To understand the non-equilibrium morphological adjustment of a river in response to environmental changes,it is essential to(i)accurately identify how past conditions of water and sediment have impacted current morph...To understand the non-equilibrium morphological adjustment of a river in response to environmental changes,it is essential to(i)accurately identify how past conditions of water and sediment have impacted current morphological adjustment of the river,and(ii)establish a corresponding simulation for non-equilibrium conditions.Based on discharge and suspended sediment concentration(SSC)as well as 82 cross-sectional data items for the Huayuankou-Lijin reach of the Lower Yellow River in the period 1965-2015,the process of adjustment of the geometry of the main channel(area,width,depth,and geomorphic coefficient),and its responses to changes in discharge and SSC for different reaches are statistically analyzed.Following this,a delayed response model(DRM)of the geometry of the main channel subjected to variations in discharge and SSC is established using a multi-step analytical model,with the discharge and SSC as the main controlling factors.The results show that the area,width,and depth of the main channel decreased initially,then increased,decreased again,and finally increased again.These features of the geometry of the channel were positively correlated with the 4-year moving average discharge and negatively with the 4-year moving average SSC.The geomorphic coefficient for the Huayuankou-Sunkou reach exhibited a trend of decrease,whereas that of the Sunkou-Lijin reach decreased initially,then increased,decreased again,and finally increased again.Except for the Huayuankou-Gaocun reach in 1965-1999,the coefficient was negatively correlated with the 4-year moving average discharge and positively with SSC.The simulated values of the morphological parameters of the main channel for all sub-reaches obtained using the DRM agreed well with the measured values.This indicates that the DRM can be used to simulate the process of response of the cross-sectional geometry of the main channel to variations in the water and sediment.The results of the model show that the adjustment of the geometry of the main channel was affected by the discharge and the SSC at present(30%)as well as for the previous 7 years(70%).The proposed model offers insights into the mechanism whereby past water and sediment influence the current morphological adjustment of the river,and provides an effective method for predicting the magnitude and trend of the geometry of the main channel under different flow conditions.展开更多
Intraductal papillary mucinous neoplasms(IPMN) of the pancreas include a spectrum of dysplasia ranging from minimal mucinous hyperplasia to invasive carcinoma and are extensive tumors that often spread along the ducta...Intraductal papillary mucinous neoplasms(IPMN) of the pancreas include a spectrum of dysplasia ranging from minimal mucinous hyperplasia to invasive carcinoma and are extensive tumors that often spread along the ductal tree.Several studies have demonstrated that preoperative imaging is not accurate enough to adapt the extent of pancreatectomy and have suggested routinely using frozen sectioning(FS) to evaluate the completeness of resection and also to check if ductal dilatation is active or passive,in order to avoid an excessive pancreatic resection.Separate main duct and branch duct analysis is needed due to the difference in the natural history of the disease.FS accuracy averages 95%.Eroded epithelium on the main duct,severe ductal inflammation mimicking dysplasia and reactive epithelial changes secondary to obstruction can lead to inappropriate FS results.FS results change the planned extent of resection in up to 30% of cases.The optimal cut-off leading to extend pancreatectomy is not consensual and our standard option is to extend pancreatec-tomy if FS reveals:(1) at least IPMN adenoma on the main duct;or(2) at least borderline IPMN on branch ducts;or(3) invasive carcinoma.However,the decision to extend resection must be taken after a multidisciplinary discussion since it does not exclusively depend on the FS result but also on age,general condition and expected prognosis after resection.The main limitation of using FS is the existence of discontinuous("skip") lesions which account for approximately 10% of IPMN in surgical series and can lead to reoperation in up to 8% of cases.展开更多
基金Key Program of National Natural Science Foundation of China,No.51639005Central Public-interest Scientific Institution Basal Research Fund of China,No.CKSF2019214/HL,No.CKSF2019411/HL。
文摘To understand the non-equilibrium morphological adjustment of a river in response to environmental changes,it is essential to(i)accurately identify how past conditions of water and sediment have impacted current morphological adjustment of the river,and(ii)establish a corresponding simulation for non-equilibrium conditions.Based on discharge and suspended sediment concentration(SSC)as well as 82 cross-sectional data items for the Huayuankou-Lijin reach of the Lower Yellow River in the period 1965-2015,the process of adjustment of the geometry of the main channel(area,width,depth,and geomorphic coefficient),and its responses to changes in discharge and SSC for different reaches are statistically analyzed.Following this,a delayed response model(DRM)of the geometry of the main channel subjected to variations in discharge and SSC is established using a multi-step analytical model,with the discharge and SSC as the main controlling factors.The results show that the area,width,and depth of the main channel decreased initially,then increased,decreased again,and finally increased again.These features of the geometry of the channel were positively correlated with the 4-year moving average discharge and negatively with the 4-year moving average SSC.The geomorphic coefficient for the Huayuankou-Sunkou reach exhibited a trend of decrease,whereas that of the Sunkou-Lijin reach decreased initially,then increased,decreased again,and finally increased again.Except for the Huayuankou-Gaocun reach in 1965-1999,the coefficient was negatively correlated with the 4-year moving average discharge and positively with SSC.The simulated values of the morphological parameters of the main channel for all sub-reaches obtained using the DRM agreed well with the measured values.This indicates that the DRM can be used to simulate the process of response of the cross-sectional geometry of the main channel to variations in the water and sediment.The results of the model show that the adjustment of the geometry of the main channel was affected by the discharge and the SSC at present(30%)as well as for the previous 7 years(70%).The proposed model offers insights into the mechanism whereby past water and sediment influence the current morphological adjustment of the river,and provides an effective method for predicting the magnitude and trend of the geometry of the main channel under different flow conditions.
文摘Intraductal papillary mucinous neoplasms(IPMN) of the pancreas include a spectrum of dysplasia ranging from minimal mucinous hyperplasia to invasive carcinoma and are extensive tumors that often spread along the ductal tree.Several studies have demonstrated that preoperative imaging is not accurate enough to adapt the extent of pancreatectomy and have suggested routinely using frozen sectioning(FS) to evaluate the completeness of resection and also to check if ductal dilatation is active or passive,in order to avoid an excessive pancreatic resection.Separate main duct and branch duct analysis is needed due to the difference in the natural history of the disease.FS accuracy averages 95%.Eroded epithelium on the main duct,severe ductal inflammation mimicking dysplasia and reactive epithelial changes secondary to obstruction can lead to inappropriate FS results.FS results change the planned extent of resection in up to 30% of cases.The optimal cut-off leading to extend pancreatectomy is not consensual and our standard option is to extend pancreatec-tomy if FS reveals:(1) at least IPMN adenoma on the main duct;or(2) at least borderline IPMN on branch ducts;or(3) invasive carcinoma.However,the decision to extend resection must be taken after a multidisciplinary discussion since it does not exclusively depend on the FS result but also on age,general condition and expected prognosis after resection.The main limitation of using FS is the existence of discontinuous("skip") lesions which account for approximately 10% of IPMN in surgical series and can lead to reoperation in up to 8% of cases.
