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Weak Co-AB-context for G_(C)-χ-injective Modules
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作者 YANG Qiang 《数学进展》 北大核心 2026年第1期103-119,共17页
In this paper,we introduce the notion of G_(C)-X-injective modules,where X denotes a class of left S-modules and C represents a faithfully semidualizing bimodule.Under the condition that X satisfies certain hypotheses... In this paper,we introduce the notion of G_(C)-X-injective modules,where X denotes a class of left S-modules and C represents a faithfully semidualizing bimodule.Under the condition that X satisfies certain hypotheses,some properties and some equivalent characterizations of G_(C)-X-injective modules are investigated,and we also show that the triple(■,cores■,■)is a weak co-AB-context.As an application,two complete cotorsion pairs and a new model structure in Mod S are given. 展开更多
关键词 C-X-injective module G_(C)-X-injective module cotorsion pair weak co-ABcontext
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Peak current reduction in presence of RF phase modulationin the dual RF system
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作者 Jiang Bocheng Zhang Yao Tsai Cheng-Ying 《强激光与粒子束》 北大核心 2026年第1期160-165,共6页
[Background]High harmonic cavities are widely used in electron storage rings to lengthen thebunch,lower the bunch peak current,thereby reducing the IBS effect,enhancing the Touschek lifetime,as well asproviding Landau... [Background]High harmonic cavities are widely used in electron storage rings to lengthen thebunch,lower the bunch peak current,thereby reducing the IBS effect,enhancing the Touschek lifetime,as well asproviding Landau damping,which is particularly important for storage rings operating with ultra-low emittance or atlow beam energy.[Purpose]To further increase the bunch length without additional hardware costs,the phasemodulation in a dual-RF system is considered.[Methods]In this paper,turn-by-turn simulations incorporating randomsynchrotron radiation excitation are conducted,and a brief analysis is presented to explain the bunch lengtheningmechanism.[Results]Simulation results reveal that the peak current can be further reduced,thereby mitigating IBSeffects and enhancing the Touschek lifetime.Although the energy spread increases,which tends to reduce thebrightness of higher-harmonic radiation from the undulator,the brightness of the fundamental harmonic can,in fact,beimproved. 展开更多
关键词 dual high-frequency system phase modulation beam bunch stretching intra-beam scattering
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Evaluation of Reinforcement Learning-Based Adaptive Modulation in Shallow Sea Acoustic Communication
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作者 Yifan Qiu Xiaoyu Yang +1 位作者 Feng Tong Dongsheng Chen 《哈尔滨工程大学学报(英文版)》 2026年第1期292-299,共8页
While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance re... While reinforcement learning-based underwater acoustic adaptive modulation shows promise for enabling environment-adaptive communication as supported by extensive simulation-based research,its practical performance remains underexplored in field investigations.To evaluate the practical applicability of this emerging technique in adverse shallow sea channels,a field experiment was conducted using three communication modes:orthogonal frequency division multiplexing(OFDM),M-ary frequency-shift keying(MFSK),and direct sequence spread spectrum(DSSS)for reinforcement learning-driven adaptive modulation.Specifically,a Q-learning method is used to select the optimal modulation mode according to the channel quality quantified by signal-to-noise ratio,multipath spread length,and Doppler frequency offset.Experimental results demonstrate that the reinforcement learning-based adaptive modulation scheme outperformed fixed threshold detection in terms of total throughput and average bit error rate,surpassing conventional adaptive modulation strategies. 展开更多
关键词 Adaptive modulation Shallow sea underwater acoustic modulation Reinforcement learning
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Impact toughness,crack initiation and propagation mechanism of Ti6422 alloy with multi-level lamellar microstructure
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作者 Jie Shen Zhihao Zhang Jianxin Xie 《International Journal of Minerals,Metallurgy and Materials》 2026年第2期595-609,共15页
The influence of different solution and aging conditions on the microstructure,impact toughness,and crack initiation and propagation mechanisms of the novel α+β titanium alloy Ti6422 was systematically investigated.... The influence of different solution and aging conditions on the microstructure,impact toughness,and crack initiation and propagation mechanisms of the novel α+β titanium alloy Ti6422 was systematically investigated.By adjusting the furnace cooling time after solution treatment and the aging temperature,Ti6422 alloy samples were developed with a multi-level lamellar microstructure,in-cluding microscaleαcolonies and α_(p) lamellae,as well as nanoscale α_(s) phases.Extending the furnace cooling time after solution treatment at 920℃ for 1 h from 240 to 540 min,followed by aging at 600℃ for 6 h,increased the α_(p) lamella content,reduced the α_(s) phase content,expanded theαcolonies and α_(p) lamellae size,and improved the impact toughness from 22.7 to 53.8 J/cm^(2).Additionally,under the same solution treatment,raising the aging temperature from 500 to 700℃ resulted in a decrease in the α_(s) phase content and a growth in the thickness of the α_(p) lamella and α_(s) phase.The impact toughness increased significantly with these changes.Samples with high α_(p) lamellae content or large α_(s) phase size exhibited high crack initiation and propagation energies.Impact deformation caused severe kinking of the α_(p) lamellae in crack initiation and propagation areas,leading to a uniform and high-density kernel average misorientation(KAM)distribu-tion,enhancing plastic deformation coordination and uniformity.Moreover,the multidirectional arrangement of coarserαcolonies and α_(p) lamellae continuously deflect the crack propagation direction,inhibiting crack propagation. 展开更多
关键词 novel titanium alloy multi-level lamellar microstructure impact toughness crack initiation and propagation
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Photoelectrocatalytic degradation of refractory organic pollutants in water:Mechanism of active species generation by modulating the photoanode micro-interface
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作者 Yuhao Ma Yufei Zhou +4 位作者 Hongli Li Cheng Fang Mingchuan Yu Shaoxia Yang Junfeng Niu 《Chinese Chemical Letters》 2026年第1期198-207,共10页
The escalating global issues of water scarcity and pollution emphasize the critical need for the rapid development of efficient and eco-friendly water treatment technologies.Photoelectrocatalytic technology has emerge... The escalating global issues of water scarcity and pollution emphasize the critical need for the rapid development of efficient and eco-friendly water treatment technologies.Photoelectrocatalytic technology has emerged as a promising solution for effectively degrading refractory organic pollutants in water under light conditions.This review delves into the advancements made in the field,focusing on strategies to enhance the generation of active species by modulating the micro-interface of the photoanode.Strategies,such as morphological control,element doping,introduction of surface oxygen vacancies,and construction of heterostructures,significantly improve the separation efficiency of photogenerated charges and the generation of active species,thereby boosting the efficiency of photoelectrocatalytic performance.Furthermore,the review explores the potential applications of photoelectrocatalytic technology in organic pollutant degradation in solutions.It also outlines the current challenges and future development directions.Despite its remarkable laboratory success,practical implementation of photoelectrocatalytic technology encounters obstacles related to stability,cost-effectiveness,and operational efficiency.Future investigations need to focus on optimizing the performance of photoelectrocatalytic materials and exploring strategies for upscaling their application in real water treatment scenarios. 展开更多
关键词 Photoelectrocatalytic degradation PHOTOANODE Interface modulation Active species MECHANISM
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Pharmacological and light-driven pupillary accommodation in guinea pigs:comparative effects of muscarinic modulators and illumination across developmental stages
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作者 Hao Wu Na Lu +5 位作者 Zhong-Bao Qiao Chi Cheng Wen-Ting Luo Ting Wan Tong Qiao Yue Di 《International Journal of Ophthalmology(English edition)》 2026年第2期211-218,共8页
AIM:To investigate the effects of different light intensities and various mydriatic and miotic drugs on pupil accommodation in guinea pigs.METHODS:Forty-two-week-old guinea pigs were randomly divided into four groups ... AIM:To investigate the effects of different light intensities and various mydriatic and miotic drugs on pupil accommodation in guinea pigs.METHODS:Forty-two-week-old guinea pigs were randomly divided into four groups to assess pupillary responses under varying light intensities(100,250,500 lx)and pharmacological interventions(1%atropine,1%cyclopentolate,1%tropicamide,or 2%pilocarpine).Baseline pupil size and eccentricity were recorded using a non-contact Python-based imaging system integrating edge detection and pixel-to-distance conversion.Direct illumination effects were measured at sequential time points,followed by drug administration and longitudinal tracking of pupillary changes.The protocol was repeated at 12wk of age for developmental comparisons.Postexperiment,enucleated eyes were analyzed to evaluate in vitro vs in vivo differences.RESULTS:Significant age-dependent differences in pupil dynamics were observed.Both 2-and 12-week-old guinea pigs exhibited marked pupil constriction under direct illumination(P<0.001),with decreased eccentricity post-constriction(P<0.001).Indirect illumination caused inconsistent pupil size changes(2-week:P=0.68;12-week:P=0.49).Pharmacologically,atropine,cyclopentolate,and tropicamide induced pupil dilation(P<0.001),whereas pilocarpine caused constriction(P<0.001).All drug groups showed reduced eccentricity(P<0.001).In vivo/in vitro comparisons revealed significant structural differences.CONCLUSION:This study investigates pupillary responses in developing guinea pigs,revealing a direct pupillary light reflex(PLR)with light intensity-dependent responses,while indirect PLR was undetectable.The differential effects of muscarinic modulators on pupillary responses underscore the critical role of cholinergic signaling in ocular accommodation,with age-related variations in sensitivity.Additionally,a novel non-contact measurement methodology achieved a precision of 0.01 mm for pupillary quantification,enhancing accuracy in ocular studies. 展开更多
关键词 PUPIL guinea pig muscarinic receptor modulator light reflex
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Suppression of ablative Rayleigh–Taylor instability by spatially modulated laser in inertial confinement fusion
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作者 Zhantao Lu Xinglong Xie +10 位作者 Xiao Liang Meizhi Sun Ping Zhu Xuejie Zhang Chunqing Xing Linjun Li Hao Xue Guoli Zhang Rashid Ul Haq Dongjun Zhang Jianqiang Zhu 《Matter and Radiation at Extremes》 2026年第1期29-38,共10页
The suppression of ablative Rayleigh–Taylor instability(ARTI)by a spatially modulated laser in inertial confinement fusion(ICF)is studied through numerical simulations.The results show that in the acceleration phase ... The suppression of ablative Rayleigh–Taylor instability(ARTI)by a spatially modulated laser in inertial confinement fusion(ICF)is studied through numerical simulations.The results show that in the acceleration phase of ICF implosion,the growth of ARTI can be suppressed by using a short-wavelength spatially modulated laser.The ARTI growth rate decreases as the wavelength of the spatially modulated laser decreases,and ARTI is completely suppressed after a certain wavelength has been reached.A spatially uniform laser is introduced to keep the state of motion of the implosion fluid consistent,and it is found that the proportion of the spatially modulated laser required for complete suppression of ARTI decreases as the wavelength continues to decrease.We also optimize the spatial intensity distribution of the spatially modulated laser.In addition,as the duration of the spatially modulated laser decreases,the proportion required for completely suppressing ARTI increases,but the required energy decreases.When the perturbation wavenumber decreases,the wavelength of the spatially modulated laser required for complete suppression of ARTI becomes longer.In the case of multimode perturbation,ARTI can also be significantly suppressed by a spatially modulated laser,and the perturbation amplitude can be reduced to less than 10% of that without a spatially modulated laser.We believe that the conclusions drawn from our simulations can provide the basis for new approaches to control ARTI in ICF. 展开更多
关键词 ablative Rayleigh Taylor instability ablative rayleigh taylor instability arti numerical simulationsthe spatially modulated laser inertial confinement fusion icf spatially modulated laserthe acceleration phase spatially uniform
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Stableδ-FA(Cs)PbI_(3)intermediate enables fabrication of large-area perovskite solar modules in ambient air
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作者 Chenyang Duan Ke Xiao +12 位作者 Yinke Wang Ye Liu Yameen Ahmed Zhentao Pang Wenjun Zhan Hongfei Sun Han Gao Haowen Luo Yuhong Zhang Xin Luo Yu Deng Makhsud I.Saidaminov Hairen Tan 《Science China Materials》 2026年第3期1456-1463,共8页
Fabrication of large-area perovskite solar modules under ambient air conditions remains a critical challenge due to air sensitivity of perovskite intermediate phases during crystallization.Here,we introduce 2-iodoimid... Fabrication of large-area perovskite solar modules under ambient air conditions remains a critical challenge due to air sensitivity of perovskite intermediate phases during crystallization.Here,we introduce 2-iodoimidazole(IIZ)into the perovskite precursor,enabling the formation of an air-stable pureδ-phase intermediate,which,upon annealing,fully transforms into a highly orientedα-phase perovskite film with reduced defects and variability.Leveraging this approach,we achieve a stabilized power conversion efficiency of 20.9%for 927.5 cm^(2)perovskite solar modules with high reproducibility.The encapsulated modules meet stringent international photovoltaic testing standards(IEC61215:2021),demonstrating excellent stability under continuous operation,thermal cycling(-40 to 85℃)and damp heat(85℃ and 85%relative humidity). 展开更多
关键词 perovskite solar modules intermediate phases ambient fabrication scalable fabrication stability
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Asymmetric triple-atomic sites with modulated electronic structure toward boosted peroxymonosulfate activation
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作者 Jinxin Li Yifan Ren +4 位作者 Jianan Gao Nadeeshani Nanayakkara Xin Wang Meng Liu Yanbiao Liu 《Chinese Chemical Letters》 2026年第2期698-703,共6页
Peroxymonosulfate(PMS)-based advanced oxidation technology has been proven to be a viable option for the decontamination of organic pollutants from water bodies.Advanced catalyst design is essential to this technology... Peroxymonosulfate(PMS)-based advanced oxidation technology has been proven to be a viable option for the decontamination of organic pollutants from water bodies.Advanced catalyst design is essential to this technology.Herein,a vanadium-doped LaFeO_(3) perovskite(LFO-V)featuring asymmetric Fe-O-V sites was rationally designed.Thanks to orbital electron interaction between Fe and V atoms,the modified electronic structure elevated electron density near the Fermi energy level while reducing the energy barrier toward effective PMS activation.This facilitated concurrent PMS reduction at the Fe sites to generate SO_(4)^(·-)and·OH(57.7%),and PMS oxidation at V sites to produce ^(1)O_(2)(42.3%).The LFO-V/PMS system demonstrated excellent tetracycline(TC)degradation performance with a 2-fold enhancement in rate constant compared to that of pristine LFO.Further,the LFO-V maintained long-term stability,and the toxicity of degradation intermediates was evaluated through microbial metabolomics.This work establishes an effective route to regulate the PMS activation pathways through precise electronic structure modulation,advancing the rational design of advanced Fenton-like catalysts. 展开更多
关键词 Electric structure modulation Fe-O-V sites Reduction-oxidation Radical species Non-radical species
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Tea polyphenol polymer film enables broadband optical modulation for hybrid mode-locked ultrafast fiber lasers
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作者 Wei Chen Kang Li +4 位作者 Cheng Gao Qingping Hu Zhengfan Li Yi Xiong Yunzhou Sun 《Chinese Physics B》 2026年第2期442-450,共9页
Materials exhibiting broadband nonlinear optical responses are critically important for ultrafast photonics applications,particularly as saturable absorbers(SAs)that facilitate broadband optical pulse generation.In th... Materials exhibiting broadband nonlinear optical responses are critically important for ultrafast photonics applications,particularly as saturable absorbers(SAs)that facilitate broadband optical pulse generation.In this study,tea polyphenolpolyvinyl alcohol(TP-PVA)composite films are synthesized via a polymer embedding method and employed as SAs to initiate ultrafast pulse operation in fiber lasers.The TP-PVA SA film exhibits excellent broadband saturable absorption performance at wavelengths of 1.0μm,1.5μm,and 2.0μm,with modulation depths of 54.21%,41.41%,and 51.16%,respectively.Stable passively mode-locked pulses with pulse widths of 588 fs,419 fs,and 743 fs are generated in Yb-,Er-,and Tm-doped fiber lasers,respectively.This work confirms the effective performance of TP-PVA as a broadband SA,and establishes a foundation for the integration of novel and sustainable materials within ultrafast photonic systems.The approach paves the way for developing compact broadband ultrafast laser systems operating in the near-infrared spectral region. 展开更多
关键词 ultrafast fiber lasers saturable absorbers broadband modulators natural dyes tea polyphenol
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微课驱动小学生英语自主学习能力提升的探究——以Module 5 Unit 9 Where will you go?第一课时自主学习为例
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作者 张兴 《视周刊》 2026年第1期34-35,共2页
一、微课设计:从知识传递到认知建构的范式转变1.微课定义微课是一种以短小精悍的数字视频为主要载体,围绕某个知识点、教学环节或特定教学主题而设计的结构化、情境化教学资源。其时长通常在5-10分钟之间,内容高度聚焦,重点突出,针对性... 一、微课设计:从知识传递到认知建构的范式转变1.微课定义微课是一种以短小精悍的数字视频为主要载体,围绕某个知识点、教学环节或特定教学主题而设计的结构化、情境化教学资源。其时长通常在5-10分钟之间,内容高度聚焦,重点突出,针对性强,符合学生的认知负荷与注意力特点,旨在通过精炼的内容和生动的呈现方式,激发学生学习兴趣,支持个性化、碎片化学习,促进自主探究与合作交流,是现代教育信息化背景下一种重要的教学辅助手段与课程资源形态。 展开更多
关键词 英语 module 5 Unit 9 能力提升 自主学习 微课
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An RMD-YOLOv11 Approach for Typical Defect Detection of PV Modules
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作者 Tao Geng Shuaibing Li +3 位作者 Yunyun Yun Yongqiang Kang Hongwei Li unmin Zhu 《Computers, Materials & Continua》 2026年第3期1804-1822,共19页
In order to address the challenges posed by complex background interference,high miss-detection rates of micro-scale defects,and limited model deployment efficiency in photovoltaic(PV)module defect detection,this pape... In order to address the challenges posed by complex background interference,high miss-detection rates of micro-scale defects,and limited model deployment efficiency in photovoltaic(PV)module defect detection,this paper proposes an efficient detection framework based on an improved YOLOv11 architecture.First,a Re-parameterized Convolution(RepConv)module is integrated into the backbone to enhance the model’s sensitivity to fine-grained defects—such as micro-cracks and hot spots—while maintaining high inference efficiency.Second,a Multi-Scale Feature Fusion Convolutional Block Attention Mechanism(MSFF-CBAM)is designed to guide the network toward critical defect regions by jointly modeling channel-wise and spatial attention.This mechanism effectively strengthens the specificity and robustness of feature representations.Third,a lightweight Dynamic Sampling Module(DySample)is employed to replace conventional upsampling operations,thereby improving the localization accuracy of small-scale defect targets.Experimental evaluations conducted on the PVEL-AD dataset demonstrate that the proposed RMDYOLOv11 model surpasses the baseline YOLOv11 in terms of mean Average Precision(mAP)@0.5,Precision,and Recall,achieving respective improvements of 4.70%,1.51%,and 5.50%.The model also exhibits notable advantages in inference speed and model compactness.Further validation on the ELPV dataset confirms the model’s generalization capability,showing respective performance gains of 1.99%,2.28%,and 1.45%across the same metrics.Overall,the enhanced model significantly improves the accuracy of micro-defect identification on PV module surfaces,effectively reducing both false negatives and false positives.This advancement provides a robust and reliable technical foundation for automated PV module defect detection. 展开更多
关键词 Photovoltaic(PV)modules YOLOv11 re-parameterization convolution attention mechanism dynamic upsampling
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MDGET-MER:Multi-Level Dynamic Gating and Emotion Transfer for Multi-Modal Emotion Recognition
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作者 Musheng Chen Qiang Wen +2 位作者 Xiaohong Qiu Junhua Wu Wenqing Fu 《Computers, Materials & Continua》 2026年第3期872-893,共22页
In multi-modal emotion recognition,excessive reliance on historical context often impedes the detection of emotional shifts,while modality heterogeneity and unimodal noise limit recognition performance.Existing method... In multi-modal emotion recognition,excessive reliance on historical context often impedes the detection of emotional shifts,while modality heterogeneity and unimodal noise limit recognition performance.Existing methods struggle to dynamically adjust cross-modal complementary strength to optimize fusion quality and lack effective mechanisms to model the dynamic evolution of emotions.To address these issues,we propose a multi-level dynamic gating and emotion transfer framework for multi-modal emotion recognition.A dynamic gating mechanism is applied across unimodal encoding,cross-modal alignment,and emotion transfer modeling,substantially improving noise robustness and feature alignment.First,we construct a unimodal encoder based on gated recurrent units and feature-selection gating to suppress intra-modal noise and enhance contextual representation.Second,we design a gated-attention crossmodal encoder that dynamically calibrates the complementary contributions of visual and audio modalities to the dominant textual features and eliminates redundant information.Finally,we introduce a gated enhanced emotion transfer module that explicitly models the temporal dependence of emotional evolution in dialogues via transfer gating and optimizes continuity modeling with a comparative learning loss.Experimental results demonstrate that the proposed method outperforms state-of-the-art models on the public MELD and IEMOCAP datasets. 展开更多
关键词 Multi-modal emotion recognition dynamic gating emotion transfer module cross-modal dynamic alignment noise robustness
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Modulation of mitochondrial dysfunction:Mechanisms and strategies for the use of natural products to treat stroke
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作者 Na Qin Rujuan Liu +3 位作者 Rong Deng Liuliu Shi Lei Wang Ting Zhu 《Neural Regeneration Research》 2026年第6期2215-2226,共12页
Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apop... Modulations of mitochondrial dysfunction,which involve a series of dynamic processes such as mitochondrial biogenesis,mitochondrial fusion and fission,mitochondrial transport,mitochondrial autophagy,mitochondrial apoptosis,and oxidative stress,play an important role in the onset and progression of stroke.With a better understanding of the critical role of mitochondrial dysfunction modulations in post-stroke neurological injury,these modulations have emerged as a potential target for stroke prevention and treatment.Additionally,since effective treatments for stroke are extremely limited and natural products currently offer some outstanding advantages,we focused on the findings and mechanisms of action related to the use of natural products for targeting mitochondrial dysfunction in the treatment of stroke.Natural products achieve neuroprotective through multi-target regulation of mitochondrial dysfunction encompassing the following processes:(1)Mitochondrial biogenesis:Cordyceps and hydroxysafflor yellow A activate the peroxisome proliferator-activated receptor gamma coactivator 1-alpha/nuclear respiratory factor pathway,promote mitochondrial DNA replication and respiratory chain protein synthesis,and thereby restore energy supply in the ischemic penumbra.(2)Mitochondrial dynamics balance:Ginsenoside Rb3 promotes Opa1-mediated neural stem cell migration and diffusion for recovery of damaged brain tissue.(3)Mitochondrial autophagy:Gypenoside XVII selectively eliminates damaged mitochondria via the phosphatase and tensin homolog-induced kinase 1/Parkin pathway and blocks reactive oxygen species and the NOD-like receptor protein 3 inflammasome cascade,thereby alleviating blood-brain barrier damage.(4)Anti-apoptotic mechanisms:Ginkgolide K inhibits Bax mitochondrial translocation and downregulates caspase-3/9 activity,reducing neuronal programmed death induced by ischemia-reperfusion.(5)Oxidative stress regulation:Scutellarin exerts antioxidant properties and improves neurological function by modulating the extracellular signal-regulated kinase 5-Kruppel-like factor 2-endothelial nitric oxide synthase signaling pathway.(6)Intercellular mitochondrial transport:Neuroprotective effects of Chrysophanol are associated with accelerated mitochondrial transfer from astrocytes to neurons.Existing studies have confirmed that natural products exhibit neuroprotective effects through multidimensional interventions targeting mitochondrial dysfunction in both ischemic and hemorrhagic stroke models.However,their clinical translation still faces challenges,such as the difficulty in standardization due to component complexity,insufficient cross-regional clinical data,and the lack of long-term safety evaluations.Future research should aim to integrate new technologies,such as single-cell sequencing and organoid models,to deeply explore the mitochondria-targeting mechanisms of natural products and validate their efficacy through multicenter clinical trials,providing theoretical support and translational pathways for the development of novel anti-stroke drugs. 展开更多
关键词 apoptosis AUTOPHAGY hemorrhagic stroke ischemic stroke mitochondrial biogenesis mitochondrial dynamics mitochondrial dysfunction modulations mitochondrial transport natural products oxidative stress
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The Immunomodulatory,Anti-Tumor,and Metabolic Regulatory Effects of Fraction D of Polysaccharide from Grifola frondosa:Clinical Experiments and Mechanistic Insights
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作者 Nurfarih Hanna Mohd Zarif Fikri Bin Mohd +1 位作者 Muhammad Nabil Fikri Bin Mohd Nurfarazuna Binti Mohd Fadrol 《Proceedings of Anticancer Research》 2026年第1期84-93,共10页
Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical eff... Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential. 展开更多
关键词 Grifola frondosa Maitake polysaccharide Fraction D Immune modulation Adjunctive cancer therapy Glycemic control Lipid metabolism Clinical trial Mechanism of action
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Lysophosphatidic acid signaling:Transmembrane modulators in the central nervous system
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作者 Alexandra Polyzou Alexandros Κ.Tsiouris +2 位作者 Charalampos Labrakakis Britta J.Eickholt George Leondaritis 《Neural Regeneration Research》 2026年第3期1104-1105,共2页
Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,includi... Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly(Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities(Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018). 展开更多
关键词 transmembrane modulators cerebrospinal fluidvaries variety lipid species lysophosphatidic acid biological fluidsincluding lysophosphatidic acid lpa saturated unsaturated fatty acids pleiotropic lipid agonist
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Pressure-Modulated Activation Energy as a Unified Descriptor of Mechanical Behavior in Metallic Glass
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作者 Huanrong Liu Jian Li +1 位作者 Shan Zhang Pengfei Guan 《Chinese Physics Letters》 2026年第1期71-82,共12页
The functional properties of glasses are governed by their formation history and the complex relaxation processes they undergo.However,under extreme conditions,glass behaviors are still elusive.In this study,we employ... The functional properties of glasses are governed by their formation history and the complex relaxation processes they undergo.However,under extreme conditions,glass behaviors are still elusive.In this study,we employ simulations with varied protocols to evaluate the effectiveness of different descriptors in predicting mechanical properties across both low-and high-pressure regimes.Our findings demonstrate that conventional structural and configurational descriptors fail to correlate with the mechanical response following pressure release,whereas the activation energy descriptor exhibits robust linearity with shear modulus after correcting for pressure effects.Notably,the soft mode parameter emerges as an ideal and computationally efficient alternative for capturing this mechanical behavior.These findings provide critical insights into the influence of pressure on glassy properties,integrating the distinct features of compressed glasses into a unified theoretical framework. 展开更多
关键词 pressure modulated activation energy predicting mechanical properties metallic glass relaxation processes functional properties mechanical behavior simulations varied protocols structural configurational descriptors
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Design of Irregular QC-LDPC Code Based Multi-Level Coded Modulation Scheme for High Speed Optical Communication Systems 被引量:8
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作者 Liqian Wang Dongdong Wang +3 位作者 Yongjing Ni Xue Chen Midou Cui Fu Yang 《China Communications》 SCIE CSCD 2019年第5期106-120,共15页
In this paper, we focus on the design of irregular QC-LDPC code based multi-level coded modulation(MLCM) scheme by jointly optimizing the component code rate and the degree distribution of the irregular QC-LDPC compon... In this paper, we focus on the design of irregular QC-LDPC code based multi-level coded modulation(MLCM) scheme by jointly optimizing the component code rate and the degree distribution of the irregular QC-LDPC component code. Firstly, the sub-channel capacities of MLCM systems is analyzed and discussed, based on which the optimal component code rate can be obtained. Secondly, an extrinsic information transfer chart based two-stage searching algorithm is proposed to find the good irregular QC-LDPC code ensembles with optimal component code rates for their corresponding sub-channels. Finally, by constructing the irregular QC-LDPC component codes from the designed ensembles with the aim of possibly enlarging the girth and reducing the number of the shortest cycles, the designed irregular QC-LDPC code based 16QAM and 64QAM MLCM systems can achieve 0.4 dB and 1.2 dB net coding gain, respectively, compared with the recently proposed regular QC-LDPC code based 16QAM and 64QAM MLCM systems. 展开更多
关键词 quasi-cyclic LOW-DENSITY parity check (QC-LDPC) code irregular extrinsic INFORMATION transfer(EXIT) chart generalized mutual information(GMI) multi-level coded modulation(MLCM)
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A new tracking error detection method using amplitude difference detection for signal waveform modulation multi-level discs 被引量:1
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作者 严明铭 裴京 潘龙法 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第10期319-323,共5页
The sub-land/sub-pit affects the characteristic of the tracking error signal which is generated by the conventional differential phase detection (DPD) method in the signal waveform modulation multi-level (SWML) re... The sub-land/sub-pit affects the characteristic of the tracking error signal which is generated by the conventional differential phase detection (DPD) method in the signal waveform modulation multi-level (SWML) read-only disc. To solve this problem, this paper proposes a new tracking error detection method using amplitude difference. Based on the diffraction theory, the amplitude difference is proportional to the tracking error and is feasible to be used for obtaining the off-track information. The experimental system of the amplitude difference detection method is developed. The experimental results show that the tracking error signal derived from the new method has better performance in uniformity and signal-to-noise ratio than that derived from the conventional DPD method in the SWML read-only disc. 展开更多
关键词 signal waveform modulation multi-level technology tracking error amplitude difference
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Classification using wavelet packet decomposition and support vector machine for digital modulations 被引量:4
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作者 Zhao Fucai Hu Yihua Hao Shiqi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第5期914-918,共5页
To make the modulation classification system more suitable for signals in a wide range of signal to noise rate (SNR), a feature extraction method based on signal wavelet packet transform modulus maxima matrix (WPT... To make the modulation classification system more suitable for signals in a wide range of signal to noise rate (SNR), a feature extraction method based on signal wavelet packet transform modulus maxima matrix (WPTMMM) and a novel support vector machine fuzzy network (SVMFN) classifier is presented. The WPTMMM feature extraction method has less computational complexity, more stability, and has the preferable advantage of robust with the time parallel moving and white noise. Further, the SVMFN uses a new definition of fuzzy density that incorporates accuracy and uncertainty of the classifiers to improve recognition reliability to classify nine digital modulation types (i.e. 2ASK, 2FSK, 2PSK, 4ASK, 4FSK, 4PSK, 16QAM, MSK, and OQPSK). Computer simulation shows that the proposed scheme has the advantages of high accuracy and reliability (success rates are over 98% when SNR is not lower than 0dB), and it adapts to engineering applications. 展开更多
关键词 modulation classification wavelet packet transform modulus maxima matrix support vector machine fuzzy density.
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