In this paper, we have demonstrated an Er-doped ultrafast laser with a single mode fiber-gradient index multimode fiber-single mode fiber(SMF-GIMF-SMF, SMS) structure as saturable absorber(SA), which can generate not ...In this paper, we have demonstrated an Er-doped ultrafast laser with a single mode fiber-gradient index multimode fiber-single mode fiber(SMF-GIMF-SMF, SMS) structure as saturable absorber(SA), which can generate not only stable single-pulse state, but also special mode-locked pulses with the characteristics of high energy and noisy behaviors at proper pump power and cavity polarization state. In addition, we have deeply investigated the real-time spectral evolutions of the mode-locked pulses through the dispersive Fourier transformation(DFT) technique. It can be found that the pulse regime can actually consist of a lot of small noise pulses with randomly varying intensities. We believe that these results will further enrich the nonlinear dynamical processes in the ultrafast lasers.展开更多
Synchronized dual-wavelength mode-locked laser is investigated numerically and experimentally in the normal dispersion regime.A programmable optical processor is introduced to shape the spectral profile and adjust the...Synchronized dual-wavelength mode-locked laser is investigated numerically and experimentally in the normal dispersion regime.A programmable optical processor is introduced to shape the spectral profile and adjust the net dispersion,which is demonstrated be a convenient and reliable approach to generate dual-color solitons.The time-stretch dispersive Fourier transform and frequency-resolved optical grating techniques are utilized to measure the spectral and temporal characteristics of dual-color solitons,respectively.The numerical results are consistent with experimental results.This work may facilitate the development of filter-based mode-locked laser and the understanding of multi-wavelength soliton dynamics.展开更多
The spatial constraints of aircraft have accelerated the development of multi-wing deployable mechanisms.These systems enable the rapid,sub-second deployment of multiple folding wings,which generate high-energy impact...The spatial constraints of aircraft have accelerated the development of multi-wing deployable mechanisms.These systems enable the rapid,sub-second deployment of multiple folding wings,which generate high-energy impacts upon locking-resulting in oscillations that can adversely affect aerodynamic performance.Despite their importance,the transient dynamic characteristics during deployment and locking remain insufficiently explored.This study presents an integrated dynamic model for a single-actuator,multi-wing deployable mechanism that accounts for joint clearances,component elasticity,and locking collisions.This model is used to analyze the influence of transient driving on the motion errors of multiple folding wings,the locking oscillation amplitude,and the complete stabilization time.Results indicate that as the driving force and transient deployment speed increase,all dynamic performance characteristics are notably affected.Specifically,raising the transient driving force from 3000 to 7000 N leads to a maximum increase of 60.8%in oscillation amplitude and 78.4%in stabilization time.By comparing the results of the prototype experiment with the theoretical model,it is found that the errors of the maximum locking oscillation amplitude and the complete stabilization time for the three groups of folding wings are all within the acceptable range,which verifies the theoretical model.These findings advance the theoretical understanding of transient deployment dynamics and locking oscillations in high-speed deployable mechanisms.展开更多
Biology is governed by macromolecular interactions,perturbation of which often lies at the heart of disease.Most therapeutic drugs,whether they are small molecules or biologics,exert their effects through impeding suc...Biology is governed by macromolecular interactions,perturbation of which often lies at the heart of disease.Most therapeutic drugs,whether they are small molecules or biologics,exert their effects through impeding such interactions,whether they are of an enzyme with its substrate or a ligand with its receptor.Conversely,a handful of approved drugs and a larger number of candidates in development have the opposite effect:They either activate or inhibit a biological output by stabilizing a preexisting complex through reducing the rate at which its components dissociate(koff).展开更多
As a major fault in the northeastern Qinghai-Xizang Plateau,the Haiyuan fault zone is important for understanding the regional deformation.Aiming at the differences in the slip rate and locking degree obtained from di...As a major fault in the northeastern Qinghai-Xizang Plateau,the Haiyuan fault zone is important for understanding the regional deformation.Aiming at the differences in the slip rate and locking degree obtained from different studies,this study constructs a refined block model(including Qilian,Alxa,Ordos,Xining,Haiyuan,and Lanzhou blocks)and uses the grid search and simulated annealing methods to invert GPS data for slip rate and locking degree of the Haiyuan fault zone.The results are as follows:(1)The sinistral slip rates in the western,middle,and eastern segments are 4.93-5.22 mm/a,1.52-4.94 mm/a,and 0.43-1.18 mm/a,decreasing eastward on the whole,while the compression rates are 0.45-1.26 mm/a,0.58-2.62 mm/a,and3.52-4.48 mm/a,increasing eastward on the whole.(2)The locking depth of the western segment increases from about 5 km to about 20 km eastward;the middle segment decreases and then increases eastward;the eastern segment concentrates at about 20 km(PHI is about 0.86).(3)The slip deficit is relatively higher in the Lenglongling,Jinqianghe,Maomaoshan,and Liupanshan faults(averaging about 3.42 mm/a,4.16 mm/a,4.23 mm/a,and 3.43 mm/a within 20 km).(4)The Qilian,Alxa,Xining,Lanzhou,and Haiyuan blocks rotate clockwise,while the Ordos block rotates counterclockwise.Additionally,by comparing different block models,the Haiyuan block should be considered independently.The Haiyuan fault zone adjusts surrounding block movements and uplifts Liupanshan mountain tectonically.The results can provide important references for understanding the regional earthquake risk and deformation mechanism.展开更多
This study presents an achievement of laser cooling of alkaline-earth atoms in the Chinese Space Station’s strontium(Sr)atomic space optical clock.The system’s core components,physical unit,optical unit,and electric...This study presents an achievement of laser cooling of alkaline-earth atoms in the Chinese Space Station’s strontium(Sr)atomic space optical clock.The system’s core components,physical unit,optical unit,and electrical unit,have a total volume of 306 L and a total mass of 163.8 kg.These compact and robust units can overcome mechanical vibrations and temperature fluctuations during space launch.The laser sources of the optical unit are composed of diode lasers,and the injection locking of slave lasers is automatically performed by a program.In the experiment,a blue magneto-optical trap of cold atoms was achieved,with the atom numbers estimated to be approximately(1.50±0.13)×10^(6) for 87Sr and(8.00±0.56)×10^(6) for 88Sr.This work establishes a foundation for atomic confinement and high-precision interrogation in space-based optical clocks and expands the frontiers of cold atom physics in microgravity.展开更多
In 2018,Baige,Xizang,witnessed two consecutive large-scale landslides,causing significant damage and drawing widespread attention.From March 2011 to February 2018,the Baige landslide exhibited a 50-m displacement with...In 2018,Baige,Xizang,witnessed two consecutive large-scale landslides,causing significant damage and drawing widespread attention.From March 2011 to February 2018,the Baige landslide exhibited a 50-m displacement without complete failure,culminating in a collapse in October 2018.The mechanisms behind its resistance to failure despite substantial deformation and the influence of the complex geo-structure within the tectonic mélange belt remain unclear.To address these questions,this study utilized a multidisciplinary approach,integrating on-site geological field mapping,surface deformation monitoring,multielectrode resistivity method,and deep displacement analysis.The aim was to evaluate the impact of the intricate geo-structure within the tectonic mélange belt on the Baige landslide events.Findings reveal that the landslide's geo-structure consists of structurally fractured,mesh-like rock masses,including heterogeneous lenticular rock masses and intermittent brittle shear zones distributed around the lens-shaped rock masses.The study underscores that the inhomogeneous and weakly deformed lenticular rock masses function as natural locked segments,governing the stability of the Baige landslide.Specifically,the relatively intact and hard granodiorite porphyry play a crucial role in locking the landslide's deformation.Deep displacement analysis indicates that the brittle shear zones act as the sliding surfaces.The progressive destruction of the locked segments and the gradual penetration of brittle shear zones,driven by gravitational potential energy,contribute to the landslide occurrence.This research provides critical insights into the formation mechanisms of large-scale landslides within tectonic mélange belts.展开更多
A cavity magnonic oscillator uses the coupling of a planar transmission line oscillator(cavity) and spin excitations(magnons) in a ferrimagnetic material to achieve superior frequency stability and reduced phase noise...A cavity magnonic oscillator uses the coupling of a planar transmission line oscillator(cavity) and spin excitations(magnons) in a ferrimagnetic material to achieve superior frequency stability and reduced phase noise. Like many low phase noise oscillators, a cavity magnonic oscillator faces the challenge that its narrow resonance profile is not well suited for injection locking amplification. This work presents an improved design for such an oscillator configured as an injection locking amplifier(ILA) with an extended lock range. The proposed design features a two-stage architecture, consisting of a pre-amplification oscillator and a cavity magnonic oscillator, separated by an isolator to prevent backward locking.By optimizing the circuit parameters of each stage, the proposed design achieved an order of magnitude increase in lock range, when compared to its predecessors, all while preserving the phase noise quality of the input, making it well-suited for narrowband, sensitive signal amplification. Furthermore, this work provides a method for using oscillators with high spectral purity as injection locking amplifiers.展开更多
Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers r...Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers remains elusive.We address this problem by managing different physical effects in mode-locked fiber lasers through extensive numerical simulations.We find that net dispersion,linear loss,gain and filter shaping can affect the quality of Nyquist pulses significantly.We also demonstrate that Nyquist pulses experience similariton shaping due to the nonlinear attractor effect in the gain medium.Our work may contribute to the design of Nyquist pulse sources and enrich the understanding of pulse shaping dynamics in mode-locked lasers.展开更多
Dissipative soliton resonance(DSR) was previously studied in separated mode-locked fiber lasers within different dispersion regimes including anomalous, near-zero and normal dispersion. Here we propose a method to stu...Dissipative soliton resonance(DSR) was previously studied in separated mode-locked fiber lasers within different dispersion regimes including anomalous, near-zero and normal dispersion. Here we propose a method to study DSR in a single mode-locked laser in these different dispersion regimes. This is achieved by virtue of a waveshaper which can control the laser dispersion readily using software, avoiding the usual tedious cutback method. We find that dispersion has a negligible effect on DSR since the pulse duration keeps constant while dispersion is varied. Moreover, we examine the dynamics of DSR on the parameters of the SA including modulation depth and saturation power, and find that the pulse duration can be changed in a large range when the saturation power is decreased. Our numerical simulations could be important to guide relative experimental studies.展开更多
This paper proposes a new upper-limb exoskeleton to reduce worker physical strain.The proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a...This paper proposes a new upper-limb exoskeleton to reduce worker physical strain.The proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task posture.The proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight relief.This paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed design.An experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling tasks.The obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.展开更多
Strand displacement reaction enables the construction of enzyme-free DNA reaction networks,thus has been widely applied to DNA circuit and nanotechnology.It has the characteristics of high efficiency,universality and ...Strand displacement reaction enables the construction of enzyme-free DNA reaction networks,thus has been widely applied to DNA circuit and nanotechnology.It has the characteristics of high efficiency,universality and regulatability.However,the existing regulation tools cannot enable effective control of the reaction sequence,which undoubtedly limits the construction of complex nucleic acid circuits.Herein,we developed a regulation tool,toehold lock,and achieved strict control of reaction sequence without loss of the main reaction signal output.Furthermore,we applied the tool to scenarios such as seesaw circuits,AND/OR logic gates,and entropy-driven circuits,and respectively demonstrated its significant superiority compared to the original method.We believe that the proposed toehold lock has greatly optimized the efficiency of DNA strand displacement-based networks,and we anticipate that the tool will be widely used in multiple fields.展开更多
Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external equipment.Therefore,it has the advantages of small size,lo...Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external equipment.Therefore,it has the advantages of small size,low integration costs,and self-locking,which shows great potential for application.However,the conventional single-channel microcavity thermal-locking method that relies solely on internal thermal balance will inevitably be disturbed by the external environment.This limitation affects the locking time and stability.Therefore,in this paper,we propose a new method for closed-loop thermal locking of a dual-channel microcavity.The thermal locking of the signal laser and the thermal regulation of the control laser are carried out respectively by synchronously drawing a dual-path tapered fiber.The theoretical model of the thermal dynamics of the dual-channel microcavity system is established,and the influence of the control-laser power on the thermal locking of the signal laser is confirmed.The deviation between the locking voltage of the signal laser and the set point value is used as a closed-loop feedback parameter to achieve long-term and highly stable mode locking of the signal laser.The results show that in the 2.63 h thermal-locking test,the locking stability is an order of magnitude higher than that of the single tapered fiber.This solution addresses the issue of thermal locking being disrupted by the external environment,and offers new possibilities for important applications such as spectroscopy and micro-optical sensor devices.展开更多
This study reports a passive mode-locked Thulium-Holmium co-doped fiber laser featuring a figure-9 shaped resonator structure.The laser utilizes a nonlinear amplifying loop mirror(NALM)as the mode-locking device.By in...This study reports a passive mode-locked Thulium-Holmium co-doped fiber laser featuring a figure-9 shaped resonator structure.The laser utilizes a nonlinear amplifying loop mirror(NALM)as the mode-locking device.By increasing pump power,the laser’s output evolution was experimentally observed,showing that bright-dark pulse pairs first split into double pulses and then into a second harmonic state.Additionally,the time intervals between bright and dark pulses and between double pulses increased with higher pump power.The RF spectrum of the bright-dark pulse pairs exhibited envelope modulation,with a modulation frequency approximately equal to the reciprocal of the time interval between bright and dark pulses.When the pump power increased from 0.46 W to 0.72 W,the reciprocal of the modulation frequency showed a linear growth trend.These findings contribute to understanding the evolution patterns of bright-dark pulse pairs in passive mode-locked fiber lasers.展开更多
According to the United Nations,a moderately aging society refers to a country where those aged 65 and above exceed 14%of the total population.Data released by the Ministry of Civil Affairs showed that there were 296....According to the United Nations,a moderately aging society refers to a country where those aged 65 and above exceed 14%of the total population.Data released by the Ministry of Civil Affairs showed that there were 296.97 million people aged 60 and above in China by the end of 2023,accounting for 21.1%of the total population.Among them,216.76 million were aged 65 and above,making up 15.4%of the total population.This indicates that China has officially crossed the threshold into a moderately aging society.展开更多
Independent living and housing stability are core principles of the psychiatric recovery process.Only when basic needs such as safe,affordable and permanent housing are met can individuals with serious mental illnesse...Independent living and housing stability are core principles of the psychiatric recovery process.Only when basic needs such as safe,affordable and permanent housing are met can individuals with serious mental illnesses(SMI)reintegrate into their community,consistently engage with mental health services and begin(or restart)recovery.'Yet,post-discharged individuals with SMI and their psychiatric care providers often grapple with where to go after discharge from psychiatric hospitalisation.This question is particularly central in safety-net hospitals serving people affected by severe health disparities with myriad deficits in social determinants of health(SDoH).In this commentary,we aim to shed light on post-discharge challenges related to housing often encountered by safety-net psychiatric hospitals and propose ways to address them.展开更多
Background: Fractures of humeral shaft in adults are common injuries. Humeral shafts non-union either from late presentation after initial treatment by traditional bone setters or failed non-operative orthodox care is...Background: Fractures of humeral shaft in adults are common injuries. Humeral shafts non-union either from late presentation after initial treatment by traditional bone setters or failed non-operative orthodox care is a major problem in this part of the world. This non-union is a major treatment challenge with increased cost of care and morbidity in this part of the world. Humeral shaft non-union can be treated with locked intra-medullary nailing (LIMN) or dynamic compression plating (DCP). Study on comparison of these methods of fixation in this part of the world is scarce in literature search, hence the reason for this study. Objective: The objectives of this study are: (1) to compare early clinical outcome following fixation of humeral shaft fracture nonunion with DCP versus LIMN;(2) to compare the time of radiologic fracture union of DCP with LIMN;(3) to compare complications following fixation of humeral shaft fracture nonunion with DCP versus LIMN. Patients and Methods: This was a randomized control study done for 2 years in which fifty adult patients with humeral shaft non-union were recruited. The patients were grouped into 2 (P = DCP & N = LIMN). Forty five of the patients completed the follow up periods of the study and then analyzed. The P group had ORIF with DCP while the N group had ORIF with LIMN. Both groups had grafting with cancellous bones. Each patient was followed up for a period of 6 months at the time which radiographic union is expected. Any patient without clinical and/or radiographic evidence of union after six months of surgery was diagnosed as having recurrent non-union. The data generated was analyzed using SPSS Version 23. The results were presented in charts and tables. The paired t-test was used while considering p value Result: Forty five patients completed follow up. There was a male preponderance (4:1), right humerus predominated (3:2). Motor vehicular accidents were the commonest cause of the fractures (62%). Most non-union fractures occurred at the level of the middle 3<sup>rd</sup> of the humeral shaft (60%). Failed TBS treatment was the commonest indication for the osteosynthesis (71%). More patients had plating (53%) compared to 47% who had LIMN. Most patients (93.4%) had union between 3 to 6 months irrespective of fixation type with no significant statistical difference between the union rate of DCP and LIMN (p value 0.06) with similar functional outcome and complication rates irrespective of the type of fixation. Conclusion: This study showed that the success rates in term of fracture union, outcome functional grades and complication rates were not directly dependent on the types of the fixation: plating or locked intra-medullary nailing.展开更多
The optoelectronic oscillator(OEO)is a typical time-delay system with rich nonlinear dynamical characteristics.Most of the previous research on OEOs has been focused on analyzing the properties of OEOs with a long tim...The optoelectronic oscillator(OEO)is a typical time-delay system with rich nonlinear dynamical characteristics.Most of the previous research on OEOs has been focused on analyzing the properties of OEOs with a long time delay,which makes it difficult to realize mode locking without additional phaselocking mechanisms.We have achieved,for the first time to our knowledge,a self-mode-locking OEO and generated stable microwave frequency combs by analyzing the characteristics of OEOs with an ultrashort time scale.In the experiment,the self-mode-locking OEOs with fundamental mode,second-order harmonic,and sixth-order harmonic were realized by adjusting the system parameters,all of which produced uniform square wave signals with tunable duty cycles,steep rising and falling edges,and periods of less than 20 ns.The self-fundamental-mode-locking OEOs with different time delays were also implemented and experimentally realized.Furthermore,the experiment revealed the self-hybrid mode-locking OEO,which is the coexistence and synchronization of the three measured self-locking modes in one OEO cavity,demonstrating the complex nonlinear dynamical behaviors of the OEO system and enabling the generation of periodic nonuniform hybrid square wave signals.The realization of the self-mode-locking OEO and the generation of flexible and stable square wave signals at ultrashort time scales enrich the study of OEO nonlinear dynamics in the realm of complex microwave waveform generation,offering promising applications in areas such as atomic clocks,radars,communications,and optoelectronic neural networks.展开更多
In this paper,three magnetrons with each of them having specifically designed multiple coupling ports,which deliver specific power distribution for developing a magnetron array based on efficient phase locking between...In this paper,three magnetrons with each of them having specifically designed multiple coupling ports,which deliver specific power distribution for developing a magnetron array based on efficient phase locking between them,are proposed to produce high powerμs-level pulses.To demonstrate the effectiveness of the magnetron with one and two coupling ports as a unit for efficient phase locking,we designed experimentally the coupling ports delivering~10%(the power distribution ratio)of the output power of the magnetron for coupling with other magnetron units.The effect of one and two coupling ports on the operating capability,including the power distribution ratio,anode current and frequency,is demonstrated by establishing an equivalent experimental model which can characterize an ideal operation of the array.The experimental results show that the power distribution ratio is~9%for the magnetron with one coupling port,and~12.5%(coupling port 1,2)for the magnetron with two coupling ports.This shows good uniformity of the coupling capability of the two coupling ports and provides guidance for optimizing the power distribution ratio of multiport magnetron units,which are critical for efficient phase locking in the proposed array in future and higher power arrays.展开更多
To compare the clinical efficacy of locking plate(LP)fixation and intramedullary nail(IMN)fixation for the treatment of post-traumatic nonunion of diaphyseal fractures of the femur and tibia.Methods:This single-center...To compare the clinical efficacy of locking plate(LP)fixation and intramedullary nail(IMN)fixation for the treatment of post-traumatic nonunion of diaphyseal fractures of the femur and tibia.Methods:This single-center retrospective comparative study included 50 adult patients with aseptic nonunion of femoral or tibial diaphyseal fractures treated at our institution between January 2015 and January 2025.Patients underwent either locking-plate(LP)fixation(n=25)or intramedullary nailing(IMN)(n=25).The primary outcome was radiographic union at 12 months postoperatively.Secondary outcomes included time to union,operative time,intraoperative blood loss,length of hospital stay,incidence of complications(superficial/deep infection,implant failure,malunion),and 12-month functional status assessed by the Lower Extremity Functional Scale(LEFS).Statistical comparisons used Welch t tests for continuous variables andχ²or Fisher exact tests for categorical variables.The protocol received institutional review board approval with waiver of informed consent.Results:Among 50 patients(LP=25;IMN=25),the 12-month union rate was 88.00%(22/25)in the LP group and 96.00%(24/25)in the IMN group(p=0.609).Time to union was shorter with IMN(6.20±1.83 vs 7.51±2.12 months;p=0.023).Operative time(110.52±25.23 vs 145.81±30.21 min;p<0.01)and intraoperative blood loss(250.41±80.64 vs 350.22±95.30 ml;p<0.01)favored IMN.Length of hospital stay was similar(6.24±1.83 vs 6.82±2.11 days;p=0.284).The incidence of superficial wound infection did not differ significantly(12.00%vs 4.00%;p=0.609).Twelve-month LEFS scores were comparable(65.44±10.21 vs 67.10±9.83;p=0.451).Conclusion:Both locking plate and intramedullary nail fixation are effective in the treatment of femoral and tibial nonunion,with high rates of union and good functional outcomes.Intramedullary nailing may be associated with a shorter time to union,reduced operative time and blood loss,and a lower risk of superficial wound infection compared to locking plate fixation.The choice of implant should be individualized based on fracture characteristics,patient factors,and surgeon preference.展开更多
基金supported by the Guangdong Basic and Applied Basic Research Foundation (No.2023A1515010093)the Shenzhen Fundamental Research Program (Stable Support Plan Program)(Nos.JCYJ20220809170611004, 20231121110828001 and 20231121113641002)the National Taipei University of Technology-Shenzhen University Joint Research Program (No.2024001)。
文摘In this paper, we have demonstrated an Er-doped ultrafast laser with a single mode fiber-gradient index multimode fiber-single mode fiber(SMF-GIMF-SMF, SMS) structure as saturable absorber(SA), which can generate not only stable single-pulse state, but also special mode-locked pulses with the characteristics of high energy and noisy behaviors at proper pump power and cavity polarization state. In addition, we have deeply investigated the real-time spectral evolutions of the mode-locked pulses through the dispersive Fourier transformation(DFT) technique. It can be found that the pulse regime can actually consist of a lot of small noise pulses with randomly varying intensities. We believe that these results will further enrich the nonlinear dynamical processes in the ultrafast lasers.
基金Project supported by the Innovation Program for Quantum Science and Technology(Grant No.2023ZD0301000)the National Natural Science Foundation of China(Grant Nos.12434018,62475073,1243000542,11621404,11561121003,11727812,61775059,12074122,62405090,62035005,and 11704123)+1 种基金the Natural Science Foundation of Shanghai(Grant No.23ZR1419000)China Postdoctoral Science Foundation(Grant Nos.2023M741188 and 2024T170275)。
文摘Synchronized dual-wavelength mode-locked laser is investigated numerically and experimentally in the normal dispersion regime.A programmable optical processor is introduced to shape the spectral profile and adjust the net dispersion,which is demonstrated be a convenient and reliable approach to generate dual-color solitons.The time-stretch dispersive Fourier transform and frequency-resolved optical grating techniques are utilized to measure the spectral and temporal characteristics of dual-color solitons,respectively.The numerical results are consistent with experimental results.This work may facilitate the development of filter-based mode-locked laser and the understanding of multi-wavelength soliton dynamics.
基金Supported by National Natural Science Foundation of China(Grant Nos.52192634,92471202,52105013,U2341237,T2388101).
文摘The spatial constraints of aircraft have accelerated the development of multi-wing deployable mechanisms.These systems enable the rapid,sub-second deployment of multiple folding wings,which generate high-energy impacts upon locking-resulting in oscillations that can adversely affect aerodynamic performance.Despite their importance,the transient dynamic characteristics during deployment and locking remain insufficiently explored.This study presents an integrated dynamic model for a single-actuator,multi-wing deployable mechanism that accounts for joint clearances,component elasticity,and locking collisions.This model is used to analyze the influence of transient driving on the motion errors of multiple folding wings,the locking oscillation amplitude,and the complete stabilization time.Results indicate that as the driving force and transient deployment speed increase,all dynamic performance characteristics are notably affected.Specifically,raising the transient driving force from 3000 to 7000 N leads to a maximum increase of 60.8%in oscillation amplitude and 78.4%in stabilization time.By comparing the results of the prototype experiment with the theoretical model,it is found that the errors of the maximum locking oscillation amplitude and the complete stabilization time for the three groups of folding wings are all within the acceptable range,which verifies the theoretical model.These findings advance the theoretical understanding of transient deployment dynamics and locking oscillations in high-speed deployable mechanisms.
文摘Biology is governed by macromolecular interactions,perturbation of which often lies at the heart of disease.Most therapeutic drugs,whether they are small molecules or biologics,exert their effects through impeding such interactions,whether they are of an enzyme with its substrate or a ligand with its receptor.Conversely,a handful of approved drugs and a larger number of candidates in development have the opposite effect:They either activate or inhibit a biological output by stabilizing a preexisting complex through reducing the rate at which its components dissociate(koff).
基金supported by the National Natural Science Foundation of China(42474003,42074007)the Fundamental Research Funds for the Central Universities(2042023kfyq01)。
文摘As a major fault in the northeastern Qinghai-Xizang Plateau,the Haiyuan fault zone is important for understanding the regional deformation.Aiming at the differences in the slip rate and locking degree obtained from different studies,this study constructs a refined block model(including Qilian,Alxa,Ordos,Xining,Haiyuan,and Lanzhou blocks)and uses the grid search and simulated annealing methods to invert GPS data for slip rate and locking degree of the Haiyuan fault zone.The results are as follows:(1)The sinistral slip rates in the western,middle,and eastern segments are 4.93-5.22 mm/a,1.52-4.94 mm/a,and 0.43-1.18 mm/a,decreasing eastward on the whole,while the compression rates are 0.45-1.26 mm/a,0.58-2.62 mm/a,and3.52-4.48 mm/a,increasing eastward on the whole.(2)The locking depth of the western segment increases from about 5 km to about 20 km eastward;the middle segment decreases and then increases eastward;the eastern segment concentrates at about 20 km(PHI is about 0.86).(3)The slip deficit is relatively higher in the Lenglongling,Jinqianghe,Maomaoshan,and Liupanshan faults(averaging about 3.42 mm/a,4.16 mm/a,4.23 mm/a,and 3.43 mm/a within 20 km).(4)The Qilian,Alxa,Xining,Lanzhou,and Haiyuan blocks rotate clockwise,while the Ordos block rotates counterclockwise.Additionally,by comparing different block models,the Haiyuan block should be considered independently.The Haiyuan fault zone adjusts surrounding block movements and uplifts Liupanshan mountain tectonically.The results can provide important references for understanding the regional earthquake risk and deformation mechanism.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB35010202)the National Natural Science Foundation of China(Grants No.62275268)。
文摘This study presents an achievement of laser cooling of alkaline-earth atoms in the Chinese Space Station’s strontium(Sr)atomic space optical clock.The system’s core components,physical unit,optical unit,and electrical unit,have a total volume of 306 L and a total mass of 163.8 kg.These compact and robust units can overcome mechanical vibrations and temperature fluctuations during space launch.The laser sources of the optical unit are composed of diode lasers,and the injection locking of slave lasers is automatically performed by a program.In the experiment,a blue magneto-optical trap of cold atoms was achieved,with the atom numbers estimated to be approximately(1.50±0.13)×10^(6) for 87Sr and(8.00±0.56)×10^(6) for 88Sr.This work establishes a foundation for atomic confinement and high-precision interrogation in space-based optical clocks and expands the frontiers of cold atom physics in microgravity.
基金supported by the National Major Scientific Instruments and Equipment Development Projects of China(No.41827808)the Major Program of the National Natural Science Foundation of China(No.42090055)Supported by Science and Technology Projects of Xizang Autonomous Region,China(No.XZ202402ZD0001)。
文摘In 2018,Baige,Xizang,witnessed two consecutive large-scale landslides,causing significant damage and drawing widespread attention.From March 2011 to February 2018,the Baige landslide exhibited a 50-m displacement without complete failure,culminating in a collapse in October 2018.The mechanisms behind its resistance to failure despite substantial deformation and the influence of the complex geo-structure within the tectonic mélange belt remain unclear.To address these questions,this study utilized a multidisciplinary approach,integrating on-site geological field mapping,surface deformation monitoring,multielectrode resistivity method,and deep displacement analysis.The aim was to evaluate the impact of the intricate geo-structure within the tectonic mélange belt on the Baige landslide events.Findings reveal that the landslide's geo-structure consists of structurally fractured,mesh-like rock masses,including heterogeneous lenticular rock masses and intermittent brittle shear zones distributed around the lens-shaped rock masses.The study underscores that the inhomogeneous and weakly deformed lenticular rock masses function as natural locked segments,governing the stability of the Baige landslide.Specifically,the relatively intact and hard granodiorite porphyry play a crucial role in locking the landslide's deformation.Deep displacement analysis indicates that the brittle shear zones act as the sliding surfaces.The progressive destruction of the locked segments and the gradual penetration of brittle shear zones,driven by gravitational potential energy,contribute to the landslide occurrence.This research provides critical insights into the formation mechanisms of large-scale landslides within tectonic mélange belts.
基金funded by NSERC Discovery Grants, NSERC Discovery Accelerator Supplements, Innovation Proof-of-Concept Grant of Research Manitoba, and Faculty of Science Research Innovation and Commercialization Grant of University of Manitoba (C.-M.H.)。
文摘A cavity magnonic oscillator uses the coupling of a planar transmission line oscillator(cavity) and spin excitations(magnons) in a ferrimagnetic material to achieve superior frequency stability and reduced phase noise. Like many low phase noise oscillators, a cavity magnonic oscillator faces the challenge that its narrow resonance profile is not well suited for injection locking amplification. This work presents an improved design for such an oscillator configured as an injection locking amplifier(ILA) with an extended lock range. The proposed design features a two-stage architecture, consisting of a pre-amplification oscillator and a cavity magnonic oscillator, separated by an isolator to prevent backward locking.By optimizing the circuit parameters of each stage, the proposed design achieved an order of magnitude increase in lock range, when compared to its predecessors, all while preserving the phase noise quality of the input, making it well-suited for narrowband, sensitive signal amplification. Furthermore, this work provides a method for using oscillators with high spectral purity as injection locking amplifiers.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11621404,11561121003,11727812,61775059,12074122,62022033,and 11704123)Shanghai Rising-Star Program,the Sustainedly Supported Foundation by the National Key Laboratory of Science and Technology on Space Microwave(Grant No.HTKT2022KL504008)+1 种基金Shanghai Natural Science Foundation(Grant No.23ZR1419000)the National Key Laboratory Foundation of China(Grant No.6142411196307).
文摘Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers remains elusive.We address this problem by managing different physical effects in mode-locked fiber lasers through extensive numerical simulations.We find that net dispersion,linear loss,gain and filter shaping can affect the quality of Nyquist pulses significantly.We also demonstrate that Nyquist pulses experience similariton shaping due to the nonlinear attractor effect in the gain medium.Our work may contribute to the design of Nyquist pulse sources and enrich the understanding of pulse shaping dynamics in mode-locked lasers.
基金Project supported by the Innovation Program for Quantum Science and Technology(Grant No.2023ZD0301000)the National Natural Science Foundation of China(Grant Nos.11621404,11561121003,11727812,61775059,12074122,62022033,and 11704123)+2 种基金Sustainedly supported by the National Key Laboratory of Science and Technology on Space Microwave(Grant No.HTKT2022KL504008)the Shanghai Natural Science Foundation(Grant No.23ZR1419000)the National Key Laboratory Foundation of China(Grant No.6142411196307)。
文摘Dissipative soliton resonance(DSR) was previously studied in separated mode-locked fiber lasers within different dispersion regimes including anomalous, near-zero and normal dispersion. Here we propose a method to study DSR in a single mode-locked laser in these different dispersion regimes. This is achieved by virtue of a waveshaper which can control the laser dispersion readily using software, avoiding the usual tedious cutback method. We find that dispersion has a negligible effect on DSR since the pulse duration keeps constant while dispersion is varied. Moreover, we examine the dynamics of DSR on the parameters of the SA including modulation depth and saturation power, and find that the pulse duration can be changed in a large range when the saturation power is decreased. Our numerical simulations could be important to guide relative experimental studies.
基金supported by the European Regional Development Fund and the Romanian Government through the Competitiveness Operational Programme 2014-2020project APOLLO,MySMIS code 155988,contract no.9/1.2.1-PTIap.2/23.02.2023.
文摘This paper proposes a new upper-limb exoskeleton to reduce worker physical strain.The proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task posture.The proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight relief.This paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed design.An experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling tasks.The obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.
基金the financial support from the National Key Research and Development Program of China(No.2021YFC2701402)the Open Research Fund of State Key Laboratory of Bioelectronics,Southeast University(No.Sklb2021-k06)+2 种基金the Open Foundation of NHC Key Laboratory of Birth Defect for Research and Prevention(Hunan Provincial Maternal and Child Health Care Hospital)(No.KF2020007)Hunan Province Assisted Reproduction and Regenerative Medicine Clinical Demonstration Center Funded Project(No.2020SK4019)the Open Foundation of Translational Medicine National Science and Technology Infrastructure(Shanghai)(No.TMSK-2021-141)。
文摘Strand displacement reaction enables the construction of enzyme-free DNA reaction networks,thus has been widely applied to DNA circuit and nanotechnology.It has the characteristics of high efficiency,universality and regulatability.However,the existing regulation tools cannot enable effective control of the reaction sequence,which undoubtedly limits the construction of complex nucleic acid circuits.Herein,we developed a regulation tool,toehold lock,and achieved strict control of reaction sequence without loss of the main reaction signal output.Furthermore,we applied the tool to scenarios such as seesaw circuits,AND/OR logic gates,and entropy-driven circuits,and respectively demonstrated its significant superiority compared to the original method.We believe that the proposed toehold lock has greatly optimized the efficiency of DNA strand displacement-based networks,and we anticipate that the tool will be widely used in multiple fields.
基金Project supported by the National Key Research and Development Program of China(Grant No.2022YFB3203400)the National Natural Science Foundation of China(Grant Nos.U21A20141,62273314,and 51821003)+1 种基金the Fundamental Research Program of Shanxi Province(Grant No.202303021223001)Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement(Grant No.201905D121001)。
文摘Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external equipment.Therefore,it has the advantages of small size,low integration costs,and self-locking,which shows great potential for application.However,the conventional single-channel microcavity thermal-locking method that relies solely on internal thermal balance will inevitably be disturbed by the external environment.This limitation affects the locking time and stability.Therefore,in this paper,we propose a new method for closed-loop thermal locking of a dual-channel microcavity.The thermal locking of the signal laser and the thermal regulation of the control laser are carried out respectively by synchronously drawing a dual-path tapered fiber.The theoretical model of the thermal dynamics of the dual-channel microcavity system is established,and the influence of the control-laser power on the thermal locking of the signal laser is confirmed.The deviation between the locking voltage of the signal laser and the set point value is used as a closed-loop feedback parameter to achieve long-term and highly stable mode locking of the signal laser.The results show that in the 2.63 h thermal-locking test,the locking stability is an order of magnitude higher than that of the single tapered fiber.This solution addresses the issue of thermal locking being disrupted by the external environment,and offers new possibilities for important applications such as spectroscopy and micro-optical sensor devices.
文摘This study reports a passive mode-locked Thulium-Holmium co-doped fiber laser featuring a figure-9 shaped resonator structure.The laser utilizes a nonlinear amplifying loop mirror(NALM)as the mode-locking device.By increasing pump power,the laser’s output evolution was experimentally observed,showing that bright-dark pulse pairs first split into double pulses and then into a second harmonic state.Additionally,the time intervals between bright and dark pulses and between double pulses increased with higher pump power.The RF spectrum of the bright-dark pulse pairs exhibited envelope modulation,with a modulation frequency approximately equal to the reciprocal of the time interval between bright and dark pulses.When the pump power increased from 0.46 W to 0.72 W,the reciprocal of the modulation frequency showed a linear growth trend.These findings contribute to understanding the evolution patterns of bright-dark pulse pairs in passive mode-locked fiber lasers.
文摘According to the United Nations,a moderately aging society refers to a country where those aged 65 and above exceed 14%of the total population.Data released by the Ministry of Civil Affairs showed that there were 296.97 million people aged 60 and above in China by the end of 2023,accounting for 21.1%of the total population.Among them,216.76 million were aged 65 and above,making up 15.4%of the total population.This indicates that China has officially crossed the threshold into a moderately aging society.
文摘Independent living and housing stability are core principles of the psychiatric recovery process.Only when basic needs such as safe,affordable and permanent housing are met can individuals with serious mental illnesses(SMI)reintegrate into their community,consistently engage with mental health services and begin(or restart)recovery.'Yet,post-discharged individuals with SMI and their psychiatric care providers often grapple with where to go after discharge from psychiatric hospitalisation.This question is particularly central in safety-net hospitals serving people affected by severe health disparities with myriad deficits in social determinants of health(SDoH).In this commentary,we aim to shed light on post-discharge challenges related to housing often encountered by safety-net psychiatric hospitals and propose ways to address them.
文摘Background: Fractures of humeral shaft in adults are common injuries. Humeral shafts non-union either from late presentation after initial treatment by traditional bone setters or failed non-operative orthodox care is a major problem in this part of the world. This non-union is a major treatment challenge with increased cost of care and morbidity in this part of the world. Humeral shaft non-union can be treated with locked intra-medullary nailing (LIMN) or dynamic compression plating (DCP). Study on comparison of these methods of fixation in this part of the world is scarce in literature search, hence the reason for this study. Objective: The objectives of this study are: (1) to compare early clinical outcome following fixation of humeral shaft fracture nonunion with DCP versus LIMN;(2) to compare the time of radiologic fracture union of DCP with LIMN;(3) to compare complications following fixation of humeral shaft fracture nonunion with DCP versus LIMN. Patients and Methods: This was a randomized control study done for 2 years in which fifty adult patients with humeral shaft non-union were recruited. The patients were grouped into 2 (P = DCP & N = LIMN). Forty five of the patients completed the follow up periods of the study and then analyzed. The P group had ORIF with DCP while the N group had ORIF with LIMN. Both groups had grafting with cancellous bones. Each patient was followed up for a period of 6 months at the time which radiographic union is expected. Any patient without clinical and/or radiographic evidence of union after six months of surgery was diagnosed as having recurrent non-union. The data generated was analyzed using SPSS Version 23. The results were presented in charts and tables. The paired t-test was used while considering p value Result: Forty five patients completed follow up. There was a male preponderance (4:1), right humerus predominated (3:2). Motor vehicular accidents were the commonest cause of the fractures (62%). Most non-union fractures occurred at the level of the middle 3<sup>rd</sup> of the humeral shaft (60%). Failed TBS treatment was the commonest indication for the osteosynthesis (71%). More patients had plating (53%) compared to 47% who had LIMN. Most patients (93.4%) had union between 3 to 6 months irrespective of fixation type with no significant statistical difference between the union rate of DCP and LIMN (p value 0.06) with similar functional outcome and complication rates irrespective of the type of fixation. Conclusion: This study showed that the success rates in term of fracture union, outcome functional grades and complication rates were not directly dependent on the types of the fixation: plating or locked intra-medullary nailing.
基金supported by the National Natural Science Foundation of China(Grant No.62301495)the Project of the National Key Laboratory of Microwave Photonics(Nanjing University of Aeronautics and Astronautics),Ministry of Education(Grant No.NJ20220007).
文摘The optoelectronic oscillator(OEO)is a typical time-delay system with rich nonlinear dynamical characteristics.Most of the previous research on OEOs has been focused on analyzing the properties of OEOs with a long time delay,which makes it difficult to realize mode locking without additional phaselocking mechanisms.We have achieved,for the first time to our knowledge,a self-mode-locking OEO and generated stable microwave frequency combs by analyzing the characteristics of OEOs with an ultrashort time scale.In the experiment,the self-mode-locking OEOs with fundamental mode,second-order harmonic,and sixth-order harmonic were realized by adjusting the system parameters,all of which produced uniform square wave signals with tunable duty cycles,steep rising and falling edges,and periods of less than 20 ns.The self-fundamental-mode-locking OEOs with different time delays were also implemented and experimentally realized.Furthermore,the experiment revealed the self-hybrid mode-locking OEO,which is the coexistence and synchronization of the three measured self-locking modes in one OEO cavity,demonstrating the complex nonlinear dynamical behaviors of the OEO system and enabling the generation of periodic nonuniform hybrid square wave signals.The realization of the self-mode-locking OEO and the generation of flexible and stable square wave signals at ultrashort time scales enrich the study of OEO nonlinear dynamics in the realm of complex microwave waveform generation,offering promising applications in areas such as atomic clocks,radars,communications,and optoelectronic neural networks.
基金This work is supported in part by National Natural Science Foundation of China(No.62401125)Natural Science Foundation of Sichuan Province(No.2023NSFSC1376)Fundamental Research Funds for the Central Universities(No.ZYGX2024J008)。
文摘In this paper,three magnetrons with each of them having specifically designed multiple coupling ports,which deliver specific power distribution for developing a magnetron array based on efficient phase locking between them,are proposed to produce high powerμs-level pulses.To demonstrate the effectiveness of the magnetron with one and two coupling ports as a unit for efficient phase locking,we designed experimentally the coupling ports delivering~10%(the power distribution ratio)of the output power of the magnetron for coupling with other magnetron units.The effect of one and two coupling ports on the operating capability,including the power distribution ratio,anode current and frequency,is demonstrated by establishing an equivalent experimental model which can characterize an ideal operation of the array.The experimental results show that the power distribution ratio is~9%for the magnetron with one coupling port,and~12.5%(coupling port 1,2)for the magnetron with two coupling ports.This shows good uniformity of the coupling capability of the two coupling ports and provides guidance for optimizing the power distribution ratio of multiport magnetron units,which are critical for efficient phase locking in the proposed array in future and higher power arrays.
文摘To compare the clinical efficacy of locking plate(LP)fixation and intramedullary nail(IMN)fixation for the treatment of post-traumatic nonunion of diaphyseal fractures of the femur and tibia.Methods:This single-center retrospective comparative study included 50 adult patients with aseptic nonunion of femoral or tibial diaphyseal fractures treated at our institution between January 2015 and January 2025.Patients underwent either locking-plate(LP)fixation(n=25)or intramedullary nailing(IMN)(n=25).The primary outcome was radiographic union at 12 months postoperatively.Secondary outcomes included time to union,operative time,intraoperative blood loss,length of hospital stay,incidence of complications(superficial/deep infection,implant failure,malunion),and 12-month functional status assessed by the Lower Extremity Functional Scale(LEFS).Statistical comparisons used Welch t tests for continuous variables andχ²or Fisher exact tests for categorical variables.The protocol received institutional review board approval with waiver of informed consent.Results:Among 50 patients(LP=25;IMN=25),the 12-month union rate was 88.00%(22/25)in the LP group and 96.00%(24/25)in the IMN group(p=0.609).Time to union was shorter with IMN(6.20±1.83 vs 7.51±2.12 months;p=0.023).Operative time(110.52±25.23 vs 145.81±30.21 min;p<0.01)and intraoperative blood loss(250.41±80.64 vs 350.22±95.30 ml;p<0.01)favored IMN.Length of hospital stay was similar(6.24±1.83 vs 6.82±2.11 days;p=0.284).The incidence of superficial wound infection did not differ significantly(12.00%vs 4.00%;p=0.609).Twelve-month LEFS scores were comparable(65.44±10.21 vs 67.10±9.83;p=0.451).Conclusion:Both locking plate and intramedullary nail fixation are effective in the treatment of femoral and tibial nonunion,with high rates of union and good functional outcomes.Intramedullary nailing may be associated with a shorter time to union,reduced operative time and blood loss,and a lower risk of superficial wound infection compared to locking plate fixation.The choice of implant should be individualized based on fracture characteristics,patient factors,and surgeon preference.
