1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-...1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-sized particles(5-50μm)to fabricate coatings[1-3].CS has been extensively used in a variety of coating applications,such as aerospace,automotive,energy,medical,marine,and others,to provide protection against high temperatures,corrosion,erosion,oxidation,and chemicals[4,5].Nowadays,the technical interest in CS is twofold:(i)as a repair process for damaged components,and(ii)as a solid-state additive manufacturing process.Compared to other fusion-based additive manufacturing(AM)technologies,Cold Spray Additive Manufacturing(CSAM)is a new member of the AM family that can enable the fabrication of deposits without undergoing melting.The chemical composition has been largely preserved from the powder to the deposit due to the minimal oxidation.The significant advantages of CSAM over other additive manufacturing processes include a high production rate,unlimited deposition size,high flexibility,and suitability for repairing damaged parts.展开更多
Merged satellite altimeter products are widely used in ocean-related fields.Currently,the altimeter merged products of archiving validation and interpretation of satellite oceanographic(AVISO)data are widely used inte...Merged satellite altimeter products are widely used in ocean-related fields.Currently,the altimeter merged products of archiving validation and interpretation of satellite oceanographic(AVISO)data are widely used internationally.Chinese National Satellite Ocean Application Service also released merged altimeter products(ALT MUL)in 2023.However,there are few studies on the quality assessment of ALT MUL.Based on the data of AVISO merged products,Jason3 satellite,tide gauge and drifter buoy,the quality assessment and effect analysis of ALT MUL merged products were carried out by means of error evaluation index,interpolation along rails,velocity inversion and power spectrum.The result shows that the average sea level anomaly(SLA)of ALT MUL is about 2 cm smaller than that of AVISO.And they are consistent with the large-scale characteristics and spatial distribution.These two SLA products are both in accordance with normal distribution.Results indicate a lesser congruence between ALT MUL and Jason3 satellite compared to AVISO.This difference may be attributed to the fact that AVISO products use Jason3 satellite as crosscalibrated reference satellite during the merged process.Comparing the matching effect of the two merged products with the tide gauge and drifter buoy,ALT MUL merged products are superior to AVISO in general.The energy spectral density was calculated by using Jason3 satellite data along the orbit,and the two merged products were interpolated to the data points along the orbit.The effective resolution of AVISO and ALT MUL merged products was 180 km and 210 km respectively through spectral calculation,indicating that AVISO merged products have higher effective resolution.展开更多
目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,...目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。展开更多
Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore （LBP） and structure-based pharmacophore （SBP）. LBP can be utilized to identify active compounds usual with low...Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore （LBP） and structure-based pharmacophore （SBP）. LBP can be utilized to identify active compounds usual with lower accuracy, and SBP is able to use for distin- guishing active compounds from inactive compounds with frequently higher missing rates. Merged pharmacophore （MP） is presented to integrate advantages and avoid shortcomings of LBP and SBP. In this work, LBP and SBP models were constructed for the study of per- oxisome proliferator receptor-alpha （PPARα） agonists. According to the comparison of the two types of pharmacophore models, mainly and secondarily pharmacological features were identified. The weight and tolerance values of these pharmacological features were adjusted to construct MP models by single-factor explorations and orthogonal experimental design based on SBP model. Then, the reliability and screening efficiency of the best MP model were validated by three databases. The best MP model was utilized to compute PPARα activity of compounds from traditional Chinese medicine. The screening efficiency of MP model outperformed individual LBP or SBP model for PPARα agonists, and was similar to combinatorial screening of LBP and SBP. However, MP model might have an advantage over the combination of LBP and SBP in evaluating the activity of compounds and avoiding the inconsistent prediction of LBP and SBP, which would be beneficial to guide drug design and optimization.展开更多
To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the...To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the basic capacity model of the on-ramp merging section. Since not all the time headways on the shoulder lane can be made full use of by on- ramp vehicles, a modified capacity model is developed, which takes the usage probability of time headway into consideration. Then, a model of capacity discount coefficient ~： is developed. Finally, based on the modified capacity model and the model of capacity discount coefficient, an empirical merge capacity model which contains the shoulder lane volume, critical gap, and the distance from nose to merging point, is constructed. Results show that, compared with other models, the proposed model is more reasonable since it takes merging section geometry into consideration, and it is easy to apply. The merge capacity varies with the shoulder lane volume, the critical gap, the distance between the nose and the merging point, and the design velocity of the shoulder lane and ramp.展开更多
In order to improve the prediction accuracy and test the generalization ability of the dam deformation analysis model, the back-propagation（BP） neural network model for dam deformation analysis is studied, and the m...In order to improve the prediction accuracy and test the generalization ability of the dam deformation analysis model, the back-propagation（BP） neural network model for dam deformation analysis is studied, and the merging model is built based on the neural network BP algorithm and the traditional statistical model. The three models mentioned above are calculated and analyzed according to the long-term deformation observation data in Chencun Dam. The analytical results show that the average prediction accuracies of the statistical model and the BP neural network model are ~ 0.477 and ＋- 0.390 mm, respectively, while the prediction accuracy of the merging model is ~0. 318 mm, which is improved by 33% and 18% compared to the other two models, respectively. And the merging model has a better generalization ability and broad applicability.展开更多
在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进...在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进步,经过恰当方法整合后的多元证据体是中医药临床指南推荐意见和循证卫生决策的有力支撑。本文基于当前国际证据合成与分级方法学前沿进展,初步提出中医药多元证据整合的方法学框架——MERGE(Merge Evidence-based Research and artificial intelliGence to support smart dEcision)框架,以期为中医药循证医学方法学体系的完善和发展提供借鉴和参考。展开更多
Precipitation, a basic component of the water cycle, is significantly important for meteorological, climatological and hydrological research. However, accurate estimation on the precipitation remains considerably chal...Precipitation, a basic component of the water cycle, is significantly important for meteorological, climatological and hydrological research. However, accurate estimation on the precipitation remains considerably challenging because of the sparsity of gauge networks and the large spatial variability of precipitation over mountainous regions. Moreover, meteorological stations in mountainous areas are often dispersed and have difficulty in accurately reflecting the intensity and evolution of precipitation events. In this study,we proposed a novel method to produce high-quality,high-resolution precipitation estimates in the Tianshan Mountains, China, based on area-to-point kriging(ATPK) downscaling and a two-step correction, i.e., probability density function matching-optimum interpolation(PDF-OI). We obtained 1-km hourly precipitation data in the Tianshan Mountains by merging estimates from the Integrated Multisatellite Measurement(IMERG) product with observations from 1065 meteorological stations in the warm season(May to September) during 2016–2018. The spatial resolution and accuracy of the merged precipitation data greatly increased compared to IMERG.According to a cross-validation with gauged observations, the correlation coefficient(CC),probability of detection(POD) and critical success index(CSI) increased from 0.30, 0.50 and 0.24 for IMERG to 0.63, 0.65 and 0.38, respectively, for the merged estimates, and the root mean squared error(RMSE), mean error(ME) and false alarm ratio(FAR)decreased from 0.46 to 0.38 mm/h, 0.06 to 0.05 mm/h and 0.69 to 0.52, respectively. The proposed method will be useful for developing high-resolution precipitation estimates in mountainous areas such as central Asia and the Belt and Road Initiative regions.展开更多
The paper first analyzes the achievement of BOE's merging case and substantiates its success,then focuses on the strategy analysis of merger of the BOE,including the guidelines,merging way,strategic overall arrang...The paper first analyzes the achievement of BOE's merging case and substantiates its success,then focuses on the strategy analysis of merger of the BOE,including the guidelines,merging way,strategic overall arrangement,culture conformity,financial guarantee etc.,in a bid to offer valuable experience and reference function for the Chinese enterprises.展开更多
基金supported by the National Natural Science Foundation of China(No.52061135101 and 52001078)the German Research Foundation(DFG,No.448318292)+3 种基金the Technology Innovation Guidance Special Foundation of Shaanxi Province(No.2023GXLH-085)the Fundamental Research Funds for the Central Universities(No.D5000240161)the Project of Key areas of innovation team in Shaanxi Province(No.2024RS-CXTD-20)The author Yingchun Xie thanks the support from the National Key R&D Program(No.2023YFE0108000).
文摘1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-sized particles(5-50μm)to fabricate coatings[1-3].CS has been extensively used in a variety of coating applications,such as aerospace,automotive,energy,medical,marine,and others,to provide protection against high temperatures,corrosion,erosion,oxidation,and chemicals[4,5].Nowadays,the technical interest in CS is twofold:(i)as a repair process for damaged components,and(ii)as a solid-state additive manufacturing process.Compared to other fusion-based additive manufacturing(AM)technologies,Cold Spray Additive Manufacturing(CSAM)is a new member of the AM family that can enable the fabrication of deposits without undergoing melting.The chemical composition has been largely preserved from the powder to the deposit due to the minimal oxidation.The significant advantages of CSAM over other additive manufacturing processes include a high production rate,unlimited deposition size,high flexibility,and suitability for repairing damaged parts.
基金The National Key R&D Program of China under contract No.2021YFC3101503the National Natural Science Foundation of China under contract Nos 42276205 and 42406195+1 种基金the Hunan Provincial Natural Science Foundation of China under contract No.2023JJ10053the Youth Independent Innovation Science Foundation under contract No.ZK24-54.
文摘Merged satellite altimeter products are widely used in ocean-related fields.Currently,the altimeter merged products of archiving validation and interpretation of satellite oceanographic(AVISO)data are widely used internationally.Chinese National Satellite Ocean Application Service also released merged altimeter products(ALT MUL)in 2023.However,there are few studies on the quality assessment of ALT MUL.Based on the data of AVISO merged products,Jason3 satellite,tide gauge and drifter buoy,the quality assessment and effect analysis of ALT MUL merged products were carried out by means of error evaluation index,interpolation along rails,velocity inversion and power spectrum.The result shows that the average sea level anomaly(SLA)of ALT MUL is about 2 cm smaller than that of AVISO.And they are consistent with the large-scale characteristics and spatial distribution.These two SLA products are both in accordance with normal distribution.Results indicate a lesser congruence between ALT MUL and Jason3 satellite compared to AVISO.This difference may be attributed to the fact that AVISO products use Jason3 satellite as crosscalibrated reference satellite during the merged process.Comparing the matching effect of the two merged products with the tide gauge and drifter buoy,ALT MUL merged products are superior to AVISO in general.The energy spectral density was calculated by using Jason3 satellite data along the orbit,and the two merged products were interpolated to the data points along the orbit.The effective resolution of AVISO and ALT MUL merged products was 180 km and 210 km respectively through spectral calculation,indicating that AVISO merged products have higher effective resolution.
文摘目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。
文摘Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore （LBP） and structure-based pharmacophore （SBP）. LBP can be utilized to identify active compounds usual with lower accuracy, and SBP is able to use for distin- guishing active compounds from inactive compounds with frequently higher missing rates. Merged pharmacophore （MP） is presented to integrate advantages and avoid shortcomings of LBP and SBP. In this work, LBP and SBP models were constructed for the study of per- oxisome proliferator receptor-alpha （PPARα） agonists. According to the comparison of the two types of pharmacophore models, mainly and secondarily pharmacological features were identified. The weight and tolerance values of these pharmacological features were adjusted to construct MP models by single-factor explorations and orthogonal experimental design based on SBP model. Then, the reliability and screening efficiency of the best MP model were validated by three databases. The best MP model was utilized to compute PPARα activity of compounds from traditional Chinese medicine. The screening efficiency of MP model outperformed individual LBP or SBP model for PPARα agonists, and was similar to combinatorial screening of LBP and SBP. However, MP model might have an advantage over the combination of LBP and SBP in evaluating the activity of compounds and avoiding the inconsistent prediction of LBP and SBP, which would be beneficial to guide drug design and optimization.
基金The National Natural Science Foundation of China(No.51278520 51278220)the Science and Technology Development Project of Jilin Province(No.20130206093SF)
文摘To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the basic capacity model of the on-ramp merging section. Since not all the time headways on the shoulder lane can be made full use of by on- ramp vehicles, a modified capacity model is developed, which takes the usage probability of time headway into consideration. Then, a model of capacity discount coefficient ~： is developed. Finally, based on the modified capacity model and the model of capacity discount coefficient, an empirical merge capacity model which contains the shoulder lane volume, critical gap, and the distance from nose to merging point, is constructed. Results show that, compared with other models, the proposed model is more reasonable since it takes merging section geometry into consideration, and it is easy to apply. The merge capacity varies with the shoulder lane volume, the critical gap, the distance between the nose and the merging point, and the design velocity of the shoulder lane and ramp.
基金The Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXLX11_0143)
文摘In order to improve the prediction accuracy and test the generalization ability of the dam deformation analysis model, the back-propagation（BP） neural network model for dam deformation analysis is studied, and the merging model is built based on the neural network BP algorithm and the traditional statistical model. The three models mentioned above are calculated and analyzed according to the long-term deformation observation data in Chencun Dam. The analytical results show that the average prediction accuracies of the statistical model and the BP neural network model are ~ 0.477 and ＋- 0.390 mm, respectively, while the prediction accuracy of the merging model is ~0. 318 mm, which is improved by 33% and 18% compared to the other two models, respectively. And the merging model has a better generalization ability and broad applicability.
文摘在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进步,经过恰当方法整合后的多元证据体是中医药临床指南推荐意见和循证卫生决策的有力支撑。本文基于当前国际证据合成与分级方法学前沿进展,初步提出中医药多元证据整合的方法学框架——MERGE(Merge Evidence-based Research and artificial intelliGence to support smart dEcision)框架,以期为中医药循证医学方法学体系的完善和发展提供借鉴和参考。
基金supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2020D01A137)the National Natural Science Foundation of China(41901363,42071075)+2 种基金Tianshan Youth Project of Xinjiang Uigur Autonomous Region Outstanding young talents(2019Q039)National Key R&D Program of China(2019YFC1510503)the Basic Research Operating Expenses of the Central Level Non-profit Research Institutes(IDM2020006)。
文摘Precipitation, a basic component of the water cycle, is significantly important for meteorological, climatological and hydrological research. However, accurate estimation on the precipitation remains considerably challenging because of the sparsity of gauge networks and the large spatial variability of precipitation over mountainous regions. Moreover, meteorological stations in mountainous areas are often dispersed and have difficulty in accurately reflecting the intensity and evolution of precipitation events. In this study,we proposed a novel method to produce high-quality,high-resolution precipitation estimates in the Tianshan Mountains, China, based on area-to-point kriging(ATPK) downscaling and a two-step correction, i.e., probability density function matching-optimum interpolation(PDF-OI). We obtained 1-km hourly precipitation data in the Tianshan Mountains by merging estimates from the Integrated Multisatellite Measurement(IMERG) product with observations from 1065 meteorological stations in the warm season(May to September) during 2016–2018. The spatial resolution and accuracy of the merged precipitation data greatly increased compared to IMERG.According to a cross-validation with gauged observations, the correlation coefficient(CC),probability of detection(POD) and critical success index(CSI) increased from 0.30, 0.50 and 0.24 for IMERG to 0.63, 0.65 and 0.38, respectively, for the merged estimates, and the root mean squared error(RMSE), mean error(ME) and false alarm ratio(FAR)decreased from 0.46 to 0.38 mm/h, 0.06 to 0.05 mm/h and 0.69 to 0.52, respectively. The proposed method will be useful for developing high-resolution precipitation estimates in mountainous areas such as central Asia and the Belt and Road Initiative regions.
文摘The paper first analyzes the achievement of BOE's merging case and substantiates its success,then focuses on the strategy analysis of merger of the BOE,including the guidelines,merging way,strategic overall arrangement,culture conformity,financial guarantee etc.,in a bid to offer valuable experience and reference function for the Chinese enterprises.
