Objective Children with autism spectrum disorder(ASD)had lower vitamin D3 levels than neurotypical(NT)children,as well as deficits in language,social,and fine motor abilities.Nanotechnology has appeared as a suitable ...Objective Children with autism spectrum disorder(ASD)had lower vitamin D3 levels than neurotypical(NT)children,as well as deficits in language,social,and fine motor abilities.Nanotechnology has appeared as a suitable answer to absorption and bioavailability problems related to vitamin D3.This study aims to investigate the influence of vitamin D3-loaded nanoemulsion supplementation on adaptive behavior and language performance in children with ASD compared to the influence of the marketed product of vitamin D3.Methods Supplementation of ASD children with an oral vitamin D3-loaded nanoemulsion was performed in group I while the marketed product of the oral vitamin D3 was used in group II for 6 months.Evaluation of their abilities and measuring the plasma levels of 2 types of vitamin D3 were performed using ultra-performance liquid chromatography before and after supplementation.Results Supplementation in group I(n=40)has led to an elevation of levels of 25(OH)and 1,25(OH)_(2) forms of vitamin D3(P<0.000,1),to behavioral improvement in the form of a reduction in ASD severity,and to a rise in the social IQ and total language age of ASD children(P=0.000,2,0.04,0.000,9,respectively).On the other hand,group II(n=40)did not show adaptive behavioral improvements.Conclusions The vitamin D3-loaded nanoemulsion provided better vitamin D3 bioavailability and a true influence on severity,adaptive behavior,fine motor abilities,and language performance,reflecting the desired benefits of the rise of vitamin D3 levels in the blood.展开更多
基金the inhouse projects funding of the National Research Centre,Cairo,Egypt(No.12060135).
文摘Objective Children with autism spectrum disorder(ASD)had lower vitamin D3 levels than neurotypical(NT)children,as well as deficits in language,social,and fine motor abilities.Nanotechnology has appeared as a suitable answer to absorption and bioavailability problems related to vitamin D3.This study aims to investigate the influence of vitamin D3-loaded nanoemulsion supplementation on adaptive behavior and language performance in children with ASD compared to the influence of the marketed product of vitamin D3.Methods Supplementation of ASD children with an oral vitamin D3-loaded nanoemulsion was performed in group I while the marketed product of the oral vitamin D3 was used in group II for 6 months.Evaluation of their abilities and measuring the plasma levels of 2 types of vitamin D3 were performed using ultra-performance liquid chromatography before and after supplementation.Results Supplementation in group I(n=40)has led to an elevation of levels of 25(OH)and 1,25(OH)_(2) forms of vitamin D3(P<0.000,1),to behavioral improvement in the form of a reduction in ASD severity,and to a rise in the social IQ and total language age of ASD children(P=0.000,2,0.04,0.000,9,respectively).On the other hand,group II(n=40)did not show adaptive behavioral improvements.Conclusions The vitamin D3-loaded nanoemulsion provided better vitamin D3 bioavailability and a true influence on severity,adaptive behavior,fine motor abilities,and language performance,reflecting the desired benefits of the rise of vitamin D3 levels in the blood.
