the skin and there is a lack of relevant previous research.In this paper,the nonlinear properties of the SMA honeycomb structure with arbitrary geometry are investigated for the first time for large deformation flexible skin applications by theoretical and experimental analysis.Firstly,a novel theoretical model of SMA honeycomb structure considering both material and geometric nonlinearity is proposed,and the corresponding calculation method of nonlinear governing equations is given based upon the shooting method and Runge–Kutta method.Then,the tensile behaviors of four kinds of SMA honeycomb structures,i.e.,U-type,V-type,cosine-type,and trapezoid-type,are analyzed and predicted by the proposed theoretical model and compared with the finite element analysis(FEA)results.Moreover,the tensile experiments were carried out by stretching U-type and V-type honeycomb structures to a global strain of 60%and 40%,respectively,to perform large deformation analysis and verify the theoretical model.Finally,experimental verification and finite element validation show that the curves of the theoretical model results,experimental results,and simulation results are in good agreement,illustrating the generalizability and accuracy of the proposed theoretical model.The theoretical model and experimental investigations in this paper are considered to provide an effective foundation for analyzing and predicting the mechanical behavior of SMA honeycomb flexible skins with large extensional deformations. 展开更多
关键词 Morphing wing Flexible skin Large deformation Geometric nonlinearity Material nonlinearity Shape memory alloy
原文传递
Flexural Nonlinear Natural Frequency Analysis of Rotational Functionally Graded Sandwich Rectangular Plates with Uniform and Inhomogeneous Pore Distributions in Thermal Environments
6
作者 Dazhi Zhang Yongqiang Li 《Acta Mechanica Solida Sinica》 2025年第4期664-676,共13页
This study investigates the nonlinear dynamic properties of rotating functionally graded sandwich rectangular plates in a thermal environment.The nonlinear vibration equations for a rotating metal-ceramic functionally... This study investigates the nonlinear dynamic properties of rotating functionally graded sandwich rectangular plates in a thermal environment.The nonlinear vibration equations for a rotating metal-ceramic functionally graded sandwich rectangular plate in a thermal environment are derived using classical thin plate theory and Hamilton’s principle,considering geometric nonlinearity,temperature-dependent material properties,and power law distribution of components through the thickness.With cantilever boundary conditions,the flexural nonlinear differential equations of the rectangular sandwich plate are obtained via the Galerkin method.Since the natural vibration differential equations exhibit nonlinear characteristics,the multiscale method is employed to derive the expression for nonlinear natural frequency.An example analysis reveals how the natural frequency of a functionally graded sandwich rectangular plate varies with rotational speed and temperature.Results show that the nonlinear/linear frequency ratio increases with rotational angular velocity Ω and thickness-to-length ratio h/a,follows a cosine-like periodic pattern with the setting angle,and shows a sharp decrease followed by a rapid increase with increasing width-to-length ratio b/a.The derived analytical solutions for nonlinear frequency provide valuable insights for assessing the dynamic characteristics of functionally graded structures. 展开更多
关键词 Rectangular plate SANDWICH Functionally graded material nonlinear natural frequency Rotational motion
原文传递
Nonlinear vibration and stability analysis of an aero-engine dual-rotor system subjected to high-frequency excitation
7
作者 Rongzhou LIN Shuangxing REN +5 位作者 Lei HOU Zeyuan CHANG Zhonggang LI Yushu CHEN Nasser A.SAEED Mohamed S.MOHAMED 《Chinese Journal of Aeronautics》 2025年第7期227-247,共21页
This paper analyzes the nonlinear dynamic characteristics and stability of Aero-Engine Dual-Rotor(AEDR)systems under high-frequency excitation,based on the Adaptive Harmonic Balance with the Asymptotic Harmonic Select... This paper analyzes the nonlinear dynamic characteristics and stability of Aero-Engine Dual-Rotor(AEDR)systems under high-frequency excitation,based on the Adaptive Harmonic Balance with the Asymptotic Harmonic Selection(AHB-AHS)method.A finite element dynamic equation for the AEDR system is introduced,considering complex nonlinearities of the intershaft bearing,unbalanced excitations,and high-frequency excitation.A solving strategy combining the AHB-AHS method and improved arclength continuation method is proposed to solve highdimensional dynamic equations containing complex nonlinearities and to track periodic solutions with parameter variations.The Floquet theory is used to analyze the types of bifurcation points in the system and the stability of periodic motions.The results indicate that high-frequency excitation can couple high-order and low-order modes,especially when the system undergoes superharmonic resonance.High-frequency excitation leads to more combination frequency harmonics,among which N_(f)ω_(1)-2ω_(2)dominates.Furthermore,changing the parameters(amplitude and frequency)of high-frequency excitation widens or shifts the unstable regions of the system.These findings contribute to understanding the mechanism of high-frequency excitation on aero-engines and demonstrate that the proposed AHB-AHS method is a powerful tool for analyzing highdimensional complex nonlinear dynamic systems under multi-frequency excitation. 展开更多
关键词 AERO-ENGINE nonlinear vibration High-dimensional rotor system INSTABILITY Harmonic balance method Adaptive harmonic balance method
原文传递
An origami-inspired nonlinear energy sink:design,modeling,and analysis
8
作者 Youcheng ZENG Hu DING J.C.JI 《Applied Mathematics and Mechanics(English Edition)》 2025年第4期601-616,共16页
Designing,modeling,and analyzing novel nonlinear elastic elements for the nonlinear energy sink(NES)have long been an attractive research topic.Since gravity is difficult to overcome,previous NES research mainly focus... Designing,modeling,and analyzing novel nonlinear elastic elements for the nonlinear energy sink(NES)have long been an attractive research topic.Since gravity is difficult to overcome,previous NES research mainly focused on horizontal vibration suppression.This study proposes an origami-inspired NES.A stacked Miura-origami(SMO)structure,consisting of two Miura-ori sheets,is adopted to construct a nonlinear elastic element.By adjusting the initial angle and the connecting crease torsional stiffness,the quasi-zero stiffness(QZS)and load-bearing capacity can be customized to match the corresponding mass,establishing the vertical SMO-NES.The dynamic model of the SMO-NES coupled with a linear oscillator(LO)is derived for vibrations in the vertical direction.The approximate analytical solutions of the dynamic equation are obtained by the harmonic balance method(HBM),and the solutions are verified numerically.The parameter design principle of the SMO-NES is provided.Finally,the vibration reduction performance of the SMO-NES is studied.The results show that the proposed SMONES can overcome gravity and achieve quasi-zero nonlinear restoring force.Therefore,the SMO-NES has the ability of wide-frequency vibration reduction,and can effectively suppress vertical vibrations.By adjusting the initial angle and connecting the crease torsional stiffness of the SMO,the SMO-NES can be achieved with different loading weights,effectively suppressing the vibrations with different primary system masses and excitation amplitudes.In conclusion,with the help of popular origami structures,this study proposes a novel NES,and starts the research of combining origami and NES. 展开更多
关键词 nonlinear energy sink(NES) stacked Miura-origami(SMO) vertical vibration quasi-zero stiffness(QZS)
在线阅读 下载PDF
The significant contribution of stochastic forcing to nonlinear energy transfer in resolvent analysis
9
作者 Youhua Wang Ting Wu Guowei He 《Theoretical & Applied Mechanics Letters》 2025年第1期1-4,共4页
Nonlinear energy transfer is represented through eddy viscosity and stochastic forcing within the framework of resolvent analysis.Previous investigations estimate the contribution of eddy-viscosity-enhanced resolvent ... Nonlinear energy transfer is represented through eddy viscosity and stochastic forcing within the framework of resolvent analysis.Previous investigations estimate the contribution of eddy-viscosity-enhanced resolvent opera-tor to nonlinear energy transfer.The present article estimates the contribution of stochastic forcing to nonlinear energy transfer and demonstrates that the contribution of stochastic forcing cannot be ignored.These results are achieved by numerically comparing the eddy-viscosity-enhanced resolvent operator and stochastic forcing with nonlinear energy transfer in turbulent channel flows.Furthermore,the numerical results indicate that composite resolvent operators can improve the prediction of nonlinear energy transfer. 展开更多
关键词 Resolvent analysis Energy transfer Eddy viscosity Stochastic forcing Composite sweeping-enhanced resolvent`
在线阅读 下载PDF
A refined nonlinear theoretical model for mechanical analysis of tunnels subjected to strike-slip faulting with multiple fault planes
10
作者 Henghong Yang Mingnian Wang +1 位作者 Li Yu Xiao Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第8期5018-5037,共20页
During strike-slip fault dislocation,multiple fault planes are commonly observed.The resulting permanent ground deformation can lead to profound structural damage to tunnels.However,existing analytical models do not c... During strike-slip fault dislocation,multiple fault planes are commonly observed.The resulting permanent ground deformation can lead to profound structural damage to tunnels.However,existing analytical models do not consider multiple fault planes.Instead,they concentrate the entire fault displacement onto a single fault plane for analysis,thereby giving rise to notable errors in the calculated results.To address this issue,a refined nonlinear theoretical model was established to analyze the mechanical responses of the tunnels subjected to multiple strike-slip fault dislocations.The analytical model considers the number of fault planes,nonlinear soil‒tunnel interactions,geometric nonlinearity,and fault zone width,leading to a significant improvement in its range of applicability and calculation accuracy.The results of the analytical model are in agreement,both qualitatively and quantitatively,with the model test and numerical results.Then,based on the proposed theoretical model,a sensitivity analysis of parameters was conducted,focusing on the variables such as the number of fault planes,fault plane distance(d),fault displacement ratio(η),burial depth(C),crossing angle(β),tunnel diameter(D),fault zone width(Wf),and strike-slip fault displacement(Δfs).The results show that the peak shear force(Vmax),bending moment(Mmax),and axial force(Nmax)decrease with increasing d.The Vmax of the tunnel is found at the fault plane with the largest fault displacement.C,D,andΔfs contribute to the increases in Vmax,Mmax,and Nmax.Additionally,increasing the number of fault planes reduces Vmax and Mmax,whereas the variation in Nmax remains minimal. 展开更多
关键词 Strike-slip fault Tunnel engineering Theoretical model Multiply fault plane nonlinear soil‒tunnel interaction Finite element method
在线阅读 下载PDF
A New Inversion-free Iterative Method for Solving the Nonlinear Matrix Equation and Its Application in Optimal Control
11
作者 GAO Xiangyu XIE Weiwei ZHANG Lina 《应用数学》 北大核心 2026年第1期143-150,共8页
In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to ... In this paper,we consider the maximal positive definite solution of the nonlinear matrix equation.By using the idea of Algorithm 2.1 in ZHANG(2013),a new inversion-free method with a stepsize parameter is proposed to obtain the maximal positive definite solution of nonlinear matrix equation X+A^(*)X|^(-α)A=Q with the case 0<α≤1.Based on this method,a new iterative algorithm is developed,and its convergence proof is given.Finally,two numerical examples are provided to show the effectiveness of the proposed method. 展开更多
关键词 nonlinear matrix equation Maximal positive definite solution Inversion-free iterative method Optimal control
在线阅读 下载PDF
Crystal structure,thermal analysis,and luminescence properties of six heterocyclic lanthanide complexes
12
作者 SONG Zihe ZHAO Jinjin +1 位作者 REN Ning ZHANG Jianjun 《无机化学学报》 北大核心 2026年第1期181-192,共12页
Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'... Six new lanthanide complexes:[Ln(3,4-DEOBA)3(4,4'-DM-2,2'-bipy)]2·2C_(2)H_(5)OH,[Ln=Dy(1),Eu(2),Tb(3),Sm(4),Ho(5),Gd(6);3,4-DEOBA-=3,4-diethoxybenzoate,4,4'-DM-2,2'-bipy=4,4'-dimethyl-2,2'-bipyridine]were successfully synthesized by the volatilization of the solution at room temperature.The crystal structures of six complexes were determined by single-crystal X-ray diffraction technology.The results showed that the complexes all have a binuclear structure,and the structures contain free ethanol molecules.Moreover,the coordination number of the central metal of each structural unit is eight.Adjacent structural units interact with each other through hydrogen bonds and further expand to form 1D chain-like and 2D planar structures.After conducting a systematic study on the luminescence properties of complexes 1-4,their emission and excitation spectra were obtained.Experimental results indicated that the fluorescence lifetimes of complexes 2 and 3 were 0.807 and 0.845 ms,respectively.The emission spectral data of complexes 1-4 were imported into the CIE chromaticity coordinate system,and their corre sponding luminescent regions cover the yellow light,red light,green light,and orange-red light bands,respectively.Within the temperature range of 299.15-1300 K,the thermal decomposition processes of the six complexes were comprehensively analyzed by using TG-DSC/FTIR/MS technology.The hypothesis of the gradual loss of ligand groups during the decomposition process was verified by detecting the escaped gas,3D infrared spectroscopy,and ion fragment information detected by mass spectrometry.The specific decomposition path is as follows:firstly,free ethanol molecules and neutral ligands are removed,and finally,acidic ligands are released;the final product is the corresponding metal oxide.CCDC:2430420,1;2430422,2;2430419,3;2430424,4;2430421,5;2430423,6. 展开更多
关键词 lanthanide complexes fluorescence property crystal structure thermal analysis
在线阅读 下载PDF
Dynamical analysis and localized waves of the n-component nonlinear Schrödinger equation with higher-order effects
13
作者 Yu Lou Guoan Xu 《Chinese Physics B》 2025年第3期204-213,共10页
Under investigation is the n-component nonlinear Schrödinger equation with higher-order effects,which describes the ultrashort pulses in the birefringent fiber.Based on the Lax pair,the eigenfunction and generali... Under investigation is the n-component nonlinear Schrödinger equation with higher-order effects,which describes the ultrashort pulses in the birefringent fiber.Based on the Lax pair,the eigenfunction and generalized Darboux transformation are derived.Next,we construct several novel higher-order localized waves and classified them into three categories:(i)higher-order rogue waves interacting with bright/antidark breathers,(ii)higher-order breather fission/fusion,(iii)higherorder breather interacting with soliton.Moreover,we explore the effects of parameters on the structure,collision process and energy distribution of localized waves and these characteristics are significantly different from previous ones.Finally,the dynamical properties of these solutions are discussed in detail. 展开更多
关键词 n-component nonlinear Schrödinger equation with higher-order effects generalized Darboux transformation localized waves soliton BREATHER rogue wave
原文传递
Changes in border-associated macrophages after stroke: Single-cell sequencing analysis 被引量:1
14
作者 Ning Yu Yang Zhao +3 位作者 Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 《Neural Regeneration Research》 2026年第1期346-356,共11页
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro... Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment. 展开更多
关键词 border-associated macrophages CLODRONATE hypoxia ISCHEMIA-REPERFUSION ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor
暂未订购
Comprehensive pan-cancer analysis of the receptor-interacting protein kinase family expression,genomic alterations,and functional implications
15
作者 Wan-Rong Li Xin Li Jian Wang 《Life Research》 2026年第1期35-44,共10页
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations... Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications. 展开更多
关键词 RIPK family pan-cancer analysis tumor mutation burden microsatellite instability gene set enrichment analysis
暂未订购
Advanced isoconversional kinetic analysis of lepidolite sulfation product decomposition reactions for selectively extracting lithium
16
作者 Yubo Liu Baozhong Ma +4 位作者 Jiahui Cheng Xiang Li Hui Yang Chengyan Wang Yongqiang Chen 《International Journal of Minerals,Metallurgy and Materials》 2026年第1期217-227,共11页
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A... The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium. 展开更多
关键词 LITHIUM LEPIDOLITE decomposition reactions KINETICS isoconversional analysis
在线阅读 下载PDF
Global research status in the treatment of glaucoma:a systematic bibliometric analysis
17
作者 Wen-Hui Liu Chang Shu +1 位作者 Bei-Di Jia Xiao-Rong Li 《International Journal of Ophthalmology(English edition)》 2026年第2期379-392,共14页
AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current resea... AIM:To present an overview of the research on global glaucoma treatment in the last decade in terms of publication year,journals,countries/regions,organizations,references,and keywords,to investigate the current research international trends and hot topics in this area.METHODS:Bibliometric analysis was conducted on 9128 articles in the Web of Science Core Collection(WoSCC;Clarivate)database.Quantitative and qualitative analysis was employed using VOSviewer(v1.6.18),Pajek(v1.0.0.0),and CiteSpace(v6.1.R2)software.RESULTS:The 9128 papers relating to glaucoma treatment were published from April 2013 to April 2023,of which 7482 articles(82%)were original research articles and 1464(18%)were review articles.The United States(2867)and Johns Hopkins University(166)were the most productive country and institution,respectively,but the University College London had the highest h-index(54).The Journal of Glaucoma was the most productive and Ophthalmology had the highest h-index compared with other journals.The Keywords of interest included treatment surgery,cyclophotocoagulation,minimally invasive glaucoma surgery(MIGS),trabeculectomy,baerveldt,epidemiology,medication adherence,nanoparticle,optical coherence tomography(OCT),gene therapy,and artificial intelligence(AI).Glaucoma surgery appeared as a current research hotspot through the analysis of keywords.CONCLUSION:This study provides insights into the research trends and potential research hotspots in the treatment of glaucoma.This will help researchers to evaluate research policies and to promote international cooperation. 展开更多
关键词 glaucoma treatment bibliometric analysis SURGERY minimally invasive glaucoma surgery NANOPARTICLE
原文传递
Combined Fault Tree Analysis and Bayesian Network for Reliability Assessment of Marine Internal Combustion Engine
18
作者 Ivana Jovanović Çağlar Karatuğ +1 位作者 Maja Perčić Nikola Vladimir 《哈尔滨工程大学学报(英文版)》 2026年第1期239-258,共20页
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ... This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels. 展开更多
关键词 Fault tree analysis Bayesian network RELIABILITY REDUNDANCY Internal combustion engine
在线阅读 下载PDF
Sensitivity analysis of rod rearrangement in criticality safety for PWR fuel assemblies under transportation accidents
19
作者 Xin‑Ling Dai De‑Chang Cai +1 位作者 Yan‑Min Zhang Jin Cai 《Nuclear Science and Techniques》 2026年第1期263-282,共20页
To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains i... To ensure the safe transportation of radioactive materials,numerous countries have established specific standards.For the transfer of fissile materials,it is imperative that the material within the packaging remains in a subcritical state during routine,normal,and accidental transport conditions.In the event of an accident,the rods within the storage tank may become rearranged,introducing uncertainty that must be accounted for to ensure that criticality analysis results are conservative.Historically,this uncertainty was addressed overly conservatively due to limited research on non-uniform arrangement scenarios,which proved unsuitable for criticality safety analysis of spent fuel packages.This paper introduced three distinct methods to non-uniformly rearrange fuel rods—Uniform Arrangement by Blocks,Layer-by-Layer Determination,and Birdcage Deformation—and meticulously evaluates the influences of rod rearrangement on the effective multiplication factor of neutrons,k eff,utilizing the Monte Carlo method.Ultimately,this study presents a holistic method capable of encompassing the entire spectrum of potential effects stemming from the rearrangement of fuel rods during rods mispositioning accident.By augmenting the safety margin,this approach proves to be adeptly suited for the criticality safety analysis of nuclear fuel transport containers. 展开更多
关键词 Criticality safety analysis Fuel transports Rods mispositioning accident Non-uniform arrangement
在线阅读 下载PDF
Heavy metal risks and policy analysis on using industrial waste salts for making value-added snow-melting agents
20
作者 Yubiao Ma Jiaxin Yin +2 位作者 Yunfei Wang Lei Wang Jianxin Zhu 《Journal of Environmental Sciences》 2026年第1期756-766,共11页
Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may po... Industrial waste salts are commonly used to make value-added snow-melting agents to ensure traffic safety in northern China during winter and spring after snowfall.However,heavy metals in industrial waste salts may pose certain environmental risks.Snow-melting agents and snow samples were collected and analyzed from highways,arterial roads,footbridges,and other locations in Beijing after the snowstorm in December 2023.It was found that the main component of snow-melting agents was sodium chloride with high concentrations of Cu,Mn,and Zn,which are not regulated in the current policies,despite the recent promotion of environmentally friendly snow-melting agents.The Pb,Zn and Cr contents of some snow samples exceeded the limitation value of surface water quality standards,potentially affecting the soil and water environment near roadsides,although the snow-melting agents comply with relevant standards,which indicates the policy gap in the management of recycled industrial salts.We reviewed and analyzed the relevant standards for snow-melting agents and industrial waste salts proposed nationally and internationally over the past 30 years.Through comparative analysis,we proposed relevant policy recommendations to the existing quality standards of snow-melting agents and the management regulations of industrial waste salts,and the formulation of corresponding usage strategies,aimed at reducing the potential environmental release of heavy metals from the use of snow-melting agents,thereby promoting more sustainable green urban development and environmentally sound waste management. 展开更多
关键词 Snow-melting agent Heavy metals Industrial waste salts recycled Comparative analysis
原文传递
上一页 1 2 250 下一页 到第
使用帮助 返回顶部