Huntington＇s disease （HD） is an inherited autosomal dominant neurodegenerative disease characterized by pro- gressive motor deficits, cognitive decline, and psychiatric symptoms. It is caused by a pathological expa...Huntington＇s disease （HD） is an inherited autosomal dominant neurodegenerative disease characterized by pro- gressive motor deficits, cognitive decline, and psychiatric symptoms. It is caused by a pathological expansion of CAG trinucleotide repeats in exon 1 of the HD gene, resulting in the translation of a mutant form of huntingtin protein （mutant Htt） with an expanded polyglutamine domain in the N-terminal region [1 ]. Despite great progress in understanding the pathogenesis of HD using multiple mouse models, the exact mechanisms by which mutant Htt induces neuronal dysfunction and death are still not completely clear, and there is no curative treatment for this disease. An important reason is that the mouse, which is the most widely used animal model in HD research, differs from the human in many aspects, including the physiology, drug metabolism, blood-brain barrier, life span, brain volume, and neuroanatomical organization [2]. Thus, it is necessary to establish HD models with higher species than rodents, such as the dog, pig, and non- human primate, so as to bridge the gap between preclinical mouse models and clinical studies.展开更多
Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, ther...Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, there exist two types of hazards models： the multiplicative hazards model and the additive hazards model. In the paper, we propose a more flexible additive-multiplicative hazards model for multiple type of recurrent gap times data, wherein some covariates are assumed to be additive while others are multiplicative. An estimating equation approach is presented to estimate the regression parameters. We establish asymptotic properties of the proposed estimators.展开更多
This study addresses the challenge of assessing gaps among the differences of test people in eight groups by matching them based on four scenarios. The proposed model called Test Employee Capability Maturity Model (TE...This study addresses the challenge of assessing gaps among the differences of test people in eight groups by matching them based on four scenarios. The proposed model called Test Employee Capability Maturity Model (TEC-MM) helps find the gaps and measure the capability and maturity levels of each sub-maturity models in four dimensions as technicality, management, business, and personality. We applied TEC-MM to a software company which has instituted test people improvement strategy and plans to be a front runner in software testing industry. The findings reveal that gaps existed and consequently affect software testing process quality.展开更多
Research has found that the“non-contact”cognitive dissonance is an increasingly common phenomenon among college students during the COVID-19 pandemic lockdown of a university in China.For this,a qualitative approach...Research has found that the“non-contact”cognitive dissonance is an increasingly common phenomenon among college students during the COVID-19 pandemic lockdown of a university in China.For this,a qualitative approach based on psychological literature,and the“Quality Gap Model”in marketing are adopted,and a“non-contact”cognitive dissonance model of college students has been constructed.According to the model,cognitive dissonance is caused by the gap between college students’individual behavior and the expectation for the“non-contact”policy,the gap between college students’expectation with the university and the reality,and the gap between the expectation for the policy provider and the perceived reality.The research further explains the psychological mechanism of this behavior.It is proposed that the impact bias“catalyzes”the“escalation”of the“non-contact”cognitive dissonance behavior among college students.To solve this problem,the gap should be filled considering the following three aspects:counter attitudinal advocacy,establishment of cognitive overlap,and cognitive transformation.The unique contribution of the present study is presentation of a new perspective on“non-contact”cognitive dissonance based on public behavior management and to provide a case of controlling and prevention from the pandemic COVID-19 in China.展开更多
In this paper, the AMSAA-BISE model with missing data is discussed. The ML estimates of model parameters and current MTBF are given, and the chi-squared test and a plot for cumulative number of failures versus cumulat...In this paper, the AMSAA-BISE model with missing data is discussed. The ML estimates of model parameters and current MTBF are given, and the chi-squared test and a plot for cumulative number of failures versus cumulative testing time are used to test the goodness of fit for the model. This paper concludes with a numerical example to verify the model.展开更多
Establishing a long air gap discharge model considering the streamer-leader transition and randomness of the discharge path is of great signiflcance to improve the accuracy of discharge characteristic prediction and o...Establishing a long air gap discharge model considering the streamer-leader transition and randomness of the discharge path is of great signiflcance to improve the accuracy of discharge characteristic prediction and optimize external insulation design.Based on fractal theory and thermal ionization theory of streamer-leader transition,this work establishes a dynamic development model for the long air gap discharge streamer-leader system,which includes streamer inception,streamer development,leader inception,development of streamer-leader system and flnal jump.The positive discharge process of a 3 m rod plate is simulated to obtain the fractal distribution of the discharge path and the law of leader development for comparison with the discharge test results.The results show that the simulation model is similar to test results in the development characteristics of leader path distribution,each stage time and leader velocity.Finally,a simulation calculation of a 50%breakdown voltage of the rod-plate gap and ball-plate gap is carried out,with results fairly consistent with test data,proving the effectiveness and practicality of the model.展开更多
Since stack effect that occurs in high-rise buildings has an effect on the indoor environment of the buildings, energy loss and smoke control in case of a fire, there is a need to conduct research on this. For an anal...Since stack effect that occurs in high-rise buildings has an effect on the indoor environment of the buildings, energy loss and smoke control in case of a fire, there is a need to conduct research on this. For an analysis of the stack effect, analysis methods on the leakage flow through gap of interior door shall be formulated. Until now, studies related to the gap leakage flow in buildings have mainly analyzed flow field and pressure in the buildings one-dimensionally using pressure difference-leakage flowrate relations of Orifice Equation and a network numerical analysis algorithm that as- sumes each compartment in the buildings as a single point. In this study, the Momentum Loss Model which enables pressure drop to be proportional to the flow velocity through the gap of door in computational domain of 3-dimensional numerical analysis was proposed to reflect the gap flow phenomenon effectively in 3-dimensional numerical analysis. Using the proposed model, 3-dimensional numerical analysis of the stack effect on the stairs in buildings was performed, and the effects of separation door and lobby between stair and accommodation on the stack effect were investigated.展开更多
The increasingly widening income gap between urban and rural areas is affected by many factors. Using the stepwise regression analysis,we find that urbanization level,socio-economic development,education level,financi...The increasingly widening income gap between urban and rural areas is affected by many factors. Using the stepwise regression analysis,we find that urbanization level,socio-economic development,education level,financial development scale and financial development efficiency have the greatest impact on the income gap between urban and rural areas. By cointegration test,it is found that there is a long-term equilibrium relationship between these five variables and the income gap between urban and rural areas. We build the state-space model to research the dynamic impact of these factors on the income gap between urban and rural areas. The results show that by improving the level of urbanization,we can effectively narrow the income gap between urban and rural areas,while socio-economic development,the improvement of education level,expansion of financial development scale and financial development efficiency all significantly expand the income gap between urban and rural areas.展开更多
文摘Huntington＇s disease （HD） is an inherited autosomal dominant neurodegenerative disease characterized by pro- gressive motor deficits, cognitive decline, and psychiatric symptoms. It is caused by a pathological expansion of CAG trinucleotide repeats in exon 1 of the HD gene, resulting in the translation of a mutant form of huntingtin protein （mutant Htt） with an expanded polyglutamine domain in the N-terminal region [1 ]. Despite great progress in understanding the pathogenesis of HD using multiple mouse models, the exact mechanisms by which mutant Htt induces neuronal dysfunction and death are still not completely clear, and there is no curative treatment for this disease. An important reason is that the mouse, which is the most widely used animal model in HD research, differs from the human in many aspects, including the physiology, drug metabolism, blood-brain barrier, life span, brain volume, and neuroanatomical organization [2]. Thus, it is necessary to establish HD models with higher species than rodents, such as the dog, pig, and non- human primate, so as to bridge the gap between preclinical mouse models and clinical studies.
基金The Science Foundation(JA12301)of Fujian Educational Committeethe Teaching Quality Project(ZL0902/TZ(SJ))of Higher Education in Fujian Provincial Education Department
文摘Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, there exist two types of hazards models： the multiplicative hazards model and the additive hazards model. In the paper, we propose a more flexible additive-multiplicative hazards model for multiple type of recurrent gap times data, wherein some covariates are assumed to be additive while others are multiplicative. An estimating equation approach is presented to estimate the regression parameters. We establish asymptotic properties of the proposed estimators.
文摘This study addresses the challenge of assessing gaps among the differences of test people in eight groups by matching them based on four scenarios. The proposed model called Test Employee Capability Maturity Model (TEC-MM) helps find the gaps and measure the capability and maturity levels of each sub-maturity models in four dimensions as technicality, management, business, and personality. We applied TEC-MM to a software company which has instituted test people improvement strategy and plans to be a front runner in software testing industry. The findings reveal that gaps existed and consequently affect software testing process quality.
文摘Research has found that the“non-contact”cognitive dissonance is an increasingly common phenomenon among college students during the COVID-19 pandemic lockdown of a university in China.For this,a qualitative approach based on psychological literature,and the“Quality Gap Model”in marketing are adopted,and a“non-contact”cognitive dissonance model of college students has been constructed.According to the model,cognitive dissonance is caused by the gap between college students’individual behavior and the expectation for the“non-contact”policy,the gap between college students’expectation with the university and the reality,and the gap between the expectation for the policy provider and the perceived reality.The research further explains the psychological mechanism of this behavior.It is proposed that the impact bias“catalyzes”the“escalation”of the“non-contact”cognitive dissonance behavior among college students.To solve this problem,the gap should be filled considering the following three aspects:counter attitudinal advocacy,establishment of cognitive overlap,and cognitive transformation.The unique contribution of the present study is presentation of a new perspective on“non-contact”cognitive dissonance based on public behavior management and to provide a case of controlling and prevention from the pandemic COVID-19 in China.
文摘In this paper, the AMSAA-BISE model with missing data is discussed. The ML estimates of model parameters and current MTBF are given, and the chi-squared test and a plot for cumulative number of failures versus cumulative testing time are used to test the goodness of fit for the model. This paper concludes with a numerical example to verify the model.
基金supported by the Natural Science Foundation of Hebei Province(No.E2021502025)。
文摘Establishing a long air gap discharge model considering the streamer-leader transition and randomness of the discharge path is of great signiflcance to improve the accuracy of discharge characteristic prediction and optimize external insulation design.Based on fractal theory and thermal ionization theory of streamer-leader transition,this work establishes a dynamic development model for the long air gap discharge streamer-leader system,which includes streamer inception,streamer development,leader inception,development of streamer-leader system and flnal jump.The positive discharge process of a 3 m rod plate is simulated to obtain the fractal distribution of the discharge path and the law of leader development for comparison with the discharge test results.The results show that the simulation model is similar to test results in the development characteristics of leader path distribution,each stage time and leader velocity.Finally,a simulation calculation of a 50%breakdown voltage of the rod-plate gap and ball-plate gap is carried out,with results fairly consistent with test data,proving the effectiveness and practicality of the model.
文摘Since stack effect that occurs in high-rise buildings has an effect on the indoor environment of the buildings, energy loss and smoke control in case of a fire, there is a need to conduct research on this. For an analysis of the stack effect, analysis methods on the leakage flow through gap of interior door shall be formulated. Until now, studies related to the gap leakage flow in buildings have mainly analyzed flow field and pressure in the buildings one-dimensionally using pressure difference-leakage flowrate relations of Orifice Equation and a network numerical analysis algorithm that as- sumes each compartment in the buildings as a single point. In this study, the Momentum Loss Model which enables pressure drop to be proportional to the flow velocity through the gap of door in computational domain of 3-dimensional numerical analysis was proposed to reflect the gap flow phenomenon effectively in 3-dimensional numerical analysis. Using the proposed model, 3-dimensional numerical analysis of the stack effect on the stairs in buildings was performed, and the effects of separation door and lobby between stair and accommodation on the stack effect were investigated.
基金Supported by Humanities and Social Sciences Project of the Ministry of Education(10YJC790111)
文摘The increasingly widening income gap between urban and rural areas is affected by many factors. Using the stepwise regression analysis,we find that urbanization level,socio-economic development,education level,financial development scale and financial development efficiency have the greatest impact on the income gap between urban and rural areas. By cointegration test,it is found that there is a long-term equilibrium relationship between these five variables and the income gap between urban and rural areas. We build the state-space model to research the dynamic impact of these factors on the income gap between urban and rural areas. The results show that by improving the level of urbanization,we can effectively narrow the income gap between urban and rural areas,while socio-economic development,the improvement of education level,expansion of financial development scale and financial development efficiency all significantly expand the income gap between urban and rural areas.
