The microstructures of pharmaceutical preparations play a pivotal role in determining their critical quality attributes(CQAs),such as drug release,content uniformity,and stability,which greatly impact the safety and e...The microstructures of pharmaceutical preparations play a pivotal role in determining their critical quality attributes(CQAs),such as drug release,content uniformity,and stability,which greatly impact the safety and efficacy of drugs.Unlike the inherent molecular structures of active pharmaceutical ingredients(APIs)and excipients,the microstructures of pharmaceutical preparations are developed during the formulation process,presenting unique analytical challenges.In this review,we primarily focus on presenting the research methods used to elucidate the microstructures of pharmaceutical preparations,including X-ray imaging(XRI),scanning electron microscopy(SEM),atomic force microscopy(AFM),Raman spectroscopy,infrared(IR)spectroscopy,and rheometer technology.Subsequently,we highlight the applications,advantages,and limitations of these methods.Finally,we discuss the current challenges and future perspectives in this field.This review aims to provide a comprehensive reference for understanding the microstructures of pharmaceutical preparations,offering new insights and potential advancements in their development.展开更多
Erratum to:Research Methods Used for Developing Academic Wordlists:A Systematic Review of Studies Published Between 2000 and 2020,Chinese Journal of Applied Linguistics,Volume 48,Issue 3,2025,pp.425-450,doi:10.1515/CJ...Erratum to:Research Methods Used for Developing Academic Wordlists:A Systematic Review of Studies Published Between 2000 and 2020,Chinese Journal of Applied Linguistics,Volume 48,Issue 3,2025,pp.425-450,doi:10.1515/CJAL-2025-0210.展开更多
The learning of English academic vocabulary has been the focus of numerous studies from the time Coxhead(2000)developed the academic word list to the present day.Various researchers have emphasized the importance of p...The learning of English academic vocabulary has been the focus of numerous studies from the time Coxhead(2000)developed the academic word list to the present day.Various researchers have emphasized the importance of possessing academic vocabulary knowledge for academic success.Recognizing this importance,it is crucial for researchers,teachers,and learners to understand the progress made in academic word lists.This systematic review first identifies,describes,appraises,and synthesizes the development of academic word lists from 2000 to 2020.It then examines the methods used by researchers in developing academic word lists among 56 studies that meet the pre-established criteria.The word lists were classified based on some criteria such as word counting units,corpora types/sizes,and exclusion criteria.Limitations,suggestions for further study,and implications are also discussed.Additionally,recommendations for future word list establishment are provided to help advance the field of word list development.展开更多
Laser display technology is the most promising display technology in the market and is widely used in many fields. However, laser speckle has been troubling the application and expansion of this technology in some fie...Laser display technology is the most promising display technology in the market and is widely used in many fields. However, laser speckle has been troubling the application and expansion of this technology in some fields. In order to better evaluate the speckle, speckle measurement methods must be studied. In this study, a dynamic measurement method for laser speckles is proposed according to the optical superposition characteristics of speckle, which can reduce the influence of non-coherent factors on the speckle measurement results. The feasibility of the dynamic speckle measurement method is verified by designing an experimental scheme.展开更多
Reproducibility is a key aspect of the scientific method as it provides evidence for research claims. It is essential to promote openness, accessibility, and collaboration within the scientific community. This article...Reproducibility is a key aspect of the scientific method as it provides evidence for research claims. It is essential to promote openness, accessibility, and collaboration within the scientific community. This article aims to provide an introduction to best practices in reproducibility that are relevant to the transportation research community, to discuss issues and barriers to reproducibility, and to describe methods for addressing these issues. This article starts by discussing openness and transparency, then discusses several key best practices for reproducibility in transportation engineering, highlighting common methods and techniques, as well as the associated benefits. The paper concludes with a discussion of the key barriers to implementing reproducibility practices in transportation research and potential solutions. The barriers include existing culture and attitudes, data sensitivity, insufficient methodological detail, lack of code sharing, limited validation, additional time and research burden, and skill and knowledge gaps. Discussing each of these items provides an opportunity for the transportation research community to evolve to become one that embraces the openness and transparency of reproducibility.展开更多
TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in TCM.Elucidating the bio-active components of TCM formulae is...TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in TCM.Elucidating the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese medicines.With the rapid development of modern instruments and technology,many new theories,methods and strategies are emerging,which upgrade the research of TCM formulae into a higher level.Only when the medicinal efficacy,bio-active components,function mechanism of TCM formulae are understood,we can guarantee TCM safety and quality control.In this paper,we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study,serum pharmacology and serum pharmacochemistry,association analysis,biochro-matography,network pharmacology,metabolomics and proteomics,so as to provide reference for the research and development of TCM in the future.展开更多
The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptanc...The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptance in diverse fields of medicine.The Delphi methods assumed a pivotal role in the last few decades to develop best practice guidance using collective intelligence where research is limited,ethically/logistically difficult or evidence is conflicting.However,the attempts to assess the quality standard of Delphi studies have reported significant variance,and details of the process followed are usually unclear.We recommend systematic quality tools for evaluation of Delphi methodology;identification of problem area of research,selection of panel,anonymity of panelists,controlled feedback,iterative Delphi rounds,consensus criteria,analysis of consensus,closing criteria,and stability of the results.Based on these nine qualitative evaluation points,we assessed the quality of Delphi studies in the medical field related to coronavirus disease 2019.There was inconsistency in reporting vital elements of Delphi methods such as identification of panel members,defining consensus,closing criteria for rounds,and presenting the results.We propose our evaluation points for researchers,medical journal editorial boards,and reviewers to evaluate the quality of the Delphi methods in healthcare research.展开更多
The root system is an important organ that plants absorb nutrients from the soil, and can synthesize the vital substances necessary for the plant. However, the study on root system is burdened with great challenges du...The root system is an important organ that plants absorb nutrients from the soil, and can synthesize the vital substances necessary for the plant. However, the study on root system is burdened with great challenges due to its underground roots. In order to further explore the research methods and techniques of plant roots, the research mainly reviewed the research methods of root system, and summarized the methods of conventional root research, such as digging method, core drilling method, container method and isotope method. The progress of CT scan method, ground penetrating radar, special environmental culture method, nucle- ar magnetic resonance method and CCD three-dimensional imaging method were reviewed. Prospects for plant root research were made according to the trends of root research methods usincl hiqh-end technolo.qy at home and abroad.展开更多
AIMTo describe the development and validation of a novel neuronavigation-based method, which allows the quan-tification of the anatomical features that define anapproach, as well as real-time visualization of the surg...AIMTo describe the development and validation of a novel neuronavigation-based method, which allows the quan-tification of the anatomical features that define anapproach, as well as real-time visualization of the surgicapyramid. METHODSThe method was initially developed with commercially-available hardware for coordinate collection （a digitizerand a frameless navigation system） and software forvolume rendering; dedicated neuronavigation software （ApproachViewer, part of GTx-UHN） was then developed. The accuracy of measurements and the possibility of volumetric rendering of surgical approaches simulated in a phantom were compared among three different methods and commercially-available radiological software. In the anatomy laboratory, ApproachViewer was applied to the comparative quantitative analysis of multiple neurosurgical approaches and was used by many surgeons who were untrained for the research method.RESULTSThe accuracy of ApproachViewer is comparable to com-mercially-available radiological software. In the anatomy laboratory, the method appears versatile. The system can be easily used after brief training. ApproachViewer allows for real-time evaluation and comparison of surgical approaches, as well as post-dissection analyses of collected data. The accuracy of the method depends on the navigation registration： with a 1-2 mm registration error, it is adequate for evaluation and comparison of most neurosurgical approaches.CONCLUSIONThis new research method and software allows semi-automated visualization, quantifcation, and comparison of neurosurgical approaches in the anatomy laboratory.展开更多
Traditional occupational disease control and prevention has remained prevalent in China over recent decades. There are appropriately 30,000 new case reports of occupational diseases annually. Although China has alread...Traditional occupational disease control and prevention has remained prevalent in China over recent decades. There are appropriately 30,000 new case reports of occupational diseases annually. Although China has already established a series of occupational disease prevention programs, occupational health risk assessment （OHRA） strategies continue to be a limitation.展开更多
Farmland weeds are an important part of farmland ecosystems.Research on farmland weeds is one of the major research fields in agricultural ecology.It is of great significance for achieving high yield,high quality and ...Farmland weeds are an important part of farmland ecosystems.Research on farmland weeds is one of the major research fields in agricultural ecology.It is of great significance for achieving high yield,high quality and high efficiency in agriculture.In recent years,research on farmland weeds has focused on investigation of weed communities,research on weed seed banks,and research on weed control.These three research directions complement each other.Among them,the investigation work of weed communities and the research of weed seed banks are helpful for us to grasp the occurrence of farmland weeds more accurately and provide references for the control of farmland weeds.This article summarizes the research directions of farmland weeds in recent years(weed community investigation,weed seed bank,weed control)and the research methods used,provide reference value for the follow-up research work of farmland weeds,and provide theoretical support for promoting the development of rural ecological industry and building beautiful villages.展开更多
Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors there...Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors therefore play a crucial role in defining the alternation of urban space--in particular, that of the centers. The main focus of this research article is on the methodology used in the survey and evaluation of ＂centralities＂ as well as their developments over the past four decades （1974-2014） in approaches to urban development that has been developed in Graz.~ The analysis has drawn on the four editions （＂evolution＂） of approaches to urban development as conceived by the city of Graz in order to examine their verbal characteristics in regard to centralities. At the same time, the analysis does not examine presentations of plans which exist in supplementary forms （e.g., explanatory reports and supplemented plans）--it restricts itself solely to the various plans set out in the STEKs.2 The highest degree of accuracy has been applied to the notion of ＂centralis＂ in approaches to urban development. The goal of the research project was to depict the modulation of the notion of ＂centrality＂ in the urban context as a space-forming dimension. Furthermore, it clearly shows the extent to which the notion of the ＂centre＂ （in the widest sense of the word） has become distanced from qualitative, spatial development and at the current time of urban development is experiencing a sort of Renaissance. In the field of ＂urban development＂, architectural references in the context of＂centrality＂ have scarcely been researched. This has led to the opening-up of a complex interdisciplinary research field. In order to make the complex architectural determinants of ＂centrality＂ more accessible to the participating disciplines, approaches to urban development have been explored in the form of a social and spatial analysis.展开更多
Psoriasis is a chronic,refractory,inflammatory skin disease that occurs in young adults.The traditional animal model cannot simulate the skin characteristics of patients with psoriasis effectively,so it is difficult t...Psoriasis is a chronic,refractory,inflammatory skin disease that occurs in young adults.The traditional animal model cannot simulate the skin characteristics of patients with psoriasis effectively,so it is difficult to be used for in-depth study of psoriasis mechanism.Immortalized human epidermal cells(HaCaT) is a non-tumor,immortalized human epidermal cell which is widely used in the study of dermatosis.HaCaT cells are the best choice for the study of psoriasis mechanism because their immu.nological characteristics and reproductive ability are coincide with the pathological features of psoriasis.This article reviews the specific methods such as establishment of cell method,cytokine and chemo.kine analysisin the pathogenesis study of psoriasis based on HaCaT cells,hoping to provide some thoughts for drug′s pharmacological activity research.展开更多
The present paper first reviewed the major concepts and practices involves in research. A small study was conducted to survey on the prevailing research questions and methods in ELT studies in China, showing a major p...The present paper first reviewed the major concepts and practices involves in research. A small study was conducted to survey on the prevailing research questions and methods in ELT studies in China, showing a major paradigm shift from qualitative studies to quantitative research and mixed methods, with little critical research identified.展开更多
Interviewing is one of the most common and most powerful research methods in sociology. To provide an overview of interviewing in social research, the preliminaries and some tactics applied in interviewing are illustr...Interviewing is one of the most common and most powerful research methods in sociology. To provide an overview of interviewing in social research, the preliminaries and some tactics applied in interviewing are illustrated firstly. Secondly, various forms of interviewing employed in social research are analyzed specifically. Finally, the issues of interviewing are critically examined.展开更多
This paper tries to apply a new and more comprehensive method to urban tourism research in an expanded field instead of only partially, unilaterally and separately focusing on the city itself. Taking the urban tourism...This paper tries to apply a new and more comprehensive method to urban tourism research in an expanded field instead of only partially, unilaterally and separately focusing on the city itself. Taking the urban tourism of Guangdong, Hong Kong and Macao as an example, it aims at presenting a new spatial system of urban tourism research and pointing out the new orientation of urban tourism research in combination of macro level and micro level, from description to explanation. The meanings of the spatial framework construction for urban tourism study are to make clear how urban tourism studies vary with the changes of dimensions of time and space. This is a meaningful discussion because it will bring great changes to the using of literatures, the opening of research perspectives on urban tourism and the upgrading of theories, so as to create a new stage for urban tourism study.展开更多
According to the rotor vortex theory,the rotor circulation and the rotor induced velocity are developed into Fourier series.The circulation distribution along blade spanwise is expressed in terms of segment-by-segment...According to the rotor vortex theory,the rotor circulation and the rotor induced velocity are developed into Fourier series.The circulation distribution along blade spanwise is expressed in terms of segment-by-segment linear functions.In consequence the induced velocity equations and the circulation equations are derived.The engineering application of the rotor vortex theory is provided.Then the induced velocity and its harmonic components are obtained to provide a quantitative basis for the vortex model.For calculating each harmonic component of the induced velocity a simplified method is put forward which considers the effects of each order circulation with neglecting those of higher order.The method saves the computer time and is of significant benefit.展开更多
The research methods of the history of Mongolian medicine refer to the general and special methods used in the understanding and research of the history of Mongolian medicine,as well as the methods of expression and c...The research methods of the history of Mongolian medicine refer to the general and special methods used in the understanding and research of the history of Mongolian medicine,as well as the methods of expression and compilation of the research achievements of the history of Mongolian medicine.There are not only analysis and generalization,abstractness and concreteness,deduction and induction,historical and logical methods,but also traditional philology methods such as textual research,exegesis and collation,as well as new methods such as field investigation method,empirical method,measurement method,comparison method,and oral account method.In the actual research process,a variety of methods are often used comprehensively.This paper mainly discusses the methods used by Professor Ba Jigemude in the study of the history of Mongolian medicine,and uses specific cases to analyze and summarize the formation and development of the history of ancient traditional medicine.展开更多
文摘The microstructures of pharmaceutical preparations play a pivotal role in determining their critical quality attributes(CQAs),such as drug release,content uniformity,and stability,which greatly impact the safety and efficacy of drugs.Unlike the inherent molecular structures of active pharmaceutical ingredients(APIs)and excipients,the microstructures of pharmaceutical preparations are developed during the formulation process,presenting unique analytical challenges.In this review,we primarily focus on presenting the research methods used to elucidate the microstructures of pharmaceutical preparations,including X-ray imaging(XRI),scanning electron microscopy(SEM),atomic force microscopy(AFM),Raman spectroscopy,infrared(IR)spectroscopy,and rheometer technology.Subsequently,we highlight the applications,advantages,and limitations of these methods.Finally,we discuss the current challenges and future perspectives in this field.This review aims to provide a comprehensive reference for understanding the microstructures of pharmaceutical preparations,offering new insights and potential advancements in their development.
文摘Erratum to:Research Methods Used for Developing Academic Wordlists:A Systematic Review of Studies Published Between 2000 and 2020,Chinese Journal of Applied Linguistics,Volume 48,Issue 3,2025,pp.425-450,doi:10.1515/CJAL-2025-0210.
文摘The learning of English academic vocabulary has been the focus of numerous studies from the time Coxhead(2000)developed the academic word list to the present day.Various researchers have emphasized the importance of possessing academic vocabulary knowledge for academic success.Recognizing this importance,it is crucial for researchers,teachers,and learners to understand the progress made in academic word lists.This systematic review first identifies,describes,appraises,and synthesizes the development of academic word lists from 2000 to 2020.It then examines the methods used by researchers in developing academic word lists among 56 studies that meet the pre-established criteria.The word lists were classified based on some criteria such as word counting units,corpora types/sizes,and exclusion criteria.Limitations,suggestions for further study,and implications are also discussed.Additionally,recommendations for future word list establishment are provided to help advance the field of word list development.
基金supported by the National Natural Science Foundation of China (No.62076160)the Natural Science Foundation of Shanghai (No.21ZR1424700)。
文摘Laser display technology is the most promising display technology in the market and is widely used in many fields. However, laser speckle has been troubling the application and expansion of this technology in some fields. In order to better evaluate the speckle, speckle measurement methods must be studied. In this study, a dynamic measurement method for laser speckles is proposed according to the optical superposition characteristics of speckle, which can reduce the influence of non-coherent factors on the speckle measurement results. The feasibility of the dynamic speckle measurement method is verified by designing an experimental scheme.
文摘Reproducibility is a key aspect of the scientific method as it provides evidence for research claims. It is essential to promote openness, accessibility, and collaboration within the scientific community. This article aims to provide an introduction to best practices in reproducibility that are relevant to the transportation research community, to discuss issues and barriers to reproducibility, and to describe methods for addressing these issues. This article starts by discussing openness and transparency, then discusses several key best practices for reproducibility in transportation engineering, highlighting common methods and techniques, as well as the associated benefits. The paper concludes with a discussion of the key barriers to implementing reproducibility practices in transportation research and potential solutions. The barriers include existing culture and attitudes, data sensitivity, insufficient methodological detail, lack of code sharing, limited validation, additional time and research burden, and skill and knowledge gaps. Discussing each of these items provides an opportunity for the transportation research community to evolve to become one that embraces the openness and transparency of reproducibility.
基金supported by the Key Research and Development Program of Shaanxi(No.2019ZDLSF04-05)the National Natural Science Foundation of China(No.81974522),the Subject Innovation Team of Shaanxi University of Chinese Medi-cine(No.2019-YL10)the Youth Innovation Team of Shaanxi Universities(2020).
文摘TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in TCM.Elucidating the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese medicines.With the rapid development of modern instruments and technology,many new theories,methods and strategies are emerging,which upgrade the research of TCM formulae into a higher level.Only when the medicinal efficacy,bio-active components,function mechanism of TCM formulae are understood,we can guarantee TCM safety and quality control.In this paper,we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study,serum pharmacology and serum pharmacochemistry,association analysis,biochro-matography,network pharmacology,metabolomics and proteomics,so as to provide reference for the research and development of TCM in the future.
文摘The Delphi technique is a systematic process of forecasting using the collective opinion of panel members.The structured method of developing consensus among panel members using Delphi methodology has gained acceptance in diverse fields of medicine.The Delphi methods assumed a pivotal role in the last few decades to develop best practice guidance using collective intelligence where research is limited,ethically/logistically difficult or evidence is conflicting.However,the attempts to assess the quality standard of Delphi studies have reported significant variance,and details of the process followed are usually unclear.We recommend systematic quality tools for evaluation of Delphi methodology;identification of problem area of research,selection of panel,anonymity of panelists,controlled feedback,iterative Delphi rounds,consensus criteria,analysis of consensus,closing criteria,and stability of the results.Based on these nine qualitative evaluation points,we assessed the quality of Delphi studies in the medical field related to coronavirus disease 2019.There was inconsistency in reporting vital elements of Delphi methods such as identification of panel members,defining consensus,closing criteria for rounds,and presenting the results.We propose our evaluation points for researchers,medical journal editorial boards,and reviewers to evaluate the quality of the Delphi methods in healthcare research.
文摘The root system is an important organ that plants absorb nutrients from the soil, and can synthesize the vital substances necessary for the plant. However, the study on root system is burdened with great challenges due to its underground roots. In order to further explore the research methods and techniques of plant roots, the research mainly reviewed the research methods of root system, and summarized the methods of conventional root research, such as digging method, core drilling method, container method and isotope method. The progress of CT scan method, ground penetrating radar, special environmental culture method, nucle- ar magnetic resonance method and CCD three-dimensional imaging method were reviewed. Prospects for plant root research were made according to the trends of root research methods usincl hiqh-end technolo.qy at home and abroad.
基金Supported by Fondazione"Giuseppe Alazio",via Torquato Tasso,22,90144 Palermo,Italy(to Doglietto F)
文摘AIMTo describe the development and validation of a novel neuronavigation-based method, which allows the quan-tification of the anatomical features that define anapproach, as well as real-time visualization of the surgicapyramid. METHODSThe method was initially developed with commercially-available hardware for coordinate collection （a digitizerand a frameless navigation system） and software forvolume rendering; dedicated neuronavigation software （ApproachViewer, part of GTx-UHN） was then developed. The accuracy of measurements and the possibility of volumetric rendering of surgical approaches simulated in a phantom were compared among three different methods and commercially-available radiological software. In the anatomy laboratory, ApproachViewer was applied to the comparative quantitative analysis of multiple neurosurgical approaches and was used by many surgeons who were untrained for the research method.RESULTSThe accuracy of ApproachViewer is comparable to com-mercially-available radiological software. In the anatomy laboratory, the method appears versatile. The system can be easily used after brief training. ApproachViewer allows for real-time evaluation and comparison of surgical approaches, as well as post-dissection analyses of collected data. The accuracy of the method depends on the navigation registration： with a 1-2 mm registration error, it is adequate for evaluation and comparison of most neurosurgical approaches.CONCLUSIONThis new research method and software allows semi-automated visualization, quantifcation, and comparison of neurosurgical approaches in the anatomy laboratory.
基金supported by the Natural Science Foundation of China(81472961)the Joint Projects of the National Health and Family Planning Commission of China and the Health Bureau of Zhejiang Province(No.WSK 2014-2-004)the Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents
文摘Traditional occupational disease control and prevention has remained prevalent in China over recent decades. There are appropriately 30,000 new case reports of occupational diseases annually. Although China has already established a series of occupational disease prevention programs, occupational health risk assessment （OHRA） strategies continue to be a limitation.
文摘Farmland weeds are an important part of farmland ecosystems.Research on farmland weeds is one of the major research fields in agricultural ecology.It is of great significance for achieving high yield,high quality and high efficiency in agriculture.In recent years,research on farmland weeds has focused on investigation of weed communities,research on weed seed banks,and research on weed control.These three research directions complement each other.Among them,the investigation work of weed communities and the research of weed seed banks are helpful for us to grasp the occurrence of farmland weeds more accurately and provide references for the control of farmland weeds.This article summarizes the research directions of farmland weeds in recent years(weed community investigation,weed seed bank,weed control)and the research methods used,provide reference value for the follow-up research work of farmland weeds,and provide theoretical support for promoting the development of rural ecological industry and building beautiful villages.
文摘Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors therefore play a crucial role in defining the alternation of urban space--in particular, that of the centers. The main focus of this research article is on the methodology used in the survey and evaluation of ＂centralities＂ as well as their developments over the past four decades （1974-2014） in approaches to urban development that has been developed in Graz.~ The analysis has drawn on the four editions （＂evolution＂） of approaches to urban development as conceived by the city of Graz in order to examine their verbal characteristics in regard to centralities. At the same time, the analysis does not examine presentations of plans which exist in supplementary forms （e.g., explanatory reports and supplemented plans）--it restricts itself solely to the various plans set out in the STEKs.2 The highest degree of accuracy has been applied to the notion of ＂centralis＂ in approaches to urban development. The goal of the research project was to depict the modulation of the notion of ＂centrality＂ in the urban context as a space-forming dimension. Furthermore, it clearly shows the extent to which the notion of the ＂centre＂ （in the widest sense of the word） has become distanced from qualitative, spatial development and at the current time of urban development is experiencing a sort of Renaissance. In the field of ＂urban development＂, architectural references in the context of＂centrality＂ have scarcely been researched. This has led to the opening-up of a complex interdisciplinary research field. In order to make the complex architectural determinants of ＂centrality＂ more accessible to the participating disciplines, approaches to urban development have been explored in the form of a social and spatial analysis.
文摘Psoriasis is a chronic,refractory,inflammatory skin disease that occurs in young adults.The traditional animal model cannot simulate the skin characteristics of patients with psoriasis effectively,so it is difficult to be used for in-depth study of psoriasis mechanism.Immortalized human epidermal cells(HaCaT) is a non-tumor,immortalized human epidermal cell which is widely used in the study of dermatosis.HaCaT cells are the best choice for the study of psoriasis mechanism because their immu.nological characteristics and reproductive ability are coincide with the pathological features of psoriasis.This article reviews the specific methods such as establishment of cell method,cytokine and chemo.kine analysisin the pathogenesis study of psoriasis based on HaCaT cells,hoping to provide some thoughts for drug′s pharmacological activity research.
文摘The present paper first reviewed the major concepts and practices involves in research. A small study was conducted to survey on the prevailing research questions and methods in ELT studies in China, showing a major paradigm shift from qualitative studies to quantitative research and mixed methods, with little critical research identified.
文摘Interviewing is one of the most common and most powerful research methods in sociology. To provide an overview of interviewing in social research, the preliminaries and some tactics applied in interviewing are illustrated firstly. Secondly, various forms of interviewing employed in social research are analyzed specifically. Finally, the issues of interviewing are critically examined.
基金Under the auspices of the National Natural Science Foundation of China (No .40201017)
文摘This paper tries to apply a new and more comprehensive method to urban tourism research in an expanded field instead of only partially, unilaterally and separately focusing on the city itself. Taking the urban tourism of Guangdong, Hong Kong and Macao as an example, it aims at presenting a new spatial system of urban tourism research and pointing out the new orientation of urban tourism research in combination of macro level and micro level, from description to explanation. The meanings of the spatial framework construction for urban tourism study are to make clear how urban tourism studies vary with the changes of dimensions of time and space. This is a meaningful discussion because it will bring great changes to the using of literatures, the opening of research perspectives on urban tourism and the upgrading of theories, so as to create a new stage for urban tourism study.
文摘According to the rotor vortex theory,the rotor circulation and the rotor induced velocity are developed into Fourier series.The circulation distribution along blade spanwise is expressed in terms of segment-by-segment linear functions.In consequence the induced velocity equations and the circulation equations are derived.The engineering application of the rotor vortex theory is provided.Then the induced velocity and its harmonic components are obtained to provide a quantitative basis for the vortex model.For calculating each harmonic component of the induced velocity a simplified method is put forward which considers the effects of each order circulation with neglecting those of higher order.The method saves the computer time and is of significant benefit.
文摘The research methods of the history of Mongolian medicine refer to the general and special methods used in the understanding and research of the history of Mongolian medicine,as well as the methods of expression and compilation of the research achievements of the history of Mongolian medicine.There are not only analysis and generalization,abstractness and concreteness,deduction and induction,historical and logical methods,but also traditional philology methods such as textual research,exegesis and collation,as well as new methods such as field investigation method,empirical method,measurement method,comparison method,and oral account method.In the actual research process,a variety of methods are often used comprehensively.This paper mainly discusses the methods used by Professor Ba Jigemude in the study of the history of Mongolian medicine,and uses specific cases to analyze and summarize the formation and development of the history of ancient traditional medicine.
