Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technol...Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.展开更多
Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understandi...Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.展开更多
Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This pap...Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This paper analyzes the existing problems in the current teaching of Chinese Medicine Processing Technology courses,discusses the necessity of reforming the teaching model under the context of integration,and proposes the construction of a"Dual-Capability Progression,Six-Dimensional Empowerment"teaching model.The aim is to enhance the teaching quality of Chinese Medicine Processing Technology courses and cultivate high-quality skilled talents in Chinese medicine processing who can meet industry demands.展开更多
Multidisciplinary collaborative simulation （MCS） is an important area of research in the domain of multidisciplinary design optimization （MDO）.Although previous research for MCS has to some extent addressed some i...Multidisciplinary collaborative simulation （MCS） is an important area of research in the domain of multidisciplinary design optimization （MDO）.Although previous research for MCS has to some extent addressed some issues like using of multiple tools,integration stability,control of step size,data synchronization,etc,further work is still necessary to study how to achieve improved precision.A theoretical model is formulated to describe and analyze the integration process of MCS.A basic algorithm with equal major steps is proposed based on the model,along with two methods of implementation for the model,namely the serial method and the parallel method.A further algorithm based on convergent integration step is proposed,which has a more flexible strategy for run-time integration.The influence of interpolation techniques on simulation performance is studied as well.Simulations of the performance of various algorithms with different interpolation techniques are performed for both a simple numerical example and a complex mechatronic product.The novel algorithm based on convergent integration step,when used with a high-order interpolation technique,has better performance in terms of precision and efficiency.The innovation of this paper is mainly on the validation of high precision of the proposed convergent integration step algorithm.展开更多
Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions,including sepsis,severe trauma/burns,hemorrhagic shock,heatstroke,and acute pa...Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions,including sepsis,severe trauma/burns,hemorrhagic shock,heatstroke,and acute pancreatitis,all of which have high incidence rates.These conditions are primarily characterized by acute multi-organ dysfunction,with sudden onset,severe illness,and high mortality rates.Additionally,critical care treatment demands substantial medical resources,imposing significant economic burdens on patients’families and society.In recent years,critical care medicine has achieved notable progress,especially in multidisciplinary integration with immunology-based fields.Collaboration across disciplines has not only accelerated advancements in critical care but also propelled the rapid development of modern immunology.This paper provides an overview and assessment of the cross-disciplinary fusion between critical care medicine and immunology,exploring how these fields related extensions mutually enhance each other.It further analyzes China’s potential to become a global leader in this area within the next 5 to 10 years.展开更多
The development of complex products is essentially concerned with multidisciplinary knowledge. Running on Internet, integration based on muhilayer federation architecture and dynamic reuse of simulation resources are ...The development of complex products is essentially concerned with multidisciplinary knowledge. Running on Internet, integration based on muhilayer federation architecture and dynamic reuse of simulation resources are the major difficulties for complex product collaborative design and simulation. Since the traditional Run-Time Infrastructure （RTI） is not good at supporting these new requirements, an extended high level architecture （HLA） multilayer federation integration architecture （MLFIA）, based on the resource management federation （RMF） and its supporting environment based Service-oriented architecture （SOA） and HLA （SOHLA） are proposed, The idea and realization of two key technologies, the dynamic creation of simulation federation based on RMF, TH RTI, an extensible HLA runtime infrastructure （RTI）, used at Internet are emphasized. Finally, an industry case about multiple unit （MU） is given.展开更多
In today’s era,multidisciplinary integration is the development trend of education,which breaks the field of a single discipline and lays the foundation for the development of education.Objectively speaking,with the ...In today’s era,multidisciplinary integration is the development trend of education,which breaks the field of a single discipline and lays the foundation for the development of education.Objectively speaking,with the integration of disciplines,a new interdisciplinary is formed.This new discipline is comprehensive and systematic;in addition,it integrates knowledge,technology,and methods.It is the result of the collision of different disciplines.As an applied course,Management Science and Engineering integrates multidisciplinary knowledge,such as science and technology,information science,and mathematics.Its main purpose is to solve various problems in social and economic development.It has a long-term impact on the development of contemporary multidisciplinary education.In the new era,in order to meet the requirements of social and economic development,the teaching of Management Science and Engineering should be based on the perspective of multidisciplinary integration,combined with the current characteristics and training mode of the discipline,explore new talent training paths,and then drive the development of the whole industry.展开更多
Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently...Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms.展开更多
In recent years,Chinese and Western medicine clinical guidelines have attracted attention.But for the existing Chinese and Western medicine experts consensus or guidelines,Chinese medicine and Western medicine were sp...In recent years,Chinese and Western medicine clinical guidelines have attracted attention.But for the existing Chinese and Western medicine experts consensus or guidelines,Chinese medicine and Western medicine were split,out of touch from the form and content.How to lay equal stress on traditional Chinese medicine and Western medicine?How to form the organic unity of Chinese medicine and Western medicine in the clinical practice?they need to reach a consensus.This article explains how to improve the efficacy of Chinese and Western medicine from different aspects.展开更多
The rapid growth of artificial intelligence has accelerated data generation,which increasingly exposes the limitations faced by traditional computational architectures,particularly in terms of energy consumption and d...The rapid growth of artificial intelligence has accelerated data generation,which increasingly exposes the limitations faced by traditional computational architectures,particularly in terms of energy consumption and data latency.In contrast,data-centric computing that integrates processing and storage has the potential of reducing latency and energy usage.Organic optoelectronic synaptic transistors have emerged as one type of promising devices to implement the data-centric com-puting paradigm owing to their superiority of flexibility,low cost,and large-area fabrication.However,sophisticated functions including vector-matrix multiplication that a single device can achieve are limited.Thus,the fabrication and utilization of organic optoelectronic synaptic transistor arrays(OOSTAs)are imperative.Here,we summarize the recent advances in OOSTAs.Various strategies for manufacturing OOSTAs are introduced,including coating and casting,physical vapor deposition,printing,and photolithography.Furthermore,innovative applications of the OOSTA system integration are discussed,including neuromor-phic visual systems and neuromorphic computing systems.At last,challenges and future perspectives of utilizing OOSTAs in real-world applications are discussed.展开更多
The rising prevalence of chronic multimorbidity poses substantial challenges to healthcare systems,necessitating the development of innovative management strategies to optimize patient care and system efficiency.The s...The rising prevalence of chronic multimorbidity poses substantial challenges to healthcare systems,necessitating the development of innovative management strategies to optimize patient care and system efficiency.The study by Fontalba-Navas et al investigates the implementation of a novel high complexity unit(HCU)specifically designed to improve the management of patients with chronic complex conditions.By adopting a multidisciplinary approach,the HCU aims to provide comprehensive,patient-centered care that enhances health outcomes and alleviates the strain on traditional hospital services.Utilizing a longitudinal analysis of data from the Basic Minimum Data Set,this study compares hospitalization metrics among the HCU,Internal Medicine,and other departments within a regional hospital throughout 2022.The findings reveal that the HCU's integrated care model significantly reduces readmission rates and boosts patient satisfaction compared to conventional care practices.The study highlights the HCU's potential as a replicable model for managing chronic multimorbidity,emphasizing its effectiveness in minimizing unnecessary hospitalizations and enhancing the overall quality of patient care.This innovative approach not only addresses the complexities associated with chronic multimorbid conditions but also offers a sustainable framework for healthcare systems confronting similar challenges.展开更多
To address the limitations of existing coupling methods in aero-engine system simulation,which fail to adaptively adjust iterative parameters and coupling relationships,which can result in low efficiency and in⁃stabil...To address the limitations of existing coupling methods in aero-engine system simulation,which fail to adaptively adjust iterative parameters and coupling relationships,which can result in low efficiency and in⁃stability,this study introduces a‘Dynamic Event-Driven Co-Simulation’algorithm integrated with decision tree algorithms.This algorithm separates the overall coupling relationships and the main solver from the primary mod⁃el,utilizing a dynamic event monitoring module to adaptively adjust simulation strategies,including iteration pa⁃rameters,coupling relationships,and convergence criteria.This facilitates efficient adaptive simulations of dy⁃namic events while balancing solution accuracy and computational efficiency.The research focuses on a twinshaft turbofan engine,establishing six system-level models that encompass overall performance and various sub⁃systems based on three coupling methods,along with a multidisciplinary multi-fidelity simulation framework in⁃corporating a 3D CFD nozzle model.The study tests both model exchange and coupled simulation methods under a 14 s transient acceleration and deceleration scenario.In a 100%throttle condition,a high-fidelity nozzle model is used to analyze the sensitivity of different convergence criteria on computational efficiency and accuracy.Re⁃sults indicate that the accuracy and efficiency achieved with this method are comparable to those of PROOSIS soft⁃ware(18 s and 35 s,respectively),while being 71%more efficient than Simulink software(62 s and 120 s,re⁃spectively).Furthermore,appropriately relaxing the convergence criteria for the 0D model(from 10-6 to 10-4)while enhancing those for the 3D model(from 3000 steps to 6000 steps)can effectively balance computational accuracy and efficiency.展开更多
BACKGROUND Pituitary macroadenomas represent a significant challenge in clinical management due to their variable presentations and complex treatment considerations.This manuscript explores the multidisciplinary appro...BACKGROUND Pituitary macroadenomas represent a significant challenge in clinical management due to their variable presentations and complex treatment considerations.This manuscript explores the multidisciplinary approach to understanding and managing pituitary macroadenomas,integrating neurosurgery,endocrinology,radiology,and pathology perspectives.AIM To summarize the literature on pituitary macroadenoma and outline the possible multidisciplinary approach in the diagnosis,management,and rehabilitation of individuals with pituitary adenomas,to add to already preexisting knowledge,in managing these cases enhancing better ocular and systemic outcomes.METHODS A search was conducted on an online publication database(PubMed)using the term“pituitary adenoma”including all results published over twenty years(2004-2024).Results were sorted for relevance,language,and completeness.RESULTS A total of 176 records were returned.The guidelines of the PRISMA 2020 statement were followed in this study.A total of 23 records were excluded due to being out of scope while a further 13 records were duplicates.Another 17 records were not available as full-length articles and were also excluded.The references of each included record was further searched for relevant publications.A total of 141 records were therefore used in this minireview.CONCLUSION Pituitary macroadenomas pose substantial clinical challenges due to their size and potential for significant hormonal and neurological impact,modern therapeutic strategies offer effective management options.Early detection and comprehensive treatment are essential for optimizing patient outcomes and maintaining quality of life.Continued research and advancements in medical technology are likely to further enhance the management and prognosis of this condition in the future.展开更多
Objective:To explore the experiences of palliative care multidisciplinary teams from the perspective of pluralistic synergy theory,aiming to enhance team collaboration.Method:Utilizing a qualitative research methodolo...Objective:To explore the experiences of palliative care multidisciplinary teams from the perspective of pluralistic synergy theory,aiming to enhance team collaboration.Method:Utilizing a qualitative research methodology,we conducted in-depth interviews with 15 palliative care team members to collect data.Results:The operational framework of palliative care multidisciplinary teams under pluralistic synergy theory involves:enhancing collaboration among team members;developing a comprehensive management model for the team;rationalizing the allocation of work tasks and durations;improving team communication and interaction through effective communication mechanisms and platforms;cultivating skilled professionals;and establishing a robust health record management system.Conclusion:The operational mechanism,informed by pluralistic synergy theory,advances the development of palliative care.展开更多
Objective:To design a preoperative checklist for coronary interventional surgery based on multidisciplinary collaboration,and verify its effect on improving the completeness rate of preoperative preparation,surgical p...Objective:To design a preoperative checklist for coronary interventional surgery based on multidisciplinary collaboration,and verify its effect on improving the completeness rate of preoperative preparation,surgical punctuality,and medical staff satisfaction.Methods:A multidisciplinary team was established involving the Department of Cardiology,Anesthesiology,Clinical Laboratory,and Interventional Surgery.Referring to the latest clinical guidelines and nursing standards,a preoperative checklist covering 8 core modules and 61 sub-items was formulated,including“1 day before surgery+day of surgery”and“doctor+nurse+patient+family member”.A total of 213 patients undergoing coronary interventional surgery in our hospital from August 2023 to February 2024(observation group)were selected to apply the checklist.The completeness rate of preoperative preparation and the on-time operation start rate were compared with 197 patients(control group)before the checklist application.The satisfaction of 34 medical staff was evaluated using a Likert 5-point scale.Results:The overall completeness rate of preoperative preparation in the observation group reached 95.72%(78.17%in the control group),among which the completeness rates of 6 sub-items such as medication,health education,and laboratory examinations reached 100%,and the completeness rate of consumables and equipment preparation was 97.1%;the on-time operation start rate was 97.3%;the satisfaction of the medical team with the checklist was 94.12%,which was significantly higher than that of the control group(82.61%),with statistically significant differences(p<0.05).Conclusion:The preoperative checklist for coronary interventional surgery designed through multidisciplinary collaboration can significantly improve the quality of preoperative preparation and surgical efficiency,and is highly recognized by the medical team,providing practical reference for perioperative safety management of interventional diagnosis and treatment.展开更多
BACKGROUND Lynch syndrome(LS),an autosomal dominant genetic disorder,is distinguished by germline mutations in the DNA mismatch repair genes,including MLH1.These mutations confer an elevated risk for the development o...BACKGROUND Lynch syndrome(LS),an autosomal dominant genetic disorder,is distinguished by germline mutations in the DNA mismatch repair genes,including MLH1.These mutations confer an elevated risk for the development of colorectal cancer(CRC)and an array of other malignancies.Timely detection,facilitated by genetic profiling and stringent molecular surveillance,is crucial.It enables the implementation of customized therapeutic strategies,which have the potential to markedly enhance patient outcomes.Despite its significant public health impact,LS is frequently underdiagnosed,underscoring the necessity for increased vigilance and the adoption of precision medicine tactics.CASE SUMMARY This case presentation focuses on a 54-year-old male patient with a strong familial predisposition to colon cancer,who was identified to have LS-associated multiple colorectal neoplasms.Utilizing a comprehensive,multidisciplinary therapeutic strategy that encompassed precision medicine,immunotherapy with pembrolizumab,and stringent molecular residual disease monitoring,we effectively managed his advanced CRC.This tailored approach led to the achievement of sustained clinical remission exceeding 30 months,illustrating the promise of personalized treatment protocols in optimizing outcomes for individuals with LS and associated colorectal malignancies.CONCLUSION A synergistic,multidisciplinary approach is essential for managing LS-associated CRC,advocating for personalized care pathways in precision medicine.展开更多
BACKGROUND Currently,there is a notable lack of reliable studies evaluating the impact of multidisciplinary treatment strategies following transarterial chemoembolization(TACE)on patients with hepatocellular carcinoma...BACKGROUND Currently,there is a notable lack of reliable studies evaluating the impact of multidisciplinary treatment strategies following transarterial chemoembolization(TACE)on patients with hepatocellular carcinoma(HCC),underscoring the urgent need for higher-level research in this area.AIM To investigate the association of multidisciplinary treatment strategies with the immunological,coagulation,and tumor biomarker responses after post-TACE in HCC.METHODS This retrospective analysis included 100 patients with HCC who were categorized based on the treatment approach into the control(patients treated with TACE alone)and experimental groups(patients receiving multidisciplinary treatment strategies post-TACE).Participant characteristics,short-term efficacy,and safety assessment as well as immunological,coagulation,and tumor biomarker res-ponses between the two groups were collected and compared.RESULTS Compared with the control group,the experimental group demonstrated a superior overall response rate,along with an increased fibrinogen,markedly improved immunological biomarker,lower prothrombin time,thrombin time,alpha-fetoprotein,carcinoembryonic antigen,and carbohydrate antigen 199 levels,as well as a decreased abnormal prothrombin incidence,and a lower overall rate of adverse reactions.Notably,no significant difference in the activated partial thromboplastin time and D-dimer levels was observed between the two groups.CONCLUSION Multidisciplinary treatment strategies post-TACE have improved the treatment outcome,the immunological response,and the coagulation function,lowered the tumor biomarker response levels,and reduced the risk of adverse reactions in patients with HCC.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)ranks as the sixth most common cancer and the third-leading cause of cancer-related deaths worldwide.The multidisciplinary tumor board(MDTB)has been recognized for improving out...BACKGROUND Hepatocellular carcinoma(HCC)ranks as the sixth most common cancer and the third-leading cause of cancer-related deaths worldwide.The multidisciplinary tumor board(MDTB)has been recognized for improving outcomes in cancer management,but its role in patients with HCC undergoing liver transplantation(LT)remains underexplored.AIM To evaluate the impact of an MDTB on survival outcomes in patients with HCC undergoing LT.METHODS We retrospectively analyzed 393 patients with HCC who underwent LT at our institution from October 2015 to October 2021.Patients were categorized into the MDTB and non-MDTB groups.We compared preoperative and postoperative characteristics,overall survival(OS),and disease-free survival(DFS)between the two groups.RESULTS Within the University of California,San Francisco(UCSF)criteria,no significant differences in OS and DFS were noted between the MDTB and non-MDTB groups.However,for patients who exceeded the UCSF criteria,the MDTB group exhibited a substantial improvement in both OS and DFS.The 1-year,3-year,and 5-year OS rates for the MDTB group in this subgroup were 88.68%,75.29%,and 61.78%,respectively,compared to 83.02%,64.07%,and 38.25%,respectively in the non-MDTB group.Similarly,DFS rates were 89.47%,71.35%,and 63.52%,respectively,vs 82.18%,53.78%,and 34.04%,respectively.CONCLUSION The MDTB approach was particularly beneficial for patients with HCC exceeding the UCSF criteria,significantly improving OS and DFS.These findings advocate for integrating MDTB into clinical practice for optimizing the management of high-risk patients with HCC undergoing LT.展开更多
This letter discusses the critical yet underrecognized intersection of chronic renal insufficiency and Nocardia brasiliensis skin infection in the case reported by Zhang et al,emphasizing the diagnostic challenges and...This letter discusses the critical yet underrecognized intersection of chronic renal insufficiency and Nocardia brasiliensis skin infection in the case reported by Zhang et al,emphasizing the diagnostic challenges and therapeutic complexities in the context of advanced age,comorbidities,and immunocompromised populations.The study’s strengths included its integration of immunological profiling and precision medicine,demonstrating that a tailored low-dose trimethoprimsulfamethoxazole regimen with pharmacokinetic monitoring can improve outcomes in geriatric patients with chronic renal insufficiency while mitigating nephrotoxicity risks.However,its limitations included a single-case design,reliance on phenotypic diagnostics,and the lack of information regarding comorbidity interactions.The findings support the use of advanced molecular tools for rapid pathogen identification and identification of co-infection.Future studies should prioritize elucidating the synergistic effects of chronic kidney disease-uremia and immunosuppression on Nocardia colonization,developing biomarkers for early detection,and conducting global epidemiological studies in endemic regions.This case underscores the importance of interdisciplinary collaboration and innovative diagnostics to optimize management of nocardiosis in vulnerable populations.展开更多
基金supported by the Shenzhen Medical Research Fund(Grant No.A2303049)Guangdong Basic and Applied Basic Research(Grant No.2023A1515010647)+1 种基金National Natural Science Foundation of China(Grant No.22004135)Shenzhen Science and Technology Program(Grant No.RCBS20210706092409020,GXWD20201231165807008,20200824162253002).
文摘Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.
基金supported by the National Social Science Fund of China(NSSFC):NSSFC Major Project“Exploration and Practice in the Development of Chinese Economics Since the Modern Era”(Grant No.17ZDA034)NSSFC Key Project“The Status and Value of Traditional Chinese Economic Thought”(Grant No.17AJL006)NSSFC General Project“The Transformation and Evolution of Chinese Economic Thought During the Republican Era”(Grant No.22BJL130).
文摘Does traditional Chinese economic thought possess genuine analytical rigor?This question lies at the heart of any serious evaluation of its theoretical value and historical significance.It also matters for understanding how best to preserve,build on its remarkable achievements,and develop its intellectual legacy.Critics such as Schumpeter and Taylor have long argued that the economic reasoning found in ancient China cannot compare with that of classical Greece or medieval Europe.Yet this view often reflects the narrow assumptions of mainstream economics,defining analysis almost entirely in terms of market exchange.As a result,it tends to overlook traditions built around statecraft,governance,and the management of economic order.A careful re-examination and Sino-Western comparative analysis of key thinkers-including Mencius,Guanzi,and Sima Qian-tells a different story.Rooted in China’s distinctive cultural and philosophical heritage,traditional Chinese economic thought not only contains the analytical dimensions(as defined by Schumpeter)but also displays a broader and more diverse set of economic reasoning.Notably,its systematic depth and intellectual precision were,in many respects,remarkably advanced.Therefore,advancing the construction of a Chinese school of economics in the new era under the framework of the“Second Integration”,i.e.,integrating the basic tenets of Marxism with China’s fine traditional culture,should,and indeed can draw essential insights from this analytical tradition.
基金Supported by Scientific Research Fund Project of Yunnan Provincial Department of Education(2025J1950).
文摘Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This paper analyzes the existing problems in the current teaching of Chinese Medicine Processing Technology courses,discusses the necessity of reforming the teaching model under the context of integration,and proposes the construction of a"Dual-Capability Progression,Six-Dimensional Empowerment"teaching model.The aim is to enhance the teaching quality of Chinese Medicine Processing Technology courses and cultivate high-quality skilled talents in Chinese medicine processing who can meet industry demands.
基金supported by National Natural Science Foundation of China (Grant No. 61074110)National Defense Pre-Research Foundation of China (Grant No. B0420060524)
文摘Multidisciplinary collaborative simulation （MCS） is an important area of research in the domain of multidisciplinary design optimization （MDO）.Although previous research for MCS has to some extent addressed some issues like using of multiple tools,integration stability,control of step size,data synchronization,etc,further work is still necessary to study how to achieve improved precision.A theoretical model is formulated to describe and analyze the integration process of MCS.A basic algorithm with equal major steps is proposed based on the model,along with two methods of implementation for the model,namely the serial method and the parallel method.A further algorithm based on convergent integration step is proposed,which has a more flexible strategy for run-time integration.The influence of interpolation techniques on simulation performance is studied as well.Simulations of the performance of various algorithms with different interpolation techniques are performed for both a simple numerical example and a complex mechatronic product.The novel algorithm based on convergent integration step,when used with a high-order interpolation technique,has better performance in terms of precision and efficiency.The innovation of this paper is mainly on the validation of high precision of the proposed convergent integration step algorithm.
基金supported by the National Science Foundation for Distinguished Young Scholars,China(82025021).
文摘Critical care medicine focuses on understanding the pathophysiological mechanisms and treatment approaches for life-threatening conditions,including sepsis,severe trauma/burns,hemorrhagic shock,heatstroke,and acute pancreatitis,all of which have high incidence rates.These conditions are primarily characterized by acute multi-organ dysfunction,with sudden onset,severe illness,and high mortality rates.Additionally,critical care treatment demands substantial medical resources,imposing significant economic burdens on patients’families and society.In recent years,critical care medicine has achieved notable progress,especially in multidisciplinary integration with immunology-based fields.Collaboration across disciplines has not only accelerated advancements in critical care but also propelled the rapid development of modern immunology.This paper provides an overview and assessment of the cross-disciplinary fusion between critical care medicine and immunology,exploring how these fields related extensions mutually enhance each other.It further analyzes China’s potential to become a global leader in this area within the next 5 to 10 years.
基金Supported by the National High Technology Research and Development Programme of China (No. 2006AA04Z160).
文摘The development of complex products is essentially concerned with multidisciplinary knowledge. Running on Internet, integration based on muhilayer federation architecture and dynamic reuse of simulation resources are the major difficulties for complex product collaborative design and simulation. Since the traditional Run-Time Infrastructure （RTI） is not good at supporting these new requirements, an extended high level architecture （HLA） multilayer federation integration architecture （MLFIA）, based on the resource management federation （RMF） and its supporting environment based Service-oriented architecture （SOA） and HLA （SOHLA） are proposed, The idea and realization of two key technologies, the dynamic creation of simulation federation based on RMF, TH RTI, an extensible HLA runtime infrastructure （RTI）, used at Internet are emphasized. Finally, an industry case about multiple unit （MU） is given.
文摘In today’s era,multidisciplinary integration is the development trend of education,which breaks the field of a single discipline and lays the foundation for the development of education.Objectively speaking,with the integration of disciplines,a new interdisciplinary is formed.This new discipline is comprehensive and systematic;in addition,it integrates knowledge,technology,and methods.It is the result of the collision of different disciplines.As an applied course,Management Science and Engineering integrates multidisciplinary knowledge,such as science and technology,information science,and mathematics.Its main purpose is to solve various problems in social and economic development.It has a long-term impact on the development of contemporary multidisciplinary education.In the new era,in order to meet the requirements of social and economic development,the teaching of Management Science and Engineering should be based on the perspective of multidisciplinary integration,combined with the current characteristics and training mode of the discipline,explore new talent training paths,and then drive the development of the whole industry.
基金National Natural Science Foundation of China(11971211,12171388).
文摘Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms.
文摘In recent years,Chinese and Western medicine clinical guidelines have attracted attention.But for the existing Chinese and Western medicine experts consensus or guidelines,Chinese medicine and Western medicine were split,out of touch from the form and content.How to lay equal stress on traditional Chinese medicine and Western medicine?How to form the organic unity of Chinese medicine and Western medicine in the clinical practice?they need to reach a consensus.This article explains how to improve the efficacy of Chinese and Western medicine from different aspects.
基金supported by the National Key Research and Development Program of China(2021YFA1101303)the National Natural Science Foundation of China(62374115)the Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-07-E00096).
文摘The rapid growth of artificial intelligence has accelerated data generation,which increasingly exposes the limitations faced by traditional computational architectures,particularly in terms of energy consumption and data latency.In contrast,data-centric computing that integrates processing and storage has the potential of reducing latency and energy usage.Organic optoelectronic synaptic transistors have emerged as one type of promising devices to implement the data-centric com-puting paradigm owing to their superiority of flexibility,low cost,and large-area fabrication.However,sophisticated functions including vector-matrix multiplication that a single device can achieve are limited.Thus,the fabrication and utilization of organic optoelectronic synaptic transistor arrays(OOSTAs)are imperative.Here,we summarize the recent advances in OOSTAs.Various strategies for manufacturing OOSTAs are introduced,including coating and casting,physical vapor deposition,printing,and photolithography.Furthermore,innovative applications of the OOSTA system integration are discussed,including neuromor-phic visual systems and neuromorphic computing systems.At last,challenges and future perspectives of utilizing OOSTAs in real-world applications are discussed.
基金Supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287.
文摘The rising prevalence of chronic multimorbidity poses substantial challenges to healthcare systems,necessitating the development of innovative management strategies to optimize patient care and system efficiency.The study by Fontalba-Navas et al investigates the implementation of a novel high complexity unit(HCU)specifically designed to improve the management of patients with chronic complex conditions.By adopting a multidisciplinary approach,the HCU aims to provide comprehensive,patient-centered care that enhances health outcomes and alleviates the strain on traditional hospital services.Utilizing a longitudinal analysis of data from the Basic Minimum Data Set,this study compares hospitalization metrics among the HCU,Internal Medicine,and other departments within a regional hospital throughout 2022.The findings reveal that the HCU's integrated care model significantly reduces readmission rates and boosts patient satisfaction compared to conventional care practices.The study highlights the HCU's potential as a replicable model for managing chronic multimorbidity,emphasizing its effectiveness in minimizing unnecessary hospitalizations and enhancing the overall quality of patient care.This innovative approach not only addresses the complexities associated with chronic multimorbid conditions but also offers a sustainable framework for healthcare systems confronting similar challenges.
文摘To address the limitations of existing coupling methods in aero-engine system simulation,which fail to adaptively adjust iterative parameters and coupling relationships,which can result in low efficiency and in⁃stability,this study introduces a‘Dynamic Event-Driven Co-Simulation’algorithm integrated with decision tree algorithms.This algorithm separates the overall coupling relationships and the main solver from the primary mod⁃el,utilizing a dynamic event monitoring module to adaptively adjust simulation strategies,including iteration pa⁃rameters,coupling relationships,and convergence criteria.This facilitates efficient adaptive simulations of dy⁃namic events while balancing solution accuracy and computational efficiency.The research focuses on a twinshaft turbofan engine,establishing six system-level models that encompass overall performance and various sub⁃systems based on three coupling methods,along with a multidisciplinary multi-fidelity simulation framework in⁃corporating a 3D CFD nozzle model.The study tests both model exchange and coupled simulation methods under a 14 s transient acceleration and deceleration scenario.In a 100%throttle condition,a high-fidelity nozzle model is used to analyze the sensitivity of different convergence criteria on computational efficiency and accuracy.Re⁃sults indicate that the accuracy and efficiency achieved with this method are comparable to those of PROOSIS soft⁃ware(18 s and 35 s,respectively),while being 71%more efficient than Simulink software(62 s and 120 s,re⁃spectively).Furthermore,appropriately relaxing the convergence criteria for the 0D model(from 10-6 to 10-4)while enhancing those for the 3D model(from 3000 steps to 6000 steps)can effectively balance computational accuracy and efficiency.
文摘BACKGROUND Pituitary macroadenomas represent a significant challenge in clinical management due to their variable presentations and complex treatment considerations.This manuscript explores the multidisciplinary approach to understanding and managing pituitary macroadenomas,integrating neurosurgery,endocrinology,radiology,and pathology perspectives.AIM To summarize the literature on pituitary macroadenoma and outline the possible multidisciplinary approach in the diagnosis,management,and rehabilitation of individuals with pituitary adenomas,to add to already preexisting knowledge,in managing these cases enhancing better ocular and systemic outcomes.METHODS A search was conducted on an online publication database(PubMed)using the term“pituitary adenoma”including all results published over twenty years(2004-2024).Results were sorted for relevance,language,and completeness.RESULTS A total of 176 records were returned.The guidelines of the PRISMA 2020 statement were followed in this study.A total of 23 records were excluded due to being out of scope while a further 13 records were duplicates.Another 17 records were not available as full-length articles and were also excluded.The references of each included record was further searched for relevant publications.A total of 141 records were therefore used in this minireview.CONCLUSION Pituitary macroadenomas pose substantial clinical challenges due to their size and potential for significant hormonal and neurological impact,modern therapeutic strategies offer effective management options.Early detection and comprehensive treatment are essential for optimizing patient outcomes and maintaining quality of life.Continued research and advancements in medical technology are likely to further enhance the management and prognosis of this condition in the future.
文摘Objective:To explore the experiences of palliative care multidisciplinary teams from the perspective of pluralistic synergy theory,aiming to enhance team collaboration.Method:Utilizing a qualitative research methodology,we conducted in-depth interviews with 15 palliative care team members to collect data.Results:The operational framework of palliative care multidisciplinary teams under pluralistic synergy theory involves:enhancing collaboration among team members;developing a comprehensive management model for the team;rationalizing the allocation of work tasks and durations;improving team communication and interaction through effective communication mechanisms and platforms;cultivating skilled professionals;and establishing a robust health record management system.Conclusion:The operational mechanism,informed by pluralistic synergy theory,advances the development of palliative care.
基金Taikang Xianlin Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University(Project No.:TKKYZX20231016)。
文摘Objective:To design a preoperative checklist for coronary interventional surgery based on multidisciplinary collaboration,and verify its effect on improving the completeness rate of preoperative preparation,surgical punctuality,and medical staff satisfaction.Methods:A multidisciplinary team was established involving the Department of Cardiology,Anesthesiology,Clinical Laboratory,and Interventional Surgery.Referring to the latest clinical guidelines and nursing standards,a preoperative checklist covering 8 core modules and 61 sub-items was formulated,including“1 day before surgery+day of surgery”and“doctor+nurse+patient+family member”.A total of 213 patients undergoing coronary interventional surgery in our hospital from August 2023 to February 2024(observation group)were selected to apply the checklist.The completeness rate of preoperative preparation and the on-time operation start rate were compared with 197 patients(control group)before the checklist application.The satisfaction of 34 medical staff was evaluated using a Likert 5-point scale.Results:The overall completeness rate of preoperative preparation in the observation group reached 95.72%(78.17%in the control group),among which the completeness rates of 6 sub-items such as medication,health education,and laboratory examinations reached 100%,and the completeness rate of consumables and equipment preparation was 97.1%;the on-time operation start rate was 97.3%;the satisfaction of the medical team with the checklist was 94.12%,which was significantly higher than that of the control group(82.61%),with statistically significant differences(p<0.05).Conclusion:The preoperative checklist for coronary interventional surgery designed through multidisciplinary collaboration can significantly improve the quality of preoperative preparation and surgical efficiency,and is highly recognized by the medical team,providing practical reference for perioperative safety management of interventional diagnosis and treatment.
基金Supported by the National Natural Science Foundation of China,No.81972790the Natural Science Foundation of Gansu Province,China,No.22JR5RA004.
文摘BACKGROUND Lynch syndrome(LS),an autosomal dominant genetic disorder,is distinguished by germline mutations in the DNA mismatch repair genes,including MLH1.These mutations confer an elevated risk for the development of colorectal cancer(CRC)and an array of other malignancies.Timely detection,facilitated by genetic profiling and stringent molecular surveillance,is crucial.It enables the implementation of customized therapeutic strategies,which have the potential to markedly enhance patient outcomes.Despite its significant public health impact,LS is frequently underdiagnosed,underscoring the necessity for increased vigilance and the adoption of precision medicine tactics.CASE SUMMARY This case presentation focuses on a 54-year-old male patient with a strong familial predisposition to colon cancer,who was identified to have LS-associated multiple colorectal neoplasms.Utilizing a comprehensive,multidisciplinary therapeutic strategy that encompassed precision medicine,immunotherapy with pembrolizumab,and stringent molecular residual disease monitoring,we effectively managed his advanced CRC.This tailored approach led to the achievement of sustained clinical remission exceeding 30 months,illustrating the promise of personalized treatment protocols in optimizing outcomes for individuals with LS and associated colorectal malignancies.CONCLUSION A synergistic,multidisciplinary approach is essential for managing LS-associated CRC,advocating for personalized care pathways in precision medicine.
文摘BACKGROUND Currently,there is a notable lack of reliable studies evaluating the impact of multidisciplinary treatment strategies following transarterial chemoembolization(TACE)on patients with hepatocellular carcinoma(HCC),underscoring the urgent need for higher-level research in this area.AIM To investigate the association of multidisciplinary treatment strategies with the immunological,coagulation,and tumor biomarker responses after post-TACE in HCC.METHODS This retrospective analysis included 100 patients with HCC who were categorized based on the treatment approach into the control(patients treated with TACE alone)and experimental groups(patients receiving multidisciplinary treatment strategies post-TACE).Participant characteristics,short-term efficacy,and safety assessment as well as immunological,coagulation,and tumor biomarker res-ponses between the two groups were collected and compared.RESULTS Compared with the control group,the experimental group demonstrated a superior overall response rate,along with an increased fibrinogen,markedly improved immunological biomarker,lower prothrombin time,thrombin time,alpha-fetoprotein,carcinoembryonic antigen,and carbohydrate antigen 199 levels,as well as a decreased abnormal prothrombin incidence,and a lower overall rate of adverse reactions.Notably,no significant difference in the activated partial thromboplastin time and D-dimer levels was observed between the two groups.CONCLUSION Multidisciplinary treatment strategies post-TACE have improved the treatment outcome,the immunological response,and the coagulation function,lowered the tumor biomarker response levels,and reduced the risk of adverse reactions in patients with HCC.
基金Supported by Natural Science Foundation of Tianjin,No.21JCYBJC01140Key Project of Tianjin Science and Technology Bureau Applied Basic Research,No.23JCZDJC01200+1 种基金Key Project of Scientific Research Plan of Tianjin Municipal Education Commission,No.2023YXZD07Project of Tianjin Science and Technology Bureau Applied Basic Research,No.23JCYBJC01800.
文摘BACKGROUND Hepatocellular carcinoma(HCC)ranks as the sixth most common cancer and the third-leading cause of cancer-related deaths worldwide.The multidisciplinary tumor board(MDTB)has been recognized for improving outcomes in cancer management,but its role in patients with HCC undergoing liver transplantation(LT)remains underexplored.AIM To evaluate the impact of an MDTB on survival outcomes in patients with HCC undergoing LT.METHODS We retrospectively analyzed 393 patients with HCC who underwent LT at our institution from October 2015 to October 2021.Patients were categorized into the MDTB and non-MDTB groups.We compared preoperative and postoperative characteristics,overall survival(OS),and disease-free survival(DFS)between the two groups.RESULTS Within the University of California,San Francisco(UCSF)criteria,no significant differences in OS and DFS were noted between the MDTB and non-MDTB groups.However,for patients who exceeded the UCSF criteria,the MDTB group exhibited a substantial improvement in both OS and DFS.The 1-year,3-year,and 5-year OS rates for the MDTB group in this subgroup were 88.68%,75.29%,and 61.78%,respectively,compared to 83.02%,64.07%,and 38.25%,respectively in the non-MDTB group.Similarly,DFS rates were 89.47%,71.35%,and 63.52%,respectively,vs 82.18%,53.78%,and 34.04%,respectively.CONCLUSION The MDTB approach was particularly beneficial for patients with HCC exceeding the UCSF criteria,significantly improving OS and DFS.These findings advocate for integrating MDTB into clinical practice for optimizing the management of high-risk patients with HCC undergoing LT.
文摘This letter discusses the critical yet underrecognized intersection of chronic renal insufficiency and Nocardia brasiliensis skin infection in the case reported by Zhang et al,emphasizing the diagnostic challenges and therapeutic complexities in the context of advanced age,comorbidities,and immunocompromised populations.The study’s strengths included its integration of immunological profiling and precision medicine,demonstrating that a tailored low-dose trimethoprimsulfamethoxazole regimen with pharmacokinetic monitoring can improve outcomes in geriatric patients with chronic renal insufficiency while mitigating nephrotoxicity risks.However,its limitations included a single-case design,reliance on phenotypic diagnostics,and the lack of information regarding comorbidity interactions.The findings support the use of advanced molecular tools for rapid pathogen identification and identification of co-infection.Future studies should prioritize elucidating the synergistic effects of chronic kidney disease-uremia and immunosuppression on Nocardia colonization,developing biomarkers for early detection,and conducting global epidemiological studies in endemic regions.This case underscores the importance of interdisciplinary collaboration and innovative diagnostics to optimize management of nocardiosis in vulnerable populations.
