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Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury 被引量:2
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作者 Liping Shi Shuyi Liu +2 位作者 Jialing Chen Hong Wang Zhengbo Wang 《Neural Regeneration Research》 2026年第1期39-56,共18页
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl... Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microglia play an important role in secondary injury and can be activated in response to traumatic brain injury.In this article,we review the origin and classification of microglia as well as the dynamic changes of microglia in traumatic brain injury.We also clarify the microglial polarization pathways and the therapeutic drugs targeting activated microglia.We found that regulating the signaling pathways involved in pro-inflammatory and anti-inflammatory microglia,such as the Toll-like receptor 4/nuclear factor-kappa B,mitogen-activated protein kinase,Janus kinase/signal transducer and activator of transcription,phosphoinositide 3-kinase/protein kinase B,Notch,and high mobility group box 1 pathways,can alleviate the inflammatory response triggered by microglia in traumatic brain injury,thereby exerting neuroprotective effects.We also reviewed the strategies developed on the basis of these pathways,such as drug and cell replacement therapies.Drugs that modulate inflammatory factors,such as rosuvastatin,have been shown to promote the polarization of antiinflammatory microglia and reduce the inflammatory response caused by traumatic brain injury.Mesenchymal stem cells possess anti-inflammatory properties,and clinical studies have confirmed their significant efficacy and safety in patients with traumatic brain injury.Additionally,advancements in mesenchymal stem cell-delivery methods—such as combinations of novel biomaterials,genetic engineering,and mesenchymal stem cell exosome therapy—have greatly enhanced the efficiency and therapeutic effects of mesenchymal stem cells in animal models.However,numerous challenges in the application of drug and mesenchymal stem cell treatment strategies remain to be addressed.In the future,new technologies,such as single-cell RNA sequencing and transcriptome analysis,can facilitate further experimental studies.Moreover,research involving non-human primates can help translate these treatment strategies to clinical practice. 展开更多
关键词 animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell MICROGLIA NEUROINFLAMMATION non-human primate signaling pathway traumatic brain injury
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Ecological Dynamics of a Logistic Population Model with Impulsive Age-selective Harvesting
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作者 DAI Xiangjun JIAO Jianjun 《应用数学》 北大核心 2026年第1期72-79,共8页
In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asy... In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asymptotic stability of the trivial solution and the positive periodic solution.Finally,numerical simulations are presented to validate our results.Our results show that age-selective harvesting is more conducive to sustainable population survival than non-age-selective harvesting. 展开更多
关键词 The logistic population model Selective harvesting Asymptotic stability EXTINCTION
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Design optimization and FEA of B-6 and B-7 levels ballistics armor:A modelling approach
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作者 Muhammad Naveed CHU Jinkui +1 位作者 Atif Ur Rehman Arsalan Hyder 《大连理工大学学报》 北大核心 2026年第1期66-77,共12页
Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is empl... Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is employed to simulate the ballistic impact of 7.62 mm armor-piercing projectiles on Aluminum AA5083-H116 and Steel Secure 500 armors,focusing on the evaluation of material deformation and penetration resistance at varying impact points.While the D-shaped armor plate is penetrated by the armor-piercing projectiles,the combination of the perforated D-shaped and base armor plates successfully halts penetration.A numerical model based on the finite element method is developed using software such as SolidWorks and ANSYS to analyze the interaction between radiator armor and bullet.The perforated design of radiator armor is to maintain airflow for radiator function,with hole sizes smaller than the bullet core diameter to protect radiator assemblies.Predictions are made regarding the brittle fracture resulting from the projectile core′s bending due to asymmetric impact,and the resulting fragments failed to penetrate the perforated base armor plate.Craters are formed on the surface of the perforated D-shaped armor plate due to the impact of projectile fragments.The numerical model accurately predicts hole growth and projectile penetration upon impact with the armor,demonstrating effective protection of the radiator assemblies by the radiator armor. 展开更多
关键词 radiator armor ballistics simulation Johnson-Cook model armor-piercing projectile perforated D-shaped armor plate
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Modeling of Precipitation over Africa:Progress,Challenges,and Prospects
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作者 A.A.AKINSANOLA C.N.WENHAJI +21 位作者 R.BARIMALALA P.-A.MONERIE R.D.DIXON A.T.TAMOFFO M.O.ADENIYI V.ONGOMA I.DIALLO M.GUDOSHAVA C.M.WAINWRIGHT R.JAMES K.C.SILVERIO A.FAYE S.S.NANGOMBE M.W.POKAM D.A.VONDOU N.C.G.HART I.PINTO M.KILAVI S.HAGOS E.N.RAJAGOPAL R.K.KOLLI S.JOSEPH 《Advances in Atmospheric Sciences》 2026年第1期59-86,共28页
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha... In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain. 展开更多
关键词 RAINFALL MONSOON climate modeling CORDEX CMIP6 convection-permitting models
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Do Higher Horizontal Resolution Models Perform Better?
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作者 Shoji KUSUNOKI 《Advances in Atmospheric Sciences》 2026年第1期259-262,共4页
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(... Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)]. 展开更多
关键词 enhancing model resolution refinement data assimilation systems section climate model climate projection higher horizontal resolution seasonal forecasting simulation seasonal migration rain bands model resolution
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PhishNet: A Real-Time, Scalable Ensemble Framework for Smishing Attack Detection Using Transformers and LLMs
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作者 Abeer Alhuzali Qamar Al-Qahtani +2 位作者 Asmaa Niyazi Lama Alshehri Fatemah Alharbi 《Computers, Materials & Continua》 2026年第1期2194-2212,共19页
The surge in smishing attacks underscores the urgent need for robust,real-time detection systems powered by advanced deep learning models.This paper introduces PhishNet,a novel ensemble learning framework that integra... The surge in smishing attacks underscores the urgent need for robust,real-time detection systems powered by advanced deep learning models.This paper introduces PhishNet,a novel ensemble learning framework that integrates transformer-based models(RoBERTa)and large language models(LLMs)(GPT-OSS 120B,LLaMA3.370B,and Qwen332B)to enhance smishing detection performance significantly.To mitigate class imbalance,we apply synthetic data augmentation using T5 and leverage various text preprocessing techniques.Our system employs a duallayer voting mechanism:weighted majority voting among LLMs and a final ensemble vote to classify messages as ham,spam,or smishing.Experimental results show an average accuracy improvement from 96%to 98.5%compared to the best standalone transformer,and from 93%to 98.5%when compared to LLMs across datasets.Furthermore,we present a real-time,user-friendly application to operationalize our detection model for practical use.PhishNet demonstrates superior scalability,usability,and detection accuracy,filling critical gaps in current smishing detection methodologies. 展开更多
关键词 Smishing attack detection phishing attacks ensemble learning CYBERSECURITY deep learning transformer-based models large language models
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ChatGPT in liver transplantation:Current applications,limitations,and future directions
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作者 Eleni Avramidou Nikolaos Kougianos +3 位作者 George Chiotis-Miehe Stella Vasileiadou Georgios Katsanos Georgios Tsoulfas 《World Journal of Transplantation》 2026年第1期75-81,共7页
Liver transplantation(LT)remains the optimal life-saving intervention for patients with end-stage liver disease.Despite the recent advances in LT several barriers,including organ allocation,donor-recipient matching,an... Liver transplantation(LT)remains the optimal life-saving intervention for patients with end-stage liver disease.Despite the recent advances in LT several barriers,including organ allocation,donor-recipient matching,and patient education,persist.With the growing progress of artificial intelligence,particularly large language models(LLMs)like ChatGPT,new applications have emerged in the field of LT.Current studies demonstrating usage of ChatGPT in LT include various areas of application,from clinical settings to research and education.ChatGPT usage can benefit both healthcare professionals,by decreasing the time spent on non-clinical work,but also LT recipients by providing accurate information.Future potential applications include the expanding usage of ChatGPT and other LLMs in the field of LT pathology and radiology as well as the automated creation of discharge summaries or other related paperwork.Additionally,the next models of ChatGPT might have the potential to provide more accurate patient education material with increased readability.Although ChatGPT usage presents promising applications,there are certain ethical and practical limitations.Key concerns include patient data privacy,information accuracy,misinformation possibility and lack of legal framework.Healthcare providers and policymakers should collaborate for the establishment of a controlled framework for the safe use of ChatGPT.The aim of this minireview is to summarize current literature on ChatGPT in LT,highlighting both opportunities and limitations,while also providing future possible applications. 展开更多
关键词 ChatGPT Liver transplantation APPLICATIONS LIMITATIONS Artificial intelligence Large language model
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An Optimized Customer Churn Prediction Approach Based on Regularized Bidirectional Long Short-Term Memory Model
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作者 Adel Saad Assiri 《Computers, Materials & Continua》 2026年第1期1783-1803,共21页
Customer churn is the rate at which customers discontinue doing business with a company over a given time period.It is an essential measure for businesses to monitor high churn rates,as they often indicate underlying ... Customer churn is the rate at which customers discontinue doing business with a company over a given time period.It is an essential measure for businesses to monitor high churn rates,as they often indicate underlying issues with services,products,or customer experience,resulting in considerable income loss.Prediction of customer churn is a crucial task aimed at retaining customers and maintaining revenue growth.Traditional machine learning(ML)models often struggle to capture complex temporal dependencies in client behavior data.To address this,an optimized deep learning(DL)approach using a Regularized Bidirectional Long Short-Term Memory(RBiLSTM)model is proposed to mitigate overfitting and improve generalization error.The model integrates dropout,L2-regularization,and early stopping to enhance predictive accuracy while preventing over-reliance on specific patterns.Moreover,this study investigates the effect of optimization techniques on boosting the training efficiency of the developed model.Experimental results on a recent public customer churn dataset demonstrate that the trained model outperforms the traditional ML models and some other DL models,such as Long Short-Term Memory(LSTM)and Deep Neural Network(DNN),in churn prediction performance and stability.The proposed approach achieves 96.1%accuracy,compared with LSTM and DNN,which attain 94.5%and 94.1%accuracy,respectively.These results confirm that the proposed approach can be used as a valuable tool for businesses to identify at-risk consumers proactively and implement targeted retention strategies. 展开更多
关键词 Customer churn prediction deep learning RBiLSTM DROPOUT baseline models
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When Large Language Models and Machine Learning Meet Multi-Criteria Decision Making: Fully Integrated Approach for Social Media Moderation
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作者 Noreen Fuentes Janeth Ugang +4 位作者 Narcisan Galamiton Suzette Bacus Samantha Shane Evangelista Fatima Maturan Lanndon Ocampo 《Computers, Materials & Continua》 2026年第1期2137-2162,共26页
This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to use... This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to user behavior and platform-driven moderation on social media.The proposed methodological framework(1)utilizes large language models for social media post analysis and categorization,(2)employs k-means clustering for content characterization,and(3)incorporates the TODIM(Tomada de Decisão Interativa Multicritério)method to determine moderation strategies based on expert judgments.In general,the fully integrated framework leverages the strengths of these intelligent systems in a more systematic evaluation of large-scale decision problems.When applied in social media moderation,this approach promotes nuanced and context-sensitive self-moderation by taking into account factors such as cultural background and geographic location.The application of this framework is demonstrated within Facebook groups.Eight distinct content clusters encompassing safety,harassment,diversity,and misinformation are identified.Analysis revealed a preference for content removal across all clusters,suggesting a cautious approach towards potentially harmful content.However,the framework also highlights the use of other moderation actions,like account suspension,depending on the content category.These findings contribute to the growing body of research on self-moderation and offer valuable insights for creating safer and more inclusive online spaces within smaller communities. 展开更多
关键词 Self-moderation user-generated content k-means clustering TODIM large language models
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Investigating the potential mechanisms of Wenqing Yin against atopic dermatitis based on network pharmacology,experimental pharmacology,and molecular docking
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作者 Yi Wang Zhen Liu +3 位作者 Si-Man Li Lin Lin Wei Dai Meng-Yue Ren 《Traditional Medicine Research》 2026年第2期1-11,共11页
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o... Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses. 展开更多
关键词 Wenqing Yin atopic dermatitis mouse model UPLC-Orbitrap-MS/MS network pharmacology
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Emphasizing the biopsychosocial dimension in post-traumatic orthopedic recovery
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作者 Ramazan Deniz BaharÇiftçi 《World Journal of Psychiatry》 2026年第1期406-412,共7页
Chronic pain and disability following acute orthopedic trauma are not only physical concerns but also deeply intertwined with psychological well-being.The recent retrospective cohort study by Yang et al,published,prov... Chronic pain and disability following acute orthopedic trauma are not only physical concerns but also deeply intertwined with psychological well-being.The recent retrospective cohort study by Yang et al,published,provides compelling evidence of significant associations between depression,anxiety,and postoperative recovery.These findings align with an expanding body of literature that confirms the need for orthopedic rehabilitation to adopt a biopsychosocial perspective.This letter contextualizes Yang et al’s study within current evidence,highlighting the roles of sleep disturbance,catastrophizing,stress,neurobiological mechanisms,and coping strategies in shaping recovery.It further emphasizes the importance of integrating nursing-led and multidisciplinary interventions to address both physical and psychological domains,ultimately promoting holistic recovery. 展开更多
关键词 Orthopedic trauma Chronic pain DISABILITY Depression ANXIETY Biopsychosocial model Coping strategies
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Multi-Objective Evolutionary Framework for High-Precision Community Detection in Complex Networks
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作者 Asal Jameel Khudhair Amenah Dahim Abbood 《Computers, Materials & Continua》 2026年第1期1453-1483,共31页
Community detection is one of the most fundamental applications in understanding the structure of complicated networks.Furthermore,it is an important approach to identifying closely linked clusters of nodes that may r... Community detection is one of the most fundamental applications in understanding the structure of complicated networks.Furthermore,it is an important approach to identifying closely linked clusters of nodes that may represent underlying patterns and relationships.Networking structures are highly sensitive in social networks,requiring advanced techniques to accurately identify the structure of these communities.Most conventional algorithms for detecting communities perform inadequately with complicated networks.In addition,they miss out on accurately identifying clusters.Since single-objective optimization cannot always generate accurate and comprehensive results,as multi-objective optimization can.Therefore,we utilized two objective functions that enable strong connections between communities and weak connections between them.In this study,we utilized the intra function,which has proven effective in state-of-the-art research studies.We proposed a new inter-function that has demonstrated its effectiveness by making the objective of detecting external connections between communities is to make them more distinct and sparse.Furthermore,we proposed a Multi-Objective community strength enhancement algorithm(MOCSE).The proposed algorithm is based on the framework of the Multi-Objective Evolutionary Algorithm with Decomposition(MOEA/D),integrated with a new heuristic mutation strategy,community strength enhancement(CSE).The results demonstrate that the model is effective in accurately identifying community structures while also being computationally efficient.The performance measures used to evaluate the MOEA/D algorithm in our work are normalized mutual information(NMI)and modularity(Q).It was tested using five state-of-the-art algorithms on social networks,comprising real datasets(Zachary,Dolphin,Football,Krebs,SFI,Jazz,and Netscience),as well as twenty synthetic datasets.These results provide the robustness and practical value of the proposed algorithm in multi-objective community identification. 展开更多
关键词 Multi-objective optimization evolutionary algorithms community detection HEURISTIC METAHEURISTIC hybrid social network MODELS
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Agglomeration and floatability characteristics of Ar plasma-modified siderite
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作者 Zhanglei Zhu Yue Li +2 位作者 Chengchi Tian Bohui Zhao Qiuyue Sheng 《International Journal of Minerals,Metallurgy and Materials》 2026年第1期153-164,共12页
Interfacial interactions between rough mineral particles have garnered considerable attention as they directly determine particle agglomeration and floatability.This study comprehensively investigates the agglomeratio... Interfacial interactions between rough mineral particles have garnered considerable attention as they directly determine particle agglomeration and floatability.This study comprehensively investigates the agglomeration characteristics of siderite particles after argon(Ar)plasma surface modification through settling tests,flocs size measurements,and fractal dimension calculations.Ar plasma surface modification promotes the agglomeration of siderite particles,as evidenced by increased floc size and density.The agglomeration mechanism induced by Ar plasma surface modification is evaluated using a theoretical model combining the surface element integration(SEI)approach,differential geometry,and the composite Simpson's rule.Changes in surface roughness,wettability,and charge are considered in this model.Compared to the unpretreated siderite particles,the energy barrier for interaction of the 30-min Ar plasma-pretreated siderite particles decreases from 2.3×10-^(17)J to 1.6×10^(-17)J.This reduction provides strong evidence for the agglomeration behavior of siderite particles.Furthermore,flotation experiments confirm that Ar plasma surface modification is conducive to the aggregation flotation of siderite.These findings offer crucial insights into particle aggregation and dispersion behaviors,with notable application in mineral flotation. 展开更多
关键词 Ar plasma surface modification ROUGHNESS SIDERITE AGGLOMERATION theoretical model
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Numerical model for rapid prediction of temperature field, mushy zone and grain size in heating−cooling combined mold (HCCM) horizontal continuous casting of C70250 alloy plates
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作者 Ling-hui MENG Fan ZHAO +3 位作者 Dong LIU Chang-jian LU Yan-bin JIANG Xin-hua LIU 《Transactions of Nonferrous Metals Society of China》 2026年第1期203-217,共15页
Machine learning-assisted methods for rapid and accurate prediction of temperature field,mushy zone,and grain size were proposed for the heating−cooling combined mold(HCCM)horizontal continuous casting of C70250 alloy... Machine learning-assisted methods for rapid and accurate prediction of temperature field,mushy zone,and grain size were proposed for the heating−cooling combined mold(HCCM)horizontal continuous casting of C70250 alloy plates.First,finite element simulations of casting processes were carried out with various parameters to build a dataset.Subsequently,different machine learning algorithms were employed to achieve high precision in predicting temperature fields,mushy zone locations,mushy zone inclination angle,and billet grain size.Finally,the process parameters were quickly optimized using a strategy consisting of random generation,prediction,and screening,allowing the mushy zone to be controlled to the desired target.The optimized parameters are 1234℃for heating mold temperature,47 mm/min for casting speed,and 10 L/min for cooling water flow rate.The optimized mushy zone is located in the middle of the second heat insulation section and has an inclination angle of roughly 7°. 展开更多
关键词 Cu alloy numerical simulation machine learning prediction model process optimization
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Wind-induced circulation driving the spatial distribution of dominant algae population in a plateau lake,Erhai,China
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作者 Jing Cao Yue Wu +4 位作者 Zeying Hou Kunlin Yang Zhaosheng Chu Zhiwei Gao Hao Yang 《Journal of Environmental Sciences》 2026年第1期741-755,共15页
Wind-induced circulation is the main form of lake flow for shallow lakes and plays an important role in algae population distribution.This study constructed a three-dimensional hydrodynamic model(EFDC)of the plateau l... Wind-induced circulation is the main form of lake flow for shallow lakes and plays an important role in algae population distribution.This study constructed a three-dimensional hydrodynamic model(EFDC)of the plateau lake Erhai,China using accuracy wind field observation,runoff data and monthly algae data during 2022–2023.The model successfully reproduced the circulation characteristics of Erhai under prevailing wind directions.The results showed that the lake flow velocity in Lake Erhai is higher in winter than in summer,with lower velocities near shore particularly in the northern and central parts of the lake.There is a negative correlation between algal biomass and flow velocity(FV)in different zones,with lower FV favoring the accumulation of algal biomass,particularly for Microcystis,Dolichospermum,and Peridinium.Additionally,due to buoyancy,cyanobacteria are highly affected by wind direction and tend to accumulate in downwind regions of the prevailing wind direction.This study demonstrates that wind-induced circulation is a crucial factor affecting the spatial distribution of dominant algae populations in shallow plateau lakes with weak hydrodynamic force.Further,the risk of bloom occurrence in Lake Erhai will be higher due to the background of global climate change and the lake’s wind speed decline.In conclusion,we suggest implementing targeted zoning measures to control algal blooms and establishing stricter regulations for nitrogen and phosphorus control to counterbalance the promotion of algal bloom accumulation in low-velocity zones caused by reduced wind speed. 展开更多
关键词 Wind-induced circulation Dominant algae populations Three-dimensional hydrodynamic model MICROCYSTIS Peridinium
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Defining and predicting textbook outcomes in laparoscopic distal pancreatectomy
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作者 Xiao-Rui Huang Deng-Sheng Zhu +6 位作者 Xin-Yi Guo Jing-Zhao Zhang Zhen Zhang Huan Zheng Tong Guo Ya-Hong Yu Zhi-Wei Zhang 《World Journal of Gastroenterology》 2026年第1期139-150,共12页
BACKGROUND Laparoscopic distal pancreatectomy(LDP)has emerged as the preferred approach for both benign and malignant lesions located in the pancreatic body and tail.Nevertheless,a notable deficiency persists in the a... BACKGROUND Laparoscopic distal pancreatectomy(LDP)has emerged as the preferred approach for both benign and malignant lesions located in the pancreatic body and tail.Nevertheless,a notable deficiency persists in the absence of a standardized,procedure-specific metric for evaluating and comparing surgical quality.A composite measure termed“textbook outcome(TO)”,which encompasses key short-term endpoints,has been validated in laparoscopic pancreatoduodenectomy but has not yet been established in dedicated LDP cohorts.The definition and prediction of TO in this context could aid in facilitating cross-institutional benchmarking and fostering advancements in quality improvement.AIM To establish procedure-specific criteria for TO and identify independent predictors of TO failure in patients undergoing LDP.METHODS Consecutive patients who underwent LDP at a single high-volume pancreatic center between January 2015 and August 2022 were retrospectively analyzed.TO was defined as the absence of clinically relevant postoperative pancreatic fistula(grade B/C),post-pancreatectomy hemorrhage(grade B/C),severe complications(Clavien-Dindo≥III),readmission within 30 days,and in-hospital or 30-day mortality.Multivariable logistic regression was employed to identify independent predictors of TO failure,and a nomogram was constructed and internally validated.RESULTS Among 405 eligible patients,286(70.6%)attained TO.Multivariable analysis revealed that female sex[odds ratio(OR)=0.62,95%confidence interval(CI):0.39-0.99]conferred a protective effect,while preoperative endoscopic ultrasound-guided fine-needle aspiration(OR=2.66,95%CI:1.05-6.73),pancreatic portal hypertension(OR=2.81,95%CI:1.06-7.45),and cystic-solid(OR=2.51,95%CI:1.34-4.69)or solid lesions(OR=1.91,95%CI:1.06-3.44)were independently associated with TO failure(all P<0.05).The derived nomogram exhibited modest discrimination and calibration when assessed in both the training and validation datasets.CONCLUSION The proposed LDP-specific definition of TO is feasible and discriminative,and the developed nomogram provides an objective tool for individualized risk assessment. 展开更多
关键词 Laparoscopic distal pancreatectomy Textbook outcome PREDICTORS Risk prediction model NOMOGRAM
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Optimizing a multimedia model to assess the differential roles of crops and natural vegetation in the fate of PAHs
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作者 Chao Su Danfeng Zheng +7 位作者 Wenlei Chen Kifayatullah Khan Hong Zhang Shuai Song Ruoyu Liang Xiaoyu Zhang Yong Liu Xianghui Cao 《Journal of Environmental Sciences》 2026年第1期413-423,共11页
Vegetation plays an important role in the environmental transport behavior of organic pollutants,however,the different roles of crops and natural vegetation have been ignored in most previous studies.In this study,we ... Vegetation plays an important role in the environmental transport behavior of organic pollutants,however,the different roles of crops and natural vegetation have been ignored in most previous studies.In this study,we developed the BETR-Urban-Rural-Veg model to quantitatively evaluate the influences of both natural vegetation and crops on the multimedia transport processes of Phenanthrene(PHE)and Benzo(a)pyrene(BaP)in mainland of China.The geographic distribution of polycyclic aromatic hydrocarbon(PAH)emissions and concentrations were consistent,displaying higher levels in northern China while lower levels in southern China.Under seasonal simulations,for both natural vegetation and crops,PAH concentrations in winter and spring were 1.5 to 27-fold higher than in summer and autumn,especially for PHE.Owing to the higher leaf area index(LAI)of natural vegetation and harvesting of crops,the filter and sequestration effect of natural vegetation was stronger than crops,while the seasonal changes of PAH concentrations in crops were more significant than natural vegetation.Temperature,precipitation rates and LAI might have important influences on seasonal concentrations and overall persistence of PAHs.PHE was more sensitive to the impacts of seasonal environmental parameters.Under different landscape scenarios,average annual PAH concentrations in natural vegetation were always a little higher than those in crops,and the overall persistence of BaP was greatly affected increasing by 15.15%-16.47%.This improved model provides a useful tool for environmental management.The results of this study are expected to support land use plans and decision-making in China's mainland. 展开更多
关键词 Multimedia fate model Natural vegetation CROPS Seasonal variabilities Landscape scenarios
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An effective deep-learning prediction of Arctic sea-ice concentration based on the U-Net model
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作者 Yifan Xie Ke Fan +2 位作者 Hongqing Yang Yi Fan Shengping He 《Atmospheric and Oceanic Science Letters》 2026年第1期34-40,共7页
Current shipping,tourism,and resource development requirements call for more accurate predictions of the Arctic sea-ice concentration(SIC).However,due to the complex physical processes involved,predicting the spatiote... Current shipping,tourism,and resource development requirements call for more accurate predictions of the Arctic sea-ice concentration(SIC).However,due to the complex physical processes involved,predicting the spatiotemporal distribution of Arctic SIC is more challenging than predicting its total extent.In this study,spatiotemporal prediction models for monthly Arctic SIC at 1-to 3-month leads are developed based on U-Net-an effective convolutional deep-learning approach.Based on explicit Arctic sea-ice-atmosphere interactions,11 variables associated with Arctic sea-ice variations are selected as predictors,including observed Arctic SIC,atmospheric,oceanic,and heat flux variables at 1-to 3-month leads.The prediction skills for the monthly Arctic SIC of the test set(from January 2018 to December 2022)are evaluated by examining the mean absolute error(MAE)and binary accuracy(BA).Results showed that the U-Net model had lower MAE and higher BA for Arctic SIC compared to two dynamic climate prediction systems(CFSv2 and NorCPM).By analyzing the relative importance of each predictor,the prediction accuracy relies more on the SIC at the 1-month lead,but on the surface net solar radiation flux at 2-to 3-month leads.However,dynamic models show limited prediction skills for surface net solar radiation flux and other physical processes,especially in autumn.Therefore,the U-Net model can be used to capture the connections among these key physical processes associated with Arctic sea ice and thus offers a significant advantage in predicting Arctic SIC. 展开更多
关键词 Arctic sea-ice concentration Deep-learning prediction U-Net model CFSv2 NorCPM
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Load of the Small-Scale Vertical Cylinder in a Wave-Current Field
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作者 Mingjie Li Binbin Zhao Wengyang Duan 《哈尔滨工程大学学报(英文版)》 2026年第1期82-94,共13页
Studies of wave-current interactions are vital for the safe design of structures.Regular waves in the presence of uniform,linear shear,and quadratic shear currents are explored by the High-Level Green-Naghdi model in ... Studies of wave-current interactions are vital for the safe design of structures.Regular waves in the presence of uniform,linear shear,and quadratic shear currents are explored by the High-Level Green-Naghdi model in this paper.The five-point central difference method is used for spatial discretization,and the fourth-order Adams predictor-corrector scheme is employed for marching in time.The domain-decomposition method is applied for the wave-current generation and absorption.The effects of currents on the wave profile and velocity field are examined under two conditions:the same velocity of currents at the still-water level and the constant flow volume of currents.Wave profiles and velocity fields demonstrate substantial differences in three types of currents owing to the diverse vertical distribution of current velocity and vorticity.Then,loads on small-scale vertical cylinders subjected to regular waves and three types of background currents with the same flow volume are investigated.The maximum load intensity and load fluctuation amplitude in uniform,linear shear,and quadratic shear currents increase sequentially.The stretched superposition method overestimates the maximum load intensity and load fluctuation amplitude in opposing currents and underestimates these values in following currents.The stretched superposition method obtains a poor approximation for strong nonlinear waves,particularly in the case of the opposing quadratic shear current. 展开更多
关键词 Wave-current interaction Cylinder load HLGN model Morison equation Regular waves
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A decision framework for rural domestic sewage treatment models and process:Evidence from Inner Mongolia Autonomous Region,China
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作者 Ying Yan Pengyu Li +5 位作者 Zixuan Wang Yubo Tan Tianlong Zheng Jianguo Liu Xiaoxia Yang Junxin Liu 《Journal of Environmental Sciences》 2026年第1期302-311,共10页
Rural domestic sewage treatment is critical for environmental protection.This study defines the spatial pattern of villages from the perspective of rural sewage treatment and develops an integrated decision-making sys... Rural domestic sewage treatment is critical for environmental protection.This study defines the spatial pattern of villages from the perspective of rural sewage treatment and develops an integrated decision-making system to propose a sewage treatment mode and scheme suitable for local conditions.By considering the village spatial layout and terrain factors,a decision tree model of residential density and terrain type was constructed with accuracies of 76.47%and 96.00%,respectively.Combined with binary classification probability unit regression,an appropriate sewage treatment mode for the village was determined with 87.00%accuracy.The Analytic Hierarchy Process(AHP),combined with the Technique for Order Preference(TOPSIS)by Similarity to an Ideal Solution model,formed the basis for optimal treatment process selection under different emission standards.Verification was conducted in 542 villages across three counties of the Inner Mongolia Autonomous Region,focusing on the standard effluent effect(0.3773),low investment cost(0.3196),and high standard effluent effect(0.5115)to determine the best treatment process for the same emission standard under different needs.The annual environmental and carbon emission benefits of sewage treatment in these villages were estimated.This model matches village density,geographic feature,and social development level,and provides scientific support and a theoretical basis for rural sewage treatment decision-making. 展开更多
关键词 Rural domestic sewage Sewage treatment model DECISION-MAKING Environmental-economic benefits Inner Mongolia
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