BACKGROUND Monomorphic epithelial intestinal T-cell lymphoma(MEITL)is a rare type of peripheral T-cell lymphoma.The clinical manifestations are diarrhea,abdominal pain,perforation and an abdominal mass.CASE SUMMARY We...BACKGROUND Monomorphic epithelial intestinal T-cell lymphoma(MEITL)is a rare type of peripheral T-cell lymphoma.The clinical manifestations are diarrhea,abdominal pain,perforation and an abdominal mass.CASE SUMMARY We present a 52-year-old female patient who was diagnosed with MEITL.Further disease progression was observed after multiline chemotherapy.Eventually,the patient died of a severe infection.CONCLUSION MEITL is a rare intestinal primary T-cell lymphoma with aggressive behavior,a high risk of severe life-threatening complications,and a poor prognosis.展开更多
BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare primary intestinal T-cell lymphoma,previously known as enteropathy-associated T-cell lymphoma type II.MEITL is an aggressive T-cell lym...BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare primary intestinal T-cell lymphoma,previously known as enteropathy-associated T-cell lymphoma type II.MEITL is an aggressive T-cell lymphoma with a poor prognosis and high mortality rate.The known major complications of MEITL are intestinal perforation and obstruction.Here,we present a case of MEITL that was diagnosed following upper gastrointestinal bleeding from an ulcerative duodenal lesion,with recurrence-free survival for 5 years.CASE SUMMARY A 68-year-old female was admitted to our hospital with melena and mild anemia.An urgent esophagogastroduodenoscopy(EGD)revealed bleeding from an ulcerative lesion in the transverse part of the duodenum,for which hemostatic treatment was performed.MEITL was diagnosed following repeated biopsies of the lesion,and cyclophosphamide,doxorubicin,vincristine,and prednisone(CHOP)chemotherapy was administered.She achieved complete remission after eight full cycles of CHOP therapy.At the last follow-up examination,EGD revealed a scarred ulcer and 18Fluorodeoxyglucose(18FDG)positron emission tomography/computed tomography showed no abnormal FDG accumulation.The patient has been in complete remission for 68 mo after initial diagnosis.CONCLUSION To rule out MEITL,it is important to carefully perform histological examination when bleeding from a duodenal ulcer is observed.展开更多
BACKGROUND Monomorphic epitheliotropic intestinal T cell lymphoma(MEITL)is a rare extranodal T-cell lymphoma that has uniformly aggressive features with a poor prognosis.No standardized treatment protocols have been e...BACKGROUND Monomorphic epitheliotropic intestinal T cell lymphoma(MEITL)is a rare extranodal T-cell lymphoma that has uniformly aggressive features with a poor prognosis.No standardized treatment protocols have been established.Previous experience has demonstrated favorable outcomes with combination chemotherapy followed by autologous hematopoietic stem cell transplant.However,many patients are unable to tolerate the toxicities.Chidamide is a new histone deacetylase inhibitor that has shown preferential efficacy in mature T-cell lymphoma.CASE SUMMARY We herein present two cases of MEITL who were both intermediate risk according to enteropathy-associated T cell lymphoma prognostic index.Case one was a 61-year-old man.He complained of upper abdominal pain and intermittent black stool for 2 mo.Imaging examination revealed that the intestinal wall was thickened.He received a partial excision of the small intestine.A chidamidebased combination regimen was given postoperatively.Eleven months later,he presented with recurrence in the bilateral lungs.He passed away 15 mo after his diagnosis.Case two was a 35-year-old woman who complained of abdominal distention for 1 mo.Positron emission tomography/computed tomography demonstrated wall thickening of the small intestine and upper sigmoid colon.Colon perforation and septic shock occurred on the fourth day of her admission.She was treated by sigmoid colostomy.Chidamide-based combination therapy was then provided.She was recurrence-free for 6 mo until lesions were found in the bilateral brain and lived for 17 mo since her diagnosis.Compared to historical data,chidamide seems to improve the prognosis of MEITL slightly.CONCLUSION MEITL is a type of aggressive lymphoma.Chidamide is a new promising approach for the treatment of MEITL.展开更多
BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo.Adva...BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo.Advances in the identification of MEITL over the last two decades have led to its recognition as a separate entity.MEITL patients,predominantly male,typically present with vague and nonspecific symptoms and diagnosis is predominantly confirmed at laparotomy.Currently,there are no standardized treatment protocols,and the optimal therapy remains unclear.CASE SUMMARY We report a case of MEITL that was initially considered to be gastrointestinal stromal tumor(GIST)and Imatinib was administered for one cycle.The 62-yearold man presented with abdominal pain,abdominal distension,and weight loss of 20 pounds.Within 2 wk,the size of the mass considerably increased on computed tomography scans.The patient underwent surgery followed by chemotherapy with CHOP(cyclophosphamide,doxorubicin,vincristine,and prednisone)and stem-cell transplant.A correct diagnosis of MEITL was established based on postoperative pathology.Immunophenotypically,the neoplastic cells fulfilled the diagnostic criteria for MEITL as they were CD3+,CD4+,CD8+,CD56+,and TIA-1+.CONCLUSION Given that MEITL has no predisposing factor and presents with vague symptoms with rapid progression,the concomitant presence of abdominal symptoms and B symptoms(weight loss,fever,and night sweats)with hypoalbuminemia,anemia,low lymphocytic count and endoscopic findings of diffuse infiltrating type lesions should alert physicians to this rare disease,especially when it comes to Asian patients.Immediate laparotomy should then be carried out followed by chemotherapy and stem-cell transplant.展开更多
We report a case of Monomorphic adenoma of aryepiglottic fold. Histopathological findings are described. This is the first case, to our knowledge, of a Monomorphic adenoma presenting at aryepiglottic fold. Complete ex...We report a case of Monomorphic adenoma of aryepiglottic fold. Histopathological findings are described. This is the first case, to our knowledge, of a Monomorphic adenoma presenting at aryepiglottic fold. Complete excision of the mass was done through laryngofissure approach.展开更多
Let Λ be an Artin algebra and let Gprj-Λ denote the class of all the finitely generated Gorenstein projective Λ-modules. In this paper, we study the components of the stable Auslander-Reiten quiver of a certain sub...Let Λ be an Artin algebra and let Gprj-Λ denote the class of all the finitely generated Gorenstein projective Λ-modules. In this paper, we study the components of the stable Auslander-Reiten quiver of a certain subcategory of the monomorphism category S(Gprj-Λ) containing boundary vertices. We describe the shape of such components. It is shown that certain components are linked to the orbits of an auto-equivalence on the stable category Gprj. In particular, for the finite components, we show that under certain mild conditions,their cardinalities are divisible by 3. We see that this three-periodicity phenomenon reoccurs several times in the paper.展开更多
Background The aim of this study was to clarify the electrocardiographic characteristics of repetitive monomorphic ventricular tachycardia (RMVT) originating from the left ventricular outflow tract, and to describe th...Background The aim of this study was to clarify the electrocardiographic characteristics of repetitive monomorphic ventricular tachycardia (RMVT) originating from the left ventricular outflow tract, and to describe the results of treatment with radiofrequency catheter ablation (RFCA).Methods Routine 12-lead surface electrocardiography and electrophysiological studies were performed on 11 RMVT patients with no organic heart disease, who were subsequently treated with RFCA directed at targets identified by pace mapping.Results The surface electrocardiogram QRS characteristics of RMVT included an atypical left bundle branch block and right axis deviation, with a low amplitude 'rs' or 'rS' pattern in lead I , an 'rS' or 'RS' pattern in V1, and a precordial R wave transition zone in V2 or V3. In 1 patient, a small S wave was observed in V5. Using pace mapping techniques, we selected the left coronary cusp as the ablation target. RMVT was eliminated in all 11 patients immediately after radiofrequency energy delivered. During a follow-up of 13 ±7 months, RMVT recurred in only 1 patient.Conclusion RMVT originating from the left ventricular outflow tract has specific electrocardiographic characteristics, and can be successfully and safely cured using RFCA directed at the left coronary cusp.展开更多
Recall that f: X→Y is a homotopy epimorphism (monomorphism), if given u, v: Y→W (u, v: W→X), uofvof implies uv (foufov implies uv). In this note, we shall consider the localization of homotopy epimorphisms andmonom...Recall that f: X→Y is a homotopy epimorphism (monomorphism), if given u, v: Y→W (u, v: W→X), uofvof implies uv (foufov implies uv). In this note, we shall consider the localization of homotopy epimorphisms andmonomorphism, 1.e. the following is considered. Problem. If f:X→Y is a homotopy epimorphism (monomorphism), then is any展开更多
Monomorphism categories of the symmetric and alternating groups are studied via Cayley's Em-bedding Theorem. It is shown that the parity is well defined in such categories. As an application, the parity in a finit...Monomorphism categories of the symmetric and alternating groups are studied via Cayley's Em-bedding Theorem. It is shown that the parity is well defined in such categories. As an application, the parity in a finite group G is classified. It is proved that any element in a group of odd order is always even and such a group can be embedded into some alternating group instead of some symmetric group in the Cayley's theorem. It is also proved that the parity in an abelian group of even order is always balanced and the parity in an nonabelian group is independent of its order.展开更多
For an acyelic quiver Q and a finite-dimensional algebra A, we give a unified form of the indecomposable injective objects in the monomorphism category Mon（Q, A） and prove that Mon（Q, A） has enough injective objects.
Higher differential objects are investigated and used for addressing three gen-eral problems.Torsionless differential modules over path algebras are characterized.The adjoint triples between triangulated categories,in...Higher differential objects are investigated and used for addressing three gen-eral problems.Torsionless differential modules over path algebras are characterized.The adjoint triples between triangulated categories,involving derived categories and singularity categories,are allowed to be constructed from those between the abelian categories C and C[ε]^(n).The partial silting properties between an abelian category C and C[ε]^(n)are trans-ferred,and if moreover,C is Frobenius,the partial silting objects of the stable monomor-phism categories of C[ε]^(n)are constructed from those of C.展开更多
A concept of homotopy regular monomorphism is introduced which is strictly between homotopy monomorphism and homotopy equivalence. And it characterizes homotopy equivalence in some sense.
基金Supported by Zhejiang Province Traditional Chinese Medicine Science and Technology Project,No.2024ZL1296.
文摘BACKGROUND Monomorphic epithelial intestinal T-cell lymphoma(MEITL)is a rare type of peripheral T-cell lymphoma.The clinical manifestations are diarrhea,abdominal pain,perforation and an abdominal mass.CASE SUMMARY We present a 52-year-old female patient who was diagnosed with MEITL.Further disease progression was observed after multiline chemotherapy.Eventually,the patient died of a severe infection.CONCLUSION MEITL is a rare intestinal primary T-cell lymphoma with aggressive behavior,a high risk of severe life-threatening complications,and a poor prognosis.
文摘BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare primary intestinal T-cell lymphoma,previously known as enteropathy-associated T-cell lymphoma type II.MEITL is an aggressive T-cell lymphoma with a poor prognosis and high mortality rate.The known major complications of MEITL are intestinal perforation and obstruction.Here,we present a case of MEITL that was diagnosed following upper gastrointestinal bleeding from an ulcerative duodenal lesion,with recurrence-free survival for 5 years.CASE SUMMARY A 68-year-old female was admitted to our hospital with melena and mild anemia.An urgent esophagogastroduodenoscopy(EGD)revealed bleeding from an ulcerative lesion in the transverse part of the duodenum,for which hemostatic treatment was performed.MEITL was diagnosed following repeated biopsies of the lesion,and cyclophosphamide,doxorubicin,vincristine,and prednisone(CHOP)chemotherapy was administered.She achieved complete remission after eight full cycles of CHOP therapy.At the last follow-up examination,EGD revealed a scarred ulcer and 18Fluorodeoxyglucose(18FDG)positron emission tomography/computed tomography showed no abnormal FDG accumulation.The patient has been in complete remission for 68 mo after initial diagnosis.CONCLUSION To rule out MEITL,it is important to carefully perform histological examination when bleeding from a duodenal ulcer is observed.
文摘BACKGROUND Monomorphic epitheliotropic intestinal T cell lymphoma(MEITL)is a rare extranodal T-cell lymphoma that has uniformly aggressive features with a poor prognosis.No standardized treatment protocols have been established.Previous experience has demonstrated favorable outcomes with combination chemotherapy followed by autologous hematopoietic stem cell transplant.However,many patients are unable to tolerate the toxicities.Chidamide is a new histone deacetylase inhibitor that has shown preferential efficacy in mature T-cell lymphoma.CASE SUMMARY We herein present two cases of MEITL who were both intermediate risk according to enteropathy-associated T cell lymphoma prognostic index.Case one was a 61-year-old man.He complained of upper abdominal pain and intermittent black stool for 2 mo.Imaging examination revealed that the intestinal wall was thickened.He received a partial excision of the small intestine.A chidamidebased combination regimen was given postoperatively.Eleven months later,he presented with recurrence in the bilateral lungs.He passed away 15 mo after his diagnosis.Case two was a 35-year-old woman who complained of abdominal distention for 1 mo.Positron emission tomography/computed tomography demonstrated wall thickening of the small intestine and upper sigmoid colon.Colon perforation and septic shock occurred on the fourth day of her admission.She was treated by sigmoid colostomy.Chidamide-based combination therapy was then provided.She was recurrence-free for 6 mo until lesions were found in the bilateral brain and lived for 17 mo since her diagnosis.Compared to historical data,chidamide seems to improve the prognosis of MEITL slightly.CONCLUSION MEITL is a type of aggressive lymphoma.Chidamide is a new promising approach for the treatment of MEITL.
文摘BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo.Advances in the identification of MEITL over the last two decades have led to its recognition as a separate entity.MEITL patients,predominantly male,typically present with vague and nonspecific symptoms and diagnosis is predominantly confirmed at laparotomy.Currently,there are no standardized treatment protocols,and the optimal therapy remains unclear.CASE SUMMARY We report a case of MEITL that was initially considered to be gastrointestinal stromal tumor(GIST)and Imatinib was administered for one cycle.The 62-yearold man presented with abdominal pain,abdominal distension,and weight loss of 20 pounds.Within 2 wk,the size of the mass considerably increased on computed tomography scans.The patient underwent surgery followed by chemotherapy with CHOP(cyclophosphamide,doxorubicin,vincristine,and prednisone)and stem-cell transplant.A correct diagnosis of MEITL was established based on postoperative pathology.Immunophenotypically,the neoplastic cells fulfilled the diagnostic criteria for MEITL as they were CD3+,CD4+,CD8+,CD56+,and TIA-1+.CONCLUSION Given that MEITL has no predisposing factor and presents with vague symptoms with rapid progression,the concomitant presence of abdominal symptoms and B symptoms(weight loss,fever,and night sweats)with hypoalbuminemia,anemia,low lymphocytic count and endoscopic findings of diffuse infiltrating type lesions should alert physicians to this rare disease,especially when it comes to Asian patients.Immediate laparotomy should then be carried out followed by chemotherapy and stem-cell transplant.
文摘We report a case of Monomorphic adenoma of aryepiglottic fold. Histopathological findings are described. This is the first case, to our knowledge, of a Monomorphic adenoma presenting at aryepiglottic fold. Complete excision of the mass was done through laryngofissure approach.
基金supported by National Natural Science Foundation of China (Grant No. 12101316)。
文摘Let Λ be an Artin algebra and let Gprj-Λ denote the class of all the finitely generated Gorenstein projective Λ-modules. In this paper, we study the components of the stable Auslander-Reiten quiver of a certain subcategory of the monomorphism category S(Gprj-Λ) containing boundary vertices. We describe the shape of such components. It is shown that certain components are linked to the orbits of an auto-equivalence on the stable category Gprj. In particular, for the finite components, we show that under certain mild conditions,their cardinalities are divisible by 3. We see that this three-periodicity phenomenon reoccurs several times in the paper.
文摘Background The aim of this study was to clarify the electrocardiographic characteristics of repetitive monomorphic ventricular tachycardia (RMVT) originating from the left ventricular outflow tract, and to describe the results of treatment with radiofrequency catheter ablation (RFCA).Methods Routine 12-lead surface electrocardiography and electrophysiological studies were performed on 11 RMVT patients with no organic heart disease, who were subsequently treated with RFCA directed at targets identified by pace mapping.Results The surface electrocardiogram QRS characteristics of RMVT included an atypical left bundle branch block and right axis deviation, with a low amplitude 'rs' or 'rS' pattern in lead I , an 'rS' or 'RS' pattern in V1, and a precordial R wave transition zone in V2 or V3. In 1 patient, a small S wave was observed in V5. Using pace mapping techniques, we selected the left coronary cusp as the ablation target. RMVT was eliminated in all 11 patients immediately after radiofrequency energy delivered. During a follow-up of 13 ±7 months, RMVT recurred in only 1 patient.Conclusion RMVT originating from the left ventricular outflow tract has specific electrocardiographic characteristics, and can be successfully and safely cured using RFCA directed at the left coronary cusp.
基金Project supported by the National Natural Science Foundation of China.
文摘Recall that f: X→Y is a homotopy epimorphism (monomorphism), if given u, v: Y→W (u, v: W→X), uofvof implies uv (foufov implies uv). In this note, we shall consider the localization of homotopy epimorphisms andmonomorphism, 1.e. the following is considered. Problem. If f:X→Y is a homotopy epimorphism (monomorphism), then is any
文摘Monomorphism categories of the symmetric and alternating groups are studied via Cayley's Em-bedding Theorem. It is shown that the parity is well defined in such categories. As an application, the parity in a finite group G is classified. It is proved that any element in a group of odd order is always even and such a group can be embedded into some alternating group instead of some symmetric group in the Cayley's theorem. It is also proved that the parity in an abelian group of even order is always balanced and the parity in an nonabelian group is independent of its order.
基金The first author was supported by the National Natural Science Foundation of China （Grant No. 11501465） and the Fundamental Research Funds for the Central Universities （XDJK2015C041）, the second author was supported by the National Natural Science Foundation of China （Grant Nos. 11271257, 11201377） and the Natural Science Foundation of Shanghai （13ZR1422500）.
文摘For an acyelic quiver Q and a finite-dimensional algebra A, we give a unified form of the indecomposable injective objects in the monomorphism category Mon（Q, A） and prove that Mon（Q, A） has enough injective objects.
基金Supported by the National Natural Science Foundation of China(Grant No.11771272)。
文摘Higher differential objects are investigated and used for addressing three gen-eral problems.Torsionless differential modules over path algebras are characterized.The adjoint triples between triangulated categories,involving derived categories and singularity categories,are allowed to be constructed from those between the abelian categories C and C[ε]^(n).The partial silting properties between an abelian category C and C[ε]^(n)are trans-ferred,and if moreover,C is Frobenius,the partial silting objects of the stable monomor-phism categories of C[ε]^(n)are constructed from those of C.
文摘A concept of homotopy regular monomorphism is introduced which is strictly between homotopy monomorphism and homotopy equivalence. And it characterizes homotopy equivalence in some sense.
