BACKGROUND Vaccines for coronavirus disease 2019(COVID-19) include Ch Ad Ox1-SARS-COV-2(Astra Zeneca),Ad26.COV2.S(Janssen),m RNA-1273(Moderna),BNT162b2(Pfizer),BBIBP-Cor V(Sinopharm),Corona Vac(Sinovac),and Bharat Bio...BACKGROUND Vaccines for coronavirus disease 2019(COVID-19) include Ch Ad Ox1-SARS-COV-2(Astra Zeneca),Ad26.COV2.S(Janssen),m RNA-1273(Moderna),BNT162b2(Pfizer),BBIBP-Cor V(Sinopharm),Corona Vac(Sinovac),and Bharat Biotech BBV152(Covaxin).AIM To find the association between COVID-19 vaccines and myocardial infarction(MI).METHODS This is a systematic review that involved searching databases such as MEDLINE,EMBASE,and Pak Medi Net after making a search strategy using Me SH and Emtree terms.Eligibility criteria were set,and studies having no mention of MI as a complication of COVID-19 vaccination,protocols,genetic studies,and animal studies were excluded.Data was extracted using a predesigned extraction table,and 29 studies were selected after screening and applying the eligibility criteria.RESULTS The majority of studies mentioned Astra Zeneca(18 studies) followed by Pfizer(14 studies) and Moderna(9 studies) in subjects reporting MI after vaccination.Out of all the studies,69% reported MI cases after the first COVID-19 vaccination dose and 14% after the second,44% reported ST-segment elevation MI,and 26% reported non-ST-segment elevation MI.The mortality rate was 29% after MI.CONCLUSION In conclusion,many studies linked MI to COVID-19 vaccinations,but no definitive association could be found.展开更多
文摘BACKGROUND Vaccines for coronavirus disease 2019(COVID-19) include Ch Ad Ox1-SARS-COV-2(Astra Zeneca),Ad26.COV2.S(Janssen),m RNA-1273(Moderna),BNT162b2(Pfizer),BBIBP-Cor V(Sinopharm),Corona Vac(Sinovac),and Bharat Biotech BBV152(Covaxin).AIM To find the association between COVID-19 vaccines and myocardial infarction(MI).METHODS This is a systematic review that involved searching databases such as MEDLINE,EMBASE,and Pak Medi Net after making a search strategy using Me SH and Emtree terms.Eligibility criteria were set,and studies having no mention of MI as a complication of COVID-19 vaccination,protocols,genetic studies,and animal studies were excluded.Data was extracted using a predesigned extraction table,and 29 studies were selected after screening and applying the eligibility criteria.RESULTS The majority of studies mentioned Astra Zeneca(18 studies) followed by Pfizer(14 studies) and Moderna(9 studies) in subjects reporting MI after vaccination.Out of all the studies,69% reported MI cases after the first COVID-19 vaccination dose and 14% after the second,44% reported ST-segment elevation MI,and 26% reported non-ST-segment elevation MI.The mortality rate was 29% after MI.CONCLUSION In conclusion,many studies linked MI to COVID-19 vaccinations,but no definitive association could be found.
