Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction ...Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction of cardiac organoids,categorizing them into three main types:cardiac spheroids,self-organizing/assembloid organoids,and organoid-on-a-chip systems.This review uniquely integrates the advances in vascularization,organ-on-chip design,and environmental cardiotoxicity modeling within cardiac organoid platforms,offering a critical synthesis that is absent in the literature.In the context of escalating environmental threats to cardiovascular health,there is an urgent need for physiologically relevant models to accurately identify cardiac toxicants and elucidate their underlying mechanisms of action.This review highlights advances in cardiac organoid applications for disease modeling—including congenital heart defects and acquired cardiovascular diseases—drug development,toxicity screening,and the study of environmentally induced cardiovascular pathogenesis.In addition,it critically examines ongoing challenges and underscores opportunities brought by bioengineering approaches.Finally,we propose future directions for developing standardized cardiac organoid platforms with clinical predictability,aiming to expand the utility of this technology across broader research applications.展开更多
With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective solutions.Catalysis,being one of the hallmarks of modern industry,off...With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective solutions.Catalysis,being one of the hallmarks of modern industry,offers a promising avenue for researchers.However,the question of how to significantly enhance the performance of catalysts has gradually drawn the attention of scholars.Defect engineering,a commonly employed and effective approach to improve catalyst activity,has become a significant research focus in the catalysis field in recent years.Nonmetal vacancies have received extensive attention due to their simple form.Consequently,exploration of metal vacancies has remained stagnant for a considerable period,resulting in a scarcity of comprehensive reviews on this topic.Therefore,based on the latest research findings,this paper summarizes and consolidates the construction strategies for metal vacancies,characterization techniques,and their roles in typical energy and environmental catalytic reactions.Additionally,it outlines potential challenges in the future,aiming to provide valuable references for researchers interested in investigating metal vacancies.展开更多
This paper focuses on the transformation of the project-based learning(PBL)teaching model driven by artificial intelligence(AI),and explores the two-way reconstruction path of teacher roles and student abilities.Combi...This paper focuses on the transformation of the project-based learning(PBL)teaching model driven by artificial intelligence(AI),and explores the two-way reconstruction path of teacher roles and student abilities.Combining metacognitive theory to analyze the pain points of traditional PBL,this paper systematically sorts out the functional reconstruction path of AI in the dimensions of teaching design,process monitoring,and evaluation feedback.Then,starting from the social role theory,this paper deeply analyzes the transformation of teacher identity and the reconstruction of student abilities in the AI-PBL fusion scenario.AI not only reshapes the logic of cultivating students’abilities but also prompts teachers to achieve deep changes in their roles at the cognitive,relational,and ethical levels.Human-machine collaboration should not replace teachers’emotional values and educational judgments,but should become a key support for optimizing the educational ecology and realizing personalized education.展开更多
In this letter,we comment on the article by Xuan Yuan et al,published in the recent issue of the World Journal of Gastroenterology.Mixed lineage kinase domainlike protein(MLKL)exhibits cell-type-specific functions in ...In this letter,we comment on the article by Xuan Yuan et al,published in the recent issue of the World Journal of Gastroenterology.Mixed lineage kinase domainlike protein(MLKL)exhibits cell-type-specific functions in liver parenchymal and non-parenchymal cells,playing dual roles in the pathogenesis of liver diseases.In hepatocytes,MLKL primarily mediates necroptosis and inhibits autophagy,thereby exacerbating liver injury.Conversely,in non-parenchymal liver cells,MLKL modulates inflammatory responses and promotes fibrotic processes,thereby driving disease progression.Notably,MLKL also demonstrates protective functions under specific conditions.For instance,MLKL can inhibit intracellular bacterial replication,promote endosomal trafficking,and facilitate the generation and release of extracellular vesicles,potentially exerting hepatoprotective effects.Understanding these cell-type-specific mechanisms of MLKL action,including its dual roles in promoting injury and providing protection,is crucial for elucidating the complex pathogenesis of liver diseases and developing targeted therapeutic strategies.展开更多
This study examines the predictive roles of foreign language classroom anxiety(FLCA),foreign language enjoyment(FLE),and foreign language boredom(FLB)in English achievement among Chinese senior high school students.De...This study examines the predictive roles of foreign language classroom anxiety(FLCA),foreign language enjoyment(FLE),and foreign language boredom(FLB)in English achievement among Chinese senior high school students.Despite extensive research on anxiety in language learning,less attention has been given to boredom,and the combined effects of these three emotions on English achievement remain under-explored,particularly among high school students in China.To address these gaps,a sample of 142 students from Guangzhou was surveyed using questionnaires to assess their emotional experiences and English achievement.The research found that FLE exhibited a positive correlation with academic performance,while FLCA and FLB showed negative associations.Notably,FLE was the most significant predictor of English achievement,followed by FLCA and FLB.Gender differences were observed,with male students reporting significantly higher levels of environmental enjoyment,while female students experienced significantly greater communication anxiety.On this basis,this paper offers suggestions on how to enhance senior high school students’FLE while mitigating FLCA and FLB,thereby promoting more effective and sustained English learning.展开更多
The related work to reveal the primary characteristics of roles underlying the existing approaches is analyzed. Then, it is demonstrated that the representation of roles is rather complex and error-prone in these appr...The related work to reveal the primary characteristics of roles underlying the existing approaches is analyzed. Then, it is demonstrated that the representation of roles is rather complex and error-prone in these approaches. Especially, the constraints among roles in the same context cannot be expressed by the current web ontology language （OWL）. To solve these problems, a novel model of role is presented and a corresponding ontology language is provided for representing this model. The key idea underlying the solution is that a role should be regarded as an element of a certain context and a context as a structured thing which is comprised of some internal elements. The structure of context possesses inherent modularity and local semantics, whereby the representation of roles and context is significantly simplified.展开更多
The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers＇ roles in this learning process in students＇ perception through the m...The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers＇ roles in this learning process in students＇ perception through the means of questionnaires and interviews. It further analyzes the possible reasons why students perceive their teachers＇ roles in such a way, in the hope of providing some implications for web-based college English autonomous learning.展开更多
This paper gives an account of characteristics of the intensive reading in English teaching, and change of teachers’ roles in the learner-centered teaching approach. Suggestions are put forward as to how to be a qual...This paper gives an account of characteristics of the intensive reading in English teaching, and change of teachers’ roles in the learner-centered teaching approach. Suggestions are put forward as to how to be a qualified teacher in the intensive reading class accordingly.展开更多
Traditionally, in a teacher-centered class, students are deprived of right, for teachers take up the platform and play a “leading” role. What are the college English teacher′s possible roles? The paper tends to she...Traditionally, in a teacher-centered class, students are deprived of right, for teachers take up the platform and play a “leading” role. What are the college English teacher′s possible roles? The paper tends to shed light on it by kicking the teacher′s traditional roles.展开更多
It is commonly known that writing is an advanced skill which is essential in language learning but at the same time the most difficult task for learners. This paper is with the aim to explore helpful roles that teache...It is commonly known that writing is an advanced skill which is essential in language learning but at the same time the most difficult task for learners. This paper is with the aim to explore helpful roles that teacher can play to help non-English major students improve their English writing, so as to help improve their writing ability in the author's context.展开更多
Natural products have gained popularity worldwide for promoting healthcare, as well as disease prevention. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloid...Natural products have gained popularity worldwide for promoting healthcare, as well as disease prevention. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation, antibacterial, antiviral, insecticidal, and antimetastatic effects on various types of cancers both in vitro and in vivo. This paper focuses on the naturally-derived alkaloids such as berberine, matrine, piperine, fritillarine, and rhynchophylline, etc., and summarizes the action mechanisms of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as drugs is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made. Following this, it is hoped that as a result of this review, there will be a greater awareness of the excellent promise that natural alkaloids show for use in the therapy of diseases.展开更多
Endoscopic ultrasound(EUS), developed in the 1980 s, was initially predominantly used for guidance of fine needle aspiration; the last 25 years, however, have witnessed a major expansion of EUS to various applications...Endoscopic ultrasound(EUS), developed in the 1980 s, was initially predominantly used for guidance of fine needle aspiration; the last 25 years, however, have witnessed a major expansion of EUS to various applications, both diagnostic and therapeutic. EUS has become much more than a tool to differentiate different tissue densities;tissue can now be characterized in great detail using modalities such as elastography; the extent of tissue vascularity can now be learned with increasing precision. Using these various techniques, targets for biopsy can be precisely pinpointed. Upon reaching the target, tissue can then be examined microscopically in real-time, ensuring optimal targeting and diagnosis. This article provides a comprehensive review of the various current roles of EUS, including drainage of lesions, visualization and characterization of lesions, injection, surgery, and vascular intervention. With EUS technology continuing to develop exponentially, the article emphasizes the future directions of each modality.展开更多
With continuing advances in technology, computer-assisted instruction provides opportunities for individualized, interactive instruction. The philosophy of constructivism has encouraged instructional designers to crea...With continuing advances in technology, computer-assisted instruction provides opportunities for individualized, interactive instruction. The philosophy of constructivism has encouraged instructional designers to create less behavioral, more democratic programs that promote learner control. In the area of ESL (English as a second language), computers are seen to be a highly motivating, instructional tool.展开更多
As a new member of carbon material family, carbon quantum dots (CQDs) have attracted tremendous attentions for their potentials in the heterogeneous photocatalysis applications. Due to the unique microstructure and op...As a new member of carbon material family, carbon quantum dots (CQDs) have attracted tremendous attentions for their potentials in the heterogeneous photocatalysis applications. Due to the unique microstructure and optical properties, the roles of CQDs played in the CQDs-based photocatalytic systems have been found to be diverse with the continuous researches in this regard. Herein, we provide a concise minireview to elaborate the multifarious roles of CQDs in photocatalysis, including photoelectron mediator and acceptor, photosensitizer, photocatalyst, reducing agent for metal salt, enhancing adsorption capacity and spectral converter. In addition, the perspectives on future research trends and challenges are proposed, which are anticipated to stimulate further research into this promising field on designing a variety of efficient CQDs-based photocatalysts for solar energy conversion. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B. V. and Science Press. All rights reserved.展开更多
The issue of improving the efficiency of college English teaching and learning has long puzzled our educators and English teachers.There are many ways to help the solving of the problem,but in China,where English is m...The issue of improving the efficiency of college English teaching and learning has long puzzled our educators and English teachers.There are many ways to help the solving of the problem,but in China,where English is mainly taught in classroom,the teacher is a very important factor to influence the result of English teaching.In order to solve the problem,the teacher must know exactly what roles he should play in the process of teaching and make some changes in his old teaching methods.展开更多
The main causes of non-point source pollution in Taihu Lake are the improper ways of crop production, animal husbandry, and daily runoff. The paper discusses the relationship between countrywomen and non-point source ...The main causes of non-point source pollution in Taihu Lake are the improper ways of crop production, animal husbandry, and daily runoff. The paper discusses the relationship between countrywomen and non-point source pollution control by 731 questionnaires in Weidu village and 466 questionnaires in Dapu Town. The roles of countrywomen have changed in families and they have close relationship with non-point source pollution. Furthermore, we discuss the possibility and methods of organizing countrywomen in non-point source pollution control.展开更多
With the rapid development of modern technology and all-round reform in national college English teaching,Internet-Based teaching mode has become a new trend of college English teaching.Therefore,in the new teaching m...With the rapid development of modern technology and all-round reform in national college English teaching,Internet-Based teaching mode has become a new trend of college English teaching.Therefore,in the new teaching mode,the teacher should turn an inculcator into an instructor,facilitator and participant in teaching;a passive user of textbook into a dominant and modeler of courses;a planner of teaching specific tasks into an organizer of teaching process,a helper and shepherd of learning knowledge.展开更多
Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex problems.GRA with constraints(GRA+)is categorized as a clas...Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex problems.GRA with constraints(GRA+)is categorized as a class of complex assignment problems.At present,there are few generally efficient solutions to this category of problems.Each special problem case requires a specific solution.Group multi-role assignment(GMRA)and GRA with conflicting agents on roles(GRACAR)are two problem cases in GRA+.The contributions of this paper include:1)The formalization of a new problem of GRA+,called group multi-role assignment with conflicting roles and agents(GMAC),which is an extension to the combination of GMRA and GRACAR;2)A practical solution based on an optimization platform;3)A sufficient condition,used in planning,for solving GMAC problems;and 4)A clear presentation of the benefits in avoiding conflicts when dealing with GMAC.The proposed methods are verified by experiments,simulations,proofs and analysis.展开更多
Herein we summarized some clean preparation examples to emphasize the concept of dual roles design(or named as "two birds one stone strategy") in green and sustainable chemistry.In those examples,the reactan...Herein we summarized some clean preparation examples to emphasize the concept of dual roles design(or named as "two birds one stone strategy") in green and sustainable chemistry.In those examples,the reactants and/or solvent play dual roles rendering a cleaner organic preparation process.Consequently,both the chemical waste and manufacturing cost could be reduced.展开更多
Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiolo...Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiological and pathological processes by participating in material and information exchange between cells,which can playmultiple roles in tumor treatment.On the one hand,exosomes can be used as carriers and biomarkers,participate in the apoptosis signaling pathway and improve chemotherapy resistance,thus playing beneficial roles in tumor treatment.On the other hand,exosomes play unfavorable roles in tumor treatment.Tumor cell exosomes contain PD-L1,which is a nuclear weapon for tumor growth,metastasis,and immunosuppression.In addition,exosomes can not only promote the epithelial-mesenchymal transition process,tumor angiogenesis and chemoresistance,but also participate in the autocrine pathway.In this review,the multiple roles of exosomes and their prospects in the treatment of tumor were reviewed in detail.展开更多
基金supported by the Innovation Promotion Program of NHC and Shanghai Key Labs,SIBPT(grant number PT2025-01)。
文摘Human cardiac organoids have revolutionized the study of cardiac development,disease modeling,drug discovery,and regenerative therapies.This review systematically discusses strategies and progress in the construction of cardiac organoids,categorizing them into three main types:cardiac spheroids,self-organizing/assembloid organoids,and organoid-on-a-chip systems.This review uniquely integrates the advances in vascularization,organ-on-chip design,and environmental cardiotoxicity modeling within cardiac organoid platforms,offering a critical synthesis that is absent in the literature.In the context of escalating environmental threats to cardiovascular health,there is an urgent need for physiologically relevant models to accurately identify cardiac toxicants and elucidate their underlying mechanisms of action.This review highlights advances in cardiac organoid applications for disease modeling—including congenital heart defects and acquired cardiovascular diseases—drug development,toxicity screening,and the study of environmentally induced cardiovascular pathogenesis.In addition,it critically examines ongoing challenges and underscores opportunities brought by bioengineering approaches.Finally,we propose future directions for developing standardized cardiac organoid platforms with clinical predictability,aiming to expand the utility of this technology across broader research applications.
基金financially supported by National Key R&D Program of China(2021YFB3500702)National Natural Science Foundation of China(Nos.21677010 and 51808037)Special fund of Beijing Key Laboratory of Indoor Air Quality Evaluation and Control(No.BZ0344KF21-04).
文摘With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective solutions.Catalysis,being one of the hallmarks of modern industry,offers a promising avenue for researchers.However,the question of how to significantly enhance the performance of catalysts has gradually drawn the attention of scholars.Defect engineering,a commonly employed and effective approach to improve catalyst activity,has become a significant research focus in the catalysis field in recent years.Nonmetal vacancies have received extensive attention due to their simple form.Consequently,exploration of metal vacancies has remained stagnant for a considerable period,resulting in a scarcity of comprehensive reviews on this topic.Therefore,based on the latest research findings,this paper summarizes and consolidates the construction strategies for metal vacancies,characterization techniques,and their roles in typical energy and environmental catalytic reactions.Additionally,it outlines potential challenges in the future,aiming to provide valuable references for researchers interested in investigating metal vacancies.
基金The 2023 Jilin Provincial Department of Education Science and Technology(Social Sciences)Research Planning Project“Research on the Organizational Models of Private Universities in Promoting Rural Revital-ization in Jilin Province”(JJKH20231426SK)。
文摘This paper focuses on the transformation of the project-based learning(PBL)teaching model driven by artificial intelligence(AI),and explores the two-way reconstruction path of teacher roles and student abilities.Combining metacognitive theory to analyze the pain points of traditional PBL,this paper systematically sorts out the functional reconstruction path of AI in the dimensions of teaching design,process monitoring,and evaluation feedback.Then,starting from the social role theory,this paper deeply analyzes the transformation of teacher identity and the reconstruction of student abilities in the AI-PBL fusion scenario.AI not only reshapes the logic of cultivating students’abilities but also prompts teachers to achieve deep changes in their roles at the cognitive,relational,and ethical levels.Human-machine collaboration should not replace teachers’emotional values and educational judgments,but should become a key support for optimizing the educational ecology and realizing personalized education.
基金Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642Health Research Project of Guizhou Province,No.gzwkj2024-324,and No.gzwkj2024-103+2 种基金WBE Liver Fibrosis Foundation,No.CFHPC2025028Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.S2024106612360.
文摘In this letter,we comment on the article by Xuan Yuan et al,published in the recent issue of the World Journal of Gastroenterology.Mixed lineage kinase domainlike protein(MLKL)exhibits cell-type-specific functions in liver parenchymal and non-parenchymal cells,playing dual roles in the pathogenesis of liver diseases.In hepatocytes,MLKL primarily mediates necroptosis and inhibits autophagy,thereby exacerbating liver injury.Conversely,in non-parenchymal liver cells,MLKL modulates inflammatory responses and promotes fibrotic processes,thereby driving disease progression.Notably,MLKL also demonstrates protective functions under specific conditions.For instance,MLKL can inhibit intracellular bacterial replication,promote endosomal trafficking,and facilitate the generation and release of extracellular vesicles,potentially exerting hepatoprotective effects.Understanding these cell-type-specific mechanisms of MLKL action,including its dual roles in promoting injury and providing protection,is crucial for elucidating the complex pathogenesis of liver diseases and developing targeted therapeutic strategies.
文摘This study examines the predictive roles of foreign language classroom anxiety(FLCA),foreign language enjoyment(FLE),and foreign language boredom(FLB)in English achievement among Chinese senior high school students.Despite extensive research on anxiety in language learning,less attention has been given to boredom,and the combined effects of these three emotions on English achievement remain under-explored,particularly among high school students in China.To address these gaps,a sample of 142 students from Guangzhou was surveyed using questionnaires to assess their emotional experiences and English achievement.The research found that FLE exhibited a positive correlation with academic performance,while FLCA and FLB showed negative associations.Notably,FLE was the most significant predictor of English achievement,followed by FLCA and FLB.Gender differences were observed,with male students reporting significantly higher levels of environmental enjoyment,while female students experienced significantly greater communication anxiety.On this basis,this paper offers suggestions on how to enhance senior high school students’FLE while mitigating FLCA and FLB,thereby promoting more effective and sustained English learning.
基金The National Natural Science Foundation of China(No.90612009,60403050),the National Basic Research Program of China (973Program)(No.2005CB321802).
文摘The related work to reveal the primary characteristics of roles underlying the existing approaches is analyzed. Then, it is demonstrated that the representation of roles is rather complex and error-prone in these approaches. Especially, the constraints among roles in the same context cannot be expressed by the current web ontology language （OWL）. To solve these problems, a novel model of role is presented and a corresponding ontology language is provided for representing this model. The key idea underlying the solution is that a role should be regarded as an element of a certain context and a context as a structured thing which is comprised of some internal elements. The structure of context possesses inherent modularity and local semantics, whereby the representation of roles and context is significantly simplified.
文摘The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers＇ roles in this learning process in students＇ perception through the means of questionnaires and interviews. It further analyzes the possible reasons why students perceive their teachers＇ roles in such a way, in the hope of providing some implications for web-based college English autonomous learning.
文摘This paper gives an account of characteristics of the intensive reading in English teaching, and change of teachers’ roles in the learner-centered teaching approach. Suggestions are put forward as to how to be a qualified teacher in the intensive reading class accordingly.
文摘Traditionally, in a teacher-centered class, students are deprived of right, for teachers take up the platform and play a “leading” role. What are the college English teacher′s possible roles? The paper tends to shed light on it by kicking the teacher′s traditional roles.
文摘It is commonly known that writing is an advanced skill which is essential in language learning but at the same time the most difficult task for learners. This paper is with the aim to explore helpful roles that teacher can play to help non-English major students improve their English writing, so as to help improve their writing ability in the author's context.
基金supported by the grants from the Key Program of Natural Science Foundation of State(Nos.90709019,81173500,81373930,81302905,81102556,81202639)the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(Nos.2011BAI03B03,2011BAI03B06,2011BAI03B08)the National Key Subject of Drug Innovation(No.2009ZX09502-005)
文摘Natural products have gained popularity worldwide for promoting healthcare, as well as disease prevention. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation, antibacterial, antiviral, insecticidal, and antimetastatic effects on various types of cancers both in vitro and in vivo. This paper focuses on the naturally-derived alkaloids such as berberine, matrine, piperine, fritillarine, and rhynchophylline, etc., and summarizes the action mechanisms of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as drugs is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made. Following this, it is hoped that as a result of this review, there will be a greater awareness of the excellent promise that natural alkaloids show for use in the therapy of diseases.
文摘Endoscopic ultrasound(EUS), developed in the 1980 s, was initially predominantly used for guidance of fine needle aspiration; the last 25 years, however, have witnessed a major expansion of EUS to various applications, both diagnostic and therapeutic. EUS has become much more than a tool to differentiate different tissue densities;tissue can now be characterized in great detail using modalities such as elastography; the extent of tissue vascularity can now be learned with increasing precision. Using these various techniques, targets for biopsy can be precisely pinpointed. Upon reaching the target, tissue can then be examined microscopically in real-time, ensuring optimal targeting and diagnosis. This article provides a comprehensive review of the various current roles of EUS, including drainage of lesions, visualization and characterization of lesions, injection, surgery, and vascular intervention. With EUS technology continuing to develop exponentially, the article emphasizes the future directions of each modality.
文摘With continuing advances in technology, computer-assisted instruction provides opportunities for individualized, interactive instruction. The philosophy of constructivism has encouraged instructional designers to create less behavioral, more democratic programs that promote learner control. In the area of ESL (English as a second language), computers are seen to be a highly motivating, instructional tool.
基金financial support from the key project of the National Natural Science Foundation of China (U1463204)the project of National Natural Science Foundation of China (NSFC) (20903023,21173045)+4 种基金the Award Program for Minjiang Scholar Professorshipthe Natural Science Foundation (NSF) of Fujian Province for Distinguished Young Investigator Grant (2012J06003)the Independent Research Project of State Key Laboratory of Photocatalysis on Energy and Environment (No.2014A05)the 1st Program of Fujian Province for Top Creative Young Talentsthe Program for Returned High-Level Overseas Chinese Scholars of Fujian Province
文摘As a new member of carbon material family, carbon quantum dots (CQDs) have attracted tremendous attentions for their potentials in the heterogeneous photocatalysis applications. Due to the unique microstructure and optical properties, the roles of CQDs played in the CQDs-based photocatalytic systems have been found to be diverse with the continuous researches in this regard. Herein, we provide a concise minireview to elaborate the multifarious roles of CQDs in photocatalysis, including photoelectron mediator and acceptor, photosensitizer, photocatalyst, reducing agent for metal salt, enhancing adsorption capacity and spectral converter. In addition, the perspectives on future research trends and challenges are proposed, which are anticipated to stimulate further research into this promising field on designing a variety of efficient CQDs-based photocatalysts for solar energy conversion. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B. V. and Science Press. All rights reserved.
文摘The issue of improving the efficiency of college English teaching and learning has long puzzled our educators and English teachers.There are many ways to help the solving of the problem,but in China,where English is mainly taught in classroom,the teacher is a very important factor to influence the result of English teaching.In order to solve the problem,the teacher must know exactly what roles he should play in the process of teaching and make some changes in his old teaching methods.
文摘The main causes of non-point source pollution in Taihu Lake are the improper ways of crop production, animal husbandry, and daily runoff. The paper discusses the relationship between countrywomen and non-point source pollution control by 731 questionnaires in Weidu village and 466 questionnaires in Dapu Town. The roles of countrywomen have changed in families and they have close relationship with non-point source pollution. Furthermore, we discuss the possibility and methods of organizing countrywomen in non-point source pollution control.
文摘With the rapid development of modern technology and all-round reform in national college English teaching,Internet-Based teaching mode has become a new trend of college English teaching.Therefore,in the new teaching mode,the teacher should turn an inculcator into an instructor,facilitator and participant in teaching;a passive user of textbook into a dominant and modeler of courses;a planner of teaching specific tasks into an organizer of teaching process,a helper and shepherd of learning knowledge.
基金supported in part by Natural Sciences and Engineering Research Council,Canada(NSERC)(RGPIN-2018-04818)the funding from the Innovation for Defence Excellence and Security(IDEaS)Program from the Canadian Department of National Defence(DND)。
文摘Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex problems.GRA with constraints(GRA+)is categorized as a class of complex assignment problems.At present,there are few generally efficient solutions to this category of problems.Each special problem case requires a specific solution.Group multi-role assignment(GMRA)and GRA with conflicting agents on roles(GRACAR)are two problem cases in GRA+.The contributions of this paper include:1)The formalization of a new problem of GRA+,called group multi-role assignment with conflicting roles and agents(GMAC),which is an extension to the combination of GMRA and GRACAR;2)A practical solution based on an optimization platform;3)A sufficient condition,used in planning,for solving GMAC problems;and 4)A clear presentation of the benefits in avoiding conflicts when dealing with GMAC.The proposed methods are verified by experiments,simulations,proofs and analysis.
基金financial support from the National Natural Science Foundation of China(Nos.21545010 and 31527803)Hunan Provincial Natural Science Foundation of China(No. 2019JJ20008)
文摘Herein we summarized some clean preparation examples to emphasize the concept of dual roles design(or named as "two birds one stone strategy") in green and sustainable chemistry.In those examples,the reactants and/or solvent play dual roles rendering a cleaner organic preparation process.Consequently,both the chemical waste and manufacturing cost could be reduced.
文摘Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiological and pathological processes by participating in material and information exchange between cells,which can playmultiple roles in tumor treatment.On the one hand,exosomes can be used as carriers and biomarkers,participate in the apoptosis signaling pathway and improve chemotherapy resistance,thus playing beneficial roles in tumor treatment.On the other hand,exosomes play unfavorable roles in tumor treatment.Tumor cell exosomes contain PD-L1,which is a nuclear weapon for tumor growth,metastasis,and immunosuppression.In addition,exosomes can not only promote the epithelial-mesenchymal transition process,tumor angiogenesis and chemoresistance,but also participate in the autocrine pathway.In this review,the multiple roles of exosomes and their prospects in the treatment of tumor were reviewed in detail.
