Building reliable intent-based,task-oriented dialog systems typically requires substantial manual effort:designers must derive intents,entities,responses,and control logic from raw conversational data,then iterate unt...Building reliable intent-based,task-oriented dialog systems typically requires substantial manual effort:designers must derive intents,entities,responses,and control logic from raw conversational data,then iterate until the assistant behaves consistently.This paper investigates how far large language models(LLMs)can automate this development.In this paper,we use two reference corpora,Let’s Go(English,public transport)and MEDIA(French,hotel booking),to prompt four LLM families(GPT-4o,Claude,Gemini,Mistral Small)and generate the core specifications required by the rasa platform.These include intent sets with example utterances,entity definitions with slot mappings,response templates,and basic dialog flows.To structure this process,we introduce a model-and platform-agnostic pipelinewith two phases.The first normalizes and validates LLM-generated artifacts,enforcing crossfile consistency andmaking slot usage explicit.The second uses a lightweight dialog harness that runs scripted tests and incrementally patches failure points until conversations complete reliably.Across eight projects,all models required some targeted repairs before training.After applying our pipeline,all reached≥70%task completion(many above 84%),while NLU performance ranged from mid-0.6 to 1.0 macro-F1 depending on domain breadth.These results show that,with modest guidance,current LLMs can produce workable end-to-end dialog prototypes directly fromraw transcripts.Our main contributions are:(i)a reusable bootstrap method aligned with industry domain-specific languages(DSLs),(ii)a small set of high-impact corrective patterns,and(iii)a simple but effective harness for closed-loop refinement across conversational platforms.展开更多
Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Ja...Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Jabbour et al.2017,Wong et al.2018,and Wu et al.2021)were replicated using ChatGPTv3.5 and Bard.Outputs(author,title,publication year,and journal)were compared to the original references and cross-referenced with medical databases for authenticity and recall.Results:Several themes emerged when comparing Bard and ChatGPT across the three reviews.Bard generated more outputs and had greater recall in Wong et al.'s review,with a broader date range in Jabbour et al.'s review.In Wu et al.'s review,ChatGPT-2 had higher recall and identified more authentic outputs than Bard-2.Conclusion:Large language models(LLMs)failed to fully replicate peer-reviewed methodologies,producing outputs with inaccuracies but identifying relevant,especially recent,articles missed by the references.While human-led PRISMA-based reviews remain the gold standard,refining LLMs for literature reviews shows potential.展开更多
Objective To develop a clinical decision and prescription generation system(CDPGS)specifically for diarrhea in traditional Chinese medicine(TCM),utilizing a specialized large language model(LLM),Qwen-TCM-Dia,to standa...Objective To develop a clinical decision and prescription generation system(CDPGS)specifically for diarrhea in traditional Chinese medicine(TCM),utilizing a specialized large language model(LLM),Qwen-TCM-Dia,to standardize diagnostic processes and prescription generation.Methods Two primary datasets were constructed:an evaluation benchmark and a fine-tuning dataset consisting of fundamental diarrhea knowledge,medical records,and chain-ofthought(CoT)reasoning datasets.After an initial evaluation of 16 open-source LLMs across inference time,accuracy,and output quality,Qwen2.5 was selected as the base model due to its superior overall performance.We then employed a two-stage low-rank adaptation(LoRA)fine-tuning strategy,integrating continued pre-training on domain-specific knowledge with instruction fine-tuning using CoT-enriched medical records.This approach was designed to embed the clinical logic(symptoms→pathogenesis→therapeutic principles→prescriptions)into the model’s reasoning capabilities.The resulting fine-tuned model,specialized for TCM diarrhea,was designated as Qwen-TCM-Dia.Model performance was evaluated for disease diagnosis and syndrome type differentiation using accuracy,precision,recall,and F1-score.Furthermore,the quality of the generated prescriptions was compared with that of established open-source TCM LLMs.Results Qwen-TCM-Dia achieved peak performance compared to both the base Qwen2.5 model and five other open-source TCM LLMs.It achieved 97.05%accuracy and 91.48%F1-score in disease diagnosis,and 74.54%accuracy and 74.21%F1-score in syndrome type differentiation.Compared with existing open-source TCM LLMs(BianCang,HuangDi,LingDan,TCMLLM-PR,and ZhongJing),Qwen-TCM-Dia exhibited higher fidelity in reconstructing the“symptoms→pathogenesis→therapeutic principles→prescriptions”logic chain.It provided complete prescriptions,whereas other models often omitted dosages or generated mismatched prescriptions.Conclusion By integrating continued pre-training,CoT reasoning,and a two-stage fine-tuning strategy,this study establishes a CDPGS for diarrhea in TCM.The results demonstrate the synergistic effect of strengthening domain representation through pre-training and activating logical reasoning via CoT.This research not only provides critical technical support for the standardized diagnosis and treatment of diarrhea but also offers a scalable paradigm for the digital inheritance of expert TCM experience and the intelligent transformation of TCM.展开更多
Classifying job offers into occupational categories is a fundamental task in human resource information systems,as it improves and streamlines indexing,search,and matching between openings and job seekers.Comprehensiv...Classifying job offers into occupational categories is a fundamental task in human resource information systems,as it improves and streamlines indexing,search,and matching between openings and job seekers.Comprehensive occupational databases such as O∗NET or ESCO provide detailed taxonomies of interrelated positions that can be leveraged to align the textual content of postings with occupational categories,thereby facilitating standardization,cross-system interoperability,and access to metadata for each occupation(e.g.,tasks,knowledge,skills,and abilities).In this work,we explore the effectiveness of fine-tuning existing language models(LMs)to classify job offers with occupational descriptors from O∗NET.This enables a more precise assessment of candidate suitability by identifying the specific knowledge and skills required for each position,and helps automate recruitment processes by mitigating human bias and subjectivity in candidate selection.We evaluate three representative BERT-like models:BERT,RoBERTa,and DeBERTa.BERT serves as the baseline encoder-only architecture;RoBERTa incorporates advances in pretraining objectives and data scale;and DeBERTa introduces architectural improvements through disentangled attention mechanisms.The best performance was achieved with the DeBERTa model,although the other models also produced strong results,and no statistically significant differences were observed acrossmodels.We also find that these models typically reach optimal performance after only a few training epochs,and that training with smaller,balanced datasets is effective.Consequently,comparable results can be obtained with models that require fewer computational resources and less training time,facilitating deployment and practical use.展开更多
Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interact...Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interactions to predict future items of interest.However,many current methods rely on unique user and item IDs,limiting their ability to represent users and items effectively,especially in zero-shot learning scenarios where training data is scarce.With the rapid development of Large Language Models(LLMs),researchers are exploring their potential to enhance recommendation systems.However,there is a semantic gap between the linguistic semantics of LLMs and the collaborative semantics of recommendation systems,where items are typically indexed by IDs.Moreover,most research focuses on item representations,neglecting personalized user modeling.To address these issues,we propose a sequential recommendation framework using LLMs,called CIT-Rec,a model that integrates Collaborative semantics for user representation and Image and Text information for item representation to enhance Recommendations.Specifically,by aligning intuitive image information with text containing semantic features,we can more accurately represent items,improving item representation quality.We focus not only on item representations but also on user representations.To more precisely capture users’personalized preferences,we use traditional sequential recommendation models to train on users’historical interaction data,effectively capturing behavioral patterns.Finally,by combining LLMs and traditional sequential recommendation models,we allow the LLM to understand linguistic semantics while capturing collaborative semantics.Extensive evaluations on real-world datasets show that our model outperforms baseline methods,effectively combining user interaction history with item visual and textual modalities to provide personalized recommendations.展开更多
Knowledge distillation has become a standard technique for compressing large language models into efficient student models,but existing methods often struggle to balance prediction accuracy with explanation quality.Re...Knowledge distillation has become a standard technique for compressing large language models into efficient student models,but existing methods often struggle to balance prediction accuracy with explanation quality.Recent approaches such as Distilling Step-by-Step(DSbS)introduce explanation supervision,yet they apply it in a uniform manner that may not fully exploit the different learning dynamics of prediction and explanation.In this work,we propose a task-structured curriculum learning(TSCL)framework that structures training into three sequential phases:(i)prediction-only,to establish stable feature representations;(ii)joint prediction-explanation,to align task outputs with rationale generation;and(iii)explanation-only,to refine the quality of rationales.This design provides a simple but effective modification to DSbS,requiring no architectural changes and adding negligible training cost.We justify the phase scheduling with ablation studies and convergence analysis,showing that an initial prediction-heavy stage followed by a balanced joint phase improves both stability and explanation alignment.Extensive experiments on five datasets(e-SNLI,ANLI,CommonsenseQA,SVAMP,and MedNLI)demonstrate that TSCL consistently outperforms strong baselines,achieving gains of+1.7-2.6 points in accuracy and 0.8-1.2 in ROUGE-L,corresponding to relative error reductions of up to 21%.Beyond lexical metrics,human evaluation and ERASERstyle faithfulness diagnostics confirm that TSCL produces more faithful and informative explanations.Comparative training curves further reveal faster convergence and lower variance across seeds.Efficiency analysis shows less than 3%overhead in wall-clock training time and no additional inference cost,making the approach practical for realworld deployment.This study demonstrates that a simple task-structured curriculum can significantly improve the effectiveness of knowledge distillation.By separating and sequencing objectives,TSCL achieves a better balance between accuracy,stability,and explanation quality.The framework generalizes across domains,including medical NLI,and offers a principled recipe for future applications in multimodal reasoning and reinforcement learning.展开更多
The use of Unmanned Aerial Vehicles(UAVs)for defect detection on railway slopes is becoming increasingly widespread due to their ability to capture high-resolution images over large,inaccessible,and topographically co...The use of Unmanned Aerial Vehicles(UAVs)for defect detection on railway slopes is becoming increasingly widespread due to their ability to capture high-resolution images over large,inaccessible,and topographically complex areas.However,current UAV-based detection methods face several critical limitations,including constrained deployment frequency,limited availability of annotated defect data,and the lack of mature risk assessment frameworks.To address these challenges,this study introduces a novel approach that integrates diffusion models with Large Language Models(LLMs)to generate highquality synthetic defect images tailored to railway slope scenarios.Furthermore,an improved transformerbased architecture is proposed,incorporating attention mechanisms and LLM-guided diffusion-generated imagery to enhance defect recognition performance under complex environmental conditions.Experimental evaluations conducted on a dataset of 300 field-collected images from high-risk railway slopes demonstrate that the proposed method significantly outperforms existing baselines in terms of precision,recall,and robustness,indicating strong applicability for real-world railway infrastructure monitoring and disaster prevention.展开更多
The collection and annotation of lar ge-scale bird datasets are resource-intensive and time-consuming processes that significantly limit the scalability and accuracy of biodiversity monitoring systems.While self-super...The collection and annotation of lar ge-scale bird datasets are resource-intensive and time-consuming processes that significantly limit the scalability and accuracy of biodiversity monitoring systems.While self-supervised learning(SSL)has emerged as a promising approach for leveraging unannotated data,current SSL methods face two critical challenges in bird species recognition:(1)long-tailed data distributions that result in poor performance on underrepresented species;and(2)domain shift issues caused by data augmentation strategies designed to mitigate class imbalance.Here we present SDNet,a novel SSL-based bird recognition framework that integrates diffusion models with large language models(LLMs)to overcome these limitations.SDNet employs LLMs to generate semantically rich textual descriptions for tail-class species by prompting the models with species taxonomy,morphological attributes,and habitat information,producing detailed natural language priors that capture fine-grained visual characteristics(e.g.,plumage patterns,body proportions,and distinctive markings).These textual descriptions are subsequently used by a conditional diffusion model to synthesize new bird image samples through cross-attention mechanisms that fuse textual embeddings with intermediate visual feature representations during the denoising process,ensuring generated images preserve species-specific morphological details while maintaining photorealistic quality.Additionally,we incorporate a Swin Transformer as the feature extraction backbone whose hierarchical window-based attention mechanism and shifted windowing scheme enable multi-scale local feature extraction that proves particularly effective at capturing finegrained discriminative patterns(such as beak shape and feather texture)while mitigating domain shift between synthetic and original images through consistent feature representations across both data sources.SDNet is validated on both a self-constructed dataset(Bird_BXS)an d a publicly available benchmark(Birds_25),demonstrating substantial improvements over conventional SSL approaches.Our results indicate that the synergistic integration of LLMs,diffusion models,and the Swin Transformer architecture contributes significantly to recognition accuracy,particularly for rare and morphologically similar species.These findings highlight the potential of SDNet for addressing fundamental limitations of existing SSL methods in avian recognition tasks and establishing a new paradigm for efficient self-supervised learning in large-scale ornithological vision applications.展开更多
Background:Despite the promise shown by large language models(LLMs)for standardized tasks,their multidimensional performance in real-world oncology decision-making remains unevaluated.This study aims to introduce a fr...Background:Despite the promise shown by large language models(LLMs)for standardized tasks,their multidimensional performance in real-world oncology decision-making remains unevaluated.This study aims to introduce a framework for evaluating LLMs and physician decisions in challenging lung cancer cases.Methods:We curated 50 challenging lung cancer cases(25 local and 25 published)classified as complex,rare,or refractory.Blinded three-dimensional,five-point Likert evaluations(1–5 for comprehensiveness,specificity,and readability)compared standalone LLMs(DeepSeek R1,Claude 3.5,Gemini 1.5,and GPT-4o),physicians by experience level(junior,intermediate,and senior),and AI-assisted juniors;intergroup differences and augmentation effects were analyzed statistically.Results:Of 50 challenging cases(18 complex,17 rare,and 15 refractory)rated by three experts,DeepSeek R1 achieved scores of 3.95±0.33,3.71±0.53,and 4.26±0.18 for comprehensiveness,specificity,and readability,respectively,positioning it between intermediate(3.68,3.68,3.75)and senior(4.50,4.64,4.53)physicians.GPT-4o and Claude 3.5 reached intermediate physician–level comprehensiveness(3.76±0.39,3.60±0.39)but junior-to-intermediate physician–level specificity(3.39±0.39,3.39±0.49).All LLMs scored higher on rare cases than intermediate physicians but fell below junior physicians in refractory-case specificity.AIassisted junior physicians showed marked gains in rare cases,with comprehensiveness rising from 2.32 to 4.29(84.8%),specificity from 2.24 to 4.26(90.8%),and readability from 2.76 to 4.59(66.0%),while specificity declined by 3.2%(3.17 to 3.07)in refractory cases.Error analysis showed complementary strengths,with physicians demonstrating reasoning stability and LLMs excelling in knowledge updating and risk management.Conclusions:LLMs performed variably in clinical decision-making tasks depending on case type,performing better in rare cases and worse in refractory cases requiring longitudinal reasoning.Complementary strengths between LLMs and physicians support case-and task-tailored human–AI collaboration.展开更多
The article addresses the problem of the absence of a common language in international communication.Using the example of the UN Security Council session of March 2,2026,dedicated to children in armed conflicts,it ana...The article addresses the problem of the absence of a common language in international communication.Using the example of the UN Security Council session of March 2,2026,dedicated to children in armed conflicts,it analyzes a paradox:all participants speak about the same values but do not hear one another.As a solution,the Philosophical Matrix is proposed-a system of maximally general comparative concepts(the identical,the different,the correlative,the opposite,the orthogonal)that explicates a universal language of thinking,which the author calls the“language of Elohim”.The cultural-historical roots of this language are traced in the first chapter of Genesis,in Heraclitus,in Laozi,and in the Sefer Yetzirah.An analysis of the March 2 speeches allows us to diagnose at which levels of thinking(reason,practical mind,pure mind,wisdom)today’s educators and politicians operate.The conclusion proposes the“Wise School”project as a practical path for returning to the“language of Elohim”through education starting from early childhood.展开更多
Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the prefere...Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the preferences of Chinese dermatologists regarding LLM-generated responses in clinical psoriasis scenarios and to assess how they prioritize key quality dimensions,including accuracy,traceability,and logicality.Methods:A cross-sectional,web-based survey was conducted between December 25,2024,and January 22,2025,following the Checklist for Reporting Results of Internet E-Surveys guidelines.A total of 1247 valid responses were collected from practicing dermatologists across 33 of China's provincial-level administrative divisions.Participants evaluated responses to five categories of clinical questions(etiology,clinical presentation,differential diagnosis,treatment,and case study)generated by five LLMs:ChatGPT-4o,Kimi.ai,Doubao,ZuoYiGPT,and Lingyi-agent.Statistical associations between participant characteristics and model preferences were examined using chi-square tests.Results:ChatGPT-4o(Model 1)emerged as the most preferred model across all clinical tasks,consistently receiving the highest number of votes in case study(n=740),clinical presentation(n=666),differential diagnosis(n=707),etiology(n=602),and treatment(n=656).Significant variation in model preference by professional title was observed only for the differential diagnosis task(χ^(2)=21.13,df=12,p=0.0485),while no significant differences were found across hospital tiers(p>0.05).In terms of evaluation dimensions,accuracy was most frequently rated as“very important”(n=635).A significant association existed between hospital tier and the most valued dimension(χ^(2)=27.667,df=9,p=0.0011),with dermatologists in primary hospitals prioritizing traceability more than their peers in higher-tier hospitals.No significant associations were found across professional titles(p=0.127).Conclusions:Chinese dermatologists suggest a strong preference for ChatGPT-4o over domestic LLMs in psoriasis-related clinical tasks.While accuracy remains the primary criterion,traceability and logicality are also critical,particularly for clinicians in lower-tier hospitals.These findings suggest that future clinical LLMs should prioritize not only content accuracy but also source transparency and structural clarity to meet the diverse needs of different clinical settings.展开更多
In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the deve...In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the development of conventional material constitutive models—such as lengthy modeling cycles and difficulties in numerical implementation—this study proposes an intelligent modeling and code generation approach powered by large languagemodels.A structured knowledge base integrating constitutive theory,numerical algorithms,and UMAT(User Material)interface specifications is constructed,and a retrieval-augmented generation strategy is employed to establish an end-to-end workflow spanning experimental data parsing,constitutive model formulation,and automatic UMAT subroutine generation.Experimental results show that the method achieves high accuracy for both a classical Johnson–Cookmodel and a physics-informed neural network(PINN)model,with key parameter identification errors below 5%.Moreover,the automatically generated UMAT subroutines yield finite element simulation results in Abaqus that are highly consistent with theoretical predictions(coefficient of determination R2>0.98)while maintaining good numerical stability.This framework is currently focused on the automatic construction of rate-dependent elastoplastic material models,and its core method also provides a clear path for extending to other constitutive categories such as hyperelasticity and viscoelasticity.This work provides an effective technical route for the rapid development and reliable numerical implementation of material constitutive models,significantly advancing the intelligence level of computational mechanics research and improving engineering application efficiency.展开更多
Aligning natural language with operating system(OS)commands allows users to performcomplex computer tasks through simple natural language descriptions.However,due to the complex nature of natural language,it still rem...Aligning natural language with operating system(OS)commands allows users to performcomplex computer tasks through simple natural language descriptions.However,due to the complex nature of natural language,it still remains challenging to achieve precise alignment.In this paper,we present ComAlign,a Chinese benchmark dataset that pairs Chinese natural language descriptions with corresponding OS commands.ComAlign covers a broad range of 82 distinct OS command types with a total of 1811 natural language descriptions.We elaborate on the construction of ComAlign and construct three baselines to evaluate the alignment accuracy on ComAlign.Experimental results show that even advanced large language models struggle with certain ambiguously phrased OS commands.Specifically,the best performing baseline achieves 46.9%alignment accuracy.We demonstrate that ComAlign is collected from realworld application scenarios,making it particularly suitable for developing and benchmarking intelligent OS and agent systems that support user-machine interactions through natural language.展开更多
Conversational recommender systems(CRSs)focus on refining preferences and providing personalized recommendations through natural language interactions and dialogue history.Large language models(LLMs)have shown outstan...Conversational recommender systems(CRSs)focus on refining preferences and providing personalized recommendations through natural language interactions and dialogue history.Large language models(LLMs)have shown outstanding performance across various domains,thereby prompting researchers to investigate their applicability in recommendation systems.However,due to the lack of task-specific knowledge and an inefficient feature extraction process,LLMs still have suboptimal performance in recommendation tasks.Therefore,external knowledge sources,such as knowledge graphs(KGs)and knowledge bases(KBs),are often introduced to address the issue of data sparsity.Compared to KGs,KBs possess higher retrieval efficiency,making them more suitable for scenarios where LLMs serve as recommenders.To this end,we introduce a novel framework integrating LLMs with KBs for enhanced retrieval generation,namely LLMKB.LLMKB initially leverages structured knowledge to create mapping dictionaries,extracting entity-relation information from heterogeneous knowledge to construct KBs.Then,LLMKB achieves the embedding calibration between user information representations and documents in KBs through retrieval model fine-tuning.Finally,LLMKB employs retrievalaugmented generation to produce recommendations based on fused text inputs,followed by post-processing.Experiment results on two public CRS datasets demonstrate the effectiveness of our framework.Our code is publicly available at the link:https://anonymous.4open.science/r/LLMKB-6FD0.展开更多
This study examines how foreign language education in the artificial intelligence(AI)era could assist the cultivation of national consciousness through a technology-enhanced pedagogy of film appreciation.Using The Wil...This study examines how foreign language education in the artificial intelligence(AI)era could assist the cultivation of national consciousness through a technology-enhanced pedagogy of film appreciation.Using The Wild Robot as a case study,we argue that cinematic narratives serve as cultural mirrors,offering immersive,reflective,and affective sites for intercultural learning.We propose a three-layered pedagogical framework-progressing from semiotic decoding,through narrative and value comparison,to creative identity construction-that integrates intelligent tools to develop both communicative competence and an agentive sense of belonging.The approach exemplifies a humanistic turn in language teaching,aiming to form“rooted global communicators”who can engage in cross-civilization dialogue with cultural confidence and critical awareness.展开更多
Anxiety,motivation,and strategy have long been seen as critical in second language acquisition.This study presents a systematic review of the literature on these variables in terms of their relationship with one anoth...Anxiety,motivation,and strategy have long been seen as critical in second language acquisition.This study presents a systematic review of the literature on these variables in terms of their relationship with one another,their effects on learning outcomes,and how they are affected by technology-assisted tools in the teaching of Chinese as a second language.This study includes 24 articles for the review study based on the criteria and process of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol(PRISMA-P)and the clustering techniques of VOSviewer.It is found that 1)anxiety,motivation,and strategy were interrelated,that is,motivation was negatively associated with anxiety but positively related to strategy,while strategy could positively predict anxiety;2)anxiety could both positively and negatively affect learning outcomes,while motivation and strategy could both positively and insignificantly influence learning outcomes;3)the technology-assisted tools used in the classroom could both positively and negatively affect the levels of these variables and learning outcomes in the L2 Chinese context.The need to explore more complicated relationships between language-specific individual variables themselves and other possible factors that affect these variables,such as cultural ones,are also discussed for future research.展开更多
Mirror neuron system （MNS） represents one past decade, and it has been found to involve in multiple of the most important discoveries of cognitive neuroscience in the aspects of brain functions including action unde...Mirror neuron system （MNS） represents one past decade, and it has been found to involve in multiple of the most important discoveries of cognitive neuroscience in the aspects of brain functions including action understanding, imitation, language understanding, empathy, action prediction and speech evolution. This manuscript reviewed the function of MNS in action understanding as well as language evolution, and specifically assessed its roles as the bridge from body language to fluent speeches. Then we discussed the speech defects of autism patients due to the disruption of MNS. Finally, given that MNS is plastic in adult brain, we proposed MNS targeted therapy provides an efficient rehabilitation approach for brain damages conditions as well as autism patients.展开更多
ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential sec...ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future directions.Through this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.展开更多
Peptide-based therapeutics hold great promise for the treatment of various diseases;however,their clinical application is often hindered by toxicity challenges.The accurate prediction of peptide toxicity is crucial fo...Peptide-based therapeutics hold great promise for the treatment of various diseases;however,their clinical application is often hindered by toxicity challenges.The accurate prediction of peptide toxicity is crucial for designing safe peptide-based therapeutics.While traditional experimental approaches are time-consuming and expensive,computational methods have emerged as viable alternatives,including similarity-based and machine learning(ML)-/deep learning(DL)-based methods.However,existing methods often struggle with robustness and generalizability.To address these challenges,we propose HyPepTox-Fuse,a novel framework that fuses protein language model(PLM)-based embeddings with conventional descriptors.HyPepTox-Fuse integrates ensemble PLM-based embeddings to achieve richer peptide representations by leveraging a cross-modal multi-head attention mechanism and Transformer architecture.A robust feature ranking and selection pipeline further refines conventional descriptors,thus enhancing prediction performance.Our framework outperforms state-of-the-art methods in cross-validation and independent evaluations,offering a scalable and reliable tool for peptide toxicity prediction.Moreover,we conducted a case study to validate the robustness and generalizability of HyPepTox-Fuse,highlighting its effectiveness in enhancing model performance.Furthermore,the HyPepTox-Fuse server is freely accessible at https://balalab-skku.org/HyPepTox-Fuse/and the source code is publicly available at https://github.com/cbbl-skku-org/HyPepTox-Fuse/.The study thus presents an intuitive platform for predicting peptide toxicity and supports reproducibility through openly available datasets.展开更多
Recently,diffusion models have emerged as a promising paradigm for molecular design and optimization.However,most diffusion-based molecular generative models focus on modeling 2D graphs or 3D geom-etries,with limited ...Recently,diffusion models have emerged as a promising paradigm for molecular design and optimization.However,most diffusion-based molecular generative models focus on modeling 2D graphs or 3D geom-etries,with limited research on molecular sequence diffusion models.The International Union of Pure and Applied Chemistry(IUPAC)names are more akin to chemical natural language than the simplified molecular input line entry system(SMILES)for organic compounds.In this work,we apply an IUPAC-guided conditional diffusion model to facilitate molecular editing from chemical natural language to chemical language(SMILES)and explore whether the pre-trained generative performance of diffusion models can be transferred to chemical natural language.We propose DiffIUPAC,a controllable molecular editing diffusion model that converts IUPAC names to SMILES strings.Evaluation results demonstrate that our model out-performs existing methods and successfully captures the semantic rules of both chemical languages.Chemical space and scaffold analysis show that the model can generate similar compounds with diverse scaffolds within the specified constraints.Additionally,to illustrate the model’s applicability in drug design,we conducted case studies in functional group editing,analogue design and linker design.展开更多
基金This publication is part of the TrustBoost project,that has received funding from MICIU/AEI/10.13039/501100011033,from FEDER,UEIt is a coordinated project by a multidisciplinary team from the Universidad Politécnica de Madrid(UPM)and University of Granada(UGR),with two subprojects that address TrustBoost’s objectives:“Enhancing Trustworthiness in Conversational AI through Multimodal Affective Awareness”(Trust Boost-UPM,ref.PID2023-150584OB-C21)“Breaking the Duality of Conversational AI:Going beyond Guided Conversations While Ensuring Compliance with Domain Rules and Constraints”(Trust Boost-UGR,ref.PID2023-150584OB-C22).
文摘Building reliable intent-based,task-oriented dialog systems typically requires substantial manual effort:designers must derive intents,entities,responses,and control logic from raw conversational data,then iterate until the assistant behaves consistently.This paper investigates how far large language models(LLMs)can automate this development.In this paper,we use two reference corpora,Let’s Go(English,public transport)and MEDIA(French,hotel booking),to prompt four LLM families(GPT-4o,Claude,Gemini,Mistral Small)and generate the core specifications required by the rasa platform.These include intent sets with example utterances,entity definitions with slot mappings,response templates,and basic dialog flows.To structure this process,we introduce a model-and platform-agnostic pipelinewith two phases.The first normalizes and validates LLM-generated artifacts,enforcing crossfile consistency andmaking slot usage explicit.The second uses a lightweight dialog harness that runs scripted tests and incrementally patches failure points until conversations complete reliably.Across eight projects,all models required some targeted repairs before training.After applying our pipeline,all reached≥70%task completion(many above 84%),while NLU performance ranged from mid-0.6 to 1.0 macro-F1 depending on domain breadth.These results show that,with modest guidance,current LLMs can produce workable end-to-end dialog prototypes directly fromraw transcripts.Our main contributions are:(i)a reusable bootstrap method aligned with industry domain-specific languages(DSLs),(ii)a small set of high-impact corrective patterns,and(iii)a simple but effective harness for closed-loop refinement across conversational platforms.
文摘Background:Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology—Head and Neck Surgery systematic literature reviews.Methods:Three PRISMA-based systematic reviews(Jabbour et al.2017,Wong et al.2018,and Wu et al.2021)were replicated using ChatGPTv3.5 and Bard.Outputs(author,title,publication year,and journal)were compared to the original references and cross-referenced with medical databases for authenticity and recall.Results:Several themes emerged when comparing Bard and ChatGPT across the three reviews.Bard generated more outputs and had greater recall in Wong et al.'s review,with a broader date range in Jabbour et al.'s review.In Wu et al.'s review,ChatGPT-2 had higher recall and identified more authentic outputs than Bard-2.Conclusion:Large language models(LLMs)failed to fully replicate peer-reviewed methodologies,producing outputs with inaccuracies but identifying relevant,especially recent,articles missed by the references.While human-led PRISMA-based reviews remain the gold standard,refining LLMs for literature reviews shows potential.
基金National Key Research and Development Program of China(2024YFC3505400)Capital Clinical Project of Beijing Municipal Science&Technology Commission(Z221100007422092)Capital’s Funds for Health Improvement and Research(2024-1-2231).
文摘Objective To develop a clinical decision and prescription generation system(CDPGS)specifically for diarrhea in traditional Chinese medicine(TCM),utilizing a specialized large language model(LLM),Qwen-TCM-Dia,to standardize diagnostic processes and prescription generation.Methods Two primary datasets were constructed:an evaluation benchmark and a fine-tuning dataset consisting of fundamental diarrhea knowledge,medical records,and chain-ofthought(CoT)reasoning datasets.After an initial evaluation of 16 open-source LLMs across inference time,accuracy,and output quality,Qwen2.5 was selected as the base model due to its superior overall performance.We then employed a two-stage low-rank adaptation(LoRA)fine-tuning strategy,integrating continued pre-training on domain-specific knowledge with instruction fine-tuning using CoT-enriched medical records.This approach was designed to embed the clinical logic(symptoms→pathogenesis→therapeutic principles→prescriptions)into the model’s reasoning capabilities.The resulting fine-tuned model,specialized for TCM diarrhea,was designated as Qwen-TCM-Dia.Model performance was evaluated for disease diagnosis and syndrome type differentiation using accuracy,precision,recall,and F1-score.Furthermore,the quality of the generated prescriptions was compared with that of established open-source TCM LLMs.Results Qwen-TCM-Dia achieved peak performance compared to both the base Qwen2.5 model and five other open-source TCM LLMs.It achieved 97.05%accuracy and 91.48%F1-score in disease diagnosis,and 74.54%accuracy and 74.21%F1-score in syndrome type differentiation.Compared with existing open-source TCM LLMs(BianCang,HuangDi,LingDan,TCMLLM-PR,and ZhongJing),Qwen-TCM-Dia exhibited higher fidelity in reconstructing the“symptoms→pathogenesis→therapeutic principles→prescriptions”logic chain.It provided complete prescriptions,whereas other models often omitted dosages or generated mismatched prescriptions.Conclusion By integrating continued pre-training,CoT reasoning,and a two-stage fine-tuning strategy,this study establishes a CDPGS for diarrhea in TCM.The results demonstrate the synergistic effect of strengthening domain representation through pre-training and activating logical reasoning via CoT.This research not only provides critical technical support for the standardized diagnosis and treatment of diarrhea but also offers a scalable paradigm for the digital inheritance of expert TCM experience and the intelligent transformation of TCM.
文摘Classifying job offers into occupational categories is a fundamental task in human resource information systems,as it improves and streamlines indexing,search,and matching between openings and job seekers.Comprehensive occupational databases such as O∗NET or ESCO provide detailed taxonomies of interrelated positions that can be leveraged to align the textual content of postings with occupational categories,thereby facilitating standardization,cross-system interoperability,and access to metadata for each occupation(e.g.,tasks,knowledge,skills,and abilities).In this work,we explore the effectiveness of fine-tuning existing language models(LMs)to classify job offers with occupational descriptors from O∗NET.This enables a more precise assessment of candidate suitability by identifying the specific knowledge and skills required for each position,and helps automate recruitment processes by mitigating human bias and subjectivity in candidate selection.We evaluate three representative BERT-like models:BERT,RoBERTa,and DeBERTa.BERT serves as the baseline encoder-only architecture;RoBERTa incorporates advances in pretraining objectives and data scale;and DeBERTa introduces architectural improvements through disentangled attention mechanisms.The best performance was achieved with the DeBERTa model,although the other models also produced strong results,and no statistically significant differences were observed acrossmodels.We also find that these models typically reach optimal performance after only a few training epochs,and that training with smaller,balanced datasets is effective.Consequently,comparable results can be obtained with models that require fewer computational resources and less training time,facilitating deployment and practical use.
基金supported by the National Key R&D Program of China[2022YFF0902703]the State Administration for Market Regulation Science and Technology Plan Project(2024MK033).
文摘Recommendation systems are key to boosting user engagement,satisfaction,and retention,particularly on media platforms where personalized content is vital.Sequential recommendation systems learn from user-item interactions to predict future items of interest.However,many current methods rely on unique user and item IDs,limiting their ability to represent users and items effectively,especially in zero-shot learning scenarios where training data is scarce.With the rapid development of Large Language Models(LLMs),researchers are exploring their potential to enhance recommendation systems.However,there is a semantic gap between the linguistic semantics of LLMs and the collaborative semantics of recommendation systems,where items are typically indexed by IDs.Moreover,most research focuses on item representations,neglecting personalized user modeling.To address these issues,we propose a sequential recommendation framework using LLMs,called CIT-Rec,a model that integrates Collaborative semantics for user representation and Image and Text information for item representation to enhance Recommendations.Specifically,by aligning intuitive image information with text containing semantic features,we can more accurately represent items,improving item representation quality.We focus not only on item representations but also on user representations.To more precisely capture users’personalized preferences,we use traditional sequential recommendation models to train on users’historical interaction data,effectively capturing behavioral patterns.Finally,by combining LLMs and traditional sequential recommendation models,we allow the LLM to understand linguistic semantics while capturing collaborative semantics.Extensive evaluations on real-world datasets show that our model outperforms baseline methods,effectively combining user interaction history with item visual and textual modalities to provide personalized recommendations.
文摘Knowledge distillation has become a standard technique for compressing large language models into efficient student models,but existing methods often struggle to balance prediction accuracy with explanation quality.Recent approaches such as Distilling Step-by-Step(DSbS)introduce explanation supervision,yet they apply it in a uniform manner that may not fully exploit the different learning dynamics of prediction and explanation.In this work,we propose a task-structured curriculum learning(TSCL)framework that structures training into three sequential phases:(i)prediction-only,to establish stable feature representations;(ii)joint prediction-explanation,to align task outputs with rationale generation;and(iii)explanation-only,to refine the quality of rationales.This design provides a simple but effective modification to DSbS,requiring no architectural changes and adding negligible training cost.We justify the phase scheduling with ablation studies and convergence analysis,showing that an initial prediction-heavy stage followed by a balanced joint phase improves both stability and explanation alignment.Extensive experiments on five datasets(e-SNLI,ANLI,CommonsenseQA,SVAMP,and MedNLI)demonstrate that TSCL consistently outperforms strong baselines,achieving gains of+1.7-2.6 points in accuracy and 0.8-1.2 in ROUGE-L,corresponding to relative error reductions of up to 21%.Beyond lexical metrics,human evaluation and ERASERstyle faithfulness diagnostics confirm that TSCL produces more faithful and informative explanations.Comparative training curves further reveal faster convergence and lower variance across seeds.Efficiency analysis shows less than 3%overhead in wall-clock training time and no additional inference cost,making the approach practical for realworld deployment.This study demonstrates that a simple task-structured curriculum can significantly improve the effectiveness of knowledge distillation.By separating and sequencing objectives,TSCL achieves a better balance between accuracy,stability,and explanation quality.The framework generalizes across domains,including medical NLI,and offers a principled recipe for future applications in multimodal reasoning and reinforcement learning.
基金supported in part by the National Natural Science Foundation of China under Grant 52432012in part by the Shanghai Science and Technology Project with 25ZR1402508。
文摘The use of Unmanned Aerial Vehicles(UAVs)for defect detection on railway slopes is becoming increasingly widespread due to their ability to capture high-resolution images over large,inaccessible,and topographically complex areas.However,current UAV-based detection methods face several critical limitations,including constrained deployment frequency,limited availability of annotated defect data,and the lack of mature risk assessment frameworks.To address these challenges,this study introduces a novel approach that integrates diffusion models with Large Language Models(LLMs)to generate highquality synthetic defect images tailored to railway slope scenarios.Furthermore,an improved transformerbased architecture is proposed,incorporating attention mechanisms and LLM-guided diffusion-generated imagery to enhance defect recognition performance under complex environmental conditions.Experimental evaluations conducted on a dataset of 300 field-collected images from high-risk railway slopes demonstrate that the proposed method significantly outperforms existing baselines in terms of precision,recall,and robustness,indicating strong applicability for real-world railway infrastructure monitoring and disaster prevention.
基金supported by the National Natural Science Foundation of China(32471964)。
文摘The collection and annotation of lar ge-scale bird datasets are resource-intensive and time-consuming processes that significantly limit the scalability and accuracy of biodiversity monitoring systems.While self-supervised learning(SSL)has emerged as a promising approach for leveraging unannotated data,current SSL methods face two critical challenges in bird species recognition:(1)long-tailed data distributions that result in poor performance on underrepresented species;and(2)domain shift issues caused by data augmentation strategies designed to mitigate class imbalance.Here we present SDNet,a novel SSL-based bird recognition framework that integrates diffusion models with large language models(LLMs)to overcome these limitations.SDNet employs LLMs to generate semantically rich textual descriptions for tail-class species by prompting the models with species taxonomy,morphological attributes,and habitat information,producing detailed natural language priors that capture fine-grained visual characteristics(e.g.,plumage patterns,body proportions,and distinctive markings).These textual descriptions are subsequently used by a conditional diffusion model to synthesize new bird image samples through cross-attention mechanisms that fuse textual embeddings with intermediate visual feature representations during the denoising process,ensuring generated images preserve species-specific morphological details while maintaining photorealistic quality.Additionally,we incorporate a Swin Transformer as the feature extraction backbone whose hierarchical window-based attention mechanism and shifted windowing scheme enable multi-scale local feature extraction that proves particularly effective at capturing finegrained discriminative patterns(such as beak shape and feather texture)while mitigating domain shift between synthetic and original images through consistent feature representations across both data sources.SDNet is validated on both a self-constructed dataset(Bird_BXS)an d a publicly available benchmark(Birds_25),demonstrating substantial improvements over conventional SSL approaches.Our results indicate that the synergistic integration of LLMs,diffusion models,and the Swin Transformer architecture contributes significantly to recognition accuracy,particularly for rare and morphologically similar species.These findings highlight the potential of SDNet for addressing fundamental limitations of existing SSL methods in avian recognition tasks and establishing a new paradigm for efficient self-supervised learning in large-scale ornithological vision applications.
文摘Background:Despite the promise shown by large language models(LLMs)for standardized tasks,their multidimensional performance in real-world oncology decision-making remains unevaluated.This study aims to introduce a framework for evaluating LLMs and physician decisions in challenging lung cancer cases.Methods:We curated 50 challenging lung cancer cases(25 local and 25 published)classified as complex,rare,or refractory.Blinded three-dimensional,five-point Likert evaluations(1–5 for comprehensiveness,specificity,and readability)compared standalone LLMs(DeepSeek R1,Claude 3.5,Gemini 1.5,and GPT-4o),physicians by experience level(junior,intermediate,and senior),and AI-assisted juniors;intergroup differences and augmentation effects were analyzed statistically.Results:Of 50 challenging cases(18 complex,17 rare,and 15 refractory)rated by three experts,DeepSeek R1 achieved scores of 3.95±0.33,3.71±0.53,and 4.26±0.18 for comprehensiveness,specificity,and readability,respectively,positioning it between intermediate(3.68,3.68,3.75)and senior(4.50,4.64,4.53)physicians.GPT-4o and Claude 3.5 reached intermediate physician–level comprehensiveness(3.76±0.39,3.60±0.39)but junior-to-intermediate physician–level specificity(3.39±0.39,3.39±0.49).All LLMs scored higher on rare cases than intermediate physicians but fell below junior physicians in refractory-case specificity.AIassisted junior physicians showed marked gains in rare cases,with comprehensiveness rising from 2.32 to 4.29(84.8%),specificity from 2.24 to 4.26(90.8%),and readability from 2.76 to 4.59(66.0%),while specificity declined by 3.2%(3.17 to 3.07)in refractory cases.Error analysis showed complementary strengths,with physicians demonstrating reasoning stability and LLMs excelling in knowledge updating and risk management.Conclusions:LLMs performed variably in clinical decision-making tasks depending on case type,performing better in rare cases and worse in refractory cases requiring longitudinal reasoning.Complementary strengths between LLMs and physicians support case-and task-tailored human–AI collaboration.
文摘The article addresses the problem of the absence of a common language in international communication.Using the example of the UN Security Council session of March 2,2026,dedicated to children in armed conflicts,it analyzes a paradox:all participants speak about the same values but do not hear one another.As a solution,the Philosophical Matrix is proposed-a system of maximally general comparative concepts(the identical,the different,the correlative,the opposite,the orthogonal)that explicates a universal language of thinking,which the author calls the“language of Elohim”.The cultural-historical roots of this language are traced in the first chapter of Genesis,in Heraclitus,in Laozi,and in the Sefer Yetzirah.An analysis of the March 2 speeches allows us to diagnose at which levels of thinking(reason,practical mind,pure mind,wisdom)today’s educators and politicians operate.The conclusion proposes the“Wise School”project as a practical path for returning to the“language of Elohim”through education starting from early childhood.
基金National Key Research and Development Program of China,Grant/Award Number:2024YFF0507404Special Clinical Business Fund for High-Level Hospitals of China-Japan Friendship Hospital,Grant/Award Number:2024-NHLHCRF-TS-01。
文摘Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the preferences of Chinese dermatologists regarding LLM-generated responses in clinical psoriasis scenarios and to assess how they prioritize key quality dimensions,including accuracy,traceability,and logicality.Methods:A cross-sectional,web-based survey was conducted between December 25,2024,and January 22,2025,following the Checklist for Reporting Results of Internet E-Surveys guidelines.A total of 1247 valid responses were collected from practicing dermatologists across 33 of China's provincial-level administrative divisions.Participants evaluated responses to five categories of clinical questions(etiology,clinical presentation,differential diagnosis,treatment,and case study)generated by five LLMs:ChatGPT-4o,Kimi.ai,Doubao,ZuoYiGPT,and Lingyi-agent.Statistical associations between participant characteristics and model preferences were examined using chi-square tests.Results:ChatGPT-4o(Model 1)emerged as the most preferred model across all clinical tasks,consistently receiving the highest number of votes in case study(n=740),clinical presentation(n=666),differential diagnosis(n=707),etiology(n=602),and treatment(n=656).Significant variation in model preference by professional title was observed only for the differential diagnosis task(χ^(2)=21.13,df=12,p=0.0485),while no significant differences were found across hospital tiers(p>0.05).In terms of evaluation dimensions,accuracy was most frequently rated as“very important”(n=635).A significant association existed between hospital tier and the most valued dimension(χ^(2)=27.667,df=9,p=0.0011),with dermatologists in primary hospitals prioritizing traceability more than their peers in higher-tier hospitals.No significant associations were found across professional titles(p=0.127).Conclusions:Chinese dermatologists suggest a strong preference for ChatGPT-4o over domestic LLMs in psoriasis-related clinical tasks.While accuracy remains the primary criterion,traceability and logicality are also critical,particularly for clinicians in lower-tier hospitals.These findings suggest that future clinical LLMs should prioritize not only content accuracy but also source transparency and structural clarity to meet the diverse needs of different clinical settings.
基金funded by the National Natural Science Foundation of China,grant number 52405341Foundation of National Key Laboratory of Computational Physics,grant number 6142A05QN24012+1 种基金Chongqing Science and Technology Committee,grant number CSTB2023NSCQ-MSX0363The Science and Technology Research Program of Chongqing Municipal Education Commission,grant number KJQN202301117.
文摘In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the development of conventional material constitutive models—such as lengthy modeling cycles and difficulties in numerical implementation—this study proposes an intelligent modeling and code generation approach powered by large languagemodels.A structured knowledge base integrating constitutive theory,numerical algorithms,and UMAT(User Material)interface specifications is constructed,and a retrieval-augmented generation strategy is employed to establish an end-to-end workflow spanning experimental data parsing,constitutive model formulation,and automatic UMAT subroutine generation.Experimental results show that the method achieves high accuracy for both a classical Johnson–Cookmodel and a physics-informed neural network(PINN)model,with key parameter identification errors below 5%.Moreover,the automatically generated UMAT subroutines yield finite element simulation results in Abaqus that are highly consistent with theoretical predictions(coefficient of determination R2>0.98)while maintaining good numerical stability.This framework is currently focused on the automatic construction of rate-dependent elastoplastic material models,and its core method also provides a clear path for extending to other constitutive categories such as hyperelasticity and viscoelasticity.This work provides an effective technical route for the rapid development and reliable numerical implementation of material constitutive models,significantly advancing the intelligence level of computational mechanics research and improving engineering application efficiency.
基金supported by the National Key Research and Development Program under Grant 2024YFB4506200the Science and Technology Innovation Program of Hunan Province under Grant 2024RC1048the National Key Laboratory Foundation Project under Grant 2024-KJWPDL-14.
文摘Aligning natural language with operating system(OS)commands allows users to performcomplex computer tasks through simple natural language descriptions.However,due to the complex nature of natural language,it still remains challenging to achieve precise alignment.In this paper,we present ComAlign,a Chinese benchmark dataset that pairs Chinese natural language descriptions with corresponding OS commands.ComAlign covers a broad range of 82 distinct OS command types with a total of 1811 natural language descriptions.We elaborate on the construction of ComAlign and construct three baselines to evaluate the alignment accuracy on ComAlign.Experimental results show that even advanced large language models struggle with certain ambiguously phrased OS commands.Specifically,the best performing baseline achieves 46.9%alignment accuracy.We demonstrate that ComAlign is collected from realworld application scenarios,making it particularly suitable for developing and benchmarking intelligent OS and agent systems that support user-machine interactions through natural language.
文摘Conversational recommender systems(CRSs)focus on refining preferences and providing personalized recommendations through natural language interactions and dialogue history.Large language models(LLMs)have shown outstanding performance across various domains,thereby prompting researchers to investigate their applicability in recommendation systems.However,due to the lack of task-specific knowledge and an inefficient feature extraction process,LLMs still have suboptimal performance in recommendation tasks.Therefore,external knowledge sources,such as knowledge graphs(KGs)and knowledge bases(KBs),are often introduced to address the issue of data sparsity.Compared to KGs,KBs possess higher retrieval efficiency,making them more suitable for scenarios where LLMs serve as recommenders.To this end,we introduce a novel framework integrating LLMs with KBs for enhanced retrieval generation,namely LLMKB.LLMKB initially leverages structured knowledge to create mapping dictionaries,extracting entity-relation information from heterogeneous knowledge to construct KBs.Then,LLMKB achieves the embedding calibration between user information representations and documents in KBs through retrieval model fine-tuning.Finally,LLMKB employs retrievalaugmented generation to produce recommendations based on fused text inputs,followed by post-processing.Experiment results on two public CRS datasets demonstrate the effectiveness of our framework.Our code is publicly available at the link:https://anonymous.4open.science/r/LLMKB-6FD0.
基金supported by the project:Hunan Provincial Educational Science Research Project“Research on Cultivating National Consciousness in College Foreign Language Courses(XJT23CGD001)”.
文摘This study examines how foreign language education in the artificial intelligence(AI)era could assist the cultivation of national consciousness through a technology-enhanced pedagogy of film appreciation.Using The Wild Robot as a case study,we argue that cinematic narratives serve as cultural mirrors,offering immersive,reflective,and affective sites for intercultural learning.We propose a three-layered pedagogical framework-progressing from semiotic decoding,through narrative and value comparison,to creative identity construction-that integrates intelligent tools to develop both communicative competence and an agentive sense of belonging.The approach exemplifies a humanistic turn in language teaching,aiming to form“rooted global communicators”who can engage in cross-civilization dialogue with cultural confidence and critical awareness.
文摘Anxiety,motivation,and strategy have long been seen as critical in second language acquisition.This study presents a systematic review of the literature on these variables in terms of their relationship with one another,their effects on learning outcomes,and how they are affected by technology-assisted tools in the teaching of Chinese as a second language.This study includes 24 articles for the review study based on the criteria and process of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol(PRISMA-P)and the clustering techniques of VOSviewer.It is found that 1)anxiety,motivation,and strategy were interrelated,that is,motivation was negatively associated with anxiety but positively related to strategy,while strategy could positively predict anxiety;2)anxiety could both positively and negatively affect learning outcomes,while motivation and strategy could both positively and insignificantly influence learning outcomes;3)the technology-assisted tools used in the classroom could both positively and negatively affect the levels of these variables and learning outcomes in the L2 Chinese context.The need to explore more complicated relationships between language-specific individual variables themselves and other possible factors that affect these variables,such as cultural ones,are also discussed for future research.
基金Sci-ence Foundation of Ministry of Education of China (No.FBB011469)
文摘Mirror neuron system （MNS） represents one past decade, and it has been found to involve in multiple of the most important discoveries of cognitive neuroscience in the aspects of brain functions including action understanding, imitation, language understanding, empathy, action prediction and speech evolution. This manuscript reviewed the function of MNS in action understanding as well as language evolution, and specifically assessed its roles as the bridge from body language to fluent speeches. Then we discussed the speech defects of autism patients due to the disruption of MNS. Finally, given that MNS is plastic in adult brain, we proposed MNS targeted therapy provides an efficient rehabilitation approach for brain damages conditions as well as autism patients.
文摘ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future directions.Through this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT,Republic of Korea(Grant No.:RS-2024-00344752)supported by the Department of Integrative Biotechnology,Sungkyunkwan University(SKKU)and the BK21 FOUR Project,Republic of Korea.
文摘Peptide-based therapeutics hold great promise for the treatment of various diseases;however,their clinical application is often hindered by toxicity challenges.The accurate prediction of peptide toxicity is crucial for designing safe peptide-based therapeutics.While traditional experimental approaches are time-consuming and expensive,computational methods have emerged as viable alternatives,including similarity-based and machine learning(ML)-/deep learning(DL)-based methods.However,existing methods often struggle with robustness and generalizability.To address these challenges,we propose HyPepTox-Fuse,a novel framework that fuses protein language model(PLM)-based embeddings with conventional descriptors.HyPepTox-Fuse integrates ensemble PLM-based embeddings to achieve richer peptide representations by leveraging a cross-modal multi-head attention mechanism and Transformer architecture.A robust feature ranking and selection pipeline further refines conventional descriptors,thus enhancing prediction performance.Our framework outperforms state-of-the-art methods in cross-validation and independent evaluations,offering a scalable and reliable tool for peptide toxicity prediction.Moreover,we conducted a case study to validate the robustness and generalizability of HyPepTox-Fuse,highlighting its effectiveness in enhancing model performance.Furthermore,the HyPepTox-Fuse server is freely accessible at https://balalab-skku.org/HyPepTox-Fuse/and the source code is publicly available at https://github.com/cbbl-skku-org/HyPepTox-Fuse/.The study thus presents an intuitive platform for predicting peptide toxicity and supports reproducibility through openly available datasets.
基金supported by the Yonsei University graduate school Department of Integrative Biotechnology.
文摘Recently,diffusion models have emerged as a promising paradigm for molecular design and optimization.However,most diffusion-based molecular generative models focus on modeling 2D graphs or 3D geom-etries,with limited research on molecular sequence diffusion models.The International Union of Pure and Applied Chemistry(IUPAC)names are more akin to chemical natural language than the simplified molecular input line entry system(SMILES)for organic compounds.In this work,we apply an IUPAC-guided conditional diffusion model to facilitate molecular editing from chemical natural language to chemical language(SMILES)and explore whether the pre-trained generative performance of diffusion models can be transferred to chemical natural language.We propose DiffIUPAC,a controllable molecular editing diffusion model that converts IUPAC names to SMILES strings.Evaluation results demonstrate that our model out-performs existing methods and successfully captures the semantic rules of both chemical languages.Chemical space and scaffold analysis show that the model can generate similar compounds with diverse scaffolds within the specified constraints.Additionally,to illustrate the model’s applicability in drug design,we conducted case studies in functional group editing,analogue design and linker design.
