BACKGROUND Hepatocellular carcinoma(HCC)is among the most aggressive primary liver cancers,leading to significant global mortality.While early diagnosis improves prognosis,treatment decisions,particularly between surg...BACKGROUND Hepatocellular carcinoma(HCC)is among the most aggressive primary liver cancers,leading to significant global mortality.While early diagnosis improves prognosis,treatment decisions,particularly between surgical resection and radiofrequency ablation(RFA),remain controversial.AIM To clarify this issue using sentiment analysis of medical literature alongside a meta-analysis of overall survival(OS).METHODS We included studies comparing liver resection and RFA,excluding case reports,editorials,and studies without relevant outcomes.A systematic search in PubMed and Web of Science identified 197 studies.Abstracts underwent sentiment analysis using Python’s Natural Language Toolkit library,categorizing them as favoring resection,ablation,or neutral.We also performed a meta-analysis using a random-effects model on 11 studies reporting hazard ratios(HRs)for OS.RESULTS Sentiment analysis revealed that 75.1%of abstracts were neutral,14.2%favored resection,and 10.7%favored RFA.The meta-analysis showed a significant survival advantage for liver resection,with a pooled HR of 0.5924(95%confidence interval:0.540-0.649).Heterogeneity was moderate(I²=39.98%).Despite the meta-analysis demonstrating clear survival benefits of liver resection,most abstracts maintained a neutral stance.This discrepancy highlights potential biases or hesitancy in drawing definitive conclusions.CONCLUSION The study emphasizes the need for clinicians to prioritize robust statistical evidence over narrative impressions.Liver resection remains the preferred treatment for HCC in eligible patients.展开更多
Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study t...Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study the effects of connection configurations on seismic responses and fragilities.Finite element models of bridges are established using OpenSees.A new ground motion screening method based on the statistical characteristic of the predominant period is proposed to avoid irregular behavior in the selection process of ground motions,and incremental dynamic analysis(IDA)is performed to develop components and systems fragility curves.The effects of damper failure on calculated results for PEDS are examined in terms of seismic response and fragility analysis.The results show that the bridge tower is the most affected component by different structural systems.For RS,the fragility of the middle tower is significantly higher than other components,and the bridge failure starts from the middle tower,exhibiting a characteristic of local failure.For FS and PEDS,the fragility of the edge tower is higher than the middle tower.The system fragility of RS is higher than FS and PEDS.Taking the failure of dampers into account is necessary to obtain reliable seismic capacity of cable-stayed bridges.展开更多
The shell traits and weight traits are measured in cultured populations of bay scallop, Argopecten irradians. The results of regression analysis show that the regression relationships for all the traits are significan...The shell traits and weight traits are measured in cultured populations of bay scallop, Argopecten irradians. The results of regression analysis show that the regression relationships for all the traits are significant (P<0.01). The correlative coefficients between body weight, as well as tissue weight with shell length, shell height and shell width are significant (P<0.05). But the correlative coefficients between the anterior and posterior auricle length with body weight as well as tissue weight are not significant (P>0.05). The multiple regression equation is obtained to estimate live body weight and tissue weight. The above traits except anterior and posterior auricle length are used for the growth and production comparison among three cultured populations, Duncan's new multiple range procedure analysis shows that all the traits in the Lingshuiqiao (LSQ) population are much more significant than those of the other two populations (P<0.01), and there is no significant difference between the Qipanmo (QPM) and Dalijia (DLJ) populations in all traits (P>0.05). The results indicate that the LSQ population has a higher growth rate and is expected to be more productive than the other two populations.展开更多
Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,th...Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,the effect of regulating autophagy and whether autophagy is detrimental or beneficial after spinal cord injury remain unclear.Therefore,in this study we evaluated the effects of autophagy regulation on spinal cord injury in rats by direct and indirect comparison,in an effort to provide a basis for further research.Data source:Relevant literature published from inception to February 1,2018 were included by searching Wanfang,CNKI,Web of Science,MEDLINE(OvidSP),PubMed and Google Scholar in English and Chinese.The keywords included"autophagy","spinal cord injury",and"rat".Data selection:The literature included in vivo experimental studies on autophagy regulation in the treatment of spinal cord injury(including intervention pre-and post-spinal cord injury).Meta-analyses were conducted at different time points to compare the therapeutic effects of promoting or inhibiting autophagy,and subgroup analyses were also conducted.Outcome measure:Basso,Beattie,and Bresnahan scores.Results:Of the 622 studies,33 studies of median quality were included in the analyses.Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=1.80,95%CI:0.81-2.79,P=0.0004),3 days(MD=0.92,95%CI:0.72-1.13,P<0.00001),1 week(MD=2.39,95%CI:1.85-2.92,P<0.00001),2 weeks(MD=3.26,95%CI:2.40-4.13,P<0.00001),3 weeks(MD=3.13,95%CI:2.51-3.75,P<0.00001)and 4 weeks(MD=3.18,95%CI:2.43-3.92,P<0.00001)after spinal cord injury with upregulation of autophagy compared with the control group(drug solvent control,such as saline group).Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=6.48,95%CI:5.83-7.13,P<0.00001),2 weeks(MD=2.43,95%CI:0.79-4.07,P=0.004),3 weeks(MD=2.96,95%CI:0.09-5.84,P=0.04)and 4 weeks(MD=4.41,95%CI:1.08-7.75,P=0.01)after spinal cord injury with downregulation of autophagy compared with the control group.Indirect comparison of upregulation and downregulation of autophagy showed no differences in Basso,Beattie,and Bresnahan scores at 1 day(MD=-4.68,95%CI:-5.840 to-3.496,P=0.94644),3 days(MD=-0.28,95%CI:-2.231-1.671,P=0.99448),1 week(MD=1.83,95%CI:0.0076-3.584,P=0.94588),2 weeks(MD=0.81,95%CI:-0.850-2.470,P=0.93055),3 weeks(MD=0.17,95%Cl:-2.771-3.111,P=0.99546)or 4 weeks(MD=-1.23,95%Cl:-4.647-2.187,P=0.98264)compared with the control group.Conclusion:Regulation of autophagy improves neurological function,whether it is upregulated or downregulated.There was no difference between upregulation and downregulation of autophagy in the treatment of spinal cord injury.The variability in results among the studies may be associated with differences in research methods,the lack of clearly defined autophagy characteristics after spinal cord injury,and the limited autophagy monitoring techniques.Thus,methods should be standardized,and the dynamic regulation of autophagy should be examined in future studies.展开更多
This study was carried out in 120 patients affected by migraine without aura, treated in 4 public health centers and randomly divided into acupuncture group (AG) and conventional drug therapy group (CDTG).
Th... This study was carried out in 120 patients affected by migraine without aura, treated in 4 public health centers and randomly divided into acupuncture group (AG) and conventional drug therapy group (CDTG).
The evaluation of clinical results was made 6 and 12 months after the beginning of treatment and was worked out as well according to socio-medical parameters. Acupuncture was applied to the following points: Touwei (ST 8), Xuanlu (GB 5), Fengchi (GB 20), Dazhui (GV 14), Lieque (LU 7), treated with the reducing method. In AG, the figure scoring the entity and frequency of migraine attacks drops from 9,823 before treatment to 1,990 6 months after and 1,590 12 months after; while in CDTG, it drops from 8,405 before treatment to 3,927 6 months after and 3,084 12 months after. In AG, the total absence from work amounted to 1,120 working days/year, with a total cost (private + social costs) of 186,677,000 Italian liras. In CDTG, the absence from work amounted to 1,404 working days/year, with a total cost of 266,614,000 Italian liras.
If we consider that in Italy the patients affected by migraine without aura are around 800,000, and that acupuncture therapy is able to save 1,332,000 Italian liras on the total average cost supported for every single patient, the application of acupuncture in the treatment of migraine without aura would allow a saving of the health expenses in Italy of over 1,000 billion liras.展开更多
Manure samples were collected by floor scrapings in animal stables from Beijing suburbs. Total nitrogen (TN), total phosphorus (TP), and total potassium (TK) were analyzed by conventional wet chemical methods. All man...Manure samples were collected by floor scrapings in animal stables from Beijing suburbs. Total nitrogen (TN), total phosphorus (TP), and total potassium (TK) were analyzed by conventional wet chemical methods. All manures showed a high variability in nutrient contents. Nutrients contents in different animal manures were significantly different. TN and TK contents in layer manures were higher than swine and dairy manures展开更多
[Objective] The twice regional rainstorms in northwest Yantai in July in 2009 and July in 2010 were expounded.[Method] The twice regional rainstorm in northwest Yantai in July in 2009 and July in 2010 were selected fo...[Objective] The twice regional rainstorms in northwest Yantai in July in 2009 and July in 2010 were expounded.[Method] The twice regional rainstorm in northwest Yantai in July in 2009 and July in 2010 were selected for comparison analysis by dint of conventional and non-conventional weather data,from the aspects of circulation background,physics quantity,and radar echo,etc.[Result] The twice large rainstorm process were regional convective strong precipitation.The rainstorm fell in the northwest of Yantai and had a strong precipitation center above 200 mm.The twice large rainstorm was affected by subtropical and shear line.The rainstorm area was related to the location of 588 dagpm line,westerly trough,and shear line.It was regional rainstorm of typical subtropical edge warm and wet airstream,combination of low vortex and shear line of westerly.The precipitation occurred around the center of water vapor flux;K index had pretty good indication effects to the generation of rainstorm.Large rainstorm occurred around the place with high K index.The K index of twice large rainstorm was larger than or equal to 34 ℃,and was close to the rainstorm falling area where K index was larger than or equal to 35 ℃.The reflection factor of twice large rainstorms at 0.5° elevation,the largest echo intensity was from 55 to 60 dBz,in strip echo from south to north,through the west peninsula,forming train effect.The data report product also had important reference basis for the report of regional large rainstorm.[Conclusion] The study provided references and basis for the report of large rainstorm in the future.展开更多
This paper raises the comparison method of operational stages of the real estate market. In order to select similar operational stages, we established an analysis model by applying fuzzy grade-of-membership clustering...This paper raises the comparison method of operational stages of the real estate market. In order to select similar operational stages, we established an analysis model by applying fuzzy grade-of-membership clustering in this paper. Firstly, we select the materials information of the real estate market in America, Germany and Japan. Secondly, the real estate markets of America, Germany and Japan are divided into several different stages. Lastly, we apply the method of fuzzy grade-of-membership clustering to select comparable stages. The result of analysis indicates that the real estate market of Japan and Germany (1960-1980) are similar to the market in China.展开更多
In this paper,a typical experiment is carried out based on a high-resolution air-sea coupled model,namely,the coupled ocean-atmosphere-wave-sediment transport(COAWST)model,on both heterogeneous many-core(SW)and homoge...In this paper,a typical experiment is carried out based on a high-resolution air-sea coupled model,namely,the coupled ocean-atmosphere-wave-sediment transport(COAWST)model,on both heterogeneous many-core(SW)and homogenous multicore(Intel)supercomputing platforms.We construct a hindcast of Typhoon Lekima on both the SW and Intel platforms,compare the simulation results between these two platforms and compare the key elements of the atmospheric and ocean modules to reanalysis data.The comparative experiment in this typhoon case indicates that the domestic many-core computing platform and general cluster yield almost no differences in the simulated typhoon path and intensity,and the differences in surface pressure(PSFC)in the WRF model and sea surface temperature(SST)in the short-range forecast are very small,whereas a major difference can be identified at high latitudes after the first 10 days.Further heat budget analysis verifies that the differences in SST after 10 days are mainly caused by shortwave radiation variations,as influenced by subsequently generated typhoons in the system.These typhoons generated in the hindcast after the first 10 days attain obviously different trajectories between the two platforms.展开更多
Over the past few decades,the metal elements(MEs)in atmospheric particles have aroused great attention.Some well-established techniques have been used to measure particlebound MEs.However,each method has its own advan...Over the past few decades,the metal elements(MEs)in atmospheric particles have aroused great attention.Some well-established techniques have been used to measure particlebound MEs.However,each method has its own advantages and disadvantages in terms of complexity,accuracy,and specific elements of interest.In this study,the performances of inductively coupled plasma-optical emission spectrometry(ICP-OES)and total reflection X-ray fluorescence spectroscopy(TXRF)were evaluated for quality control to analyze data accuracy and precision.The statistic methods(Deming regression and significance testing)were applied for intercomparison between ICP-OES and TXRF measurements for same lowloading PM_(2.5)samples in Weizhou Island.The results from the replicate analysis of standard filters(SRM 2783)and field filters samples indicated that 10 MEs(K,Ca,V,Cr,Mn,Fe,Ni,Cu,Zn,and Pb)showed good accuracies and precision for both techniques.The higher accuracy tended to the higher precision in the MEs analysis process.In addition,the interlab comparisons illustrated that V and Mn all had good agreements between ICP-OES and TXRF.The measurements of K,Cu and Zn were more reliable by TXRF analysis for low-loading PM_(2.5).ICP-OES was more accurate for the determinations for Ca,Cr,Ni and Pb,owing to the overlapping spectral lines and low sensitivity during TXRF analysis.The measurements of Fe,influenced by low-loading PM_(2.5),were not able to determine which instrument could obtain more reliable results.These conclusions could provide reference information to choose suitable instrument for the determination of MEs in low-loading PM_(2.5)samples.展开更多
The aim of this research was to analyze the PPM of Armenian Premier League using 25 GPS 10 Hz(K-Sport,Montelabbate,Italy),in order to compare data from literature from major European championship.In total 25 matches w...The aim of this research was to analyze the PPM of Armenian Premier League using 25 GPS 10 Hz(K-Sport,Montelabbate,Italy),in order to compare data from literature from major European championship.In total 25 matches were analyzed from one team militant in Armenian Premier League(10 wins,10 loses and 5 draws),33 different players(age 24.3±4.2,height 1.76±4.2 and weight 74±3.5)and in total 270 performances(10.8 for matches).Matches were divided in First Half(T1),Second Half(T2),Second Half Substitution(T2 Sub),Full Match,Full Match Substitution(Full Match Sub)and Total Match(Total)that include all the players detected during a games.Furthermore,all matches were divided even by quarters 0-15,15-30,30-45,45-60,60-75 and 75-90,only players that played all match were included in this analyses,in order to check the performance decreasing during the time.All data were added in an Excel Spreadsheet in order to build a database,to organize and better analyze data,cataloging events for data,results,and role of players.Average data from Armenian Premier League in comparison with literature data from European and Italian Championship show that in every parameter,the Armenian Premier League is under the average.This is obviously related to the non-high level of the Armenian football that is in fact placed at the 106°place of the FIFA ranking(update 7 June 2019).Physical data represent an indicator of performance but also of the qualitative level of the league and of individual players.For this reason,the use of the match analysis can be decisive to verify the PPM,in order to better evaluate the championships,teams,and players,in order to build an easier search and discovery of talents.展开更多
-- In this paper, by using two sets of composite data of developed and undeveloped depressions over the South China Sea, we analyze and compare the dynamic structures, the heating fields and the vorticity budget resid...-- In this paper, by using two sets of composite data of developed and undeveloped depressions over the South China Sea, we analyze and compare the dynamic structures, the heating fields and the vorticity budget residuals of two different types of depressions. Our conclusions are as follows:The two types of depressions are similar in thermodynamical and dynamical structures. The main differ ences are : in the high layer of developed depression there is a divergence field, with a center near the zero line of vertical wind shear, and over undeveloped depression, the divergence field is weaker and the vertical wind at its center is greater than 5 m s-1. The thermodynamical field of the former is asymmetrical and that of the latter is quasi - symmetrical. As far as the dynamics structure is concerned, the convergence in the lower layer and the difference of divergence between the upper and lower layers of developed depression is three tmies larger than that of undeveloped depression. The upward motion and heating field at the center of developed depression is also stronger than that of undeveloped one.The vorticity budget of the two types of depressions is mainly determined by the divergence term, the vorticity advection term and the vertical transport term. The residual term is also important.The principal contribution comes from the divergence term . This is more significant for developed depression than for undeveloped depression.展开更多
The NEutron Detector Array(NEDA)is designed to be coupled to gamma-ray spectrometers to enhance the sensitivity of the setup by enabling reaction channel selection through counting of the evaporated neutrons.This arti...The NEutron Detector Array(NEDA)is designed to be coupled to gamma-ray spectrometers to enhance the sensitivity of the setup by enabling reaction channel selection through counting of the evaporated neutrons.This article presents the implementation of a double trigger condition system for NEDA,which improves the acquisition of neutrons and reduces the number of gamma rays acquired.Two independent triggers are generated in the double trigger condition system:one based on charge comparison(CC)and the other on time-of-flight(TOF).These triggers can be combined using OR and AND logic,offering four distinct trigger modes.The developed firmware is added to the previous one in the Virtex 6 field programmable gate array(FPGA)present in the system,which also includes signal processing,baseline correction,and various trigger logic blocks.The performance of the trigger system is evaluated using data from the E703 experiment performed at GANIL.The four trigger modes are applied to the same data,and a subsequent offline analysis is performed.It is shown that most of the detected neutrons are preserved with the AND mode,and the total number of gamma rays is significantly reduced.Compared with the CC trigger mode,the OR trigger mode allows increasing the selection of neutrons.In addition,it is demonstrated that if the OR mode is selected,the online CC trigger threshold can be raised without losing neutrons.展开更多
From the viewpoint of disaster prevention in the urban areas, this paper analyzes the value of urban public security system, selects typical cases to make a comparison of Chinese and foreign public security treatment ...From the viewpoint of disaster prevention in the urban areas, this paper analyzes the value of urban public security system, selects typical cases to make a comparison of Chinese and foreign public security treatment mechanisms, and makes systematic summarization of the Chinese and foreign historic experiences. Then, the paper puts forward some designs on structure of the Chinese urban public security system structure. This paper is of the opinion that at present the management of urban public security concerning unexpected incidents should be strengthened. The effective way is to set up the sound urban public security system, urban public security mechanism and related laws and regulations.展开更多
There are similarities and differences in the construction of the two poems:Charlotte Mew’s"Rooms"and Philip Larkin’s"Home is so Sad(HISS)".Both convey a sense of regret and loss through the port...There are similarities and differences in the construction of the two poems:Charlotte Mew’s"Rooms"and Philip Larkin’s"Home is so Sad(HISS)".Both convey a sense of regret and loss through the portrayal of abandoned rooms.However,"Rooms"highlights the despair upon the withering away of life and the slow,painful approach of death,while"HISS"expresses the pain upon the loss of loved ones.The rooms in each poem may have different roles in the lives of their owners,but in each case,they form a significant linkage of the past and present,and ultimately symbolise the abandonment of human heart itself.展开更多
1 Introduction Currently,all six different continents have discovered potash deposits and potash-bearing salt lake saline water.However,the distribution is extremely uneven,which is mostly concentrated in Canada,Russi...1 Introduction Currently,all six different continents have discovered potash deposits and potash-bearing salt lake saline water.However,the distribution is extremely uneven,which is mostly concentrated in Canada,Russia,Middle-Asia and展开更多
This paper is to make a comparison on Chinese and English sounds under contrastive analysis with the consideration of that Chinese teachers of English would be better able to foresee their students' difficulty and...This paper is to make a comparison on Chinese and English sounds under contrastive analysis with the consideration of that Chinese teachers of English would be better able to foresee their students' difficulty and consequently be better able to do their teaching plan in practice.展开更多
The heterogeneity of traumatic brain injury(TBI)-induced secondary injury has greatly hampered the development of effective treatments for TBI patients.Targeting common processes across species may be an innovative st...The heterogeneity of traumatic brain injury(TBI)-induced secondary injury has greatly hampered the development of effective treatments for TBI patients.Targeting common processes across species may be an innovative strategy to combat debilitating TBI.In the present study, a cross-species transcriptome comparison was performed for the first time to determine the fundamental processes of secondary brain injury in Sprague-Dawley rat and C57/BL6 mouse models of TBI, caused by acute controlled cortical impact.The RNA sequencing data from the mouse model of TBI were downloaded from the Gene Expression Omnibus(ID: GSE79441) at the National Center for Biotechnology Information.For the rat data, peri-injury cerebral cortex samples were collected for transcriptomic analysis 24 hours after TBI.Differentially expressed gene-based functional analysis revealed that common features between the two species were mainly involved in the regulation and activation of the innate immune response, including complement cascades as well as Toll-like and nucleotide oligomerization domain-like receptor pathways.These findings were further corroborated by gene set enrichment analysis.Moreover, transcription factor analysis revealed that the families of signal transducers and activators of transcription(STAT), basic leucine zipper(BZIP), Rel homology domain(RHD), and interferon regulatory factor(IRF) transcription factors play vital regulatory roles in the pathophysiological processes of TBI, and are also largely associated with inflammation.These findings suggest that targeting the common innate immune response might be a promising therapeutic approach for TBI.The animal experimental procedures were approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No.201802001) on June 6, 2018.展开更多
A statistical approach to evaluate the subjective perception of the annoyance caused by the vehicle noise was presented in this paper. After recording the noises of Sanfeng, Huali and Xiali at speeds of 30, 40, 50, 60...A statistical approach to evaluate the subjective perception of the annoyance caused by the vehicle noise was presented in this paper. After recording the noises of Sanfeng, Huali and Xiali at speeds of 30, 40, 50, 60, 70 and 80 km/h respectively, the annoyance of the vehicle noises was evaluated in the testing room using paired comparison method, and the sound quality metrics and subjective annoyance were then distilled. Loudness, sharpness, roughness, periodicity and impulsiveness were selected for each of the vehicle noises. By correlation analysis method, it can be found that loudness has a higher correlation （0.91） with annoyance than other parameters. Meanwhile, sharpness, periodicity, roughness and impulsiveness have correlation with subjective perception with correlation coefficients being 0.84, -0.82, 0.62 and 0.87, respectively. The result of multiple regression analysis shows that calculated annoyance obtained by the regression equation can explain the perceptual annoyance and the regressed evaluation model is feasible to evaluate the sound quality of vehicle.展开更多
A new researching method on clothing comfort perception is developed.By it the skin surface temperature changes and subjective psychological perception of human body sections stimulated by the same cold stimulation ar...A new researching method on clothing comfort perception is developed.By it the skin surface temperature changes and subjective psychological perception of human body sections stimulated by the same cold stimulation are studied.With the multiple comparison analysis method the changing laws of skin temperature of main human body sections is obtained.展开更多
文摘BACKGROUND Hepatocellular carcinoma(HCC)is among the most aggressive primary liver cancers,leading to significant global mortality.While early diagnosis improves prognosis,treatment decisions,particularly between surgical resection and radiofrequency ablation(RFA),remain controversial.AIM To clarify this issue using sentiment analysis of medical literature alongside a meta-analysis of overall survival(OS).METHODS We included studies comparing liver resection and RFA,excluding case reports,editorials,and studies without relevant outcomes.A systematic search in PubMed and Web of Science identified 197 studies.Abstracts underwent sentiment analysis using Python’s Natural Language Toolkit library,categorizing them as favoring resection,ablation,or neutral.We also performed a meta-analysis using a random-effects model on 11 studies reporting hazard ratios(HRs)for OS.RESULTS Sentiment analysis revealed that 75.1%of abstracts were neutral,14.2%favored resection,and 10.7%favored RFA.The meta-analysis showed a significant survival advantage for liver resection,with a pooled HR of 0.5924(95%confidence interval:0.540-0.649).Heterogeneity was moderate(I²=39.98%).Despite the meta-analysis demonstrating clear survival benefits of liver resection,most abstracts maintained a neutral stance.This discrepancy highlights potential biases or hesitancy in drawing definitive conclusions.CONCLUSION The study emphasizes the need for clinicians to prioritize robust statistical evidence over narrative impressions.Liver resection remains the preferred treatment for HCC in eligible patients.
基金National Key R&D Program of China under Grant No.2022YFC3003603。
文摘Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study the effects of connection configurations on seismic responses and fragilities.Finite element models of bridges are established using OpenSees.A new ground motion screening method based on the statistical characteristic of the predominant period is proposed to avoid irregular behavior in the selection process of ground motions,and incremental dynamic analysis(IDA)is performed to develop components and systems fragility curves.The effects of damper failure on calculated results for PEDS are examined in terms of seismic response and fragility analysis.The results show that the bridge tower is the most affected component by different structural systems.For RS,the fragility of the middle tower is significantly higher than other components,and the bridge failure starts from the middle tower,exhibiting a characteristic of local failure.For FS and PEDS,the fragility of the edge tower is higher than the middle tower.The system fragility of RS is higher than FS and PEDS.Taking the failure of dampers into account is necessary to obtain reliable seismic capacity of cable-stayed bridges.
文摘The shell traits and weight traits are measured in cultured populations of bay scallop, Argopecten irradians. The results of regression analysis show that the regression relationships for all the traits are significant (P<0.01). The correlative coefficients between body weight, as well as tissue weight with shell length, shell height and shell width are significant (P<0.05). But the correlative coefficients between the anterior and posterior auricle length with body weight as well as tissue weight are not significant (P>0.05). The multiple regression equation is obtained to estimate live body weight and tissue weight. The above traits except anterior and posterior auricle length are used for the growth and production comparison among three cultured populations, Duncan's new multiple range procedure analysis shows that all the traits in the Lingshuiqiao (LSQ) population are much more significant than those of the other two populations (P<0.01), and there is no significant difference between the Qipanmo (QPM) and Dalijia (DLJ) populations in all traits (P>0.05). The results indicate that the LSQ population has a higher growth rate and is expected to be more productive than the other two populations.
基金supported by the Beijing Excellent Talent Training Foundation of China,No.2017000021469G215(to DZhang)the Natural Science Foundation of Capital Medical University of China,No.PYZ2018081(to DZhang)the Youth Science Foundation of Beijing Tiantan Hospital of China,No.2016-YQN-14(to DZhang)
文摘Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,the effect of regulating autophagy and whether autophagy is detrimental or beneficial after spinal cord injury remain unclear.Therefore,in this study we evaluated the effects of autophagy regulation on spinal cord injury in rats by direct and indirect comparison,in an effort to provide a basis for further research.Data source:Relevant literature published from inception to February 1,2018 were included by searching Wanfang,CNKI,Web of Science,MEDLINE(OvidSP),PubMed and Google Scholar in English and Chinese.The keywords included"autophagy","spinal cord injury",and"rat".Data selection:The literature included in vivo experimental studies on autophagy regulation in the treatment of spinal cord injury(including intervention pre-and post-spinal cord injury).Meta-analyses were conducted at different time points to compare the therapeutic effects of promoting or inhibiting autophagy,and subgroup analyses were also conducted.Outcome measure:Basso,Beattie,and Bresnahan scores.Results:Of the 622 studies,33 studies of median quality were included in the analyses.Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=1.80,95%CI:0.81-2.79,P=0.0004),3 days(MD=0.92,95%CI:0.72-1.13,P<0.00001),1 week(MD=2.39,95%CI:1.85-2.92,P<0.00001),2 weeks(MD=3.26,95%CI:2.40-4.13,P<0.00001),3 weeks(MD=3.13,95%CI:2.51-3.75,P<0.00001)and 4 weeks(MD=3.18,95%CI:2.43-3.92,P<0.00001)after spinal cord injury with upregulation of autophagy compared with the control group(drug solvent control,such as saline group).Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=6.48,95%CI:5.83-7.13,P<0.00001),2 weeks(MD=2.43,95%CI:0.79-4.07,P=0.004),3 weeks(MD=2.96,95%CI:0.09-5.84,P=0.04)and 4 weeks(MD=4.41,95%CI:1.08-7.75,P=0.01)after spinal cord injury with downregulation of autophagy compared with the control group.Indirect comparison of upregulation and downregulation of autophagy showed no differences in Basso,Beattie,and Bresnahan scores at 1 day(MD=-4.68,95%CI:-5.840 to-3.496,P=0.94644),3 days(MD=-0.28,95%CI:-2.231-1.671,P=0.99448),1 week(MD=1.83,95%CI:0.0076-3.584,P=0.94588),2 weeks(MD=0.81,95%CI:-0.850-2.470,P=0.93055),3 weeks(MD=0.17,95%Cl:-2.771-3.111,P=0.99546)or 4 weeks(MD=-1.23,95%Cl:-4.647-2.187,P=0.98264)compared with the control group.Conclusion:Regulation of autophagy improves neurological function,whether it is upregulated or downregulated.There was no difference between upregulation and downregulation of autophagy in the treatment of spinal cord injury.The variability in results among the studies may be associated with differences in research methods,the lack of clearly defined autophagy characteristics after spinal cord injury,and the limited autophagy monitoring techniques.Thus,methods should be standardized,and the dynamic regulation of autophagy should be examined in future studies.
文摘 This study was carried out in 120 patients affected by migraine without aura, treated in 4 public health centers and randomly divided into acupuncture group (AG) and conventional drug therapy group (CDTG).
The evaluation of clinical results was made 6 and 12 months after the beginning of treatment and was worked out as well according to socio-medical parameters. Acupuncture was applied to the following points: Touwei (ST 8), Xuanlu (GB 5), Fengchi (GB 20), Dazhui (GV 14), Lieque (LU 7), treated with the reducing method. In AG, the figure scoring the entity and frequency of migraine attacks drops from 9,823 before treatment to 1,990 6 months after and 1,590 12 months after; while in CDTG, it drops from 8,405 before treatment to 3,927 6 months after and 3,084 12 months after. In AG, the total absence from work amounted to 1,120 working days/year, with a total cost (private + social costs) of 186,677,000 Italian liras. In CDTG, the absence from work amounted to 1,404 working days/year, with a total cost of 266,614,000 Italian liras.
If we consider that in Italy the patients affected by migraine without aura are around 800,000, and that acupuncture therapy is able to save 1,332,000 Italian liras on the total average cost supported for every single patient, the application of acupuncture in the treatment of migraine without aura would allow a saving of the health expenses in Italy of over 1,000 billion liras.
文摘Manure samples were collected by floor scrapings in animal stables from Beijing suburbs. Total nitrogen (TN), total phosphorus (TP), and total potassium (TK) were analyzed by conventional wet chemical methods. All manures showed a high variability in nutrient contents. Nutrients contents in different animal manures were significantly different. TN and TK contents in layer manures were higher than swine and dairy manures
文摘[Objective] The twice regional rainstorms in northwest Yantai in July in 2009 and July in 2010 were expounded.[Method] The twice regional rainstorm in northwest Yantai in July in 2009 and July in 2010 were selected for comparison analysis by dint of conventional and non-conventional weather data,from the aspects of circulation background,physics quantity,and radar echo,etc.[Result] The twice large rainstorm process were regional convective strong precipitation.The rainstorm fell in the northwest of Yantai and had a strong precipitation center above 200 mm.The twice large rainstorm was affected by subtropical and shear line.The rainstorm area was related to the location of 588 dagpm line,westerly trough,and shear line.It was regional rainstorm of typical subtropical edge warm and wet airstream,combination of low vortex and shear line of westerly.The precipitation occurred around the center of water vapor flux;K index had pretty good indication effects to the generation of rainstorm.Large rainstorm occurred around the place with high K index.The K index of twice large rainstorm was larger than or equal to 34 ℃,and was close to the rainstorm falling area where K index was larger than or equal to 35 ℃.The reflection factor of twice large rainstorms at 0.5° elevation,the largest echo intensity was from 55 to 60 dBz,in strip echo from south to north,through the west peninsula,forming train effect.The data report product also had important reference basis for the report of regional large rainstorm.[Conclusion] The study provided references and basis for the report of large rainstorm in the future.
文摘This paper raises the comparison method of operational stages of the real estate market. In order to select similar operational stages, we established an analysis model by applying fuzzy grade-of-membership clustering in this paper. Firstly, we select the materials information of the real estate market in America, Germany and Japan. Secondly, the real estate markets of America, Germany and Japan are divided into several different stages. Lastly, we apply the method of fuzzy grade-of-membership clustering to select comparable stages. The result of analysis indicates that the real estate market of Japan and Germany (1960-1980) are similar to the market in China.
基金This work is supported by the National Key Research and Development Plan program of the Ministry of Science and Technology of China(No.2016YFB0201100)Additionally,this work is supported by the National Laboratory for Marine Science and Technology(Qingdao)Major Project of the Aoshan Science and Technology Innovation Program(No.2018ASKJ01-04)the Open Fundation of Key Laboratory of Marine Science and Numerical Simulation,Ministry of Natural Resources(No.2021-YB-02).
文摘In this paper,a typical experiment is carried out based on a high-resolution air-sea coupled model,namely,the coupled ocean-atmosphere-wave-sediment transport(COAWST)model,on both heterogeneous many-core(SW)and homogenous multicore(Intel)supercomputing platforms.We construct a hindcast of Typhoon Lekima on both the SW and Intel platforms,compare the simulation results between these two platforms and compare the key elements of the atmospheric and ocean modules to reanalysis data.The comparative experiment in this typhoon case indicates that the domestic many-core computing platform and general cluster yield almost no differences in the simulated typhoon path and intensity,and the differences in surface pressure(PSFC)in the WRF model and sea surface temperature(SST)in the short-range forecast are very small,whereas a major difference can be identified at high latitudes after the first 10 days.Further heat budget analysis verifies that the differences in SST after 10 days are mainly caused by shortwave radiation variations,as influenced by subsequently generated typhoons in the system.These typhoons generated in the hindcast after the first 10 days attain obviously different trajectories between the two platforms.
基金supported by the National Natural Science Foundation of China(No.42075182)the Science and Technology Pre-research Project for Collaborative Prevention and Control on O3 and PM2.5 Compound Pollution(No.DQGG202026)the Three-dimensional Comprehensive Observation Research Program for O3and PM2.5Compound Pollution in Key Areas in Summer 2021(No.DQGG2021101)
文摘Over the past few decades,the metal elements(MEs)in atmospheric particles have aroused great attention.Some well-established techniques have been used to measure particlebound MEs.However,each method has its own advantages and disadvantages in terms of complexity,accuracy,and specific elements of interest.In this study,the performances of inductively coupled plasma-optical emission spectrometry(ICP-OES)and total reflection X-ray fluorescence spectroscopy(TXRF)were evaluated for quality control to analyze data accuracy and precision.The statistic methods(Deming regression and significance testing)were applied for intercomparison between ICP-OES and TXRF measurements for same lowloading PM_(2.5)samples in Weizhou Island.The results from the replicate analysis of standard filters(SRM 2783)and field filters samples indicated that 10 MEs(K,Ca,V,Cr,Mn,Fe,Ni,Cu,Zn,and Pb)showed good accuracies and precision for both techniques.The higher accuracy tended to the higher precision in the MEs analysis process.In addition,the interlab comparisons illustrated that V and Mn all had good agreements between ICP-OES and TXRF.The measurements of K,Cu and Zn were more reliable by TXRF analysis for low-loading PM_(2.5).ICP-OES was more accurate for the determinations for Ca,Cr,Ni and Pb,owing to the overlapping spectral lines and low sensitivity during TXRF analysis.The measurements of Fe,influenced by low-loading PM_(2.5),were not able to determine which instrument could obtain more reliable results.These conclusions could provide reference information to choose suitable instrument for the determination of MEs in low-loading PM_(2.5)samples.
文摘The aim of this research was to analyze the PPM of Armenian Premier League using 25 GPS 10 Hz(K-Sport,Montelabbate,Italy),in order to compare data from literature from major European championship.In total 25 matches were analyzed from one team militant in Armenian Premier League(10 wins,10 loses and 5 draws),33 different players(age 24.3±4.2,height 1.76±4.2 and weight 74±3.5)and in total 270 performances(10.8 for matches).Matches were divided in First Half(T1),Second Half(T2),Second Half Substitution(T2 Sub),Full Match,Full Match Substitution(Full Match Sub)and Total Match(Total)that include all the players detected during a games.Furthermore,all matches were divided even by quarters 0-15,15-30,30-45,45-60,60-75 and 75-90,only players that played all match were included in this analyses,in order to check the performance decreasing during the time.All data were added in an Excel Spreadsheet in order to build a database,to organize and better analyze data,cataloging events for data,results,and role of players.Average data from Armenian Premier League in comparison with literature data from European and Italian Championship show that in every parameter,the Armenian Premier League is under the average.This is obviously related to the non-high level of the Armenian football that is in fact placed at the 106°place of the FIFA ranking(update 7 June 2019).Physical data represent an indicator of performance but also of the qualitative level of the league and of individual players.For this reason,the use of the match analysis can be decisive to verify the PPM,in order to better evaluate the championships,teams,and players,in order to build an easier search and discovery of talents.
文摘-- In this paper, by using two sets of composite data of developed and undeveloped depressions over the South China Sea, we analyze and compare the dynamic structures, the heating fields and the vorticity budget residuals of two different types of depressions. Our conclusions are as follows:The two types of depressions are similar in thermodynamical and dynamical structures. The main differ ences are : in the high layer of developed depression there is a divergence field, with a center near the zero line of vertical wind shear, and over undeveloped depression, the divergence field is weaker and the vertical wind at its center is greater than 5 m s-1. The thermodynamical field of the former is asymmetrical and that of the latter is quasi - symmetrical. As far as the dynamics structure is concerned, the convergence in the lower layer and the difference of divergence between the upper and lower layers of developed depression is three tmies larger than that of undeveloped depression. The upward motion and heating field at the center of developed depression is also stronger than that of undeveloped one.The vorticity budget of the two types of depressions is mainly determined by the divergence term, the vorticity advection term and the vertical transport term. The residual term is also important.The principal contribution comes from the divergence term . This is more significant for developed depression than for undeveloped depression.
基金supported by MICIU MCIN/AEI/10.13039/501100011033Spain with Grant PID2020-118265GB-C42,-C44,PRTR-C17.I01Generalitat Valenciana,Spain with Grant CIPROM/2022/54,ASFAE/2022/031,CIAPOS/2021/114 and by the EU NextGenerationEU,ESF funds.This work was also supported by the National Science Centre(NCN),Poland(Grant No.2020/39/D/ST2/00466).
文摘The NEutron Detector Array(NEDA)is designed to be coupled to gamma-ray spectrometers to enhance the sensitivity of the setup by enabling reaction channel selection through counting of the evaporated neutrons.This article presents the implementation of a double trigger condition system for NEDA,which improves the acquisition of neutrons and reduces the number of gamma rays acquired.Two independent triggers are generated in the double trigger condition system:one based on charge comparison(CC)and the other on time-of-flight(TOF).These triggers can be combined using OR and AND logic,offering four distinct trigger modes.The developed firmware is added to the previous one in the Virtex 6 field programmable gate array(FPGA)present in the system,which also includes signal processing,baseline correction,and various trigger logic blocks.The performance of the trigger system is evaluated using data from the E703 experiment performed at GANIL.The four trigger modes are applied to the same data,and a subsequent offline analysis is performed.It is shown that most of the detected neutrons are preserved with the AND mode,and the total number of gamma rays is significantly reduced.Compared with the CC trigger mode,the OR trigger mode allows increasing the selection of neutrons.In addition,it is demonstrated that if the OR mode is selected,the online CC trigger threshold can be raised without losing neutrons.
文摘From the viewpoint of disaster prevention in the urban areas, this paper analyzes the value of urban public security system, selects typical cases to make a comparison of Chinese and foreign public security treatment mechanisms, and makes systematic summarization of the Chinese and foreign historic experiences. Then, the paper puts forward some designs on structure of the Chinese urban public security system structure. This paper is of the opinion that at present the management of urban public security concerning unexpected incidents should be strengthened. The effective way is to set up the sound urban public security system, urban public security mechanism and related laws and regulations.
文摘There are similarities and differences in the construction of the two poems:Charlotte Mew’s"Rooms"and Philip Larkin’s"Home is so Sad(HISS)".Both convey a sense of regret and loss through the portrayal of abandoned rooms.However,"Rooms"highlights the despair upon the withering away of life and the slow,painful approach of death,while"HISS"expresses the pain upon the loss of loved ones.The rooms in each poem may have different roles in the lives of their owners,but in each case,they form a significant linkage of the past and present,and ultimately symbolise the abandonment of human heart itself.
基金funded by National Program on Key Basic Research Project of China - 973 Program" Potash formation mechanism, conditions and late evolution in Ordovician ancient epicontinental sea basin, Erdos" (No. 2011CB403001)China Geological survey work Program - " Potash resources investigation and evaluation in Northern Shaanxi Ordovician Salt Basin " (No. 1212011085516)
文摘1 Introduction Currently,all six different continents have discovered potash deposits and potash-bearing salt lake saline water.However,the distribution is extremely uneven,which is mostly concentrated in Canada,Russia,Middle-Asia and
文摘This paper is to make a comparison on Chinese and English sounds under contrastive analysis with the consideration of that Chinese teachers of English would be better able to foresee their students' difficulty and consequently be better able to do their teaching plan in practice.
基金supported by the National Natural Science Foundation of China, Nos.81471238, 81771327(both to BYL)Construction of Central Nervous System Injury Basic Science and Clinical Translational Research Platform, Budget of Beijing Municipal Health Commission 2020, No.PXM2020_026280_000002(to BYL)。
文摘The heterogeneity of traumatic brain injury(TBI)-induced secondary injury has greatly hampered the development of effective treatments for TBI patients.Targeting common processes across species may be an innovative strategy to combat debilitating TBI.In the present study, a cross-species transcriptome comparison was performed for the first time to determine the fundamental processes of secondary brain injury in Sprague-Dawley rat and C57/BL6 mouse models of TBI, caused by acute controlled cortical impact.The RNA sequencing data from the mouse model of TBI were downloaded from the Gene Expression Omnibus(ID: GSE79441) at the National Center for Biotechnology Information.For the rat data, peri-injury cerebral cortex samples were collected for transcriptomic analysis 24 hours after TBI.Differentially expressed gene-based functional analysis revealed that common features between the two species were mainly involved in the regulation and activation of the innate immune response, including complement cascades as well as Toll-like and nucleotide oligomerization domain-like receptor pathways.These findings were further corroborated by gene set enrichment analysis.Moreover, transcription factor analysis revealed that the families of signal transducers and activators of transcription(STAT), basic leucine zipper(BZIP), Rel homology domain(RHD), and interferon regulatory factor(IRF) transcription factors play vital regulatory roles in the pathophysiological processes of TBI, and are also largely associated with inflammation.These findings suggest that targeting the common innate immune response might be a promising therapeutic approach for TBI.The animal experimental procedures were approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No.201802001) on June 6, 2018.
基金Supported by Province and University Cooperation Fund of Yunnan Province (No. 2003HBBAA02A049).
文摘A statistical approach to evaluate the subjective perception of the annoyance caused by the vehicle noise was presented in this paper. After recording the noises of Sanfeng, Huali and Xiali at speeds of 30, 40, 50, 60, 70 and 80 km/h respectively, the annoyance of the vehicle noises was evaluated in the testing room using paired comparison method, and the sound quality metrics and subjective annoyance were then distilled. Loudness, sharpness, roughness, periodicity and impulsiveness were selected for each of the vehicle noises. By correlation analysis method, it can be found that loudness has a higher correlation （0.91） with annoyance than other parameters. Meanwhile, sharpness, periodicity, roughness and impulsiveness have correlation with subjective perception with correlation coefficients being 0.84, -0.82, 0.62 and 0.87, respectively. The result of multiple regression analysis shows that calculated annoyance obtained by the regression equation can explain the perceptual annoyance and the regressed evaluation model is feasible to evaluate the sound quality of vehicle.
基金Supported by the national education ministry key research project 02107
文摘A new researching method on clothing comfort perception is developed.By it the skin surface temperature changes and subjective psychological perception of human body sections stimulated by the same cold stimulation are studied.With the multiple comparison analysis method the changing laws of skin temperature of main human body sections is obtained.
