Many cancers can exploit nearby neurons to promote their growth, but in extracranial tumors, these interactions are generally attributed to the secretion of growth factors or indirect effects(Padmanaban et al., 2024;R...Many cancers can exploit nearby neurons to promote their growth, but in extracranial tumors, these interactions are generally attributed to the secretion of growth factors or indirect effects(Padmanaban et al., 2024;Renz et al., 2018). Recently, in a study published in Nature, Wang's group(Zhi et al., 2025) discovered that gastric cancer(GC) can form neural circuits with adjacent nociceptive sensory nerves and utilize these malignant circuits to promote cancer growth and metastasis.展开更多
Our previous studies have histomorphologically confirmed that nanofibrous poly（3-hydroxybutyrate- co-3-hydroxyvalerate） conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on ...Our previous studies have histomorphologically confirmed that nanofibrous poly（3-hydroxybutyrate- co-3-hydroxyvalerate） conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） conduit and autologous sciatic nerve to bridge 30-ram-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional re- covery was evaluated per month by behavioral analyses, including toe out angle, toe spread anal- ysis, walking track analysis, extensor postural thrust, swimming test, open-field analysis and no- ciceptive function. Results showed that rat sciatic nerve functional recovery was similar after nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） conduit and autologous nerve grafting. These findings suggest that nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） conduit is suitable in use for repair of long-segment sciatic nerve defects.展开更多
基金supported by the Major Project of Natural Science Foundation of Zhejiang Province (D25H300005)the National Natural Science Foundation of China (32000799)。
文摘Many cancers can exploit nearby neurons to promote their growth, but in extracranial tumors, these interactions are generally attributed to the secretion of growth factors or indirect effects(Padmanaban et al., 2024;Renz et al., 2018). Recently, in a study published in Nature, Wang's group(Zhi et al., 2025) discovered that gastric cancer(GC) can form neural circuits with adjacent nociceptive sensory nerves and utilize these malignant circuits to promote cancer growth and metastasis.
基金supported by Tonekabon Branch,Islamic Azad University,Tonekabon,Iran,No.73/442453
文摘Our previous studies have histomorphologically confirmed that nanofibrous poly（3-hydroxybutyrate- co-3-hydroxyvalerate） conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） conduit and autologous sciatic nerve to bridge 30-ram-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional re- covery was evaluated per month by behavioral analyses, including toe out angle, toe spread anal- ysis, walking track analysis, extensor postural thrust, swimming test, open-field analysis and no- ciceptive function. Results showed that rat sciatic nerve functional recovery was similar after nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） conduit and autologous nerve grafting. These findings suggest that nanofibrous poly（3-hydroxybutyrate-co-3-hydroxyvalerate） conduit is suitable in use for repair of long-segment sciatic nerve defects.
