A highly efficient and convenient procedure for the enantioselective synthesis of (S)-Rivastigmine, a cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parki...A highly efficient and convenient procedure for the enantioselective synthesis of (S)-Rivastigmine, a cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson’s disease, is accomplished by the treatment of versatile, readily accessible (S)-(-)-2-methyl-2-propanesulfinamide with 3-hydroxyacetophenone. This protocol provides high yield and excellent enantiomeric excess in short step synthesis.展开更多
The bottleneck of strontium compounds preparing from celestite is the promotion of Sr/S isolation efficiency.Low energy consumption and zero release method for isolating Sr/S in preparing Sr(OH)2 process from celestit...The bottleneck of strontium compounds preparing from celestite is the promotion of Sr/S isolation efficiency.Low energy consumption and zero release method for isolating Sr/S in preparing Sr(OH)2 process from celestite in mild condition was described.Sr element remained in precipitation with formation of Sr(OH)2,while S element entered into leachate with formation of Na2SO4.The effects of initial concentration of NaOH,conversion temperature,liquid-to-solid(L/S)ratio and conversion time on Sr/S ratio of samples for celestite conversion were systematically investigated by experiments.The results demonstrated that the efficiency of Sr/S isolation increased with the initial concentration of NaOH,L/S ratio and conversion time,and decreased with conversion temperature.The maximum conversion ratio of Sr(OH)2 was 93.88%under the optimum condition,whose Sr/S ratio of sample could reach to 41.16.It illustrated that better isolation efficiency of celestite could be achieved in alkaline treatment.The results of SEM-EDS analyses demonstrated that the conversion reaction was a dissolution-precipitation process.展开更多
The manual picking of strawberries is inefficient and costly,limiting scalability and economic benefits.Mechanizing this process reduces labor demands,improves working conditions,and modernizes the strawberry industry...The manual picking of strawberries is inefficient and costly,limiting scalability and economic benefits.Mechanizing this process reduces labor demands,improves working conditions,and modernizes the strawberry industry.Target detection technology,crucial for mechanized picking,must accurately determine strawberry maturity.This study presents an enhanced YOLOv8s model addressing current machine learning issues like accuracy,parameters,and complexity.The improved model replaces the Bottleneck structure in C2f with the FasterNet network,integrates an efficient multi-scale attention mechanism,and uses the Ghost module in the backbone to reduce computational load while maintaining performance.It also introduces Wise-IoU for bounding box regression loss,improving recognition accuracy.The YOLOv8s-FEGW model achieves a 93.8%mAP in detecting strawberry ripeness,with significant reductions in parameters(36.8%),complexity(34.6%),and model size(37.7%),alongside a 12.7% Frames Per Second(FPS)boost.These enhancements result in excellent detection capabilities,supporting agricultural automation and intelligence.展开更多
Poisson's equation is solved numerically by two direct methods, viz. Block Cyclic Reduction (BCR) method and Fourier Method. Qualitative and quantitative comparison between the numerical solutions obtained by two ...Poisson's equation is solved numerically by two direct methods, viz. Block Cyclic Reduction (BCR) method and Fourier Method. Qualitative and quantitative comparison between the numerical solutions obtained by two methods indicates that BCR method is superior to Fourier method in terms of speed and accuracy. Therefore. BCR method is applied to solve (?)2(?)= ζ and (?)2X= D from observed vorticity and divergent values. Thereafter the rotational and divergent components of the horizontal monsoon wind in the lower troposphere are reconstructed and are com pared with the results obtained by Successive Over-Relaxation (SOR) method as this indirect method is generally in more use for obtaining the streamfunction ((?)) and velocity potential (X) fields in NWP models. It is found that the results of BCR method are more reliable than SOR method.展开更多
The present study aims to analyzse alternative passive design solutions for enhancing building energy and hygrothermal efficiency in the Sahelian zone.To achieve this,a model representing a standard single-storey ceme...The present study aims to analyzse alternative passive design solutions for enhancing building energy and hygrothermal efficiency in the Sahelian zone.To achieve this,a model representing a standard single-storey cementhollow block dwelling building and its relevant parameters was input into EnergyPlus,combined with OpenStudio or SketchUp.Scenarios were then analyzed to evaluate the effects of roof solar reflectivity,wall external insulation,natural ventilation,and their combined options.First,the base case,serving as a reference model,was validated using measured and simulated temperatures by calculating the scientific criteria,such as the NBME and CVRMSE coefficients recommended by the ASHRAE and IPVM standards.Additionally,the numerical simulation was used to compare interior temperatures,discomfort hours,thermal parameters,and the hygrothermal index(IHT)across seven cases studied.The reference model simulation indicated that cement-based hollow blocks are less effective for building envelopes in the Sahelian climate,with 51.48%discomfort hours and an IHT of 1.6,as shown in the Givoni diagram.The results revealed that the wall external insulation was the most effective passive solution,with 56%of comfort hours and an IHT of 0.7,which indicates the expected position of the model within the hygrothermal comfort zone of the Sahelian climate.Combining passive strategies yields the best scenario,resulting in a 28.25%reduction in annual total discomfort hours compared to the base case.These simulations demonstrated the effectiveness of accessible passive design solutions applicable in dwelling construction for the sustainable development of countries in the Sahelian climate.展开更多
The construction and operation of sulfur-containing gas storage are often more difficult than a non-sulfur storage facility due to the need to prevent environmental contamination from H_(2)S leaks,as well as the corro...The construction and operation of sulfur-containing gas storage are often more difficult than a non-sulfur storage facility due to the need to prevent environmental contamination from H_(2)S leaks,as well as the corrosive effects of H_(2)S on production facilities.Rapid elutriation of H_(2)S from the reservoir during the construction of the gas storage is an effective way to avoid these problems.However,the existing H_(2)S elutriation method has low efficiency and high economic cost,which limits the development of reconstructed gas storage of sulfur-containing gas reservoirs.To improve the efficiency of H_(2)S elutriation in sulfur-containing gas reservoirs and enhance the economic benefits,a numerical simulation model of multiphase flow components was established to study the migration law of H_(2)S in the multi-cycle operation of gas storage.Based on the H_(2)S migrate law,the displacement H_(2)S elutriation method was developed,and the elutriation mechanism and elutriation efficiency of the two methods were compared and analyzed.In addition,the main controlling factors affecting the H_(2)S elutriation efficiency were investigated,and the H_(2)S elutriation scheme of H gas storage was optimized.The results indicate that H_(2)S migrates between near-well and far-well regions under pressure differentials.The traditional H_(2)S elutriation method relies on concentration gradient diffusion,whereas the displacement elutriation approach leverages pressure differentials with higher H_(2)S elutriation efficiency.For the displacement elutriation method,higher reservoir permeability enhances the peak-shaving capacity of the gas storage but has a minor impact on H_(2)S elutriation when the formation permeability is between 30 and 100 mD.The elutriation efficiency is significantly higher when wells are drilled in the high structural parts of the reservoir compared to the low structural parts.Longer displacement elutriation time within a cycle improves H_(2)S elutriation efficiency but reduces the working gas volume of the storage.Therefore,the optimal displacement time for H gas storage is 60 days.An optimized H_(2)S elutriation scheme enabled the working gas to meet the national first-class natural gas standard within 10 cycles.This study elucidates H_(2)S migration patterns,H_(2)S elutriation mechanisms,and key influence factors on H_(2)S elutriation efficiency,offering valuable technical insights for sour gas storage operations.展开更多
Although momentum strategies result in abnormal profitability,thereby challenging the efficient market hypothesis(EMH),concerns persist regarding their reliability due to their significant volatility and susceptibilit...Although momentum strategies result in abnormal profitability,thereby challenging the efficient market hypothesis(EMH),concerns persist regarding their reliability due to their significant volatility and susceptibility to substantial losses.In this study,we investigate the limitations of these strategies and propose a solution.Our literature review reveals that the volatile profits are due to statistical analyses that assume the persistence of past patterns,leading to unreliable results in out-of-sample scenarios when underlying mechanisms evolve.Statistical analysis,the predominant method in financial economics,often proves inadequate in explaining market fluctuations and predicting crashes.To overcome these limitations,a paradigm shift towards dynamic approaches is essential.Drawing inspiration from three groundbreaking economists,we introduce the extended Samuelson model(ESM),a dynamic model that connects price changes to market participant actions.This paradigm transition uncovers several significant findings.First,timely signals indicate momentum initiations,cessations,and reversals,validated using S&P 500 data from 1999 to 2023.Second,ESM predicts the 1987 Black Monday crash weeks in advance,offering a new perspective on its underlying cause.Third,we classify sequential stock price data into eight distinct market states,including their thresholds for transitions,laying the groundwork for market trend predictions and risk assessments.Fourth,the ESM is shown to be a compelling alternative to EMH,offering potent explanatory and predictive power based on a single,realistic assumption.Our findings suggest that ESM has the potential to provide policymakers with proactive tools,enabling financial institutions to enhance their risk assessment and management strategies.展开更多
文摘A highly efficient and convenient procedure for the enantioselective synthesis of (S)-Rivastigmine, a cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson’s disease, is accomplished by the treatment of versatile, readily accessible (S)-(-)-2-methyl-2-propanesulfinamide with 3-hydroxyacetophenone. This protocol provides high yield and excellent enantiomeric excess in short step synthesis.
基金Project(2015-GX-108A)supported by Qinghai Provincial Science and Technology Support Program,China
文摘The bottleneck of strontium compounds preparing from celestite is the promotion of Sr/S isolation efficiency.Low energy consumption and zero release method for isolating Sr/S in preparing Sr(OH)2 process from celestite in mild condition was described.Sr element remained in precipitation with formation of Sr(OH)2,while S element entered into leachate with formation of Na2SO4.The effects of initial concentration of NaOH,conversion temperature,liquid-to-solid(L/S)ratio and conversion time on Sr/S ratio of samples for celestite conversion were systematically investigated by experiments.The results demonstrated that the efficiency of Sr/S isolation increased with the initial concentration of NaOH,L/S ratio and conversion time,and decreased with conversion temperature.The maximum conversion ratio of Sr(OH)2 was 93.88%under the optimum condition,whose Sr/S ratio of sample could reach to 41.16.It illustrated that better isolation efficiency of celestite could be achieved in alkaline treatment.The results of SEM-EDS analyses demonstrated that the conversion reaction was a dissolution-precipitation process.
基金funded by the National Engineering Research Center of Special Equipment and Power System for Ship and Marine Engineering and the Shanghai Engineering Research Center of Ship Intelligent Maintenance and Energy Efficiency Control(20DZ2252300).
文摘The manual picking of strawberries is inefficient and costly,limiting scalability and economic benefits.Mechanizing this process reduces labor demands,improves working conditions,and modernizes the strawberry industry.Target detection technology,crucial for mechanized picking,must accurately determine strawberry maturity.This study presents an enhanced YOLOv8s model addressing current machine learning issues like accuracy,parameters,and complexity.The improved model replaces the Bottleneck structure in C2f with the FasterNet network,integrates an efficient multi-scale attention mechanism,and uses the Ghost module in the backbone to reduce computational load while maintaining performance.It also introduces Wise-IoU for bounding box regression loss,improving recognition accuracy.The YOLOv8s-FEGW model achieves a 93.8%mAP in detecting strawberry ripeness,with significant reductions in parameters(36.8%),complexity(34.6%),and model size(37.7%),alongside a 12.7% Frames Per Second(FPS)boost.These enhancements result in excellent detection capabilities,supporting agricultural automation and intelligence.
文摘Poisson's equation is solved numerically by two direct methods, viz. Block Cyclic Reduction (BCR) method and Fourier Method. Qualitative and quantitative comparison between the numerical solutions obtained by two methods indicates that BCR method is superior to Fourier method in terms of speed and accuracy. Therefore. BCR method is applied to solve (?)2(?)= ζ and (?)2X= D from observed vorticity and divergent values. Thereafter the rotational and divergent components of the horizontal monsoon wind in the lower troposphere are reconstructed and are com pared with the results obtained by Successive Over-Relaxation (SOR) method as this indirect method is generally in more use for obtaining the streamfunction ((?)) and velocity potential (X) fields in NWP models. It is found that the results of BCR method are more reliable than SOR method.
文摘The present study aims to analyzse alternative passive design solutions for enhancing building energy and hygrothermal efficiency in the Sahelian zone.To achieve this,a model representing a standard single-storey cementhollow block dwelling building and its relevant parameters was input into EnergyPlus,combined with OpenStudio or SketchUp.Scenarios were then analyzed to evaluate the effects of roof solar reflectivity,wall external insulation,natural ventilation,and their combined options.First,the base case,serving as a reference model,was validated using measured and simulated temperatures by calculating the scientific criteria,such as the NBME and CVRMSE coefficients recommended by the ASHRAE and IPVM standards.Additionally,the numerical simulation was used to compare interior temperatures,discomfort hours,thermal parameters,and the hygrothermal index(IHT)across seven cases studied.The reference model simulation indicated that cement-based hollow blocks are less effective for building envelopes in the Sahelian climate,with 51.48%discomfort hours and an IHT of 1.6,as shown in the Givoni diagram.The results revealed that the wall external insulation was the most effective passive solution,with 56%of comfort hours and an IHT of 0.7,which indicates the expected position of the model within the hygrothermal comfort zone of the Sahelian climate.Combining passive strategies yields the best scenario,resulting in a 28.25%reduction in annual total discomfort hours compared to the base case.These simulations demonstrated the effectiveness of accessible passive design solutions applicable in dwelling construction for the sustainable development of countries in the Sahelian climate.
基金supported by the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202401501,KJZD-M202401501).
文摘The construction and operation of sulfur-containing gas storage are often more difficult than a non-sulfur storage facility due to the need to prevent environmental contamination from H_(2)S leaks,as well as the corrosive effects of H_(2)S on production facilities.Rapid elutriation of H_(2)S from the reservoir during the construction of the gas storage is an effective way to avoid these problems.However,the existing H_(2)S elutriation method has low efficiency and high economic cost,which limits the development of reconstructed gas storage of sulfur-containing gas reservoirs.To improve the efficiency of H_(2)S elutriation in sulfur-containing gas reservoirs and enhance the economic benefits,a numerical simulation model of multiphase flow components was established to study the migration law of H_(2)S in the multi-cycle operation of gas storage.Based on the H_(2)S migrate law,the displacement H_(2)S elutriation method was developed,and the elutriation mechanism and elutriation efficiency of the two methods were compared and analyzed.In addition,the main controlling factors affecting the H_(2)S elutriation efficiency were investigated,and the H_(2)S elutriation scheme of H gas storage was optimized.The results indicate that H_(2)S migrates between near-well and far-well regions under pressure differentials.The traditional H_(2)S elutriation method relies on concentration gradient diffusion,whereas the displacement elutriation approach leverages pressure differentials with higher H_(2)S elutriation efficiency.For the displacement elutriation method,higher reservoir permeability enhances the peak-shaving capacity of the gas storage but has a minor impact on H_(2)S elutriation when the formation permeability is between 30 and 100 mD.The elutriation efficiency is significantly higher when wells are drilled in the high structural parts of the reservoir compared to the low structural parts.Longer displacement elutriation time within a cycle improves H_(2)S elutriation efficiency but reduces the working gas volume of the storage.Therefore,the optimal displacement time for H gas storage is 60 days.An optimized H_(2)S elutriation scheme enabled the working gas to meet the national first-class natural gas standard within 10 cycles.This study elucidates H_(2)S migration patterns,H_(2)S elutriation mechanisms,and key influence factors on H_(2)S elutriation efficiency,offering valuable technical insights for sour gas storage operations.
文摘Although momentum strategies result in abnormal profitability,thereby challenging the efficient market hypothesis(EMH),concerns persist regarding their reliability due to their significant volatility and susceptibility to substantial losses.In this study,we investigate the limitations of these strategies and propose a solution.Our literature review reveals that the volatile profits are due to statistical analyses that assume the persistence of past patterns,leading to unreliable results in out-of-sample scenarios when underlying mechanisms evolve.Statistical analysis,the predominant method in financial economics,often proves inadequate in explaining market fluctuations and predicting crashes.To overcome these limitations,a paradigm shift towards dynamic approaches is essential.Drawing inspiration from three groundbreaking economists,we introduce the extended Samuelson model(ESM),a dynamic model that connects price changes to market participant actions.This paradigm transition uncovers several significant findings.First,timely signals indicate momentum initiations,cessations,and reversals,validated using S&P 500 data from 1999 to 2023.Second,ESM predicts the 1987 Black Monday crash weeks in advance,offering a new perspective on its underlying cause.Third,we classify sequential stock price data into eight distinct market states,including their thresholds for transitions,laying the groundwork for market trend predictions and risk assessments.Fourth,the ESM is shown to be a compelling alternative to EMH,offering potent explanatory and predictive power based on a single,realistic assumption.Our findings suggest that ESM has the potential to provide policymakers with proactive tools,enabling financial institutions to enhance their risk assessment and management strategies.
