Phishing emails have experienced a rapid surge in cyber threats globally,especially following the emergence of the COVID-19 pandemic.This form of attack has led to substantial financial losses for numerous organizatio...Phishing emails have experienced a rapid surge in cyber threats globally,especially following the emergence of the COVID-19 pandemic.This form of attack has led to substantial financial losses for numerous organizations.Although variousmodels have been constructed to differentiate legitimate emails fromphishing attempts,attackers continuously employ novel strategies to manipulate their targets into falling victim to their schemes.This form of attack has led to substantial financial losses for numerous organizations.While efforts are ongoing to create phishing detection models,their current level of accuracy and speed in identifying phishing emails is less than satisfactory.Additionally,there has been a concerning rise in the frequency of phished emails recently.Consequently,there is a pressing need for more efficient and high-performing phishing detection models to mitigate the adverse impact of such fraudulent messages.In the context of this research,a comprehensive analysis is conducted on both components of an email message—namely,the email header and body.Sentence-level characteristics are extracted and leveraged in the construction of a new phishing detection model.This model utilizes K Nearest Neighbor(KNN)introducing the novel dimension of sentence-level analysis.Established datasets fromKagglewere employed to train and validate the model.The evaluation of this model’s effectiveness relies on key performance metrics including accuracy of 0.97,precision,recall,and F1-measure.展开更多
[Objectives]To detect content of Pb,Cd,Hg,As,Cu,Zn,and Cr in Lysimachia christinae,and to analyze the pollution level.[Methods]Seven kinds of elements in L.christinae were determined by Inductively coupled plasma mass...[Objectives]To detect content of Pb,Cd,Hg,As,Cu,Zn,and Cr in Lysimachia christinae,and to analyze the pollution level.[Methods]Seven kinds of elements in L.christinae were determined by Inductively coupled plasma mass spectrometry and analyzed by single index and comprehensive index.[Results]The seven heavy metal elements showed good linearity in their respective concentration ranges.The recoveries of the samples were 84.5%-109.5%,and the RSD values were 2.30%-5.10%.Comparing the measured results of heavy metal elements with the limit values stipulated in the 2020 edition of the Chinese Pharmacopoeia and other standards,the Cr element in 19 batches of samples exceeded the standard,and the Zn element in 7 batches of samples exceeded the standard.The exceeding rates were 100.0%and 36.8%,respectively;the content of other heavy metal elements did not exceed the standard.The order of individual index from large to small was Cr,Zn,Cd,Hg,Cu,As,and Pb,and the average comprehensive pollution level was mild pollution and above.[Conclusions]L.christinae was mainly polluted by Cr,followed by Zn;this study can provide basic data for drafting of the limit standard for heavy metal elements in L.christinae.展开更多
Glycidyl methaerylate (GMA) is a recently recognized chemical mutagen. In order to explore the mutagenicity and mutagenic process of GMA, plasmid pBR322 was used for in vitro binding, mutant screening, and restriction...Glycidyl methaerylate (GMA) is a recently recognized chemical mutagen. In order to explore the mutagenicity and mutagenic process of GMA, plasmid pBR322 was used for in vitro binding, mutant screening, and restriction enzyme mapping. The binding between GMA and DNA in vitro has been verified by means of a spectrophotometric method. When pBR322 and GMAbound pBR322 were used to transform Eschenchia coli HB101, the following results were obtained: (1) The transformation efficiency of GMA-bound pBR322 was much lower than that of pBR322 alone. (2) GMA-bound pBR322 induced phenotype changes in competent cells (i.e., tetracycline-resistance inactivation or ampicillin-resistance inactivation). There were two mutants of pBR322, Ap~RTc~S and Ap~STc~R, in the transformants and a deductive mutant Ap~STc~S in the nontranstormants. (3) All of the selected mutants were stable and heritable. (4) When restriction enzyme maps were used to analyze the mutant Ap~RTc~S, four of seven maps were changed. some sites were shifted to other resistant gene regions, for example, sites of Bgll, EcoRl, Ilindlll. Hinclll, etc., and there was a new recognition site for Hindi (252). We did not observe any DNA fragment insertion or deletion on any maps. Our results suggest that when GMA is covalently linked to the plasmid DNA, it gives rise to a premutagenic lesion of DNA that is converted in vivo into a point mutation. (C)1990 Academic Press, Inc.展开更多
In this paper we firstly select main factors relating to urbanization level of Xiantao District in Hubei Province by main element, then, make model of urbanization level by analysis of multiple liner regression, and l...In this paper we firstly select main factors relating to urbanization level of Xiantao District in Hubei Province by main element, then, make model of urbanization level by analysis of multiple liner regression, and lastly predict its urbanization level展开更多
In Garze Tibetan autonomous prefecture inSichuan province, China, 41 echinococciasis patientswho had received surgical treatment were recruitedin the study, and 82 health persons who had livedin Garze for at least 10 ...In Garze Tibetan autonomous prefecture inSichuan province, China, 41 echinococciasis patientswho had received surgical treatment were recruitedin the study, and 82 health persons who had livedin Garze for at least 10 years were selected ascontrols. The serum levels of Zn, Se and Cu of thecases and controls were detected. The resultsshowed that most echinococciasis cases weredistributed in Shiqu county （17.1%, 7/41）, and only1 case was distributed in Yajiang county （2.4%）. Themale to female ratio of the cases was 1：1.56. Theechinococciasis patients were mainly aged 30-39years （36.59%, 15/41）. And, the cases aged 20-49years accounted for 68.29% （28/41）. Comparedwith health controls, the serum levels of Zn and Seof the cases significantly declined. However, theserum level of Cu of the cases had no significantlychange. It was confirmed that the serum levels ofZn and Se were interrelated with the prevalence ofechinococciasis.展开更多
Analysis results of the average annual sea levels in the Caspian Sea obtained from ground and satellite observations, corresponding to solar activity characteristics, magnetic field data, and length of day are present...Analysis results of the average annual sea levels in the Caspian Sea obtained from ground and satellite observations, corresponding to solar activity characteristics, magnetic field data, and length of day are presented. Spectra of the indicated processes were investigated and their approximation models were also built. Previously assumed statistical relationships between space-geophysical processes and Caspian Sea level(CSL) changes were confirmed. A close connection was revealed between the low-frequency models of the solar and geomagnetic activity parameters and the CSL changes. Predictions extending into the next decades showed a high probability of an increase in the CSL and a decrease of the compared space-geophysical parameters.展开更多
Based on the specific situation of Hu’nan Province, this paper formulates an evaluation index system of agricultural informatization, and uses the comprehensive index method to analyze and evaluate the level of agric...Based on the specific situation of Hu’nan Province, this paper formulates an evaluation index system of agricultural informatization, and uses the comprehensive index method to analyze and evaluate the level of agricultural informatization in Hu’nan Province. The overall process of the comprehensive index method is that firstly, a set of index system for evaluation should be formulated, then the data of each index should be standardized, and finally the comprehensive index value should be calculated through weighted summation. Based on the established index evaluation system and model, this paper analyzes and evaluates the development of agricultural informatization in Hu’nan Province by using the ten-year index raw data of 14 cities in Hu’nan from 2010 to 2019.展开更多
This study aims to investigate the regional variations of trabecular morphological parameters and mechanical parameters of the femoral head,as well as to determine the relationship between trabecular morphological and...This study aims to investigate the regional variations of trabecular morphological parameters and mechanical parameters of the femoral head,as well as to determine the relationship between trabecular morphological and mechanical parameters.Seven femoral heads from patients with fractured proximal femur were scanned using a micro-CT system.Each femoral head was divided into 12 sub-regions according to the trabecular orientation.One 125 mm^3 trabecular cubic model was reconstructed from each sub-region.A total of 81 trabecular models were reconstructed,except three destroyed sub-regions from two femoral heads during the surgery.Trabecular morphological parameters,i.e.trabecular separation（Tb.Sp）,trabecular thickness（Tb.Th）,specific bone surface（BS/B V）,bone volume fraction（BV/TV）,structural model index（SMI）,and degree of anisotropy（DA） were measured.Micro-finite element analyses were performed for each cube to obtain the apparent Young＇s modulus and tissue level von Mises stress distribution under 1%compressive strain along three orthogonal directions,respectively.Results revealed significant regional variations in the morphological parameters（P〈0.05）.Young＇s moduli along the trabecular orientation were significantly higher than those along the other two directions.In general,trabecular mechanical properties in the medial region were lower than those in the lateral region.Trabecular mechanical parameters along the trabecular orientation were significantly correlated with BS/BV,BV/TV,Tb.Th,and DA.In this study,regional variations of microstructural features and mechanical properties in the femoral head of patients with proximal femur fracture were thoroughly investigated at the tissue level.The results of this study will help to elucidate the mechanism of femoral head fracture for reducing fracture risk and developing treatment strategies for the elderly.展开更多
An improved method using kernel density estimation （KDE） and confidence level is presented for model validation with small samples. Decision making is a challenging problem because of input uncertainty and only smal...An improved method using kernel density estimation （KDE） and confidence level is presented for model validation with small samples. Decision making is a challenging problem because of input uncertainty and only small samples can be used due to the high costs of experimental measurements. However, model validation provides more confidence for decision makers when improving prediction accuracy at the same time. The confidence level method is introduced and the optimum sample variance is determined using a new method in kernel density estimation to increase the credibility of model validation. As a numerical example, the static frame model validation challenge problem presented by Sandia National Laboratories has been chosen. The optimum bandwidth is selected in kernel density estimation in order to build the probability model based on the calibration data. The model assessment is achieved using validation and accreditation experimental data respectively based on the probability model. Finally, the target structure prediction is performed using validated model, which are consistent with the results obtained by other researchers. The results demonstrate that the method using the improved confidence level and kernel density estimation is an effective approach to solve the model validation problem with small samples.展开更多
Sea Level Pressure（SLP） data for the period 1950–2012 at 61 stations located in or around the Balkan Peninsula was used. The main concept is that intra-annual course of SLP represents the best different air masses ...Sea Level Pressure（SLP） data for the period 1950–2012 at 61 stations located in or around the Balkan Peninsula was used. The main concept is that intra-annual course of SLP represents the best different air masses that are situated over the Balkan Peninsula during the year. The method for differentiation of climatic zones is cluster analysis. A hierarchical clustering technique–average linkage between groups with Pearson correlation for measurement of intervals was employed in the research. The climate of the Balkan Peninsula is transitional between oceanic and continental and also between subtropical and temperate climates. Several major changes in atmospheric circulation over the Balkan Peninsula have happened over the period 1950–2012. There is a serious increase of the influence of the Azores High in the period January–Marchwhich leads to an increase of SLP and enhances oceanic influence. There is an increase of the influence of the north-west extension of the monsoonal low in the period June–September. This leads to more continental climatebut also to more tropical air masses over the Balkan Peninsula. Accordinglythe extent of subtropical climate widens in northern direction. There is an increase of the influence of the Siberian High in the period October–December. This influence covers central and eastern part of the peninsula in October and Novemberand it reaches western parts in December. Thusthe climate becomes more continental.展开更多
Daily PM_（2.5）（particulate matter with an aerodynamic diameter of below 2.5 μm） mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences（CRAES）, in the nor...Daily PM_（2.5）（particulate matter with an aerodynamic diameter of below 2.5 μm） mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences（CRAES）, in the northern part of the Beijing urban area, from December 2013 to April 2015. Two pairs of Teflon（T1/T2） and Quartz（Q1/Q2） samples were obtained, for a total number of 1352 valid filters. Results showed elevated pollution in Beijing,with an annual mean PM_（2.5）mass concentration of 102 μg/m^3. According to the calculated PM_（2.5）mass concentration, 50% of our sampling days were acceptable（PM_（2.5）〈 75 μg/m^3）, 30% had slight/medium pollution（75–150 μg/m^3）, and 7% had severe pollution（〉 250 μg/m^3）. Sampling interruption occurred frequently for the Teflon filter group（75%） in severe pollution periods,resulting in important data being missing. Further analysis showed that high PM_（2.5）combined with high relative humidity（RH） gave rise to the interruptions. The seasonal variation of PM_（2.5）was presented, with higher monthly average mass concentrations in winter（peak value in February, 422 μg/m^3）, and lower in summer（7 μg/m^3 in June）. From May to August, the typical summer period, least severe pollution events were observed, with high precipitation levels accelerating the process of wet deposition to remove PM_（2.5）. The case of February presented the most serious pollution, with monthly averaged PM_（2.5）of 181 μg/m^3 and 32% of days with severe pollution. The abundance of PM_（2.5）in winter could be related to increased coal consumption for heating needs.展开更多
BackgroundThe relationship between lipids and coronary artery disease has been well established. However, this is not the case between lipids and heart failure. Ironically, high lipid levels are associated with better...BackgroundThe relationship between lipids and coronary artery disease has been well established. However, this is not the case between lipids and heart failure. Ironically, high lipid levels are associated with better outcomes in heart failure, but the mechan-isms underlying the phenomenon are not fully understood. This study was performed to test the hypothesis that reduced intestinal lipid absorption due to venous congestion may lead to low lipid levels.MethodsWe collected data of clinical characteristics, echocardio-graph, and lipid profile in 442 unselected patients with congestive heart failure. Correlations between lipid levels[including total cho-lesterol（TCL）, high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, and triglycerides（TG）]and right ventricle end diastolic diameter （RVEDD）, left ventricle end diastolic diameter （LVEDD）, right atrium diameter （RA）, left atrium diameter （LA）, or left ventricle ejection fraction （LVEF） were analyzed using Pearson correlation and partial correlation. RVEDD, LVEDD, RA, and LA were indexed to the body surface area.ResultsThere was a significantly inverse correlation between TCL le-vels and RVEDD （r=-0.34,P〈0.001） and RA （r=-0.36,P〈0.001）. Other lipids such as LDL-C, HDL-C, and TG had asimilar inverse correlation with RVEDD and RA. All these correlations remained unchanged after adjusting for age, gender, smoking status, physical activity levels, comorbidities, and medication use.ConclusionsLipid levels were inversely correlated to RVEDD in patients with congestive heart failure; however, because this was an observational study, further investigation is needed to verify our results as wellas identify a causal relationship, if any.展开更多
Sentiment analysis is a fine‐grained analysis task that aims to identify the sentiment polarity of a specified sentence.Existing methods in Chinese sentiment analysis tasks only consider sentiment features from a sin...Sentiment analysis is a fine‐grained analysis task that aims to identify the sentiment polarity of a specified sentence.Existing methods in Chinese sentiment analysis tasks only consider sentiment features from a single pole and scale and thus cannot fully exploit and utilise sentiment feature information,making their performance less than ideal.To resolve the problem,the authors propose a new method,GP‐FMLNet,that integrates both glyph and phonetic information and design a novel feature matrix learning process for phonetic features with which to model words that have the same pinyin information but different glyph information.Our method solves the problem of misspelling words influencing sentiment polarity prediction results.Specifically,the authors iteratively mine character,glyph,and pinyin features from the input comments sentences.Then,the authors use soft attention and matrix compound modules to model the phonetic features,which empowers their model to keep on zeroing in on the dynamic‐setting words in various positions and to dispense with the impacts of the deceptive‐setting ones.Ex-periments on six public datasets prove that the proposed model fully utilises the glyph and phonetic information and improves on the performance of existing Chinese senti-ment analysis algorithms.展开更多
With the advancements in internet facilities,people are more inclined towards the use of online services.The service providers shelve their items for e-users.These users post their feedbacks,reviews,ratings,etc.after ...With the advancements in internet facilities,people are more inclined towards the use of online services.The service providers shelve their items for e-users.These users post their feedbacks,reviews,ratings,etc.after the use of the item.The enormous increase in these reviews has raised the need for an automated system to analyze these reviews to rate these items.Sentiment Analysis(SA)is a technique that performs such decision analysis.This research targets the ranking and rating through sentiment analysis of these reviews,on different aspects.As a case study,Songs are opted to design and test the decision model.Different aspects of songs namely music,lyrics,song,voice and video are picked.For the reason,reviews of 20 songs are scraped from YouTube,pre-processed and formed a dataset.Different machine learning algorithms—Naïve Bayes(NB),Gradient Boost Tree,Logistic Regression LR,K-Nearest Neighbors(KNN)and Artificial Neural Network(ANN)are applied.ANN performed the best with 74.99%accuracy.Results are validated using K-Fold.展开更多
The concentrations of 16 polycyclic aromatic hydrocarbons（PAHs） were determined in surface sediment samples from nine sites located at the Iguau River Basin in the Metropolitan Region of Curitiba,Brazil to evaluate ...The concentrations of 16 polycyclic aromatic hydrocarbons（PAHs） were determined in surface sediment samples from nine sites located at the Iguau River Basin in the Metropolitan Region of Curitiba,Brazil to evaluate their distribution and sources.The total concentration of the PAHs was greater for sediments from highly urbanized areas,while the sediments from the Iraí Environmental Protection Area（Iraí EPA） showed significantly low concentrations.The sediments from the Iguau and Barigui rivers were classified as highly contaminated,while those from the Cercado and Curralinho rivers were classified as moderately contaminated.The predominance of PAHs containing two to four aromatic rings in most of the samples suggested the direct input of raw sewage into the water resources evaluated.Benzo[g,h,i]perylene,dibenzo[a,h]anthracene and indeno[1,2,3-cd]pyrene were predominant in sediments from the areas under the greatest urban and industrial development.The correlation between thermodynamic stability and the kinetics of evolution presented by the isomeric pairs indicated that combustion is the predominant source of PAHs in the sediments because the combustion of fossil fuels affected most of the points evaluated,followed by combustion of biomass and eventually combustion of oil product inputs.In general,the results showed that areas under strong urban influence,as well as the Iraí EPA,receive contributions of PAHs from similar sources.展开更多
Fire is one of the extreme loading events that a building may experience during its service life and can have severe consequences on the safety of its occupants,first responders,and the structure.Steel framed building...Fire is one of the extreme loading events that a building may experience during its service life and can have severe consequences on the safety of its occupants,first responders,and the structure.Steel framed buildings under severe fires can experience high levels of instability at a local or global level,which in turn can lead to the partial or progressive collapse of the structure.However,in current practice,fire resistance of structures is obtained without due consideration to a number of critical factors,and this is mainly due to the high level of complexity in undertaking advanced analysis of structures under fire exposure.This paper presents a parametric study on a ten-story braced steel framed building subjected to fire exposure wherein six different parameters are evaluated:fire severity,fire spread,load paths,temperature-induced creep,local instability,and analysis regime.Results from validated finite element models are utilized to evaluate the influence of the different parameters and recommend critical parameters to be incorporated in the analysis.Results show that the susceptibility of fire-induced progressive collapse significantly depends on the severity of the fire exposure scenario,including fire intensity,fire spread,and extent of burning.Also,accounting for the full effects of transient creep in fire-induced progressive collapse analysis is needed to obtain conservative failure times under severe to very intense fire exposure.Additionally,results from the parametric study infer that the sectional classification of a steel section based on local instability can alter under fire exposure and this effect is more critical in steel columns located in the higher stories of the building;a nonslender column at ambient conditions can transform to a slender section at elevated temperatures.This can induce temperature-induced local instability in the column and lead to an early onset of instability at member and structural levels.展开更多
A proper operating strategy is helpful to improve the off-design performance of combined cooling,heating and power(CCHP)systems,providing high efficiency and low emission.The energy level difference graphic analysis m...A proper operating strategy is helpful to improve the off-design performance of combined cooling,heating and power(CCHP)systems,providing high efficiency and low emission.The energy level difference graphic analysis method is used to identify energy level as well as exergy destruction of the part-load process.This method illustrates the energy efficiency upgrading mechanism of the flue gas reinjecting(FGR)operating strategy.It is referenced to a reducing turbine inlet temperature(TIT)operating strategy.By comparison,the FGR operating strategy leads to a 2.62%exergy distribution reduction in a gas turbine at an 85%load level due to the decrease of the energy level difference.When the output power is reduced further,the FGR operating strategy is supplanted by the TIT operating strategy with the limit of compressor inlet temperature.However,the opposite results of exergy distribution are presented in the exhaust-heat recovery devices.A heat-driven refrigeration and power cycle is introduced in a typical CCHP system as a solution.Moreover,the results suggest that the operational flexibility of the CCHP system is improved by enlarging the ratio of cooling to electricity.展开更多
In this paper we propose a controllability and observability measure at switch level for CMOS circuits based on the cost analysis approach.The complexity of the algorithm is nearly linear.
The Intermediate-Range Nuclear Forces Treaty(INF Treaty)is a milestone in the history of arms control negotiations between the United States and the Soviet Union,but there are continuous disputes during its existence....The Intermediate-Range Nuclear Forces Treaty(INF Treaty)is a milestone in the history of arms control negotiations between the United States and the Soviet Union,but there are continuous disputes during its existence.From February 2,2019,the United States announced the suspension of its obligations under the INF Treaty and officially started the withdrawal process.On the same day,the Russian president also announced the suspension of implementation.The factors behind the successive withdrawal are complicated and are related to the development of the international arms control system in the future.This paper mainly focuses on the analysis of the reasons for the withdrawal by comparing the two sides under the same perspective through the levels of analysis.展开更多
文摘Phishing emails have experienced a rapid surge in cyber threats globally,especially following the emergence of the COVID-19 pandemic.This form of attack has led to substantial financial losses for numerous organizations.Although variousmodels have been constructed to differentiate legitimate emails fromphishing attempts,attackers continuously employ novel strategies to manipulate their targets into falling victim to their schemes.This form of attack has led to substantial financial losses for numerous organizations.While efforts are ongoing to create phishing detection models,their current level of accuracy and speed in identifying phishing emails is less than satisfactory.Additionally,there has been a concerning rise in the frequency of phished emails recently.Consequently,there is a pressing need for more efficient and high-performing phishing detection models to mitigate the adverse impact of such fraudulent messages.In the context of this research,a comprehensive analysis is conducted on both components of an email message—namely,the email header and body.Sentence-level characteristics are extracted and leveraged in the construction of a new phishing detection model.This model utilizes K Nearest Neighbor(KNN)introducing the novel dimension of sentence-level analysis.Established datasets fromKagglewere employed to train and validate the model.The evaluation of this model’s effectiveness relies on key performance metrics including accuracy of 0.97,precision,recall,and F1-measure.
基金Supported by Risk Monitoring Task Project of Chongqing Drug Administration in 2020。
文摘[Objectives]To detect content of Pb,Cd,Hg,As,Cu,Zn,and Cr in Lysimachia christinae,and to analyze the pollution level.[Methods]Seven kinds of elements in L.christinae were determined by Inductively coupled plasma mass spectrometry and analyzed by single index and comprehensive index.[Results]The seven heavy metal elements showed good linearity in their respective concentration ranges.The recoveries of the samples were 84.5%-109.5%,and the RSD values were 2.30%-5.10%.Comparing the measured results of heavy metal elements with the limit values stipulated in the 2020 edition of the Chinese Pharmacopoeia and other standards,the Cr element in 19 batches of samples exceeded the standard,and the Zn element in 7 batches of samples exceeded the standard.The exceeding rates were 100.0%and 36.8%,respectively;the content of other heavy metal elements did not exceed the standard.The order of individual index from large to small was Cr,Zn,Cd,Hg,Cu,As,and Pb,and the average comprehensive pollution level was mild pollution and above.[Conclusions]L.christinae was mainly polluted by Cr,followed by Zn;this study can provide basic data for drafting of the limit standard for heavy metal elements in L.christinae.
文摘Glycidyl methaerylate (GMA) is a recently recognized chemical mutagen. In order to explore the mutagenicity and mutagenic process of GMA, plasmid pBR322 was used for in vitro binding, mutant screening, and restriction enzyme mapping. The binding between GMA and DNA in vitro has been verified by means of a spectrophotometric method. When pBR322 and GMAbound pBR322 were used to transform Eschenchia coli HB101, the following results were obtained: (1) The transformation efficiency of GMA-bound pBR322 was much lower than that of pBR322 alone. (2) GMA-bound pBR322 induced phenotype changes in competent cells (i.e., tetracycline-resistance inactivation or ampicillin-resistance inactivation). There were two mutants of pBR322, Ap~RTc~S and Ap~STc~R, in the transformants and a deductive mutant Ap~STc~S in the nontranstormants. (3) All of the selected mutants were stable and heritable. (4) When restriction enzyme maps were used to analyze the mutant Ap~RTc~S, four of seven maps were changed. some sites were shifted to other resistant gene regions, for example, sites of Bgll, EcoRl, Ilindlll. Hinclll, etc., and there was a new recognition site for Hindi (252). We did not observe any DNA fragment insertion or deletion on any maps. Our results suggest that when GMA is covalently linked to the plasmid DNA, it gives rise to a premutagenic lesion of DNA that is converted in vivo into a point mutation. (C)1990 Academic Press, Inc.
文摘In this paper we firstly select main factors relating to urbanization level of Xiantao District in Hubei Province by main element, then, make model of urbanization level by analysis of multiple liner regression, and lastly predict its urbanization level
基金financially supported by the Grant for the National Major Science and Technology Project(grant No.2012ZX10004-220,No.2008ZX10004-011)
文摘In Garze Tibetan autonomous prefecture inSichuan province, China, 41 echinococciasis patientswho had received surgical treatment were recruitedin the study, and 82 health persons who had livedin Garze for at least 10 years were selected ascontrols. The serum levels of Zn, Se and Cu of thecases and controls were detected. The resultsshowed that most echinococciasis cases weredistributed in Shiqu county （17.1%, 7/41）, and only1 case was distributed in Yajiang county （2.4%）. Themale to female ratio of the cases was 1：1.56. Theechinococciasis patients were mainly aged 30-39years （36.59%, 15/41）. And, the cases aged 20-49years accounted for 68.29% （28/41）. Comparedwith health controls, the serum levels of Zn and Seof the cases significantly declined. However, theserum level of Cu of the cases had no significantlychange. It was confirmed that the serum levels ofZn and Se were interrelated with the prevalence ofechinococciasis.
文摘Analysis results of the average annual sea levels in the Caspian Sea obtained from ground and satellite observations, corresponding to solar activity characteristics, magnetic field data, and length of day are presented. Spectra of the indicated processes were investigated and their approximation models were also built. Previously assumed statistical relationships between space-geophysical processes and Caspian Sea level(CSL) changes were confirmed. A close connection was revealed between the low-frequency models of the solar and geomagnetic activity parameters and the CSL changes. Predictions extending into the next decades showed a high probability of an increase in the CSL and a decrease of the compared space-geophysical parameters.
文摘Based on the specific situation of Hu’nan Province, this paper formulates an evaluation index system of agricultural informatization, and uses the comprehensive index method to analyze and evaluate the level of agricultural informatization in Hu’nan Province. The overall process of the comprehensive index method is that firstly, a set of index system for evaluation should be formulated, then the data of each index should be standardized, and finally the comprehensive index value should be calculated through weighted summation. Based on the established index evaluation system and model, this paper analyzes and evaluates the development of agricultural informatization in Hu’nan Province by using the ten-year index raw data of 14 cities in Hu’nan from 2010 to 2019.
基金supported by the National Natural Science Foundation of China(Nos.11322223,11432016,81471753 and 11272134)the 973 Program(No.2012CB821202)
文摘This study aims to investigate the regional variations of trabecular morphological parameters and mechanical parameters of the femoral head,as well as to determine the relationship between trabecular morphological and mechanical parameters.Seven femoral heads from patients with fractured proximal femur were scanned using a micro-CT system.Each femoral head was divided into 12 sub-regions according to the trabecular orientation.One 125 mm^3 trabecular cubic model was reconstructed from each sub-region.A total of 81 trabecular models were reconstructed,except three destroyed sub-regions from two femoral heads during the surgery.Trabecular morphological parameters,i.e.trabecular separation（Tb.Sp）,trabecular thickness（Tb.Th）,specific bone surface（BS/B V）,bone volume fraction（BV/TV）,structural model index（SMI）,and degree of anisotropy（DA） were measured.Micro-finite element analyses were performed for each cube to obtain the apparent Young＇s modulus and tissue level von Mises stress distribution under 1%compressive strain along three orthogonal directions,respectively.Results revealed significant regional variations in the morphological parameters（P〈0.05）.Young＇s moduli along the trabecular orientation were significantly higher than those along the other two directions.In general,trabecular mechanical properties in the medial region were lower than those in the lateral region.Trabecular mechanical parameters along the trabecular orientation were significantly correlated with BS/BV,BV/TV,Tb.Th,and DA.In this study,regional variations of microstructural features and mechanical properties in the femoral head of patients with proximal femur fracture were thoroughly investigated at the tissue level.The results of this study will help to elucidate the mechanism of femoral head fracture for reducing fracture risk and developing treatment strategies for the elderly.
基金Funding of Jiangsu Innovation Program for Graduate Education (CXZZ11_0193)NUAA Research Funding (NJ2010009)
文摘An improved method using kernel density estimation （KDE） and confidence level is presented for model validation with small samples. Decision making is a challenging problem because of input uncertainty and only small samples can be used due to the high costs of experimental measurements. However, model validation provides more confidence for decision makers when improving prediction accuracy at the same time. The confidence level method is introduced and the optimum sample variance is determined using a new method in kernel density estimation to increase the credibility of model validation. As a numerical example, the static frame model validation challenge problem presented by Sandia National Laboratories has been chosen. The optimum bandwidth is selected in kernel density estimation in order to build the probability model based on the calibration data. The model assessment is achieved using validation and accreditation experimental data respectively based on the probability model. Finally, the target structure prediction is performed using validated model, which are consistent with the results obtained by other researchers. The results demonstrate that the method using the improved confidence level and kernel density estimation is an effective approach to solve the model validation problem with small samples.
文摘Sea Level Pressure（SLP） data for the period 1950–2012 at 61 stations located in or around the Balkan Peninsula was used. The main concept is that intra-annual course of SLP represents the best different air masses that are situated over the Balkan Peninsula during the year. The method for differentiation of climatic zones is cluster analysis. A hierarchical clustering technique–average linkage between groups with Pearson correlation for measurement of intervals was employed in the research. The climate of the Balkan Peninsula is transitional between oceanic and continental and also between subtropical and temperate climates. Several major changes in atmospheric circulation over the Balkan Peninsula have happened over the period 1950–2012. There is a serious increase of the influence of the Azores High in the period January–Marchwhich leads to an increase of SLP and enhances oceanic influence. There is an increase of the influence of the north-west extension of the monsoonal low in the period June–September. This leads to more continental climatebut also to more tropical air masses over the Balkan Peninsula. Accordinglythe extent of subtropical climate widens in northern direction. There is an increase of the influence of the Siberian High in the period October–December. This influence covers central and eastern part of the peninsula in October and Novemberand it reaches western parts in December. Thusthe climate becomes more continental.
基金supported by the State Environmental Protection Commonweal Trade Scientific Research,Ministry of Environmental Protection of China (No.2013467010)The financial support of this special fund for the public service sector and research support from the staff of Chinese Research Academy of Environmental Sciences (CRAES) (Z141100002714002)
文摘Daily PM_（2.5）（particulate matter with an aerodynamic diameter of below 2.5 μm） mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences（CRAES）, in the northern part of the Beijing urban area, from December 2013 to April 2015. Two pairs of Teflon（T1/T2） and Quartz（Q1/Q2） samples were obtained, for a total number of 1352 valid filters. Results showed elevated pollution in Beijing,with an annual mean PM_（2.5）mass concentration of 102 μg/m^3. According to the calculated PM_（2.5）mass concentration, 50% of our sampling days were acceptable（PM_（2.5）〈 75 μg/m^3）, 30% had slight/medium pollution（75–150 μg/m^3）, and 7% had severe pollution（〉 250 μg/m^3）. Sampling interruption occurred frequently for the Teflon filter group（75%） in severe pollution periods,resulting in important data being missing. Further analysis showed that high PM_（2.5）combined with high relative humidity（RH） gave rise to the interruptions. The seasonal variation of PM_（2.5）was presented, with higher monthly average mass concentrations in winter（peak value in February, 422 μg/m^3）, and lower in summer（7 μg/m^3 in June）. From May to August, the typical summer period, least severe pollution events were observed, with high precipitation levels accelerating the process of wet deposition to remove PM_（2.5）. The case of February presented the most serious pollution, with monthly averaged PM_（2.5）of 181 μg/m^3 and 32% of days with severe pollution. The abundance of PM_（2.5）in winter could be related to increased coal consumption for heating needs.
文摘BackgroundThe relationship between lipids and coronary artery disease has been well established. However, this is not the case between lipids and heart failure. Ironically, high lipid levels are associated with better outcomes in heart failure, but the mechan-isms underlying the phenomenon are not fully understood. This study was performed to test the hypothesis that reduced intestinal lipid absorption due to venous congestion may lead to low lipid levels.MethodsWe collected data of clinical characteristics, echocardio-graph, and lipid profile in 442 unselected patients with congestive heart failure. Correlations between lipid levels[including total cho-lesterol（TCL）, high-density lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, and triglycerides（TG）]and right ventricle end diastolic diameter （RVEDD）, left ventricle end diastolic diameter （LVEDD）, right atrium diameter （RA）, left atrium diameter （LA）, or left ventricle ejection fraction （LVEF） were analyzed using Pearson correlation and partial correlation. RVEDD, LVEDD, RA, and LA were indexed to the body surface area.ResultsThere was a significantly inverse correlation between TCL le-vels and RVEDD （r=-0.34,P〈0.001） and RA （r=-0.36,P〈0.001）. Other lipids such as LDL-C, HDL-C, and TG had asimilar inverse correlation with RVEDD and RA. All these correlations remained unchanged after adjusting for age, gender, smoking status, physical activity levels, comorbidities, and medication use.ConclusionsLipid levels were inversely correlated to RVEDD in patients with congestive heart failure; however, because this was an observational study, further investigation is needed to verify our results as wellas identify a causal relationship, if any.
基金Science and Technology Innovation 2030‐“New Generation Artificial Intelligence”major project,Grant/Award Number:2020AAA0108703。
文摘Sentiment analysis is a fine‐grained analysis task that aims to identify the sentiment polarity of a specified sentence.Existing methods in Chinese sentiment analysis tasks only consider sentiment features from a single pole and scale and thus cannot fully exploit and utilise sentiment feature information,making their performance less than ideal.To resolve the problem,the authors propose a new method,GP‐FMLNet,that integrates both glyph and phonetic information and design a novel feature matrix learning process for phonetic features with which to model words that have the same pinyin information but different glyph information.Our method solves the problem of misspelling words influencing sentiment polarity prediction results.Specifically,the authors iteratively mine character,glyph,and pinyin features from the input comments sentences.Then,the authors use soft attention and matrix compound modules to model the phonetic features,which empowers their model to keep on zeroing in on the dynamic‐setting words in various positions and to dispense with the impacts of the deceptive‐setting ones.Ex-periments on six public datasets prove that the proposed model fully utilises the glyph and phonetic information and improves on the performance of existing Chinese senti-ment analysis algorithms.
文摘With the advancements in internet facilities,people are more inclined towards the use of online services.The service providers shelve their items for e-users.These users post their feedbacks,reviews,ratings,etc.after the use of the item.The enormous increase in these reviews has raised the need for an automated system to analyze these reviews to rate these items.Sentiment Analysis(SA)is a technique that performs such decision analysis.This research targets the ranking and rating through sentiment analysis of these reviews,on different aspects.As a case study,Songs are opted to design and test the decision model.Different aspects of songs namely music,lyrics,song,voice and video are picked.For the reason,reviews of 20 songs are scraped from YouTube,pre-processed and formed a dataset.Different machine learning algorithms—Naïve Bayes(NB),Gradient Boost Tree,Logistic Regression LR,K-Nearest Neighbors(KNN)and Artificial Neural Network(ANN)are applied.ANN performed the best with 74.99%accuracy.Results are validated using K-Fold.
文摘The concentrations of 16 polycyclic aromatic hydrocarbons（PAHs） were determined in surface sediment samples from nine sites located at the Iguau River Basin in the Metropolitan Region of Curitiba,Brazil to evaluate their distribution and sources.The total concentration of the PAHs was greater for sediments from highly urbanized areas,while the sediments from the Iraí Environmental Protection Area（Iraí EPA） showed significantly low concentrations.The sediments from the Iguau and Barigui rivers were classified as highly contaminated,while those from the Cercado and Curralinho rivers were classified as moderately contaminated.The predominance of PAHs containing two to four aromatic rings in most of the samples suggested the direct input of raw sewage into the water resources evaluated.Benzo[g,h,i]perylene,dibenzo[a,h]anthracene and indeno[1,2,3-cd]pyrene were predominant in sediments from the areas under the greatest urban and industrial development.The correlation between thermodynamic stability and the kinetics of evolution presented by the isomeric pairs indicated that combustion is the predominant source of PAHs in the sediments because the combustion of fossil fuels affected most of the points evaluated,followed by combustion of biomass and eventually combustion of oil product inputs.In general,the results showed that areas under strong urban influence,as well as the Iraí EPA,receive contributions of PAHs from similar sources.
文摘Fire is one of the extreme loading events that a building may experience during its service life and can have severe consequences on the safety of its occupants,first responders,and the structure.Steel framed buildings under severe fires can experience high levels of instability at a local or global level,which in turn can lead to the partial or progressive collapse of the structure.However,in current practice,fire resistance of structures is obtained without due consideration to a number of critical factors,and this is mainly due to the high level of complexity in undertaking advanced analysis of structures under fire exposure.This paper presents a parametric study on a ten-story braced steel framed building subjected to fire exposure wherein six different parameters are evaluated:fire severity,fire spread,load paths,temperature-induced creep,local instability,and analysis regime.Results from validated finite element models are utilized to evaluate the influence of the different parameters and recommend critical parameters to be incorporated in the analysis.Results show that the susceptibility of fire-induced progressive collapse significantly depends on the severity of the fire exposure scenario,including fire intensity,fire spread,and extent of burning.Also,accounting for the full effects of transient creep in fire-induced progressive collapse analysis is needed to obtain conservative failure times under severe to very intense fire exposure.Additionally,results from the parametric study infer that the sectional classification of a steel section based on local instability can alter under fire exposure and this effect is more critical in steel columns located in the higher stories of the building;a nonslender column at ambient conditions can transform to a slender section at elevated temperatures.This can induce temperature-induced local instability in the column and lead to an early onset of instability at member and structural levels.
基金supported by the National Natural Science Foundation of China(Grant No.52006213)。
文摘A proper operating strategy is helpful to improve the off-design performance of combined cooling,heating and power(CCHP)systems,providing high efficiency and low emission.The energy level difference graphic analysis method is used to identify energy level as well as exergy destruction of the part-load process.This method illustrates the energy efficiency upgrading mechanism of the flue gas reinjecting(FGR)operating strategy.It is referenced to a reducing turbine inlet temperature(TIT)operating strategy.By comparison,the FGR operating strategy leads to a 2.62%exergy distribution reduction in a gas turbine at an 85%load level due to the decrease of the energy level difference.When the output power is reduced further,the FGR operating strategy is supplanted by the TIT operating strategy with the limit of compressor inlet temperature.However,the opposite results of exergy distribution are presented in the exhaust-heat recovery devices.A heat-driven refrigeration and power cycle is introduced in a typical CCHP system as a solution.Moreover,the results suggest that the operational flexibility of the CCHP system is improved by enlarging the ratio of cooling to electricity.
文摘In this paper we propose a controllability and observability measure at switch level for CMOS circuits based on the cost analysis approach.The complexity of the algorithm is nearly linear.
文摘The Intermediate-Range Nuclear Forces Treaty(INF Treaty)is a milestone in the history of arms control negotiations between the United States and the Soviet Union,but there are continuous disputes during its existence.From February 2,2019,the United States announced the suspension of its obligations under the INF Treaty and officially started the withdrawal process.On the same day,the Russian president also announced the suspension of implementation.The factors behind the successive withdrawal are complicated and are related to the development of the international arms control system in the future.This paper mainly focuses on the analysis of the reasons for the withdrawal by comparing the two sides under the same perspective through the levels of analysis.
