Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure ...Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,展开更多
Introduction:This study aims to report the epidemiological trends and provide updated estimates and lifetime risks for breast and cervical cancers among women in Guangdong province.Methods:A Bayesian age-period-cohort...Introduction:This study aims to report the epidemiological trends and provide updated estimates and lifetime risks for breast and cervical cancers among women in Guangdong province.Methods:A Bayesian age-period-cohort model was applied to project incidence and mortality rates for 2023.The adjusted for multiple primaries(AMP)method was used to calculate the lifetime risks of developing and dying from breast and cervical cancer.Joinpoint analysis was employed to describe the temporal trends.Results:The age-standardized incidence rate(ASIR)of female breast cancer increased from 2012 to 2019 in Guangdong province,with a particularly pronounced increase noted in the rural areas.The ASIR for cervical cancer among women aged over 55 increased in both urban and rural areas,whereas a declining trend was observed among women under the age of 55.The age-standardized mortality rates(ASMRs)for both breast cancer and cervical cancer demonstrated upward trends among women aged over 55,while no significant trend in ASMR was found for women under 55 years.In 2023,the estimated incidence rates of breast cancer and cervical cancer would be 50.81/10^(5)(ASIR would be 35.57/10^(5))and 15.31/10^(5)(ASIR would be 10.41/10^(5))respectively,with corresponding mortality rates of 10.78/10^(5)(ASMR would be 7.15/10^(5))and 6.11/10^(5)(ASMR would be 3.93/10^(5))for these cancers.Conclusions:Breast cancer continues to pose a significant threat to women’s health in both rural and urban areas of Guangdong,whereas cancer prevention and control programs for cervical cancer have shown positive impacts among the younger population.Greater emphasis should be placed on women aged over 55 to halt the rising mortality rates of both cancers within this population.展开更多
基金supported by Japan Society for the Promotion of Science(JSPS)Grant-in-Aid for young scientists(B)15K19984JSPS Fujita Memorial Fund for Medical Research,Takeda Science Foundation+1 种基金Uehara Memorial FoundationCentral Research Institute of Fukuoka University(No.161042)
文摘Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,
基金Supported by the talent support project established by Guangdong Provincial Center for Disease Control and Prevention[2023D010].
文摘Introduction:This study aims to report the epidemiological trends and provide updated estimates and lifetime risks for breast and cervical cancers among women in Guangdong province.Methods:A Bayesian age-period-cohort model was applied to project incidence and mortality rates for 2023.The adjusted for multiple primaries(AMP)method was used to calculate the lifetime risks of developing and dying from breast and cervical cancer.Joinpoint analysis was employed to describe the temporal trends.Results:The age-standardized incidence rate(ASIR)of female breast cancer increased from 2012 to 2019 in Guangdong province,with a particularly pronounced increase noted in the rural areas.The ASIR for cervical cancer among women aged over 55 increased in both urban and rural areas,whereas a declining trend was observed among women under the age of 55.The age-standardized mortality rates(ASMRs)for both breast cancer and cervical cancer demonstrated upward trends among women aged over 55,while no significant trend in ASMR was found for women under 55 years.In 2023,the estimated incidence rates of breast cancer and cervical cancer would be 50.81/10^(5)(ASIR would be 35.57/10^(5))and 15.31/10^(5)(ASIR would be 10.41/10^(5))respectively,with corresponding mortality rates of 10.78/10^(5)(ASMR would be 7.15/10^(5))and 6.11/10^(5)(ASMR would be 3.93/10^(5))for these cancers.Conclusions:Breast cancer continues to pose a significant threat to women’s health in both rural and urban areas of Guangdong,whereas cancer prevention and control programs for cervical cancer have shown positive impacts among the younger population.Greater emphasis should be placed on women aged over 55 to halt the rising mortality rates of both cancers within this population.
