Background:Clinical features and outcomes of heart failure(HF)with mid-range ejection fraction(HFmrEF)remain controversial.Thus,we systematically reviewed literatures of clinical research to assess and analyze charact...Background:Clinical features and outcomes of heart failure(HF)with mid-range ejection fraction(HFmrEF)remain controversial.Thus,we systematically reviewed literatures of clinical research to assess and analyze characteristics and prognosis of patients with HFmrEF.Methods:PubMed,Embase,and Web of Science were searched for cohort studies up to April 23,2019.Clinical features and multivariate adjusted hazard ratios(HRs)of endpoints of short-term all-cause mortality(SAM),long-term all-cause mortality(LAM),long-term cardiovascular death(LCD)and long-term HF rehospitalization(LHR)among patients with HFmrEF and HF with preserved ejection fraction(HFpEF),HF with reduced ejection fraction(HFrEF)were well addressed.The primary outcome was LAM.Results:Totally 19 studies were included in this study with 164,678 patients enrolled.The follow-up time of LAM was 3.6±2.5 years.HRs of LAM,SAM,LCD,LHR indicated that the risks of patients with HFmrEF were higher than HFpEF patients but lower than HFrEF patients,as for LAM,HFmrEF:HFpEF(reference)HR:1.07,95%confidence interval(CI):1.00-1.15(I2=63%,P=0.0005);HFmrEF:HFrEF(reference)HR:0.80,95%CI:0.73-0.88(I2=70%,P<0.0001).However,HFmrEF patients had the lowest rate in LAM(30.94%),SAM(2.73%),LCD(17.45%),LHR(26.36%)compared with the other two groups.Conclusions:This systematic review and meta-analysis compared features and prognosis between patients with HFmrEF and HFpEF,HFrEF by HRs.There appeared a special"separation phenomenon"showing rates of endpoints were inconsistent with their hazards in patients with HFmrEF compared with HFpEF patients.展开更多
Alkali-free aluminosilicate glass has several advantages,including a low thermal expansion coefficient and density,high elastic modulus,and excellent chemical and thermal stability,making it an ideal substrate materia...Alkali-free aluminosilicate glass has several advantages,including a low thermal expansion coefficient and density,high elastic modulus,and excellent chemical and thermal stability,making it an ideal substrate material for TFT-LCD and OLED applications.Understanding the relationship between the composition-microstructure-properties of this glass is crucial for designing materials with optimal properties and suitable process parameters.In this work,we investigated how the composition affects the microstructure and properties of alkali-free aluminosilicate substrate glass.We elucidated the relationship between composition-microstructure-properties through experiments and molecular dynamics simulations.As B_(2)O_(3) replaced Al_(2)O_(3) in the glass,the content of[AlO_(4)]in the network structure decreased,while the amounts of[BO_(3)]and[BO_(4)]increased.The triangular structure of[BO_(3)]expanded the network,reduced its connectivity,and loosened the overall structure.Consequently,the glass melt's viscosity,viscous activation energy,and melting temperature decreased.This study provided essential data and a theoretical foundation for industrial production based on the composition-microstructure-properties relationship.展开更多
基金This study was supported by grants from the China Cardiovascular Association-Cardiac Rehabilitation and Metabolic Therapy Research Fund(No.CCA-CRMT-1805)the Science and Technology Funding of Tianjin Chest Hospital(No.2018XKZ17).
文摘Background:Clinical features and outcomes of heart failure(HF)with mid-range ejection fraction(HFmrEF)remain controversial.Thus,we systematically reviewed literatures of clinical research to assess and analyze characteristics and prognosis of patients with HFmrEF.Methods:PubMed,Embase,and Web of Science were searched for cohort studies up to April 23,2019.Clinical features and multivariate adjusted hazard ratios(HRs)of endpoints of short-term all-cause mortality(SAM),long-term all-cause mortality(LAM),long-term cardiovascular death(LCD)and long-term HF rehospitalization(LHR)among patients with HFmrEF and HF with preserved ejection fraction(HFpEF),HF with reduced ejection fraction(HFrEF)were well addressed.The primary outcome was LAM.Results:Totally 19 studies were included in this study with 164,678 patients enrolled.The follow-up time of LAM was 3.6±2.5 years.HRs of LAM,SAM,LCD,LHR indicated that the risks of patients with HFmrEF were higher than HFpEF patients but lower than HFrEF patients,as for LAM,HFmrEF:HFpEF(reference)HR:1.07,95%confidence interval(CI):1.00-1.15(I2=63%,P=0.0005);HFmrEF:HFrEF(reference)HR:0.80,95%CI:0.73-0.88(I2=70%,P<0.0001).However,HFmrEF patients had the lowest rate in LAM(30.94%),SAM(2.73%),LCD(17.45%),LHR(26.36%)compared with the other two groups.Conclusions:This systematic review and meta-analysis compared features and prognosis between patients with HFmrEF and HFpEF,HFrEF by HRs.There appeared a special"separation phenomenon"showing rates of endpoints were inconsistent with their hazards in patients with HFmrEF compared with HFpEF patients.
基金the Anhui Provincial Key Research and Development Plan(Grant No.2023z04020014,202304a05020019)the Fundamental Research Funds for the Central Universities of China(Grant No.PA2023GDSK0056).
文摘Alkali-free aluminosilicate glass has several advantages,including a low thermal expansion coefficient and density,high elastic modulus,and excellent chemical and thermal stability,making it an ideal substrate material for TFT-LCD and OLED applications.Understanding the relationship between the composition-microstructure-properties of this glass is crucial for designing materials with optimal properties and suitable process parameters.In this work,we investigated how the composition affects the microstructure and properties of alkali-free aluminosilicate substrate glass.We elucidated the relationship between composition-microstructure-properties through experiments and molecular dynamics simulations.As B_(2)O_(3) replaced Al_(2)O_(3) in the glass,the content of[AlO_(4)]in the network structure decreased,while the amounts of[BO_(3)]and[BO_(4)]increased.The triangular structure of[BO_(3)]expanded the network,reduced its connectivity,and loosened the overall structure.Consequently,the glass melt's viscosity,viscous activation energy,and melting temperature decreased.This study provided essential data and a theoretical foundation for industrial production based on the composition-microstructure-properties relationship.
