Lower-grade gliomas(including low-and intermediate-grade gliomas,World Health Organization grades II and III)are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have tr...Lower-grade gliomas(including low-and intermediate-grade gliomas,World Health Organization grades II and III)are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have traditionally been classified based on their presumed histogenesis as astrocytomas,oligodendrogliomas,or oligoastrocytomas.Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century,it suffers from high intra-and inter-observer variability and does not adequately predict clinical outcomes.Based on integrated analysis of multiplatform genomic data from The Cancer Genome Atlas,lower-grade gliomas have been found to segregate into three cohesive,clinically relevant molecular classes.Molecular classes were closely aligned with the status of isocitrate dehydrogenase(IDH)mutations,tumor protein 53 mutations and the co-deletion of chromosome arms 1 p and 19q,but were not closely aligned with histologic classes.These findings emphasize the potential for improved definition of clinically relevant disease subsets using integrated molecular approaches and highlight the importance of biomarkers for brain tumor classification.展开更多
In the present paper, an attempt is made to obtain the degree of approximation of conjugate of functions (signals) belonging to the generalized weighted W(LP, ξ(t)), (p ≥ 1)-class, by using lower triangular matrix o...In the present paper, an attempt is made to obtain the degree of approximation of conjugate of functions (signals) belonging to the generalized weighted W(LP, ξ(t)), (p ≥ 1)-class, by using lower triangular matrix operator of conjugate series of its Fourier series.展开更多
文摘Lower-grade gliomas(including low-and intermediate-grade gliomas,World Health Organization grades II and III)are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have traditionally been classified based on their presumed histogenesis as astrocytomas,oligodendrogliomas,or oligoastrocytomas.Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century,it suffers from high intra-and inter-observer variability and does not adequately predict clinical outcomes.Based on integrated analysis of multiplatform genomic data from The Cancer Genome Atlas,lower-grade gliomas have been found to segregate into three cohesive,clinically relevant molecular classes.Molecular classes were closely aligned with the status of isocitrate dehydrogenase(IDH)mutations,tumor protein 53 mutations and the co-deletion of chromosome arms 1 p and 19q,but were not closely aligned with histologic classes.These findings emphasize the potential for improved definition of clinically relevant disease subsets using integrated molecular approaches and highlight the importance of biomarkers for brain tumor classification.
基金supported by the NSFC(1080110530871444)+2 种基金the Key Project of Natural Science of Anhui Provincial Department of Education(KJ2009A44)the Doctoral Special Fund of Hefei University of Technology(GDBJ2010-012)the Key Project of Science and Technology of Anhui Province(08010302070)
文摘In this paper, we give a lower bound exp（2.2 × 10~8 ） for those discriminants of real quadratic fields Q（√ d） with d= N^2-4 and h（d）=1.
文摘In the present paper, an attempt is made to obtain the degree of approximation of conjugate of functions (signals) belonging to the generalized weighted W(LP, ξ(t)), (p ≥ 1)-class, by using lower triangular matrix operator of conjugate series of its Fourier series.
