Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
In the sixth generation mobile communication(6G) system,Non-Terrestrial Networks(NTN),as a supplement to terrestrial network,can meet the requirements of wide area intelligent connection and global ubiquitous seamless...In the sixth generation mobile communication(6G) system,Non-Terrestrial Networks(NTN),as a supplement to terrestrial network,can meet the requirements of wide area intelligent connection and global ubiquitous seamless access,establish intelligent connection for wide area objects,and provide intelligent services.Due to issues such as massive access,doppler shift,and limited spectrum resources in NTN,research on resource management is crucial for optimizing NTN performance.In this paper,a comprehensive survey of multi-pattern heterogeneous NTN resource management is provided.Firstly,the key technologies involved in NTN resource management is summarized.Secondly,NTN resource management is discussed from network pattern and resource pattern.The network pattern focuses on the application of different optimization methods to different network dimension communication resource management,and the resource type pattern focuses on the research and application of multi-domain resource management such as computation,cache,communication and sensing.Finally,future research directions and challenges of 6G NTN resource management are discussed.展开更多
With the rapid development of information technology,the scale of the network is expanding,and the complexity is increasing day by day.The traditional network management is facing great challenges.The emergence of sof...With the rapid development of information technology,the scale of the network is expanding,and the complexity is increasing day by day.The traditional network management is facing great challenges.The emergence of software-defined network(SDN)technology has brought revolutionary changes to modern network management.This paper aims to discuss the application and prospects of SDN technology in modern network management.Firstly,the basic principle and architecture of SDN are introduced,including the separation of control plane and data plane,centralized control and open programmable interface.Then,it analyzes the advantages of SDN technology in network management,such as simplifying network configuration,improving network flexibility,optimizing network resource utilization,and realizing fast fault recovery.The application examples of SDN in data center networks and WAN optimization management are analyzed.This paper also discusses the development status and trend of SDN in enterprise networks,including the integration of technologies such as cloud computing,big data,and artificial intelligence,the construction of an intelligent and automated network management platform,the improvement of network management efficiency and quality,and the openness and interoperability of network equipment.Finally,the advantages and challenges of SDN technology are summarized,and its future development direction is provided.展开更多
To investigate the targets and mechanism of Hedysarum Multijugum Maxim(HMM)in treatment of bladder cancer(BC).Based on Traditional Chinese Medicine Systems Pharmacology(TCMSP)and gene databases,active substances and p...To investigate the targets and mechanism of Hedysarum Multijugum Maxim(HMM)in treatment of bladder cancer(BC).Based on Traditional Chinese Medicine Systems Pharmacology(TCMSP)and gene databases,active substances and potential targets of HMM were screened,and the HMM-active substances-targets-BC(HATB)regulatory network and PPI network were constructed.Hub targets were screened by Cytoscape.The main active substances and Hub targets were molecularly docked with AutoDock and visualized by PyMOL.12 Hub targets were screened.Molecular docking showed that active substances mainly acted on MAPK14,MAPK1 and CCND1.The bindings of calycosin to MAPK14,formononetin to MAPK14,and calycosin to CCND1 were stable.展开更多
The 5G-R network is on the verge of entering the construction stage.Given that the dedicated network for railways is closely linked to train operation safety,there are extremely high requirements for network security....The 5G-R network is on the verge of entering the construction stage.Given that the dedicated network for railways is closely linked to train operation safety,there are extremely high requirements for network security.As a result,there is an urgent need to conduct research on 5G-R network security.To comprehensively enhance the end-to-end security protection of the 5G-R network,this study summarized the security requirements of the GSM-R network,analyzed the security risks and requirements faced by the 5G-R network,and proposed an overall 5G-R network security architecture.The security technical schemes were detailed from various aspects:5G-R infrastructure security,terminal access security,networking security,operation and maintenance security,data security,and network boundary security.Additionally,the study proposed leveraging the 5G-R security situation awareness system to achieve a comprehensive upgrade from basic security technologies to endogenous security capabilities within the 5G-R system.展开更多
Security attributes are the premise and foundation for implementing Attribute-Based Access Control(ABAC)mechanisms.However,when dealing with massive volumes of unstructured text big data resources,the current attribut...Security attributes are the premise and foundation for implementing Attribute-Based Access Control(ABAC)mechanisms.However,when dealing with massive volumes of unstructured text big data resources,the current attribute management methods based on manual extraction face several issues,such as high costs for attribute extraction,long processing times,unstable accuracy,and poor scalability.To address these problems,this paper proposes an attribute mining technology for access control institutions based on hybrid capsule networks.This technology leverages transfer learning ideas,utilizing Bidirectional Encoder Representations from Transformers(BERT)pre-trained language models to achieve vectorization of unstructured text data resources.Furthermore,we have designed a novel end-to-end parallel hybrid network structure,where the parallel networks handle global and local information features of the text that they excel at,respectively.By employing techniques such as attention mechanisms,capsule networks,and dynamic routing,effective mining of security attributes for access control resources has been achieved.Finally,we evaluated the performance level of the proposed attribute mining method for access control institutions through experiments on the medical referral text resource dataset.The experimental results show that,compared with baseline algorithms,our method adopts a parallel network structure that can better balance global and local feature information,resulting in improved overall performance.Specifically,it achieves a comprehensive performance enhancement of 2.06%to 8.18%in the F1 score metric.Therefore,this technology can effectively provide attribute support for access control of unstructured text big data resources.展开更多
In this editorial,we comment on the article by Micucci et al published in the recent issue.We focus on the heterogenous nature of gastric cancer(GC)and the potential benefits of integrating traditional Chinese medicin...In this editorial,we comment on the article by Micucci et al published in the recent issue.We focus on the heterogenous nature of gastric cancer(GC)and the potential benefits of integrating traditional Chinese medicine(TCM)with the modern technology of network pharmacology(NP)and omics sequencing.GC is a heterogenous disease,as it incorporates several biochemical pathways that contribute to pathogenesis.TCM acknowledges the multifactorial,heterogenous nature of disease and utilizes an integrative approach to medicine.NP,a modern philosophy within drug development,integrates traditional knowledge of nutraceuticals and modern technologies to address the complex interactions of pathways within the body.Omics technologies,which is at the core of precision medicine,has allowed for this newfound principle of drug development.Metabolic pathways are better distinguished,leading to more targeted drug development.However,the use of omics technology needs to be employed to better characterize the subtypes of GC.This will allow TCM’s use of nutraceuticals in the application of NP to better target metabolic pathways that may aid in the prevention of GC as well as enhance treatment.展开更多
The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them w...The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.展开更多
BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide ...Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.展开更多
[Objective] To analyze the key factor in agricultural technology diffusion- technology support, and to explore the method to quicken the diffusion of agricultural technology. [Method] The technology acquisition advant...[Objective] To analyze the key factor in agricultural technology diffusion- technology support, and to explore the method to quicken the diffusion of agricultural technology. [Method] The technology acquisition advantage of social network was il- lustrated by summarizing the status and characteristics of agricultural technology and technology supporting types in the process of agriculture technology diffusion. [Result] The multi-layer, complex, persistence, systematization features of agricultural technol- ogy require support and help of technology from surrounding social network to ulti- mately internalize the technology. [Conclusion] Using social networks for the technol- ogy support will be a powerful supplement to the system of agricultural technology diffusion.展开更多
Based on the advantages of both Grid and peer-to-peer （P2P） networks, an overlay network in the Grid environment is constructed by P2P technologies by a modified version of the Chord protocol. In this mechanism, dif...Based on the advantages of both Grid and peer-to-peer （P2P） networks, an overlay network in the Grid environment is constructed by P2P technologies by a modified version of the Chord protocol. In this mechanism, different nodes＇ accesses to different resources are determined by their contribution. Therefore, the heterogeneous resources of virtual organizations in large-scale Grid can be effectively integrated, and the key node failure as well as system bottleneck in the traditional Grid environment is eliminated. The experimental results indicate that this management mechanism can achieve better average performance in the Grid environment and maintain the P2P characteristics as well.展开更多
Wireless transmission method in wireless sensor networks has put forward higher requirements for private protection technology. According to the packet loss problem of private protection algorithm based on slice techn...Wireless transmission method in wireless sensor networks has put forward higher requirements for private protection technology. According to the packet loss problem of private protection algorithm based on slice technology, this paper proposes the data private protection algorithm with redundancy mechanism, which ensures privacy by privacy homomorphism mechanism and guarantees redundancy by carrying hidden data. Moreover,it selects the routing tree generated by CTP(Collection Tree Protocol) as routing path for data transmission. By dividing at the source node, it adds the hidden information and also the privacy homomorphism. At the same time,the information feedback tree is established between the destination node and the source node. In addition, the destination node immediately sends the packet loss information and the encryption key via the information feedback tree to the source node. As a result,it improves the reliability and privacy of data transmission and ensures the data redundancy.展开更多
Various force disturbances influence the thrust force of linear motors when a linear motor （LM） is running. Among all of force disturbances, the force ripple is the dominant while a linear motor runs in low speed. I...Various force disturbances influence the thrust force of linear motors when a linear motor （LM） is running. Among all of force disturbances, the force ripple is the dominant while a linear motor runs in low speed. In order to suppress the force ripple, back propagation（BP） neural network is proposed to learn the function of the force ripple of linear motors, and the acquisition method of training samples is proposed based on a disturbance observer. An off-line BP neural network is used mainly because of its high running efficiency and the real-time requirement of the servo control system of a linear motor. By using the function, the force ripple is on-line compensated according to the position of the LM. The experimental results show that the force ripple is effectively suppressed by the compensation of the BP neural network.展开更多
The home network is a major concern for the growth of digital and information society. Yet, how to guarantee the security of its digital content and protect the legal benefits for each section of the value chain becom...The home network is a major concern for the growth of digital and information society. Yet, how to guarantee the security of its digital content and protect the legal benefits for each section of the value chain becomes a crucial "bottleneck" in the home network development. The Digital Rights Management (DRM) technology provides total solution for usage, storage, transfer, and tracing the digital contents and rights. Its basic features are systematic and controllability. Considering the growth of the new media and services and the requirements of the Intellectual Property Rights (IPR) protection in a home network, it's necessary to solve consistency problems in usage, storage, and transfer of contents and rights. In addition, it is inevitable to conduct researches of key techniques such as end-to-end secure transmission, conditional access and play, and right description.展开更多
Patent transfer has been regarded as an important channel for the nations and regions to acquire external technology,and also a direct research object to depict the relationship between supply and demand of technology...Patent transfer has been regarded as an important channel for the nations and regions to acquire external technology,and also a direct research object to depict the relationship between supply and demand of technology flow.Therefore,based on traceable patent transfer data,this article has established a dual-pipeline theoretical framework of transnational-domestic technology transfer from the interaction of the global and local(glocal)perspective,and combines social networks,GIS spatial analysis as well as spatial econometric model to discover the spatial evolution of China’s transnational technology channels and its determinant factors.It is found that:(1)The spatial heterogeneity of the overall network is significant while gradually weakened over time.(2)The eastward shift of the core cities involved in transnational technology channels is accelerating,from the hubs in North America(New York Bay Area,Silicon Valley,Caribbean offshore financial center,etc.)and West Europe(London offshore financial center etc.)to East Asia(Tokyo and Seoul)and Southeast Asia(Singapore),which illustrates China has decreased reliance on the technology from the USA and West Europe.(3)The four major innovation clusters:Beijing-Tianjin-Hebei region(Beijing as the hub),Yangtze River Delta(Shanghai as the hub),The Greater Bay Area(Shenzhen and Hong Kong as the hubs)and north Taiwan(Taipei and Hsinchu as the hubs),are regarded as global technology innovation hubs and China’s distribution centers in transnational technology flow.Among those,Chinese Hong Kong’s betweenness role of technology is strengthened due to linkage of transnational corporations and their branches,and low tax coverage of offshore finance,thus becoming the top city for technology transfer.Meanwhile,Chinese Taiwan’s core position is diminishing.(4)The breadth,intensity,and closeness of domestic technology transfer are conducive to the expansion of transnational technology import channels.Additionally,local economic level has positive effect on transnational technology transfer channels while technology strength and external economic linkage have multifaceted influences.展开更多
The heterogeneous network convergence is the trend of future network development. However, many bottlenecks exist in the converged system such as high time delay, high energy consumption, and low data rate. Multi-Radi...The heterogeneous network convergence is the trend of future network development. However, many bottlenecks exist in the converged system such as high time delay, high energy consumption, and low data rate. Multi-Radio Cooperation (MRC) technology is specially designed to overcome these bottlenecks and to satisfy the requirements of heterogeneous network convergence. MRC can improve network capacity, reduce the energy consumption of radio devices, and decrease handover latency between heterogeneous networks by the cooperation of multiple radios, and by efficient management and feasible allocation of multi-radio resources. MRC makes real seamless heterogeneous network convergence possible.展开更多
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
基金supported in part by the National Natural Science Foundation of China under Grant 62225103,U22B2003,U2441227,and U24A20211the Beijing Natural Science Foundation under Grant L241008+3 种基金the Defense Industrial Technology Development Program JCKY2022110C010the National Key Laboratory of Wireless Communications Foundation under Grant IFN20230201the Fundamental Research Funds for the Central Universities under Grant FRFTP-22-002C2the Xiaomi Fund of Young Scholar。
文摘In the sixth generation mobile communication(6G) system,Non-Terrestrial Networks(NTN),as a supplement to terrestrial network,can meet the requirements of wide area intelligent connection and global ubiquitous seamless access,establish intelligent connection for wide area objects,and provide intelligent services.Due to issues such as massive access,doppler shift,and limited spectrum resources in NTN,research on resource management is crucial for optimizing NTN performance.In this paper,a comprehensive survey of multi-pattern heterogeneous NTN resource management is provided.Firstly,the key technologies involved in NTN resource management is summarized.Secondly,NTN resource management is discussed from network pattern and resource pattern.The network pattern focuses on the application of different optimization methods to different network dimension communication resource management,and the resource type pattern focuses on the research and application of multi-domain resource management such as computation,cache,communication and sensing.Finally,future research directions and challenges of 6G NTN resource management are discussed.
文摘With the rapid development of information technology,the scale of the network is expanding,and the complexity is increasing day by day.The traditional network management is facing great challenges.The emergence of software-defined network(SDN)technology has brought revolutionary changes to modern network management.This paper aims to discuss the application and prospects of SDN technology in modern network management.Firstly,the basic principle and architecture of SDN are introduced,including the separation of control plane and data plane,centralized control and open programmable interface.Then,it analyzes the advantages of SDN technology in network management,such as simplifying network configuration,improving network flexibility,optimizing network resource utilization,and realizing fast fault recovery.The application examples of SDN in data center networks and WAN optimization management are analyzed.This paper also discusses the development status and trend of SDN in enterprise networks,including the integration of technologies such as cloud computing,big data,and artificial intelligence,the construction of an intelligent and automated network management platform,the improvement of network management efficiency and quality,and the openness and interoperability of network equipment.Finally,the advantages and challenges of SDN technology are summarized,and its future development direction is provided.
基金2025 Open Experimental Special Fund of Beijing Institute of Technology, “Applications and Practices of R Language in Bioinformatics”。
文摘To investigate the targets and mechanism of Hedysarum Multijugum Maxim(HMM)in treatment of bladder cancer(BC).Based on Traditional Chinese Medicine Systems Pharmacology(TCMSP)and gene databases,active substances and potential targets of HMM were screened,and the HMM-active substances-targets-BC(HATB)regulatory network and PPI network were constructed.Hub targets were screened by Cytoscape.The main active substances and Hub targets were molecularly docked with AutoDock and visualized by PyMOL.12 Hub targets were screened.Molecular docking showed that active substances mainly acted on MAPK14,MAPK1 and CCND1.The bindings of calycosin to MAPK14,formononetin to MAPK14,and calycosin to CCND1 were stable.
文摘The 5G-R network is on the verge of entering the construction stage.Given that the dedicated network for railways is closely linked to train operation safety,there are extremely high requirements for network security.As a result,there is an urgent need to conduct research on 5G-R network security.To comprehensively enhance the end-to-end security protection of the 5G-R network,this study summarized the security requirements of the GSM-R network,analyzed the security risks and requirements faced by the 5G-R network,and proposed an overall 5G-R network security architecture.The security technical schemes were detailed from various aspects:5G-R infrastructure security,terminal access security,networking security,operation and maintenance security,data security,and network boundary security.Additionally,the study proposed leveraging the 5G-R security situation awareness system to achieve a comprehensive upgrade from basic security technologies to endogenous security capabilities within the 5G-R system.
基金supported by National Natural Science Foundation of China(No.62102449).
文摘Security attributes are the premise and foundation for implementing Attribute-Based Access Control(ABAC)mechanisms.However,when dealing with massive volumes of unstructured text big data resources,the current attribute management methods based on manual extraction face several issues,such as high costs for attribute extraction,long processing times,unstable accuracy,and poor scalability.To address these problems,this paper proposes an attribute mining technology for access control institutions based on hybrid capsule networks.This technology leverages transfer learning ideas,utilizing Bidirectional Encoder Representations from Transformers(BERT)pre-trained language models to achieve vectorization of unstructured text data resources.Furthermore,we have designed a novel end-to-end parallel hybrid network structure,where the parallel networks handle global and local information features of the text that they excel at,respectively.By employing techniques such as attention mechanisms,capsule networks,and dynamic routing,effective mining of security attributes for access control resources has been achieved.Finally,we evaluated the performance level of the proposed attribute mining method for access control institutions through experiments on the medical referral text resource dataset.The experimental results show that,compared with baseline algorithms,our method adopts a parallel network structure that can better balance global and local feature information,resulting in improved overall performance.Specifically,it achieves a comprehensive performance enhancement of 2.06%to 8.18%in the F1 score metric.Therefore,this technology can effectively provide attribute support for access control of unstructured text big data resources.
文摘In this editorial,we comment on the article by Micucci et al published in the recent issue.We focus on the heterogenous nature of gastric cancer(GC)and the potential benefits of integrating traditional Chinese medicine(TCM)with the modern technology of network pharmacology(NP)and omics sequencing.GC is a heterogenous disease,as it incorporates several biochemical pathways that contribute to pathogenesis.TCM acknowledges the multifactorial,heterogenous nature of disease and utilizes an integrative approach to medicine.NP,a modern philosophy within drug development,integrates traditional knowledge of nutraceuticals and modern technologies to address the complex interactions of pathways within the body.Omics technologies,which is at the core of precision medicine,has allowed for this newfound principle of drug development.Metabolic pathways are better distinguished,leading to more targeted drug development.However,the use of omics technology needs to be employed to better characterize the subtypes of GC.This will allow TCM’s use of nutraceuticals in the application of NP to better target metabolic pathways that may aid in the prevention of GC as well as enhance treatment.
文摘The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
基金supported by the National Key Research and Development Program(Grant No.2024YFA0917200)the Projects of the Chinese Center for Disease Control and Prevention(Grant No.BB2110240093)World Medical History under the Education Innovation Plan of the University of Science and Technology of China(Grant No.2024YCHX07).
文摘Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being.
基金Supported by the National Social Science Foundation of China:the Sociological Study on the Technology Adoption Behaviors of Farmers(08BSH049)~~
文摘[Objective] To analyze the key factor in agricultural technology diffusion- technology support, and to explore the method to quicken the diffusion of agricultural technology. [Method] The technology acquisition advantage of social network was il- lustrated by summarizing the status and characteristics of agricultural technology and technology supporting types in the process of agriculture technology diffusion. [Result] The multi-layer, complex, persistence, systematization features of agricultural technol- ogy require support and help of technology from surrounding social network to ulti- mately internalize the technology. [Conclusion] Using social networks for the technol- ogy support will be a powerful supplement to the system of agricultural technology diffusion.
基金The National Natural Science Foundation of China(No60573133)the National Basic Research Program of China (973Program)(No2003CB314801)
文摘Based on the advantages of both Grid and peer-to-peer （P2P） networks, an overlay network in the Grid environment is constructed by P2P technologies by a modified version of the Chord protocol. In this mechanism, different nodes＇ accesses to different resources are determined by their contribution. Therefore, the heterogeneous resources of virtual organizations in large-scale Grid can be effectively integrated, and the key node failure as well as system bottleneck in the traditional Grid environment is eliminated. The experimental results indicate that this management mechanism can achieve better average performance in the Grid environment and maintain the P2P characteristics as well.
基金sponsored by the National Key R&D Program of China(No.2018YFB1003201)the National Natural Science Foundation of China(No.61672296,No.61602261)Major Natural Science Research Projects in Colleges and Universities of Jiangsu Province(No.18KJA520008)
文摘Wireless transmission method in wireless sensor networks has put forward higher requirements for private protection technology. According to the packet loss problem of private protection algorithm based on slice technology, this paper proposes the data private protection algorithm with redundancy mechanism, which ensures privacy by privacy homomorphism mechanism and guarantees redundancy by carrying hidden data. Moreover,it selects the routing tree generated by CTP(Collection Tree Protocol) as routing path for data transmission. By dividing at the source node, it adds the hidden information and also the privacy homomorphism. At the same time,the information feedback tree is established between the destination node and the source node. In addition, the destination node immediately sends the packet loss information and the encryption key via the information feedback tree to the source node. As a result,it improves the reliability and privacy of data transmission and ensures the data redundancy.
基金National Natural Science Foundation of China(No. 60474021)
文摘Various force disturbances influence the thrust force of linear motors when a linear motor （LM） is running. Among all of force disturbances, the force ripple is the dominant while a linear motor runs in low speed. In order to suppress the force ripple, back propagation（BP） neural network is proposed to learn the function of the force ripple of linear motors, and the acquisition method of training samples is proposed based on a disturbance observer. An off-line BP neural network is used mainly because of its high running efficiency and the real-time requirement of the servo control system of a linear motor. By using the function, the force ripple is on-line compensated according to the position of the LM. The experimental results show that the force ripple is effectively suppressed by the compensation of the BP neural network.
基金China Next Generation Internet Project(No.CNGI-04-12-2A)
文摘The home network is a major concern for the growth of digital and information society. Yet, how to guarantee the security of its digital content and protect the legal benefits for each section of the value chain becomes a crucial "bottleneck" in the home network development. The Digital Rights Management (DRM) technology provides total solution for usage, storage, transfer, and tracing the digital contents and rights. Its basic features are systematic and controllability. Considering the growth of the new media and services and the requirements of the Intellectual Property Rights (IPR) protection in a home network, it's necessary to solve consistency problems in usage, storage, and transfer of contents and rights. In addition, it is inevitable to conduct researches of key techniques such as end-to-end secure transmission, conditional access and play, and right description.
基金Major Project of National Social Science Foundation of China,No.21ZDA011。
文摘Patent transfer has been regarded as an important channel for the nations and regions to acquire external technology,and also a direct research object to depict the relationship between supply and demand of technology flow.Therefore,based on traceable patent transfer data,this article has established a dual-pipeline theoretical framework of transnational-domestic technology transfer from the interaction of the global and local(glocal)perspective,and combines social networks,GIS spatial analysis as well as spatial econometric model to discover the spatial evolution of China’s transnational technology channels and its determinant factors.It is found that:(1)The spatial heterogeneity of the overall network is significant while gradually weakened over time.(2)The eastward shift of the core cities involved in transnational technology channels is accelerating,from the hubs in North America(New York Bay Area,Silicon Valley,Caribbean offshore financial center,etc.)and West Europe(London offshore financial center etc.)to East Asia(Tokyo and Seoul)and Southeast Asia(Singapore),which illustrates China has decreased reliance on the technology from the USA and West Europe.(3)The four major innovation clusters:Beijing-Tianjin-Hebei region(Beijing as the hub),Yangtze River Delta(Shanghai as the hub),The Greater Bay Area(Shenzhen and Hong Kong as the hubs)and north Taiwan(Taipei and Hsinchu as the hubs),are regarded as global technology innovation hubs and China’s distribution centers in transnational technology flow.Among those,Chinese Hong Kong’s betweenness role of technology is strengthened due to linkage of transnational corporations and their branches,and low tax coverage of offshore finance,thus becoming the top city for technology transfer.Meanwhile,Chinese Taiwan’s core position is diminishing.(4)The breadth,intensity,and closeness of domestic technology transfer are conducive to the expansion of transnational technology import channels.Additionally,local economic level has positive effect on transnational technology transfer channels while technology strength and external economic linkage have multifaceted influences.
基金the Natural Science Foundation of Jiangsu Province under Grant No.BK2007729
文摘The heterogeneous network convergence is the trend of future network development. However, many bottlenecks exist in the converged system such as high time delay, high energy consumption, and low data rate. Multi-Radio Cooperation (MRC) technology is specially designed to overcome these bottlenecks and to satisfy the requirements of heterogeneous network convergence. MRC can improve network capacity, reduce the energy consumption of radio devices, and decrease handover latency between heterogeneous networks by the cooperation of multiple radios, and by efficient management and feasible allocation of multi-radio resources. MRC makes real seamless heterogeneous network convergence possible.
