Objective:To explore the clinical effect of improved incision in the extraction of impacted mandibular wisdom teeth.Methods:160 patients who were treated in our hospital from October,2024 to April,2025 and had their m...Objective:To explore the clinical effect of improved incision in the extraction of impacted mandibular wisdom teeth.Methods:160 patients who were treated in our hospital from October,2024 to April,2025 and had their mandibular impacted wisdom teeth removed according to the doctor’s advice were randomly divided into observation group and control group.The observation group used modified incision,while the control group used traditional triangular incision.The operation time,intraoperative visual analogue scale(VAS)pain score,pain VAS score on the 1st,2nd and 3rd day after operation,facial swelling on the 2nd day after operation,mouth opening limitation on the 2nd day after operation and the incidence of dry socket after operation were recorded and compared between the two groups.Results:There was no significant difference in operation time between the two groups(p>0.05).The VAS score of pain in the observation group was significantly lower than that in the control group at each time point during and after operation(p<0.05).On the second day after operation,the facial swelling and mouth opening limitation in the observation group were significantly lighter than those in the control group(p<0.05).The incidence of dry socket in the observation group was 1.25%(1/80),which was significantly lower than that in the control group(8.75%,7/80),and the difference was statistically significant(p<0.05).Conclusion:The application of modified triangular incision in the extraction of impacted mandibular wisdom teeth can effectively relieve the pain during and after operation,reduce postoperative facial swelling and mouth opening limitation,and reduce the incidence of dry socket.展开更多
The instance segmentation of impacted teeth in the oral panoramic X-ray images is hotly researched.However,due to the complex structure,low contrast,and complex background of teeth in panoramic X-ray images,the task o...The instance segmentation of impacted teeth in the oral panoramic X-ray images is hotly researched.However,due to the complex structure,low contrast,and complex background of teeth in panoramic X-ray images,the task of instance segmentation is technically tricky.In this study,the contrast between impacted Teeth and periodontal tissues such as gingiva,periodontalmembrane,and alveolar bone is low,resulting in fuzzy boundaries of impacted teeth.Amodel based on Teeth YOLACT is proposed to provide amore efficient and accurate solution for the segmentation of impacted teeth in oral panoramic X-ray films.Firstly,a Multi-scale Res-Transformer Module(MRTM)is designed.In the module,depthwise separable convolutions with different receptive fields are used to enhance the sensitivity of the model to lesion size.Additionally,the Vision Transformer is integrated to improve the model’s ability to perceive global features.Secondly,the Context Interaction-awareness Module(CIaM)is designed to fuse deep and shallow features.The deep semantic features guide the shallow spatial features.Then,the shallow spatial features are embedded into the deep semantic features,and the cross-weighted attention mechanism is used to aggregate the deep and shallow features efficiently,and richer context information is obtained.Thirdly,the Edge-preserving perceptionModule(E2PM)is designed to enhance the teeth edge features.The first-order differential operator is used to get the tooth edge weight,and the perception ability of tooth edge features is improved.The shallow spatial feature is fused by linear mapping,weight concatenation,and matrix multiplication operations to preserve the tooth edge information.Finally,comparison experiments and ablation experiments are conducted on the oral panoramic X-ray image datasets.The results show that the APdet,APseg,ARdet,ARseg,mAPdet,and mAPseg indicators of the proposed model are 89.9%,91.9%,77.4%,77.6%,72.8%,and 73.5%,respectively.This study further verifies the application potential of the method combining multi-scale feature extraction,multi-scale feature fusion,and edge perception enhancement in medical image segmentation,which provides a valuable reference for future related research.展开更多
This paper deeply discusses the causes of gear howling noise,the identification and analysis of multi-source excitation,the transmission path of dynamic noise,simulation and experimental research,case analysis,optimiz...This paper deeply discusses the causes of gear howling noise,the identification and analysis of multi-source excitation,the transmission path of dynamic noise,simulation and experimental research,case analysis,optimization effect,etc.,aiming to better provide a certain guideline and reference for relevant researchers.展开更多
背景:人脱落乳牙牙髓干细胞具有较强的增殖和分化潜能,且具有较少的伦理争议和免疫排斥等优点,逐渐成为干细胞领域的研究热点。目的:总结近年来关于人乳牙牙髓干细胞分泌组的研究进展,探究其发挥治疗作用的分子机制,分析当前面临的问题...背景:人脱落乳牙牙髓干细胞具有较强的增殖和分化潜能,且具有较少的伦理争议和免疫排斥等优点,逐渐成为干细胞领域的研究热点。目的:总结近年来关于人乳牙牙髓干细胞分泌组的研究进展,探究其发挥治疗作用的分子机制,分析当前面临的问题并展望未来发展方向。方法:选择CNKI、PubMed数据库,中文检索词为“人脱落乳牙髓干细胞,间充质干细胞,分泌组,外泌体,条件培养基”;英文检索词为“stem cells from human exfoliated deciduous teeth,mesenchymal stem cells,secretome,exosome,conditioned medium”,初检获得文献642篇,选择近5年内的最新研究文献,以及近10年内影响因子超过5分的相关文献,由全体作者共同对检索文献进行评估,排除重复内容以及内容陈旧、相关性差的文献569篇,最终纳入73篇文献进行综述。结果与结论:人脱落乳牙牙髓干细胞因具备独特的生物学特性,近年来已成为组织工程与再生医学领域的重要研究对象。这类干细胞源自儿童生理性脱落的乳牙牙髓组织,具有多向分化潜能(如成骨、成神经、成血管等)、来源广泛且伦理争议小等显著优势。研究表明,人脱落乳牙牙髓干细胞不仅表现出比骨髓间充质干细胞更强的增殖能力,其免疫调节特性和低免疫原性更使它在骨组织修复、神经再生、牙周组织重建等领域展现出独特的临床应用价值。随着再生医学研究范式的转变,无细胞治疗策略的兴起为人脱落乳牙牙髓干细胞的应用开辟了新方向。无细胞治疗策略通过提取人脱落乳牙牙髓干细胞分泌组——包含外泌体、细胞因子、趋化因子、生长因子等多种生物活性物质的功能性组分,规避了传统活细胞移植中可能存在的细胞存活率低、免疫排斥反应及潜在致瘤性等风险。研究发现,人脱落乳牙牙髓干细胞分泌组可通过旁分泌机制介导血管生成、免疫调节、抗炎及抗凋亡等多重生物学效应,在肝损伤修复、心肌缺血治疗、骨缺损再生等动物模型中已展现出显著疗效。当前研究热点聚焦于通过工程化技术解析人脱落乳牙牙髓干细胞分泌组的分子组成,构建具有时空可控性的无细胞治疗体系。人脱落乳牙牙髓干细胞分泌组有望在精准医学框架下实现标准化生产与质量控制,为退行性疾病治疗和创伤修复提供创新解决方案。展开更多
文摘Objective:To explore the clinical effect of improved incision in the extraction of impacted mandibular wisdom teeth.Methods:160 patients who were treated in our hospital from October,2024 to April,2025 and had their mandibular impacted wisdom teeth removed according to the doctor’s advice were randomly divided into observation group and control group.The observation group used modified incision,while the control group used traditional triangular incision.The operation time,intraoperative visual analogue scale(VAS)pain score,pain VAS score on the 1st,2nd and 3rd day after operation,facial swelling on the 2nd day after operation,mouth opening limitation on the 2nd day after operation and the incidence of dry socket after operation were recorded and compared between the two groups.Results:There was no significant difference in operation time between the two groups(p>0.05).The VAS score of pain in the observation group was significantly lower than that in the control group at each time point during and after operation(p<0.05).On the second day after operation,the facial swelling and mouth opening limitation in the observation group were significantly lighter than those in the control group(p<0.05).The incidence of dry socket in the observation group was 1.25%(1/80),which was significantly lower than that in the control group(8.75%,7/80),and the difference was statistically significant(p<0.05).Conclusion:The application of modified triangular incision in the extraction of impacted mandibular wisdom teeth can effectively relieve the pain during and after operation,reduce postoperative facial swelling and mouth opening limitation,and reduce the incidence of dry socket.
基金supported in part by the National Natural Science Foundation of China(Grant No.62062003)Natural Science Foundation of Ningxia(Grant No.2023AAC03293).
文摘The instance segmentation of impacted teeth in the oral panoramic X-ray images is hotly researched.However,due to the complex structure,low contrast,and complex background of teeth in panoramic X-ray images,the task of instance segmentation is technically tricky.In this study,the contrast between impacted Teeth and periodontal tissues such as gingiva,periodontalmembrane,and alveolar bone is low,resulting in fuzzy boundaries of impacted teeth.Amodel based on Teeth YOLACT is proposed to provide amore efficient and accurate solution for the segmentation of impacted teeth in oral panoramic X-ray films.Firstly,a Multi-scale Res-Transformer Module(MRTM)is designed.In the module,depthwise separable convolutions with different receptive fields are used to enhance the sensitivity of the model to lesion size.Additionally,the Vision Transformer is integrated to improve the model’s ability to perceive global features.Secondly,the Context Interaction-awareness Module(CIaM)is designed to fuse deep and shallow features.The deep semantic features guide the shallow spatial features.Then,the shallow spatial features are embedded into the deep semantic features,and the cross-weighted attention mechanism is used to aggregate the deep and shallow features efficiently,and richer context information is obtained.Thirdly,the Edge-preserving perceptionModule(E2PM)is designed to enhance the teeth edge features.The first-order differential operator is used to get the tooth edge weight,and the perception ability of tooth edge features is improved.The shallow spatial feature is fused by linear mapping,weight concatenation,and matrix multiplication operations to preserve the tooth edge information.Finally,comparison experiments and ablation experiments are conducted on the oral panoramic X-ray image datasets.The results show that the APdet,APseg,ARdet,ARseg,mAPdet,and mAPseg indicators of the proposed model are 89.9%,91.9%,77.4%,77.6%,72.8%,and 73.5%,respectively.This study further verifies the application potential of the method combining multi-scale feature extraction,multi-scale feature fusion,and edge perception enhancement in medical image segmentation,which provides a valuable reference for future related research.
文摘This paper deeply discusses the causes of gear howling noise,the identification and analysis of multi-source excitation,the transmission path of dynamic noise,simulation and experimental research,case analysis,optimization effect,etc.,aiming to better provide a certain guideline and reference for relevant researchers.
文摘背景:人脱落乳牙牙髓干细胞具有较强的增殖和分化潜能,且具有较少的伦理争议和免疫排斥等优点,逐渐成为干细胞领域的研究热点。目的:总结近年来关于人乳牙牙髓干细胞分泌组的研究进展,探究其发挥治疗作用的分子机制,分析当前面临的问题并展望未来发展方向。方法:选择CNKI、PubMed数据库,中文检索词为“人脱落乳牙髓干细胞,间充质干细胞,分泌组,外泌体,条件培养基”;英文检索词为“stem cells from human exfoliated deciduous teeth,mesenchymal stem cells,secretome,exosome,conditioned medium”,初检获得文献642篇,选择近5年内的最新研究文献,以及近10年内影响因子超过5分的相关文献,由全体作者共同对检索文献进行评估,排除重复内容以及内容陈旧、相关性差的文献569篇,最终纳入73篇文献进行综述。结果与结论:人脱落乳牙牙髓干细胞因具备独特的生物学特性,近年来已成为组织工程与再生医学领域的重要研究对象。这类干细胞源自儿童生理性脱落的乳牙牙髓组织,具有多向分化潜能(如成骨、成神经、成血管等)、来源广泛且伦理争议小等显著优势。研究表明,人脱落乳牙牙髓干细胞不仅表现出比骨髓间充质干细胞更强的增殖能力,其免疫调节特性和低免疫原性更使它在骨组织修复、神经再生、牙周组织重建等领域展现出独特的临床应用价值。随着再生医学研究范式的转变,无细胞治疗策略的兴起为人脱落乳牙牙髓干细胞的应用开辟了新方向。无细胞治疗策略通过提取人脱落乳牙牙髓干细胞分泌组——包含外泌体、细胞因子、趋化因子、生长因子等多种生物活性物质的功能性组分,规避了传统活细胞移植中可能存在的细胞存活率低、免疫排斥反应及潜在致瘤性等风险。研究发现,人脱落乳牙牙髓干细胞分泌组可通过旁分泌机制介导血管生成、免疫调节、抗炎及抗凋亡等多重生物学效应,在肝损伤修复、心肌缺血治疗、骨缺损再生等动物模型中已展现出显著疗效。当前研究热点聚焦于通过工程化技术解析人脱落乳牙牙髓干细胞分泌组的分子组成,构建具有时空可控性的无细胞治疗体系。人脱落乳牙牙髓干细胞分泌组有望在精准医学框架下实现标准化生产与质量控制,为退行性疾病治疗和创伤修复提供创新解决方案。
