With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions...With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying reasons.This comprehension is crucial for making informed strategic decisions in various business and societal contexts.However,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause extraction.To address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment mechanisms.The model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause pairs.Second,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among tasks.The proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 score.Experimental results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its effectiveness.This research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-cause pair extraction.However,the study’s limitation lies in the data sources,potentially restricting the generalizability of the findings.展开更多
A high pattern resolution is critical for fabricating roll-to-roll printed electronics(R2RPE)products.For enhanced overlay alignment accuracy,position errors between the printer and the substrate web must be eliminate...A high pattern resolution is critical for fabricating roll-to-roll printed electronics(R2RPE)products.For enhanced overlay alignment accuracy,position errors between the printer and the substrate web must be eliminated,particularly in inkjet printing applications.This paper proposes a novel five-degree-of-freedom(5-DOF)flexure-based alignment stage to adjust the posture of an inkjet printer head.The stage effectively compensates for positioning errors between the actuation mechanism and manipulated objects through a series-parallel combination of compliant substructures.Voice coil motors(VCMs)and linear motors serve as actuators to achieve the required motion.Theoretical models were established using a pseudo-rigid-body model(PRBM)methodology and were validated through finite element analysis(FEA).Finally,an alignment stage prototype was fabricated for an experiment.The prototype test results showed that the developed positioning platform attains 5-DOF motion capabilities with 335.1μm×418.9μm×408.1μm×3.4 mrad×3.29 mrad,with cross-axis coupling errors below 0.11%along y-and z-axes.This paper pro-poses a novel 5-DOF flexure-based alignment stage that can be used for error compensation in R2RPE and effectively improves the interlayer alignment accuracy of multi-layer printing.展开更多
In the work of numerical control reformation of general machine tool, the installation and debugging of machine tool is a crucial part. For the C6132 machine tool, and make the use of electrical and mechanical alignme...In the work of numerical control reformation of general machine tool, the installation and debugging of machine tool is a crucial part. For the C6132 machine tool, and make the use of electrical and mechanical alignment, parameter adjusting, numerical control lathe accuracy debugging and performance examination has been used to finish a series of tailing in the work of numerical control reformation of general machine tool. In this paper, the detailed process of electrical and mechanical alignment, parameter adjusting, numerical control lathe accuracy debugging and performance examination has been demonstrated, meanwhile, the specific operational approach of these work programs has been discussed. Therefore, the present results provides essential reference and approach for the numerical control reformation of general machine tool.展开更多
Polyacrylonitrile(PAN)/multi-walled carbon nanotubes(MWNTs)nanocomposites were prepared by an in-situ polymerization method and the fibers from these composites were obtained by a wet-spinning process.The orientation ...Polyacrylonitrile(PAN)/multi-walled carbon nanotubes(MWNTs)nanocomposites were prepared by an in-situ polymerization method and the fibers from these composites were obtained by a wet-spinning process.The orientation behavior of MWNTs in the PAN fibers was investigated by X-ray diffraction and sound velocity methods.The dispersion and the alignment of the nanotubes were also studied by scanning electron microscopy.展开更多
Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology...Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology for the planning, deigning and production of cutting guides. This study aims to compare PST to conventional technique in terms of mechanical axis alignment and component positioning. Patients and method: 109 TKA were performed for 78 patients in 2 groups. Group A included 69 conventional TKA in 55 patients and Group B included 40 patient-specific TKA in 23 patient. Postoperative long-film X-rays were done for all patients to observe the mechanical axis, anatomical axis, lateral distal femoral mechanical angle and medial proximal tibial angle. Results: No statistically significant difference was found between the two groups regarding alignment or component positioning. Conclusion: Both techniques have shown similar results in restoring the mechanical axis and alignment after TKA. However, PST had the advantages of reduced blood loss and shorter operative time.展开更多
Knee osteoarthritis(OA) is a progressive joint disease hallmarked by cartilage and bone breakdown and associated with changes to all of the tissues in the joint,ultimately causing pain,stiffness,deformity and disabili...Knee osteoarthritis(OA) is a progressive joint disease hallmarked by cartilage and bone breakdown and associated with changes to all of the tissues in the joint,ultimately causing pain,stiffness,deformity and disability in many people.Radiographs are commonly used for the clinical assessment of knee OA incidence and progression,and to assess for risk factors.One risk factor for the incidence and progression of knee OA is malalignment of the lower extremities(LE).The hipknee-ankle(HKA) angle,assessed from a full-length LE radiograph,is ideally used to assess LE alignment.Careful attention to LE positioning is necessary to obtain the most accurate measurement of the HKA angle.Since full-length LE radiographs are not always available,the femoral shaft-tibial shaft(FS-TS) angle may be calculated from a knee radiograph instead.However,the FS-TS angle is more variable than the HKA angle and it should be used with caution.Knee radiographs are used to assess the severity of knee OA and its progression.There are three types of ordinal grading scales for knee OA:global,composite and individual feature scales.Each grade on a global scale describes one or more features of knee OA.The entire description must be met for a specific grade to be assigned.The KellgrenLawrence scale is the most commonly-used global scale.Composite scales grade several features of knee OA individually and sum the grades to create a total score.One example is the compartmental grading scale for knee OA.Composite scales can respond to change in a variety of presentations of knee OA.Individual feature scales assess one or more OA features individually and do not calculate a total score.They are most often used to monitor change in one OA feature,commonly joint space narrowing.The most commonly-used individual feature scale is the OA Research Society International atlas.Each type of scale has its advantages;however,composite scales may offer greater content validity.Responsiveness to change is unknown for most scales and deserves further evaluation.展开更多
Achieving optimal alignment in total knee arthroplasty(TKA) is a critical factor in ensuring optimal outcomes and long-term implant survival. Traditionally, mechanical alignment has been favored to achieve neutral pos...Achieving optimal alignment in total knee arthroplasty(TKA) is a critical factor in ensuring optimal outcomes and long-term implant survival. Traditionally, mechanical alignment has been favored to achieve neutral postoperative joint alignment. However, contemporary approaches, such as kinematic alignments and hybrid techniques including adjusted mechanical, restricted kinematic, inverse kinematic, and functional alignments, are gaining attention for their ability to restore native joint kinematics and anatomical alignment, potentially leading to enhanced functional outcomes and greater patient satisfaction. The ongoing debate on optimal alignment strategies considers the following factors: long-term implant durability, functional improvement, and resolution of individual anatomical variations. Furthermore, advancements of computer-navigated and robotic-assisted surgery have augmented the precision in implant positioning and objective measurements of soft tissue balance. Despite ongoing debates on balancing implant longevity and functional outcomes, there is an increasing advocacy for personalized alignment strategies that are tailored to individual anatomical variations. This review evaluates the spectrum of various alignment techniques in TKA, including mechanical alignment, patient-specific kinematic approaches, and emerging hybrid methods. Each technique is scrutinized based on its fundamental principles, procedural techniques, inherent advantages, and potential limitations, while identifying significant clinical gaps that underscore the need for further investigation.展开更多
A homogeneous and compact super-aligned carbon nanotube(SACNT)-reinforced nickel-matrix composite was successfully prepared by electrodeposition. The mechanical properties of the laminar SACNT/Ni composites were subst...A homogeneous and compact super-aligned carbon nanotube(SACNT)-reinforced nickel-matrix composite was successfully prepared by electrodeposition. The mechanical properties of the laminar SACNT/Ni composites were substantially improved compared with those of pure nickel. With increasing content of SACNTs, the tensile strength of the composite increased and the elongation decreased because of the high-strength SACNTs bearing part of an applied load and the fine-grained strengthening mechanism. The nanohardness of the SACNT/Ni composites was improved from 3.92 GPa(pure nickel) to 4.62 GPa(Ni-4 vol%SACNTs). The uniform distribution of SACNTs in the composites and strong interfacial bonding between the SACNTs and the nickel matrix resulted in an improvement of the mechanical properties of the SACNT/Ni composites. The introduced SACNTs refined the nickel grains, increased the amount of crystal twins, and changed the preferred orientation of grain growth.展开更多
Total Knee Arthroplasty (TKA) is a procedure to replace the diseased or damaged knee joint with artificial prosthesis for the relief of disabling pain and restoring the function of knee. Total Knee Arthroplasty (TKA) ...Total Knee Arthroplasty (TKA) is a procedure to replace the diseased or damaged knee joint with artificial prosthesis for the relief of disabling pain and restoring the function of knee. Total Knee Arthroplasty (TKA) is one of the most common and successful procedures in modern orthopedics and is spreading through the world. Many surgeons are developing their skill but it needs experience and patience for successful outcomes. There are different factors which affect the outcome after total knee arthroplasty, among them;the coronal alignment of lower limb plays a major role. Many studies have supported that neutral mechanical alignment after total knee arthroplasty leads to better function. The aim of this review is to evaluate clinical outcome with reference to the coronal alignment of the limb and safety based on Western Ontario and McMaster Universities (WOMAC), Knee Society Score (KSS) score.展开更多
<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">The number of total knee arthroplasty (TKA) surgeries performed each ye...<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">The number of total knee arthroplasty (TKA) surgeries performed each year is increasing worldwide and mechanical alignment (MA) is currently seen as the gold standard procedure. However, taking neutral alignment as the universal goal may be mistaken. In our hospital, we currently conduct kinematically aligned TKA (KA-TKA). Three different types of implants are used</span><span style="font-family:Verdana;">:</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> the cruciate-retaining (CR) type, cruciate-sacrificing (CS) type, or bi-cruciate-retained (BCR) type. We aimed to compare the coronal alignment observed following KA-TKA and MA-TKA and in normal knees, as well as that achieved with different types of implants. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The study comprised 206 knees of Japanese patients who underwent KA-TKA using varying implants in our Hospital between May 2019 and April 2020. Measurements of pre- and postoperative coronal alignment were determined from weight-bearing full-leg standing radiographs. The postoperative results were </span><span style="font-family:Verdana;">compared to measurements taken from patients who underwent MA-TKA (</span><span style="font-family:Verdana;">N = 96) and normal knees (N = 60). </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">No significant differences between the KA-TKA group and normal knees were found for the medial proximal tibial angle (MPTA) (–4.2<span style="white-space:nowrap;">°</span> </span></span><span style="font-family:;" "=""><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 2.6<span style="white-space:nowrap;">°</span> vs –3.8<span style="white-space:nowrap;">°</span> </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 2.5<span style="white-space:nowrap;">°</span>) or joint line orientation angle (JLOA) (0.2<span style="white-space:nowrap;">°</span> </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 1.9<span style="white-space:nowrap;">°</span> vs 0.3<span style="white-space:nowrap;">°</span> </span><span style="font-family:Verdana;">±</span><span><span style="font-family:Verdana;"> 1.4<span style="white-space:nowrap;">°</span>). However, when MA-TKA was compared to KA-TKA and normal knees, there were significant differences in both the MPTA and JLOA (</span><i><span style="font-family:Verdana;">p </span></i><span style="font-family:Verdana;">< 0.01). Furthermore, for the different implant types, MPTA exhibited significantly greater varus alignment when a CS-type was used than with the other two. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Here, we demonstrated that following KA-TKA, the articular surface of the tibia exhibited a similar varus alignment as that of normal knees, meaning that the technique reproduces the native knee. Furthermore, KA is patient-specific, and does not have the same failures as MA-TKA. Therefore, we anticipate a paradigm shift from mechanical to kinematic alignment, which may help reduce the dissatisfaction rate of TKA patients.</span></span></span>展开更多
While advanced Large Language Models(LLMs)can simulate human-like prosocial behaviors,the degree to which they align with human prosocial values and the underlying afective mechanisms remain unclear.This study address...While advanced Large Language Models(LLMs)can simulate human-like prosocial behaviors,the degree to which they align with human prosocial values and the underlying afective mechanisms remain unclear.This study addressed these gaps using the third-party punishment(TPP)paradigm,comparing LLM agents(GPT and DeepSeek series)with human participants(n=100).The LLM agents(n=500,100 agents per model)were one-to-one constructed based on the demographic and psychological features of human participants.Prompt engineering was employed to initiate TPP games and record punitive decisions and afective responses in LLM agents.Results revealed that:(1)GPT-4o,DeepSeek-V3,and DeepSeek-R1 models demonstrated stronger fairness value alignment,choosing punitive options more frequently than humans in TPP games;(2)all LLMs replicated the human pathway from unfairness through negative afective response to punitive decisions,with stronger mediation efects of negative emotions observed in DeepSeek models than GPT models;(3)only DeepSeek-R1 exhibited the human-like positive feedback loop from previous punitive decisions to positive afective feedback and subsequent punitive choices;(4)most LLMs(excluding GPT-3.5)showed signifcant representational similarity to human afect-decision patterns;(5)notably,all LLMs displayed rigid afective dynamics,characterized by lower afective variability and higher afective inertia than the fexible,contextsensitive fuctuations observed in humans.These fndings highlight notable advances in prosocial value alignment but underscore the necessity to enhance their afective dynamics to foster robust,adaptive prosocial LLMs.Such advancements could not only accelerate LLMs'alignment with human values but also provide empirical support for the broader applicability of prosocial theories to LLM agents.展开更多
文摘With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant importance.Emotion-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying reasons.This comprehension is crucial for making informed strategic decisions in various business and societal contexts.However,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause extraction.To address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment mechanisms.The model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause pairs.Second,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among tasks.The proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 score.Experimental results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its effectiveness.This research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-cause pair extraction.However,the study’s limitation lies in the data sources,potentially restricting the generalizability of the findings.
基金Supported by Natural Science Research Project of Anhui Educational Committee(Grant No.2024AH040010).
文摘A high pattern resolution is critical for fabricating roll-to-roll printed electronics(R2RPE)products.For enhanced overlay alignment accuracy,position errors between the printer and the substrate web must be eliminated,particularly in inkjet printing applications.This paper proposes a novel five-degree-of-freedom(5-DOF)flexure-based alignment stage to adjust the posture of an inkjet printer head.The stage effectively compensates for positioning errors between the actuation mechanism and manipulated objects through a series-parallel combination of compliant substructures.Voice coil motors(VCMs)and linear motors serve as actuators to achieve the required motion.Theoretical models were established using a pseudo-rigid-body model(PRBM)methodology and were validated through finite element analysis(FEA).Finally,an alignment stage prototype was fabricated for an experiment.The prototype test results showed that the developed positioning platform attains 5-DOF motion capabilities with 335.1μm×418.9μm×408.1μm×3.4 mrad×3.29 mrad,with cross-axis coupling errors below 0.11%along y-and z-axes.This paper pro-poses a novel 5-DOF flexure-based alignment stage that can be used for error compensation in R2RPE and effectively improves the interlayer alignment accuracy of multi-layer printing.
文摘In the work of numerical control reformation of general machine tool, the installation and debugging of machine tool is a crucial part. For the C6132 machine tool, and make the use of electrical and mechanical alignment, parameter adjusting, numerical control lathe accuracy debugging and performance examination has been used to finish a series of tailing in the work of numerical control reformation of general machine tool. In this paper, the detailed process of electrical and mechanical alignment, parameter adjusting, numerical control lathe accuracy debugging and performance examination has been demonstrated, meanwhile, the specific operational approach of these work programs has been discussed. Therefore, the present results provides essential reference and approach for the numerical control reformation of general machine tool.
基金the Action on Scientists and Engineers to Serve Enterprises,China(No.2009GJE20016)Natural Science Foundation of Shanghai,China(No.09ZR1401500)+1 种基金Shanghai Leading Academic Discipline Project,China(No.B603)Program of Introducing Talents of Discipline to Universities,China(No.111-2-04)
文摘Polyacrylonitrile(PAN)/multi-walled carbon nanotubes(MWNTs)nanocomposites were prepared by an in-situ polymerization method and the fibers from these composites were obtained by a wet-spinning process.The orientation behavior of MWNTs in the PAN fibers was investigated by X-ray diffraction and sound velocity methods.The dispersion and the alignment of the nanotubes were also studied by scanning electron microscopy.
文摘Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology for the planning, deigning and production of cutting guides. This study aims to compare PST to conventional technique in terms of mechanical axis alignment and component positioning. Patients and method: 109 TKA were performed for 78 patients in 2 groups. Group A included 69 conventional TKA in 55 patients and Group B included 40 patient-specific TKA in 23 patient. Postoperative long-film X-rays were done for all patients to observe the mechanical axis, anatomical axis, lateral distal femoral mechanical angle and medial proximal tibial angle. Results: No statistically significant difference was found between the two groups regarding alignment or component positioning. Conclusion: Both techniques have shown similar results in restoring the mechanical axis and alignment after TKA. However, PST had the advantages of reduced blood loss and shorter operative time.
文摘Knee osteoarthritis(OA) is a progressive joint disease hallmarked by cartilage and bone breakdown and associated with changes to all of the tissues in the joint,ultimately causing pain,stiffness,deformity and disability in many people.Radiographs are commonly used for the clinical assessment of knee OA incidence and progression,and to assess for risk factors.One risk factor for the incidence and progression of knee OA is malalignment of the lower extremities(LE).The hipknee-ankle(HKA) angle,assessed from a full-length LE radiograph,is ideally used to assess LE alignment.Careful attention to LE positioning is necessary to obtain the most accurate measurement of the HKA angle.Since full-length LE radiographs are not always available,the femoral shaft-tibial shaft(FS-TS) angle may be calculated from a knee radiograph instead.However,the FS-TS angle is more variable than the HKA angle and it should be used with caution.Knee radiographs are used to assess the severity of knee OA and its progression.There are three types of ordinal grading scales for knee OA:global,composite and individual feature scales.Each grade on a global scale describes one or more features of knee OA.The entire description must be met for a specific grade to be assigned.The KellgrenLawrence scale is the most commonly-used global scale.Composite scales grade several features of knee OA individually and sum the grades to create a total score.One example is the compartmental grading scale for knee OA.Composite scales can respond to change in a variety of presentations of knee OA.Individual feature scales assess one or more OA features individually and do not calculate a total score.They are most often used to monitor change in one OA feature,commonly joint space narrowing.The most commonly-used individual feature scale is the OA Research Society International atlas.Each type of scale has its advantages;however,composite scales may offer greater content validity.Responsiveness to change is unknown for most scales and deserves further evaluation.
文摘Achieving optimal alignment in total knee arthroplasty(TKA) is a critical factor in ensuring optimal outcomes and long-term implant survival. Traditionally, mechanical alignment has been favored to achieve neutral postoperative joint alignment. However, contemporary approaches, such as kinematic alignments and hybrid techniques including adjusted mechanical, restricted kinematic, inverse kinematic, and functional alignments, are gaining attention for their ability to restore native joint kinematics and anatomical alignment, potentially leading to enhanced functional outcomes and greater patient satisfaction. The ongoing debate on optimal alignment strategies considers the following factors: long-term implant durability, functional improvement, and resolution of individual anatomical variations. Furthermore, advancements of computer-navigated and robotic-assisted surgery have augmented the precision in implant positioning and objective measurements of soft tissue balance. Despite ongoing debates on balancing implant longevity and functional outcomes, there is an increasing advocacy for personalized alignment strategies that are tailored to individual anatomical variations. This review evaluates the spectrum of various alignment techniques in TKA, including mechanical alignment, patient-specific kinematic approaches, and emerging hybrid methods. Each technique is scrutinized based on its fundamental principles, procedural techniques, inherent advantages, and potential limitations, while identifying significant clinical gaps that underscore the need for further investigation.
基金partially financially supported by the Tsinghua University Initiative Scientific Research Program(No.20111080980)the High Technology Research and Development Program of China(No.2013AA031201)
文摘A homogeneous and compact super-aligned carbon nanotube(SACNT)-reinforced nickel-matrix composite was successfully prepared by electrodeposition. The mechanical properties of the laminar SACNT/Ni composites were substantially improved compared with those of pure nickel. With increasing content of SACNTs, the tensile strength of the composite increased and the elongation decreased because of the high-strength SACNTs bearing part of an applied load and the fine-grained strengthening mechanism. The nanohardness of the SACNT/Ni composites was improved from 3.92 GPa(pure nickel) to 4.62 GPa(Ni-4 vol%SACNTs). The uniform distribution of SACNTs in the composites and strong interfacial bonding between the SACNTs and the nickel matrix resulted in an improvement of the mechanical properties of the SACNT/Ni composites. The introduced SACNTs refined the nickel grains, increased the amount of crystal twins, and changed the preferred orientation of grain growth.
文摘Total Knee Arthroplasty (TKA) is a procedure to replace the diseased or damaged knee joint with artificial prosthesis for the relief of disabling pain and restoring the function of knee. Total Knee Arthroplasty (TKA) is one of the most common and successful procedures in modern orthopedics and is spreading through the world. Many surgeons are developing their skill but it needs experience and patience for successful outcomes. There are different factors which affect the outcome after total knee arthroplasty, among them;the coronal alignment of lower limb plays a major role. Many studies have supported that neutral mechanical alignment after total knee arthroplasty leads to better function. The aim of this review is to evaluate clinical outcome with reference to the coronal alignment of the limb and safety based on Western Ontario and McMaster Universities (WOMAC), Knee Society Score (KSS) score.
文摘<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">The number of total knee arthroplasty (TKA) surgeries performed each year is increasing worldwide and mechanical alignment (MA) is currently seen as the gold standard procedure. However, taking neutral alignment as the universal goal may be mistaken. In our hospital, we currently conduct kinematically aligned TKA (KA-TKA). Three different types of implants are used</span><span style="font-family:Verdana;">:</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> the cruciate-retaining (CR) type, cruciate-sacrificing (CS) type, or bi-cruciate-retained (BCR) type. We aimed to compare the coronal alignment observed following KA-TKA and MA-TKA and in normal knees, as well as that achieved with different types of implants. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The study comprised 206 knees of Japanese patients who underwent KA-TKA using varying implants in our Hospital between May 2019 and April 2020. Measurements of pre- and postoperative coronal alignment were determined from weight-bearing full-leg standing radiographs. The postoperative results were </span><span style="font-family:Verdana;">compared to measurements taken from patients who underwent MA-TKA (</span><span style="font-family:Verdana;">N = 96) and normal knees (N = 60). </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">No significant differences between the KA-TKA group and normal knees were found for the medial proximal tibial angle (MPTA) (–4.2<span style="white-space:nowrap;">°</span> </span></span><span style="font-family:;" "=""><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 2.6<span style="white-space:nowrap;">°</span> vs –3.8<span style="white-space:nowrap;">°</span> </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 2.5<span style="white-space:nowrap;">°</span>) or joint line orientation angle (JLOA) (0.2<span style="white-space:nowrap;">°</span> </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> 1.9<span style="white-space:nowrap;">°</span> vs 0.3<span style="white-space:nowrap;">°</span> </span><span style="font-family:Verdana;">±</span><span><span style="font-family:Verdana;"> 1.4<span style="white-space:nowrap;">°</span>). However, when MA-TKA was compared to KA-TKA and normal knees, there were significant differences in both the MPTA and JLOA (</span><i><span style="font-family:Verdana;">p </span></i><span style="font-family:Verdana;">< 0.01). Furthermore, for the different implant types, MPTA exhibited significantly greater varus alignment when a CS-type was used than with the other two. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Here, we demonstrated that following KA-TKA, the articular surface of the tibia exhibited a similar varus alignment as that of normal knees, meaning that the technique reproduces the native knee. Furthermore, KA is patient-specific, and does not have the same failures as MA-TKA. Therefore, we anticipate a paradigm shift from mechanical to kinematic alignment, which may help reduce the dissatisfaction rate of TKA patients.</span></span></span>
基金supported by the National Natural Science Foundation of China(Grant Nos.32271110,62441614)the Tsinghua University Initiative Scientific Research Program(Grant No.20235080047)。
文摘While advanced Large Language Models(LLMs)can simulate human-like prosocial behaviors,the degree to which they align with human prosocial values and the underlying afective mechanisms remain unclear.This study addressed these gaps using the third-party punishment(TPP)paradigm,comparing LLM agents(GPT and DeepSeek series)with human participants(n=100).The LLM agents(n=500,100 agents per model)were one-to-one constructed based on the demographic and psychological features of human participants.Prompt engineering was employed to initiate TPP games and record punitive decisions and afective responses in LLM agents.Results revealed that:(1)GPT-4o,DeepSeek-V3,and DeepSeek-R1 models demonstrated stronger fairness value alignment,choosing punitive options more frequently than humans in TPP games;(2)all LLMs replicated the human pathway from unfairness through negative afective response to punitive decisions,with stronger mediation efects of negative emotions observed in DeepSeek models than GPT models;(3)only DeepSeek-R1 exhibited the human-like positive feedback loop from previous punitive decisions to positive afective feedback and subsequent punitive choices;(4)most LLMs(excluding GPT-3.5)showed signifcant representational similarity to human afect-decision patterns;(5)notably,all LLMs displayed rigid afective dynamics,characterized by lower afective variability and higher afective inertia than the fexible,contextsensitive fuctuations observed in humans.These fndings highlight notable advances in prosocial value alignment but underscore the necessity to enhance their afective dynamics to foster robust,adaptive prosocial LLMs.Such advancements could not only accelerate LLMs'alignment with human values but also provide empirical support for the broader applicability of prosocial theories to LLM agents.
