The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, pa...The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyI-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral .impairment might be a specific indicator of schizophrenia-related cognitive impairment.展开更多
Tauopathies represent a class of neurodegenerative diseases(NDs),including Alzheimer’s disease(AD),progressive supranuclear palsy(PSP),Pick’s disease(PiD),and corticobasal degeneration(CBD),defined by intracellular ...Tauopathies represent a class of neurodegenerative diseases(NDs),including Alzheimer’s disease(AD),progressive supranuclear palsy(PSP),Pick’s disease(PiD),and corticobasal degeneration(CBD),defined by intracellular accumulation of misfolded and hyperphosphorylated tau protein.The pathogenic cascade involves hyperphosphorylation,conformational changes,and aggregation into neurofibrillary tangles(NFTs),which are spatially and functionally linked to neuronal dysfunction,synaptic loss,and progressive cognitive and motor decline.To elucidate tau-mediated mechanisms,diverse transgenic rodent models expressing wild-type or mutant forms of human TAU have been generated.Although these models have advanced understanding of tau aggregation and propagation,tau-targeting therapies have failed to produce clinical benefits,raising concerns about the precise mechanism underlying tauopathies and the fidelity of animal models in evaluating therapeutic targets.This review systematically examines the neuropathological and behavioral phenotypes across established rodent and non-human primate(NHP)tauopathy models,highlighting mechanistic insights into tau-driven pathology.The advantages,limitations,and translational barriers of each model are critically evaluated to inform the development of more predictive preclinical platforms for therapeutic discovery.展开更多
Subject Code:H09With the support by the National Natural Science Foundation of China,a collaborative study by the research group led by Prof.Chen Yongchang(陈永昌)and Ji Weizhi from the Yunnan Key Laboratory of Primat...Subject Code:H09With the support by the National Natural Science Foundation of China,a collaborative study by the research group led by Prof.Chen Yongchang(陈永昌)and Ji Weizhi from the Yunnan Key Laboratory of Primate Biomedicine Research&Institute of Primate Translational Medicine,Kunming University展开更多
基金supported by National Basic Research Development Program (973 program) of China (2012CB825500, 2011CB707800)National Natural Science Foundation of China (31271168, 91132307/H09, 61178051)Finnish-Chinese Joint Project of National Natural Science Foundation of China (813111172)
文摘The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyI-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral .impairment might be a specific indicator of schizophrenia-related cognitive impairment.
基金supported by the National Key Research and Development Program of China(2021YFF0702201,2021YFF0702204)Natural Science Foundation of Guangdong Province(2022A1515012651)。
文摘Tauopathies represent a class of neurodegenerative diseases(NDs),including Alzheimer’s disease(AD),progressive supranuclear palsy(PSP),Pick’s disease(PiD),and corticobasal degeneration(CBD),defined by intracellular accumulation of misfolded and hyperphosphorylated tau protein.The pathogenic cascade involves hyperphosphorylation,conformational changes,and aggregation into neurofibrillary tangles(NFTs),which are spatially and functionally linked to neuronal dysfunction,synaptic loss,and progressive cognitive and motor decline.To elucidate tau-mediated mechanisms,diverse transgenic rodent models expressing wild-type or mutant forms of human TAU have been generated.Although these models have advanced understanding of tau aggregation and propagation,tau-targeting therapies have failed to produce clinical benefits,raising concerns about the precise mechanism underlying tauopathies and the fidelity of animal models in evaluating therapeutic targets.This review systematically examines the neuropathological and behavioral phenotypes across established rodent and non-human primate(NHP)tauopathy models,highlighting mechanistic insights into tau-driven pathology.The advantages,limitations,and translational barriers of each model are critically evaluated to inform the development of more predictive preclinical platforms for therapeutic discovery.
文摘Subject Code:H09With the support by the National Natural Science Foundation of China,a collaborative study by the research group led by Prof.Chen Yongchang(陈永昌)and Ji Weizhi from the Yunnan Key Laboratory of Primate Biomedicine Research&Institute of Primate Translational Medicine,Kunming University
