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A review on the design of ternary logic circuits 被引量:2
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作者 Xiao-Yuan Wang Chuan-Tao Dong +1 位作者 Zhi-Ru Wu Zhi-Qun Cheng 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第12期7-18,共12页
A multi-valued logic system is a promising alternative to traditional binary logic because it can reduce the complexity,power consumption, and area of circuit implementation. This article briefly summarizes the develo... A multi-valued logic system is a promising alternative to traditional binary logic because it can reduce the complexity,power consumption, and area of circuit implementation. This article briefly summarizes the development of ternary logic and its advantages in digital logic circuits. The schemes, characteristics, and application of ternary logic circuits based on CMOS, CNTFET, memristor, and other devices and processes are reviewed in this paper, providing some reference for the further research and development of ternary logic circuits. 展开更多
关键词 ternary logic circuit MEMRISTOR digital logic circuit circuit design
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A weighted averaging method for signal probability of logic circuit combined with reconvergent fan-out structures
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作者 Xiao Jie Ma Weifeng +1 位作者 William Lee Shi Zhanhui 《Journal of Southeast University(English Edition)》 EI CAS 2018年第2期173-181,共9页
By analyzing the structures of circuits,a novel approach for signal probability estimation of very large-scale integration(VLSI)based on the improved weighted averaging algorithm(IWAA)is proposed.Considering the failu... By analyzing the structures of circuits,a novel approach for signal probability estimation of very large-scale integration(VLSI)based on the improved weighted averaging algorithm(IWAA)is proposed.Considering the failure probability of the gate,first,the first reconvergent fan-ins corresponding to the reconvergent fan-outs were identified to locate the important signal correlation nodes based on the principle of homologous signal convergence.Secondly,the reconvergent fan-in nodes of the multiple reconverging structure in the circuit were identified by the sensitization path to determine the interference sources to the signal probability calculation.Then,the weighted signal probability was calculated by combining the weighted average approach to correct the signal probability.Finally,the reconvergent fan-out was quantified by the mixed-calculation strategy of signal probability to reduce the impact of multiple reconvergent fan-outs on the accuracy.Simulation results on ISCAS85 benchmarks circuits show that the proposed method has approximate linear time-space consumption with the increase in the number of the gate,and its accuracy is 4.2%higher than that of the IWAA. 展开更多
关键词 improved weighted averaging algorithm signal probability estimation gate error rate combinational logic circuits
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DESIGN OF TWO-PHASE SINUSOIDAL POWER CLOCK AND CLOCKED TRANSMISSION GATE ADIABATIC LOGIC CIRCUIT 被引量:5
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作者 Wang Pengjun Yu Junjun 《Journal of Electronics(China)》 2007年第2期225-231,共7页
First the research is conducted on the design of the two-phase sinusoidal power clock generator in this paper. Then the design of the new adiabatic logic circuit adopting the two-phase sinusoidal power clocks--Clocked... First the research is conducted on the design of the two-phase sinusoidal power clock generator in this paper. Then the design of the new adiabatic logic circuit adopting the two-phase sinusoidal power clocks--Clocked Transmission Gate Adiabatic Logic (CTGAL) circuit is presented. This circuit makes use of the clocked transmission gates to sample the input signals, then the output loads are charged and discharged in a fully adiabatic manner by using bootstrapped N-Channel Metal Oxide Semiconductor (NMOS) and Complementary Metal Oxide Semiconductor (CMOS) latch structure. Finally, with the parameters of Taiwan Semiconductor Manufacturing Company (TSMC) 0.25um CMOS device, the transient energy consumption of CTGAL, Bootstrap Charge-Recovery Logic (BCRL) and Pass-transistor Adiabatic Logic (PAL) including their clock generators is simulated. The simulation result indicates that CTGAL circuit has the characteristic of remarkably low energy consumption. 展开更多
关键词 circuit design Two-phase sinusoidal power clock Clock generator Clocked Transmission Gate Adiabatic logic (CTGAL) circuit
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A Comparative Study of Majority/Minority Logic Circuit Synthesis Methods for Post-CMOS Nanotechnologies 被引量:1
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作者 Amjad Almatrood Harpreet Singh 《Engineering(科研)》 2017年第10期890-915,共26页
The physical limitations of complementary metal-oxide semiconductor?(CMOS) technology have led many researchers to consider other alternative technologies. Quantum-dot cellular automate (QCA), single electron tunnelin... The physical limitations of complementary metal-oxide semiconductor?(CMOS) technology have led many researchers to consider other alternative technologies. Quantum-dot cellular automate (QCA), single electron tunneling (SET), tunneling phase logic (TPL), spintronic devices, etc., are some of the nanotechnologies that are being considered as possible replacements for CMOS. In these nanotechnologies, the basic logic units used to implement circuits are majority and/or minority gates. Several majority/minority logic circuit synthesis methods have been proposed. In this paper, we give a comparative study of the existing majority/minority logic circuit synthesis methods that are capable of synthesizing multi-input multi-output Boolean functions. Each of these methods is discussed in detail. The optimization priorities given to different factors such as gates, levels, inverters, etc., vary with technologies. Based on these optimization factors, the results obtained from different synthesis methods are compared. The paper also analyzes the optimization capabilities of different methods and discusses directions for future research in the synthesis of majority/minority logic networks. 展开更多
关键词 logic Design logic Optimization MAJORITY logic circuitS Post-CMOS Technologies
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A Novel High-Performance Lekage-Tolerant, Wide Fan-In Domino Logic Circuit in Deep-Submicron Technology
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作者 Ajay Dadoria Kavita Khare +1 位作者 T. K. Gupta R. P. Singh 《Circuits and Systems》 2015年第4期103-111,共9页
As technology shrinks in modern era the demand on high speed, low power consumption and small chip area in microprocessors is come into existence. In this paper we have presented a new class of domino circuit design f... As technology shrinks in modern era the demand on high speed, low power consumption and small chip area in microprocessors is come into existence. In this paper we have presented a new class of domino circuit design for low power consumption, faster circuit speed and high performance. Due to wide fan-in domino logic, its logic gate suffer from noise sensitivity, if we improve sensitivity, sub-threshold and gate oxide leakage current dominate in evaluation network, which increases the power consumption and reduces the performance of the circuit. The proposed circuit improves the dynamic power consumption and reduces the delay which improves the speed of the circuit. Simulation is performed in BISM4 Cadence environment at 65 nm process technology, with supply voltage 1 V at 100 MHz frequency and bottleneck operating temperature of 27&deg;C with CL = 1 fF. From the result average power improvement by proposed circuit 1 & 2 for 8 input OR gate is 10.1%, 15.28% SFLD, 48.56%, 51.49% CKD, 55.17%, 57.71% HSD and improvement of delay is 1.10%, 12.76% SFLD, 19.13%, 28.63% CKD, 4.32%, 15.59% HSD, 19.138%, 44.25% DFD respectively. 展开更多
关键词 High Speed Integrated circuit Dynamic logic circuit UNITY Noise Gain (UNG) DOMINO logic circuit Noise Immunity
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Two Analytical Methods for Detection and Elimination of the Static Hazard in Combinational Logic Circuits
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作者 Mihai Grigore Timis Alexandru Valachi +1 位作者 Alexandru Barleanu Andrei Stan 《Circuits and Systems》 2013年第7期466-471,共6页
In this paper, the authors continue the researches described in [1], that consists in a comparative study of two methods to eliminate the static hazard from logical functions, by using the form of Product of Sums (POS... In this paper, the authors continue the researches described in [1], that consists in a comparative study of two methods to eliminate the static hazard from logical functions, by using the form of Product of Sums (POS), static hazard “0”. In the first method, it used the consensus theorem to determine the cover term that is equal with the product of the two residual implicants, and in the second method it resolved a Boolean equation system. The authors observed that in the second method the digital hazard can be earlier detected. If the Boolean equation system is incompatible (doesn’t have solutions), the considered logical function doesn’t have the static 1 hazard regarding the coupled variable. Using the logical computations, this method permits to determine the needed transitions to eliminate the digital hazard. 展开更多
关键词 Combinational circuitS STATIC HAZARD logic Design BOOLEAN Functions
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Tribotronic triggers and sequential logic circuits 被引量:2
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作者 Li Min Zhang Zhi Wei Yang +3 位作者 Yao Kun Pang Tao Zhou Chi Zhang Zhong Lin Wang 《Nano Research》 SCIE EI CAS CSCD 2017年第10期3534-3542,共9页
In this paper, a floating-gate tribotronic transistor (FGTT) based on a mobile triboelectric layer and a traditional silicon-based field-effect transistor (FET) is proposed. In the FGTT, the triboelectric charges ... In this paper, a floating-gate tribotronic transistor (FGTT) based on a mobile triboelectric layer and a traditional silicon-based field-effect transistor (FET) is proposed. In the FGTT, the triboelectric charges in the layer created by contact electrification can be used to modulate charge carrier transport in the transistor. Based on the FGTTs and FETs, a tribotronic negated AND (NAND) gate that achieves mechanical-electrical coupled inputs, logic operations, and electrical level outputs is fabricated. By further integrating tribotronic NAND gates with traditional digital circuits, several basic units such as the tribotronic S-R trigger, D trigger, and T trigger have been demonstrated. Additionally, tribotronic sequential logic circuits such as registers and counters have also been integrated to enable external contact triggered storage and computation. In contrast to the conventional sequential logic units controlled by electrical signals, contact-triggered tribotronic sequential logic circuits are able to realize direct interaction and integration with the external environment. This development can lead to their potential application in micro/nano-sensors, electromechanical storage, interactive control, and intelligent instrumentation. 展开更多
关键词 tribotronics tribotronic transistor triboelectric nanogenerator TRIGGER sequential logic circuits
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On the operating speed and energy efficiency of GaN-based monolithic complementary logic circuits for integrated power conversion systems 被引量:2
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作者 Zheyang Zheng Han Xu +1 位作者 Li Zhang Kevin J.Chen 《Fundamental Research》 CAS 2021年第6期661-671,共11页
Gallium nitride(GaN)-based power conversion systems exhibit striking competitiveness in realizing compact and high-efficiency power management modules.Recently emerging GaN-based p-channel field-effect transistors(FET... Gallium nitride(GaN)-based power conversion systems exhibit striking competitiveness in realizing compact and high-efficiency power management modules.Recently emerging GaN-based p-channel field-effect transistors(FETs)and monolithic integration techniques enable the implementation of GaN-based complementary logic(CL)circuits and thereby offer an additional pathway to improving the system-level energy efficiency and functional-ity.In this article,holistic analyses are conducted to evaluate the potential benefits of introducing GaN CL circuits into the integrated power systems,based on the material limit of GaN and state-of-the-art experimental results.It is revealed that the propagation delay of a single-stage CL gate based on the commercial p-GaN gate power HEMT(high-electron-mobility transistor)platform could be as short as sub-nanosecond,which sufficiently satis-fies the requirement of power conversion systems typically with operating frequencies less than 10 MHz.With the currently adopted n-FET-based logic gates(e.g.,directly coupled FET logic)replaced by CL gates,the power consumption of peripheral logic circuits could be substantially suppressed by more than 10^(3) times,mainly due to the elimination of the pronounced static power loss.Consequently,the energy efficiency of the entire system could be substantially improved. 展开更多
关键词 Gallium nitride Complementary logic circuits Power integration Energy efficiency
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A novel circuit design for complementary resistive switch-based stateful logic operations
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作者 王小平 陈林 +1 位作者 沈轶 徐博文 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第5期461-469,共9页
Recently, it has been demonstrated that memristors can be utilized as logic operations and memory elements. In this paper, we present a novel circuit design for complementary resistive switch(CRS)-based stateful log... Recently, it has been demonstrated that memristors can be utilized as logic operations and memory elements. In this paper, we present a novel circuit design for complementary resistive switch(CRS)-based stateful logic operations. The proposed circuit can automatically write the destructive CRS cells back to the original states. In addition, the circuit can be used in massive passive crossbar arrays which can reduce sneak path current greatly. Moreover, the steps for CRS logic operations using our proposed circuit are reduced compared with previous circuit designs. We validate the effectiveness of our scheme through Hspice simulations on the logic circuits. 展开更多
关键词 MEMRISTOR complementary resistive switch crossbar arrays logic circuits
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An approach to predicting dynamic power dissipation of coupled interconnect network in dynamic CMOS logic circuits
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作者 黄刚 杨华中 +1 位作者 罗嵘 汪蕙 《Science in China(Series F)》 2002年第4期286-298,共13页
In deep submicron (DSM) integrated circuits (IC), coupling capacitors between interconnects become dominant over grounded capacitors. As a result, the dynamic power dissipation of one node is no longer only in relatio... In deep submicron (DSM) integrated circuits (IC), coupling capacitors between interconnects become dominant over grounded capacitors. As a result, the dynamic power dissipation of one node is no longer only in relation to the signal on that node, and it also depends on signals on its neighbor nodes through coupling capacitors. Thus, for their limitation in dealing with ca-pacitively coupled nets, past jobs on power estimation are facing rigorous challenges and need to be ameliorated. This paper proposes and proves a simple and fast approach to predicting dynamic power dissipation of coupled interconnect networks: a coupling capacitor in dynamic CMOS logic circuits is decoupled and mapped into an equivalent cell containing an XOR gate and a grounded capacitor, and the whole circuit after mapping, consuming the same power as the original one, could be easily managed by generally-used gate-level power estimation tools. This paper also investigates the correlation coefficient method (CCM). Given the signal probabilities and the correlation coefficients between signals, the dynamic power of interconnect networks can be calculated by using CCM. It can be proved that the decoupling method and CCM draw identical results, that is to say, the decoupling method implicitly preserves correlation properties between signals and there is no accuracy loss in the decoupling process. Moreover, it is addressed that the coupling capacitors in static CMOS circuits could be decoupled and mapped into an equivalent cell containing a more complicated logic block, and the power can be obtained by the probability method for dynamic CMOS logic circuits. 展开更多
关键词 INTERCONNECT power estimation coupling capacitors correlation coefficient dynamic CMOS logic circuits signal probability.
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OPTIMIZATION OF MULTIPLE-OUTPUT EXCLUSIVE-OR LOGIC CIRCUITS
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作者 张彦仲 《Science China Mathematics》 SCIE 1990年第5期625-633,共9页
A method is presented for optimizing multiple-output exclusive-OR logic circuits. The effect of common gates on the optimization of logic circuits is studied. The concepts of common function, residue function and rema... A method is presented for optimizing multiple-output exclusive-OR logic circuits. The effect of common gates on the optimization of logic circuits is studied. The concepts of common function, residue function and remainder term are introduced. A computer method for searching the optimum polarity is proposed. This method can be used to design the logic circuit which needs the minimum number of exclusive-OR gates. 展开更多
关键词 exclusive-OR logic circuitS optimization.
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Logic Picture-Based Dynamic Power Estimation for Unit Gate-Delay Model CMOS Circuits
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作者 Omnia S. Ahmed Mohamed F. Abu-Elyazeed +2 位作者 Mohamed B. Abdelhalim Hassanein H. Amer Ahmed H. Madian 《Circuits and Systems》 2013年第3期276-279,共4页
In this research, a fast methodology to calculate the exact value of the average dynamic power consumption for CMOS combinational logic circuits is developed. The delay model used is the unit-delay model where all gat... In this research, a fast methodology to calculate the exact value of the average dynamic power consumption for CMOS combinational logic circuits is developed. The delay model used is the unit-delay model where all gates have the same propagation delay. The main advantages of this method over other techniques are its accuracy, as it is deterministic and it requires less computational effort compared to exhaustive simulation approaches. The methodology uses the Logic Pictures concept for obtaining the nodes’ toggle rates. The proposed method is applied to well-known circuits and the results are compared to exhaustive simulation and Monte Carlosimulation methods. 展开更多
关键词 Dynamic Power ESTIMATION logic PICTURES CMOS Digital logic circuits TOGGLE Rate Unit-Delay Model
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Leakage Reduction Using DTSCL and Current Mirror SCL Logic Structures for LP-LV Circuits
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作者 Sanjeev Rai Ram Awadh Mishra Sudarshan Tiwari 《Circuits and Systems》 2013年第1期20-28,共9页
This paper presents a novel approach to design robust Source Coupled Logic (SCL) for implementing ultra low power circuits. In this paper, we propose two different source coupled logic structures and analyze the perfo... This paper presents a novel approach to design robust Source Coupled Logic (SCL) for implementing ultra low power circuits. In this paper, we propose two different source coupled logic structures and analyze the performance of these structures with STSCL (Sub-threshold SCL). The first design under consideration is DTPMOS as load device which analyses the performance of Dynamic Threshold SCL (DTSCL) Logic with previous source coupled logic for ultra low power operation. DTSCL circuits exhibit a better power-delay Performance compared with the STSCL Logic. It can be seen that the proposed circuit provides 56% reduction in power delay product. The second design under consideration uses basic current mirror active load device to provide required voltage swing. Current mirror source coupled logic (CMSCL) can be used for high speed operation. The advantage of this design is that it provides 54% reduction in power delay product over conventional STSCL. The main drawback of this design is that it provides a higher power dissipation compared to other source coupled logic structures. The proposed circuit provides lower sensitivity to temperature and power supply variation, with a superior control over power dissipation. Measurements of test structures simulated in 0.18 μm CMOS technology shows that the proposed DTSCL logic concept can be utilized successfully for bias currents as low as 1 pA. Measurements show that existing standard cell libraries offer a good solution for ultra low power SCL circuits. Cadence Virtuoso schematic editor and Spectre Simulation tools have been used. 展开更多
关键词 CMOS Integrated circuitS CMOS logic circuit Dynamic Threshold MOS (DTMOS) Power-Delay Product Source-Coupled logic (SCL) SUB-THRESHOLD CMOS SUB-THRESHOLD SCL Ultra-Low-Power circuitS Weak Inversion LP-LV(Low Power-Low Voltage)
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基于GT-CA的铁路继电电路逻辑仿真方法研究
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作者 杨明 马亮 +1 位作者 郭进 于楫玉 《中国铁道科学》 北大核心 2025年第4期210-221,共12页
针对现有继电电路分析过程的复杂性和不透明性,以及大规模电路分析困难的问题,提出基于图论(GT)和元胞自动机(CA)的铁路继电电路逻辑功能仿真方法。首先,对继电电路进行形式化描述,并引入短电路概念以简化电路结构;其次,制定将继电电路... 针对现有继电电路分析过程的复杂性和不透明性,以及大规模电路分析困难的问题,提出基于图论(GT)和元胞自动机(CA)的铁路继电电路逻辑功能仿真方法。首先,对继电电路进行形式化描述,并引入短电路概念以简化电路结构;其次,制定将继电电路转化为有向图的规则,并基于基尔霍夫电流定律设计有向图方向的判断规则,构建继电电路的元胞自动机模型并制定其演化规则;最后,通过实际继电电路的测试案例,展示电路的动态执行过程,并与预期执行结果进行对比,以验证仿真方法的正确性和有效性。结果表明:4种测试场景下的仿真过程及结果与预期效果一致,基于GT-CA的铁路继电电路逻辑仿真方法具备准确实现铁路继电电路逻辑功能仿真的能力,可为铁路继电电路的设计校验和故障查找提供理论参考和技术支撑。 展开更多
关键词 铁路继电电路 图论 元胞自动机 逻辑功能仿真
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可重构铁电数据选择器设计及在映射中的应用
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作者 吴乾火 王伦耀 +2 位作者 查晓婧 储著飞 夏银水 《电子与信息学报》 北大核心 2025年第9期3321-3332,共12页
目前以铁电晶体管(FeFET)为基础的存算一体逻辑电路的映射以阵列为主,该文提出一种以铁电晶体管-数据选择器(FeFET-MUX)为基本电路单元存算一体逻辑电路的实现方法。该方法主要包含两方面内容:(1)提出一种可重构的Fe FET-MUX电路,该电... 目前以铁电晶体管(FeFET)为基础的存算一体逻辑电路的映射以阵列为主,该文提出一种以铁电晶体管-数据选择器(FeFET-MUX)为基本电路单元存算一体逻辑电路的实现方法。该方法主要包含两方面内容:(1)提出一种可重构的Fe FET-MUX电路,该电路具有结构共享和数据输入端可扩展的特点。(2)提出适合该Fe FET-MUX映射的逻辑函数分割方法,通过将待实现的逻辑函数表示成二元决策图(BDD),然后将BDD分割成适合FeFETMUX映射的子BDD集合,最后完成逻辑函数用FeFET-MUX的映射。该文所提FeFET-MUX电路的逻辑功能用已有的FeFET模型进行仿真验证,用于映射的BDD分割算法用C++实现。实验结果表明,相比于传统的非结构共享二选一FeFET-MUX电路的映射结果,采用所提结构共享FeFET-MUX电路结合BDD分割算法,FeFET的使用数量平均可以减少79.9%。 展开更多
关键词 逻辑电路映射 存算一体 铁电晶体管电路 数据选择器 二元决策图分割
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基于忆阻器-CMOS的典型组合逻辑电路设计 被引量:2
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作者 吴建新 夏景圆 +2 位作者 王锡胜舜 戴高乐 钟祎 《华中科技大学学报(自然科学版)》 北大核心 2025年第3期127-134,共8页
首先介绍忆阻器的通用模型原理及性能;随后对比例逻辑方法进行改良,优化逻辑单元结构;最后利用新型比例逻辑方法设计编码器、译码器、全加器、数据选择器等逻辑电路,并使用LTSPICE对设计的电路进行仿真验证和性能测试.分析结果表明:设... 首先介绍忆阻器的通用模型原理及性能;随后对比例逻辑方法进行改良,优化逻辑单元结构;最后利用新型比例逻辑方法设计编码器、译码器、全加器、数据选择器等逻辑电路,并使用LTSPICE对设计的电路进行仿真验证和性能测试.分析结果表明:设计的逻辑电路功能正确,具有功耗低、器件数量少的特点,使电路的复杂度大幅降低,为电路设计提供一种新的思路. 展开更多
关键词 忆阻器 互补金属氧化物半导体(CMOS) 逻辑电路 LTSPICE 比例逻辑
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考虑制造缺陷的微电子器件筛选优化研究
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作者 郑志薇 赵冉冉 +2 位作者 陈岑 陈昊 翟国富 《上海航天(中英文)》 2025年第4期112-119,共8页
高可靠的军用微电子器件是航天国防武器质量的基石。设计制造是可靠性的源头,筛选试验是保障可靠性的重要手段。大量的筛选也提高了元器件使用成本,以降低成本为导向的筛选试验优化研究迫在眉睫。目前,国内外已在筛选试验与制造缺陷的... 高可靠的军用微电子器件是航天国防武器质量的基石。设计制造是可靠性的源头,筛选试验是保障可靠性的重要手段。大量的筛选也提高了元器件使用成本,以降低成本为导向的筛选试验优化研究迫在眉睫。目前,国内外已在筛选试验与制造缺陷的相关性领域有许多研究,美国固态技术协会更是给出了通过管控制造缺陷来裁剪优化后期筛选试验的筛选优化标准。本文在解析美国筛选优化标准、剖析与老炼相关的制造缺陷的基础上,结合国产1479支4-16线译码器的生产过程检测数据,分析老炼试验裁剪需要具备的条件。并对动态老炼参数失效的器件和正常器件进行电参数分析。电参数分析结果显示:与一次筛选240 h的动态老炼相比,二次筛选中40 h的动态老炼中器件的输入高电平电流变化量更大;二次筛选中40 h的动态老炼使静态电流显著减小,一次筛选240 h的动态老炼使静态电流显著增大,即动态老炼时长与参数漂移是非线性相关的,并非老炼时长越长对器件的影响越大。电参数分析结果证明了老炼试验时长优化的可能性。 展开更多
关键词 筛选试验 数字逻辑电路 制造缺陷 老炼 时长优化
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肿瘤响应人工基因线路设计及其在溶瘤病毒治疗中的应用
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作者 胡凌风 尹剑丽 +1 位作者 马小丁 叶海峰 《生命科学》 2025年第8期962-971,共10页
传统放化疗及免疫检查点抑制剂仅对部分肿瘤患者有效,嵌合抗原受体T细胞(chimeric antigen receptor T-cell,CAR-T)等细胞疗法在实体瘤中则因缺乏特异性抗原、免疫抑制微环境及组织屏障等因素,疗效受限。大量关键肿瘤标志物位于细胞内部... 传统放化疗及免疫检查点抑制剂仅对部分肿瘤患者有效,嵌合抗原受体T细胞(chimeric antigen receptor T-cell,CAR-T)等细胞疗法在实体瘤中则因缺乏特异性抗原、免疫抑制微环境及组织屏障等因素,疗效受限。大量关键肿瘤标志物位于细胞内部,常规免疫识别策略难以靶及,进一步限制治疗精准性。合成生物学通过模块化设计与人工智能优化,构建“感知-决策-执行”闭环的肿瘤响应型基因线路,借助逻辑门整合乏氧、异常信号通路、肿瘤特异性表达的转录因子和微小RNA(microRNA,miRNA)等多维输入,实现多重判别与高特异性杀伤。溶瘤病毒(oncolytic viruses,OVs)因天然肿瘤趋向性与免疫激活作用,成为实体瘤基因治疗的重要平台。将人工合成基因线路嵌入OVs构建智能溶瘤病毒,可在肿瘤特异环境下精准启动复制与治疗基因表达,并结合光遗传学或小分子开关实现时空调控。本文综述肿瘤响应型基因线路的设计原则,梳理智能溶瘤病毒的转化进展及其与免疫检查点抑制剂、CAR-T和放疗的联合策略,探讨容量受限、全身递送效率低与宿主免疫干扰等挑战,并展望人工智能辅助设计与新型递送平台的发展前景。 展开更多
关键词 肿瘤响应的人工合成基因线路 智能溶瘤病毒 逻辑线路 动态调控 联合治疗
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大尺寸碘化钠制备厂房的联锁控制系统设计
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作者 闫平 李永 +3 位作者 何高魁 王国宝 郑玉来 王强 《自动化仪表》 2025年第2期71-74,共4页
为了解决在制备大尺寸碘化钠晶体过程中可能存在的安全问题,特别是高温环境下晶体制备装置可能产生的化学原料挥发问题,需要设计安全联锁控制系统,以保障试验人员的安全。采用可编程逻辑控制器(PLC)作为主要控制装置,辅以其他监测设备,... 为了解决在制备大尺寸碘化钠晶体过程中可能存在的安全问题,特别是高温环境下晶体制备装置可能产生的化学原料挥发问题,需要设计安全联锁控制系统,以保障试验人员的安全。采用可编程逻辑控制器(PLC)作为主要控制装置,辅以其他监测设备,设计了试验厂房的安全联锁控制系统方案。该系统采用巡检联锁、浓度监测装置联锁以及南北两侧门装置联锁技术,具备操作对象锁定、设备运行状态监测和区域进入限制功能。设计完成后,对联锁系统进行了搭建,并对制备过程中可能遇到的危险情况进行了模拟。在模拟过程中,安全联锁控制系统取得了良好的运行结果,使系统的可行性和可靠性得以验证。该安全联锁控制系统的设计方案对于化工试验安全生产过程具有可靠性,为类似试验的安全设计提供了有效的设计方案。 展开更多
关键词 试验厂房 安全联锁 可编程逻辑控制器 控制电路设计 硬件设计 晶体制备
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基于光电和吸阻综合检测的卷烟二元复合滤棒残缺检测装置
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作者 杨彩虹 潘昱亭 +5 位作者 朱开林 施云霞 丁聪龙 杨壘 曹柱祥 蔡培良 《机电工程技术》 2025年第11期170-174,共5页
为解决香烟生产中二元复合滤棒存在残缺质量而无相关检测对其进行有效检测和剔除等问题,采用光电边缘检测和吸阻检测的综合检测技术,通过光纤直接测量滤棒输送过程中的长度与偏移,结合气压稳压与压力-电压转换模块间接检测烟支滤棒端的... 为解决香烟生产中二元复合滤棒存在残缺质量而无相关检测对其进行有效检测和剔除等问题,采用光电边缘检测和吸阻检测的综合检测技术,通过光纤直接测量滤棒输送过程中的长度与偏移,结合气压稳压与压力-电压转换模块间接检测烟支滤棒端的气流阻力。实验证明,所提方法能有效检测香烟内部滤棒残缺,该方法能有效识别并剔除长度缩短超过5 mm及吸阻超限(大于20 Pa)的残缺滤棒,检测与剔除率高达90%,显著提升了烟支复合滤嘴的质量控制水平。基于光电与吸阻检测方法的综合检测装置实现了对烟支复合滤棒的有效检测,装置创新性地融合了直接测量与间接分析技术,为香烟生产质量监控提供了高效、精准的解决方案,提升了香烟生产的质量控制水平,解决了行业内的实际问题,为卷烟行业的智能化、精细化发展提供了有力支持。 展开更多
关键词 二元复合滤棒 空管烟 光电边缘检测 与门电路逻辑 吸阻 负压检测
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