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The jointing stress analysis of one-shot seal-off high-voltage vacuum interrupters
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作者 赵智忠 邹积岩 +2 位作者 丛吉远 文化宾 孙辉 《China Welding》 EI CAS 2006年第2期50-54,共5页
The free shrinkage of ceramic or metal is restricted due to solidification of the solder. Hence the shrinkage stress arises and the jointing strength is reduced during the brazing of high-voltage vacuum interrupters ... The free shrinkage of ceramic or metal is restricted due to solidification of the solder. Hence the shrinkage stress arises and the jointing strength is reduced during the brazing of high-voltage vacuum interrupters (HVVIs). The solder bound contour was gained by solved energy bound equation. The finite element model of weld beads was established with Surface Evolver software. Then the stress in two different cooling techniques ( natural cooling and force cooling) was calculated with ANSYS. Comparing the stress, a better cooling technique was selected for HVVIs. Its cooling time is shortened by 3 hours while the jointing stress doesn' t increase and the tensile strength of ceramic to metal seal is not decreased. The stress-rupture tests have validated the calculated results. More important, a method is found, by which the brazing technique could be improved in advance instead of blind experiments. 展开更多
关键词 high-voltage vacuum interrupters brazing cooling technique finite element jointing stress
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New insights into the pain of knee osteoarthritis:the characteristics of deep pain and abnormal central processing 被引量:1
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作者 CHEN Mu-Lan DU Yu-Qing +4 位作者 XU Bo-Yang ZHAO Feng HU Xiao-Qing WANG Yun ZHANG Ying 《生理学报》 北大核心 2026年第1期47-56,共10页
Knee osteoarthritis(KOA)represents one of the most common causes of chronic pain.The high prevalence and disability rates of KOA impose a severe burden on both individuals and society.In contrast to cutaneous pain,KOA... Knee osteoarthritis(KOA)represents one of the most common causes of chronic pain.The high prevalence and disability rates of KOA impose a severe burden on both individuals and society.In contrast to cutaneous pain,KOA-induced joint pain is characterized as a deep tissue pain that potentially involves distinct subgroups of peripheral sensory neurons and central processing mechanisms.Furthermore,KOA pain is closely related to locomotion activity.Impaired sensorimotor integration and pain mutually reinforce each other in KOA,forming a vicious cycle that exacerbates disease progression.In this review,we highlight the key differences between KOA pain and cutaneous pain,and the latter has been extensively studied in the pain field.We hope to offer new insights into the central mechanisms and development of new treatment strategies for KOA based on the interactions between impaired sensorimotor integration and chronic joint pain. 展开更多
关键词 chronic pain joint pain sensorimotor integration INTEROCEPTION NEUROPLASTICITY
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Novel use of bisphosphonates to improve surgical outcomes in experimental bone tuberculosis
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作者 Veronika V Petukhova Alexander Yu Mushkin +6 位作者 Alexey S Maletin Marine Z Dogonadze Natalia V Zabolotnykh Marina E Dyakova Dilyara S Esmedlyaeva Tatiana I Vinogradova Mikhail M Kostik 《World Journal of Orthopedics》 2026年第1期119-131,共13页
BACKGROUND Tuberculous osteitis is a chronic,granulomatous bone infection that frequently results in impaired bone healing following surgery.Despite surgical intervention and prolonged anti-tuberculous therapy,complet... BACKGROUND Tuberculous osteitis is a chronic,granulomatous bone infection that frequently results in impaired bone healing following surgery.Despite surgical intervention and prolonged anti-tuberculous therapy,complete bone regeneration often remains unachieved,contributing to subsequent orthopedic complications.AIM To investigate the efficacy and safety of pamidronate in promoting bone regeneration following surgical treatment of experimental animal tuberculous osteitis.METHODS A controlled randomized basic study of rabbit femoral tuberculosis induced by Mycobacterium tuberculosis strain H37Rv included surgical removal of infected tissue and implantation of osteoinductive bone grafts with the following animal allocation to one of three groups:(1)Bisphosphonates alone;(2)Bisphosphonates combined with anti-tuberculous therapy;and(3)Anti-tuberculous therapy alone.The control group consisted of animals that received no surgical or medical treatment.Clinical evaluations,biochemical markers,micro-computed tomography imaging,and histomorphometry analyses were conducted at 3 months and 6 months postoperatively.RESULTS Pamidronate treatment significantly reduced early implant resorption,increased osteoblastic activity,improved trabecular bone regeneration,and maintained graft integrity compared to the anti-tuberculous therapy-only group.Histologically,pamidronate led to enhanced vascular remodeling and increased bone matrix formation.Crucially,bisphosphonate therapy demonstrated safety,compatibility with anti-tuberculous medications,and did not exacerbate tuberculous inflammation.Furthermore,micro-computed tomography analysis revealed a significant increase in trabecular thickness and density in pamidronate-treated groups,underscoring the anabolic effects of bisphosphonates.Morphometric evaluation confirmed a marked reduction in osteoclast number and activity at graft interfaces.These combined radiological,histological,and biochemical data collectively demonstrate the efficacy of pamidronate as an adjunctive agent in enhancing bone repair outcomes following surgical intervention for tuberculous osteitis.CONCLUSION A single intravenous dose of pamidronate significantly enhances bone regeneration and prevents implant resorption following surgical treatment of tuberculous osteitis.The following prospective studies are needed. 展开更多
关键词 TUBERCULOSIS Bone and joint tuberculosis PAMIDRONATE BISPHOSPHONATES Bone regeneration Bone grafting Bone resorption
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A Review of Evidence-Based Research on Rehabilitation Nursing after Joint Replacement Surgery
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作者 Ying Wang 《Journal of Clinical and Nursing Research》 2026年第1期41-47,共7页
With the intensification of population aging,knee and hip joint replacement surgeries have become core methods for treating end-stage joint diseases,with over a million cases performed globally each year.Postoperative... With the intensification of population aging,knee and hip joint replacement surgeries have become core methods for treating end-stage joint diseases,with over a million cases performed globally each year.Postoperative rehabilitation nursing,as a crucial aspect of enhancing surgical outcomes,reducing complications,and facilitating patients’return to normal life,has its scientific and effective protocols directly influencing patient prognosis.This article systematically reviews the core research findings on rehabilitation nursing after joint replacement surgery based on the concept of evidence-based medicine,aiming to provide references for the formulation of standardized and personalized rehabilitation nursing plans in clinical settings. 展开更多
关键词 Joint replacement surgery Rehabilitation nursing Evidence-based medicine Functional recovery Complication prevention
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Shear performance of NPR bolt under varying prestress levels
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作者 Wenhui Bian Kexue Wang +3 位作者 Jun Yang Qingshuo Hao Zhaoxi Zhai Xuefei Hong 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期528-541,共14页
The negative Poisson’s ratio(NPR)bolt is an innovative support element distinguished by its high strength,elongation,and a slightly negative Poisson’s ratio.Unlike conventional prestressed(PR)bolts with a positive P... The negative Poisson’s ratio(NPR)bolt is an innovative support element distinguished by its high strength,elongation,and a slightly negative Poisson’s ratio.Unlike conventional prestressed(PR)bolts with a positive Poisson’s ratio,the NPR bolt exhibits a quasi-ideal plastic response without a prominent yield platform,enabling it to sustain high prestress with a substantial safety margin,which is particularly advantageous for jointed rock masses.However,investigations into the shear resistance mechanisms of NPR bolts under varying prestress levels remain limited.This study conducted full-scale double shear tests to assess the shear strength,deformation behavior,energy absorption,and failure mechanisms of NPR bolts under different prestress conditions.To ensure a fair comparison with PR bolts,a prestress utilization coefficient(PUC)was introduced.The results reveal that at a PUC of 0.25,the NPR bolt achieved peak axial force,shear displacement,and peak shear force values that are 2.41,1.88,and 2.13 times greater than those of the PR bolt,respectively.Shear performance was optimized at a prestress level of 100 kN,with energy absorption reaching 47.1 kJ,which is 2.8 times that of the PR bolt.Furthermore,the necking ratio was significantly reduced,indicating more distributed plastic deformation and delayed failure.Field applications verified the superior performance,resulting in a 27.4%reduction in roof settlement and enhanced structural integrity.These findings confirm that NPR bolts possess excellent shear resistance,energy absorption,and deformation adaptability,and optimizing prestress significantly enhances their support performance,providing a strong basis for geotechnical engineering applications. 展开更多
关键词 NPR bolt Jointed rock mass Prestressed force Shear test Shear performance
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The effect of exercise rehabilitation on bone mineral density,muscle strength,and physical function outcomes in ACL ruptures:A randomized controlled clinical trial
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作者 Yue Wu Ruilan Dai +4 位作者 Yunan Zhou Wenqiang Yan Shuang Ren Xi Gong Yingfang Ao 《Sports Medicine and Health Science》 2026年第2期185-192,共8页
The purpose is to explore the effects of Exercise rehabilitation(ER)on bone mineral density(BMD)of the knee,muscle strength(MS),and physical function(PF)after ACL rupture.Finally,A total of 58 patients were randomized... The purpose is to explore the effects of Exercise rehabilitation(ER)on bone mineral density(BMD)of the knee,muscle strength(MS),and physical function(PF)after ACL rupture.Finally,A total of 58 patients were randomized into 2 groups(Control Group[CON]:conventional treatment,male=16,female=13,age=[31.63±8.01]years;Exercise rehabilitation group[ER]:6-week ER on CON basis,male=17,female=12,age=[31.26±7.07]years).At baseline and 6 weeks,the knee BMD was measured using DEXA,MS and PF measures were recorded by isokinetic strength test,IKDC,Lysholm,and VAS score.T-tests,analysis of variance(ANOVA),and Mann-Whitney tests were used for comparisons.The BMD outcomes:after a 6-week period,the BMD of the CON([1.47±0.24]g·cm^(-2))was significantly lower than that of the ER([1.65±0.37]g·cm^(-2))at lateral condyle of femur(LCF)(p=0.041).MS outcomes:at 6 weeks,the relative peak torque(RPT)of the quadriceps and hamstrings during concentric contractions in ER group were significantly higher than that in CON group(p<0.001,p=0.017).Similarly,during eccentric contractions in ER group,the RPT of the quadriceps and the H/Q ratio revealed significant variations from the CON group(p=0.033,p=0.043).PF outcomes:the IKDC,Lysholm,and VAS scores of the ER group were significantly improved compared to the CON group(p<0.001,p<0.001,p=0.002).The conclusion is that 6 weeks of ER intervention for patients with ACL rupture can effectively delay the decline of BMD in the LCF of the knee joint,and enhance the restoration of MS and PF.This provides guidance for clinical rehabilitation. 展开更多
关键词 Anterior cruciate ligament REHABILITATION Bone mineral density Joint function
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Research on Vehicle Joint Radar Communication Resource Optimization Method Based on GNN-DRL
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作者 Zeyu Chen Jian Sun +1 位作者 Zhengda Huan Ziyi Zhang 《Computers, Materials & Continua》 2026年第2期1430-1446,共17页
To address the issues of poor adaptability in resource allocation and low multi-agent cooperation efficiency in Joint Radar and Communication(JRC)systems under dynamic environments,an intelligent optimization framewor... To address the issues of poor adaptability in resource allocation and low multi-agent cooperation efficiency in Joint Radar and Communication(JRC)systems under dynamic environments,an intelligent optimization framework integrating Deep Reinforcement Learning(DRL)and Graph Neural Network(GNN)is proposed.This framework models resource allocation as a Partially Observable Markov Game(POMG),designs a weighted reward function to balance radar and communication efficiencies,adopts the Multi-Agent Proximal Policy Optimization(MAPPO)framework,and integrates Graph Convolutional Networks(GCN)and Graph Sample and Aggregate(Graph-SAGE)to optimize information interaction.Simulations show that,compared with traditional methods and pure DRL methods,the proposed framework achieves improvements in performance metrics such as communication success rate,Average Age of Information(AoI),and policy convergence speed,effectively enabling resource management in complex environments.Moreover,the proposed GNN-DRL-based intelligent optimization framework obtains significantly better performance for resource management in multi-agent JRC systems than traditional methods and pure DRL methods. 展开更多
关键词 Graph neural network joint radar and communication resource allocation multi-agent collaboration
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Quantifying and mapping the heterogeneity of rock joint roughness and shear strength for rapid field assessment
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作者 Changshuo Wang Chen Huang +4 位作者 Rui Yong Guangjian Liu Pengju An Zhongjun Ma Jibo Qin 《International Journal of Mining Science and Technology》 2026年第1期149-167,共19页
Rock mass stability is significantly influenced by the heterogeneity of rock joint roughness and shear strength.While modern technology facilitates assessing roughness heterogeneity,evaluating shear strength heterogen... Rock mass stability is significantly influenced by the heterogeneity of rock joint roughness and shear strength.While modern technology facilitates assessing roughness heterogeneity,evaluating shear strength heterogeneity remains challenging.To address this,this study first captures the morphology of large-scale(1000 mm × 1000 mm) slate and granite joints via 3D laser scanning.Analysis of these surfaces and corresponding push/pull tests on carved specimens revealed a potential correlation between the heterogeneity of roughness and shear strength.A comparative evaluation of five statistical metrics identified information entropy(Hs) as the most robust indicator for quantifying rock joint heterogeneity.Further analysis using Hsreveals that the heterogeneity is anisotropic and,critically,that shear strength heterogeneity is governed not only by roughness heterogeneity but is also significantly influenced by the mean roughness value,normal stress,and intact rock tensile strength.Consequently,a simple comparison of roughness Hsvalues is insufficient for reliably comparing shear strength heterogeneity.To overcome this limitation,a theoretical framework is developed to explicitly map fundamental roughness statistics(mean and heterogeneity) to shear strength heterogeneity.This framework culminates in a practical workflow that allows for the rapid,field-based assessment of shear strength heterogeneity using readily obtainable rock joint roughness data. 展开更多
关键词 Rock joint heterogeneity ROUGHNESS Shear strength Information entropy Push/pull test Rapid field assessment
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Single and Joint Acute Toxicity Effects of Glyphosate Isopropyl Amine Salt(GIS)and Atrazine(ATZ)on Juvenile Zebrafish(Danio rerio)
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作者 Emmanuel Godfrey Maneno Shiqi WEI +3 位作者 Xi CHEN Mingxiao LI Shunlong MENG Meshack Chubwa Maguru 《Agricultural Biotechnology》 2026年第1期22-25,共4页
The widespread use of herbicides such as glyphosate isopropyl amine salt(GIS)and atrazine(ATZ)poses significant risks to aquatic ecosystems.This study investigated the single and joint acute toxicity of a 1:1 GIS-ATZ ... The widespread use of herbicides such as glyphosate isopropyl amine salt(GIS)and atrazine(ATZ)poses significant risks to aquatic ecosystems.This study investigated the single and joint acute toxicity of a 1:1 GIS-ATZ mixture on zebrafish(Danio rerio).Acute tests determined 96-h LC_(50) values of 123.41 mg/L for GIS and 103.95 mg/L for ATZ.In the joint toxicity test,these values decreased to 60.96 and 50.88 mg/L,respectively.The Additive Index(AI)analysis revealed a consistent synergistic interaction between the herbicides at all exposure intervals.These findings underscore the enhanced ecological threat of herbicide mixtures and highlight the necessity of considering joint effects in environmental risk assessments. 展开更多
关键词 Acute toxicity Joint toxicity Glyphosate isopropyl amine salt ATRAZINE Zebrafish(Danio rerio)
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Face-Pedestrian Joint Feature Modeling with Cross-Category Dynamic Matching for Occlusion-Robust Multi-Object Tracking
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作者 Qin Hu Hongshan Kong 《Computers, Materials & Continua》 2026年第1期870-900,共31页
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba... To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions. 展开更多
关键词 Cross-category dynamic binding joint feature modeling face-pedestrian association multi object tracking occlusion robustness
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Deep Learning in Electromyography Signal-based Lower Limb Angle Prediction and Activity Classification
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作者 Gundala Jhansi Rani Mohammad Farukh Hashmi 《Journal of Bionic Engineering》 2026年第1期274-290,共17页
This research presents a Human Lower Limb Activity Recognition(HLLAR)system that identifies specific activities and predicts the angles of the knees simultaneously,based on the EMG signals.The HLLAR systems streamline... This research presents a Human Lower Limb Activity Recognition(HLLAR)system that identifies specific activities and predicts the angles of the knees simultaneously,based on the EMG signals.The HLLAR systems streamlines the research on the lower limb activities.The HILLAR model includes Discrete Hermite Wavelets Transform-based Synchrosqueezing(DHWTS),Deep Two-Layer Multiscale Convolutional Neural Network(DTLMCNN),and Generalized Regression Neural Network(GRNN)as feature extraction,activity recognition,and knee angle prediction respectively.Electromyography signal-based automatic lower limb activity detection is crucial to rehabilitation and human movement analysis.Yet several of these methods face issues in feature extraction in complex data,overlapping signals,extraction of crucial parameters,and adaptation constraints.This research aims classify lower limb activities and predict knee joint angles from electromy-ography signals using HILLAR model.The model is validated on two datasets,comprising 26 subjects performing three classes of activities:walking,standing,and sitting.The proposed model obtained a classification accuracy of 99.95%,along with significant achievements in precision(99.93%),recall(99.91%),and F1-score(99.93%).The generalized regression neural network predicted angles of the knee joint with a root mean squared error of 1.25%.Robustness is demonstrated through consistent results in five-fold cross-validation and statistical significance testing(p-value=0.004,McNemar's test).Additionally,the proposed model showed superior performance over baseline methods by reducing error rates by 18%and decreasing processing time to 0.98 s. 展开更多
关键词 ELECTROMYOGRAPHY Lower limb motion recognition Knee joint angle prediction Convolutional neural network Wavelet transform
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Microstructure evolution and corrosion behavior of refill friction stir spot welding joint for dissimilar Al alloys
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作者 Fang-yuan JIANG Da ZHANG +3 位作者 Yan-kun MA Jiang-tao XIONG Wei GUO Jing-long LI 《Transactions of Nonferrous Metals Society of China》 2026年第1期80-95,共16页
The dissimilar 2B06 and 7B04 Al alloy joints were prepared by refill friction stir spot welding(RFSSW),and the microstructural evolution and corrosion behavior of the joints were investigated.Based on microstructural ... The dissimilar 2B06 and 7B04 Al alloy joints were prepared by refill friction stir spot welding(RFSSW),and the microstructural evolution and corrosion behavior of the joints were investigated.Based on microstructural analysis,the welded joints exhibit distinct microstructural zones,including the stir zone(SZ),thermomechanically affected zone(TMAZ),and heat-affected zone(HAZ).The grain size of each zone is in the order of HAZ>TMAZ>SZ.Notably,the TMAZ and HAZ contain significantly larger secondary-phase particles compared to the SZ,with particle size in the HAZ increasing at higher rotational speeds.Electrochemical tests indicate that corrosion susceptibility follows the sequence of HAZ>TMAZ>SZ>BM,with greater sensitivity observed at increased rotational speeds.Post-corrosion mechanical performance degradation primarily arises from crevice corrosion at joint overlaps,but not from the changes in the microstructure. 展开更多
关键词 refill friction stir spot welding high strength Al alloy dissimilar joint microstructure evolution corrosion behavior
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Deep reinforcement learning-based adaptive collision avoidance method for UAV in joint operational airspace
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作者 Yan Shen Xuejun Zhang +1 位作者 Yan Li Weidong Zhang 《Defence Technology(防务技术)》 2026年第2期142-159,共18页
As joint operations have become a key trend in modern military development,unmanned aerial vehicles(UAVs)play an increasingly important role in enhancing the intelligence and responsiveness of combat systems.However,t... As joint operations have become a key trend in modern military development,unmanned aerial vehicles(UAVs)play an increasingly important role in enhancing the intelligence and responsiveness of combat systems.However,the heterogeneity of aircraft,partial observability,and dynamic uncertainty in operational airspace pose significant challenges to autonomous collision avoidance using traditional methods.To address these issues,this paper proposes an adaptive collision avoidance approach for UAVs based on deep reinforcement learning.First,a unified uncertainty model incorporating dynamic wind fields is constructed to capture the complexity of joint operational environments.Then,to effectively handle the heterogeneity between manned and unmanned aircraft and the limitations of dynamic observations,a sector-based partial observation mechanism is designed.A Dynamic Threat Prioritization Assessment algorithm is also proposed to evaluate potential collision threats from multiple dimensions,including time to closest approach,minimum separation distance,and aircraft type.Furthermore,a Hierarchical Prioritized Experience Replay(HPER)mechanism is introduced,which classifies experience samples into high,medium,and low priority levels to preferentially sample critical experiences,thereby improving learning efficiency and accelerating policy convergence.Simulation results show that the proposed HPER-D3QN algorithm outperforms existing methods in terms of learning speed,environmental adaptability,and robustness,significantly enhancing collision avoidance performance and convergence rate.Finally,transfer experiments on a high-fidelity battlefield airspace simulation platform validate the proposed method's deployment potential and practical applicability in complex,real-world joint operational scenarios. 展开更多
关键词 Unmanned aerial vehicle Collision avoidance Deep reinforcement learning Joint operational airspace Hierarchical prioritized experience replay
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Interfacial elemental diffusion behavior and microstructure evolution of DP780/TC4 joints by laser welding with H62 interlayer
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作者 Su-Yun Ye Tao-Tao Li +4 位作者 Rui-Feng Li Kai Qi Xiao-Lin Bi Hua-Wei Sun Gang Song 《Journal of Iron and Steel Research International》 2026年第1期427-442,共16页
A thorny problem in the miscible Ti/Fe system is the unavoidable formation of numerous brittle intermetallic compounds(IMCs).Adding H62 interlayer is an essential method to reduce the brittle IMCs or decrease the brit... A thorny problem in the miscible Ti/Fe system is the unavoidable formation of numerous brittle intermetallic compounds(IMCs).Adding H62 interlayer is an essential method to reduce the brittle IMCs or decrease the brittleness.A joint with good formability and tensile properties was obtained.The microstructure and element distribution of the joint were observed by metallographic microscopy,scanning electron microscopy and electron probe microanalysis.The shear resistance exhibited an initial increase,followed by a subsequent decrease,with an increase in heat input.It reached a maximum value of 2470 N at a welding energy of 267 kJ/m.The Fe-Ti brittle IMCs in TC4/DP780 joints are replaced by Fe-Cu phase and Cu-Ti phase,which reduces the brittleness at TC4/DP780 interface.The results show that the TC4/DP780 joint forms numerousα-Cu andγ-Fe solid solutions through the mutual diffusion and solid solution between H62 and TC4 layers of metals,which effectively inhibits the diffusion of Ti atoms and reduces the formation of brittle Ti-Fe IMCs.At the H62/TC4 interface,a composite layer composed of Cu-Ti IMCs and Cu-based solid solutions is formed.The composite layer grows dendritically from the TC4 alloy to the H62 interlayer.The microstructure at the TC4/DP780 interface changes from fine dendrites to coarse dendrites with the increase in Ti content and heat input.When the heat input is lower,the interfacial elements do not react sufficiently.When the heat input is excessive,microcracks appear at the TC4/DP780 interface,which limits the improvement of mechanical properties of TC4/DP780 joint. 展开更多
关键词 TC4/DP780 joint H62 interlayer Shear resistance Microstructure evolution
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LOXL2 deletion triggers TMJ osteoarthritis, while overexpression protects it from NF-κB-induced chondrocyte apoptosis
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作者 Rajnikant Dilip Raut Chumki Choudhury +8 位作者 Faiza Ali Amit kumar Chakraborty Mohammed Moeeduddin Ahmed Cheyleann Del Valle Ponce De Leon Harshal V.Modh Pushkar Mehra Yuwei Fan Alejandro Almarza Manish V.Bais 《International Journal of Oral Science》 2026年第1期78-89,共12页
Temporomandibular joint osteoarthritis(TMJ-OA) affects a significant proportion of the population worldwide.However,there has been no substantial progress in the development of FDA-approved drugs for treatment due to ... Temporomandibular joint osteoarthritis(TMJ-OA) affects a significant proportion of the population worldwide.However,there has been no substantial progress in the development of FDA-approved drugs for treatment due to a lack of understanding of the specific factors regulating key TMJ-OA molecular mechanisms.Lysyl Oxidase-Like-2(LOXL2) promotes knee joint cartilage protection and is down regulated in a TMJ-OA animal model.We evaluated the role of LOXL2 in TMJ cartilage,its molecular mechanism,and gene networks using in vivo Loxl2 knockout mice(Acan-Cre;Loxl2^(flox/flox)) and ex vivo goat TMJ cartilage.Our results show that Loxl2 knockout in mouse cartilage upregulates Il1b,Mmp9,Mmp13,Adamts4,and Adamts5,but reduces the levels of aggrecan and proteoglycan.Loxl2 deleted TMJ cartilage show a higher enrichment of inflammatory response,TNFA signaling via NF-κB,extracellular matrix(ECM),and collagen degradation pathway network.Conversely,LOXL2 treatment reduces interleukin-1beta(IL-1β)-induced expression of Mmp13,protects mitochondrial function,and ECM from degeneration.Importantly,LOXL2attenuates IL-1 β-induced chondrocyte apoptosis via the phosphorylation of NF-κB and expression of the pain-related gene PTGS2(encodes COX2).Taken together,Loxl2 knockout mice exacerbate TMJ-OA through cartilage/ECM degradation,mitochondrial dysfunction,chondrocyte apoptosis,and inflammatory gene expression,whereas LOXL2 treatment mitigate these effects. 展开更多
关键词 tmj cartilageits chondrocyte apoptosis gene networks temporomandibular joint osteoarthritis tmj oa nf b inflammatory response molecular mechanismslysyl tmj osteoarthritis
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Science and Solidarity--What drought-prone Burkina Faso can learn from China’s irrigation systems
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作者 ROUKIATOU ALINE BENIWENDE PAMTABA 《ChinAfrica》 2026年第1期58-59,共2页
As part of my master’s programme in resource use and environmental science at China Agricultural University,I had the privilege of joining a study trip to the Shiyang River Basin and its surrounding areas from 17 to ... As part of my master’s programme in resource use and environmental science at China Agricultural University,I had the privilege of joining a study trip to the Shiyang River Basin and its surrounding areas from 17 to 21 July 2025.This trip to Gansu Province was organised under the China-Africa Joint Centre for Agricultural Demonstration and Training in Arid Regions programme,an initiative aligned with President Xi Jinping’s call for deeper China-Africa cooperation. 展开更多
关键词 Shiyang River Basin resource use environmental science Burkina Faso drought prone resource use environmental science China Africa joint centre China
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Coronal plane alignment of the knee phenotypes and ankle joint coronal plane alignment patterns in Egyptian population
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作者 Ahmed A Khalifa Mohamed Moustafa +3 位作者 Shikuria Lemma Mostafa Fayez Ahmed M Abdelaal Amr A Fadle 《World Journal of Orthopedics》 2026年第1期67-80,共14页
BACKGROUND In an era leaning toward a personalized alignment of total knee arthroplasty,coronal plane alignment of the knee(CPAK)phenotypes for each population are studied;furthermore,other possible variables affectin... BACKGROUND In an era leaning toward a personalized alignment of total knee arthroplasty,coronal plane alignment of the knee(CPAK)phenotypes for each population are studied;furthermore,other possible variables affecting the alignment,such as ankle joint alignment,should be considered.AIM To determine CPAK distribution in the North African(Egyptian)population with knee osteoarthritis and to assess ankle joint line orientation(AJLO)adaptations across different CPAK types.METHODS A cross-sectional study was conducted on patients with primary knee osteoarthritis and normal ankle joints.Radiographic parameters included the mechanical lateral distal femoral angle,medial proximal tibial angle,and the derived calculations of joint line obliquity(JLO)and arithmetic hip-knee-ankle angle(aHKA).The tibial plafond horizontal angle(TPHA)was used for AJLO assessment,where 0°is neutral(type N),<0°is varus(type A),and>0°is valgus(type B).The nine CPAK types were further divided into 27 subtypes after incorporating the three AJLO types.RESULTS A total of 527 patients(1054 knees)were included for CPAK classification,and 435 patients(870 knees and ankles)for AJLO assessment.The mean age was 57.2±7.8 years,with 79.5%females.Most knees(76.4%)demonstrated varus alignment(mean aHKA was-5.51°±4.84°)and apex distal JLO(55.3%)(mean JLO was 176.43°±4.53°).CPAK types I(44.3%),IV(28.6%),and II(10%)were the most common.Regarding AJLO,70.2%of ankles exhibited varus orientation(mean TPHA was-5.21°±6.45°).The most frequent combined subtypes were CPAK type I-A(33.7%),IV-A(21.5%),and I-N(6.9%).A significant positive correlation was found between the TPHA and aHKA(r=0.40,P<0.001).CONCLUSION In this North African cohort,varus knee alignment with apex distal JLO and varus AJLO predominated.CPAK types I,IV,and II were the most common types,while subtypes I-A,IV-A,and I-N were commonly occurring after incorporating AJLO types;furthermore,the AJLO was significantly correlated to aHKA. 展开更多
关键词 Coronal plane alignment of the knee classification Coronal alignment Ankle joint alignment Knee arthroplasty Knee replacement North African population
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Satellite handover strategies based on minimum routing hops for mega LEO satellite networks
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作者 ZHU Hongtao WANG Xinyu +2 位作者 WANG Zhenyong LI Dezhi GUO Qing 《Journal of Systems Engineering and Electronics》 2026年第1期64-74,共11页
Mega low Earth orbit(LEO)satellite networks serve as effective complements to terrestrial networks.However,the dual mobility of users and LEO satellites makes inter-satellite handovers more frequent for users.Moreover... Mega low Earth orbit(LEO)satellite networks serve as effective complements to terrestrial networks.However,the dual mobility of users and LEO satellites makes inter-satellite handovers more frequent for users.Moreover,there are both ascending and descending segments in widely deployed walker-delta constellations.Even if the locations of users do not change,when the access satellites of the communicating parties are not in the same ascending or descending segment,the end-to-end latency between them will increase.To address this challenge,the self-decision handover(SDH)strategy and the joint decision handover(JDH)strategy are proposed,and they both incorporate the routing hops as a crucial handover criterion to minimize the end-to-end latency.In addition,the shortest route hop-count algorithm is designed to assist in the handover decision-making process.Simulations demonstrate that the proposed handover strategies outperform the traditional handover strategies in terms of the number of handovers and end-to-end latency. 展开更多
关键词 mega low Earth orbit(LEO)satellite network walker-delta constellation self-decision handover joint decision handover minimum routing hop
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Dynamic instability and catastrophe mechanisms of surrounding rock with rigid-flexible coupling supporting structure under bidirectional impact loading
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作者 YANG Rong-zhou XU Ying +2 位作者 ZHANG Quan HE Man-chao YU Mei-lu 《Journal of Central South University》 2026年第1期224-256,共33页
Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"ove... Aiming at the problem of dynamic instability of hard-brittle jointed rock surrounding in deep tunnel/roadway engineering,combining with the support concepts of"coupling rigidity with flexibility"and"overcoming rigidity by flexibility",the prevention and control method with"rigid-flexible coupling(R-F-C)"was put forward.Through numerical simulation calculation,the impact damage process,acoustic emission(AE)evolution characteristics,and element stress/displacement evolution characteristics of unsupported surrounding rock structure model,rigid supporting surrounding rock structure model,and"R-F-C"supporting surrounding rock structure model under horizontal bidirectional impact loading were compared and analyzed.Based on the theory of stress wave propagation,the dynamic instability catastrophe mechanism of three kinds of supporting structure models induced by horizontal bidirectional impact loading was revealed.Based on the Mohr-Coulomb strength theory,the stress discrimination methods of dynamic catastrophe of surrounding rock induced by horizontal bidirectional impact loading under three kinds of supporting structures were proposed.Combined with the above numerical simulation study,the explosion impact physical and mechanical test of"R-F-C"surrounding rock supporting plate structure was further designed and carried out.Finally,combined with the"conceptual model of ball-cliff potential energy instability",the energy driving theory and energy transformation mechanism of impact-induced rockburst under three kinds of supporting structures were discussed deeply.The research results provided a scientific basis for further promoting the effective application of"R-F-C"supporting structure in the prevention and control of dynamic instability of deep tunnel/roadway surrounding rock. 展开更多
关键词 jointed surrounding rock rigid-flexible coupling(R-F-C)supporting structure stress wave propagation acoustic emission(AE) damage evolution impact instability catastrophe mechanism
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Influence of different illuminations with xenon or microwave sulfur lamp on jointing and tillering of wheat 被引量:2
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作者 CHEN Qilin LIU Yuequn +3 位作者 YU Xinjian CHEN Jinxing WENG Jun XU Chunhe 《Chinese Science Bulletin》 SCIE EI CAS 2002年第17期1433-1437,1498,共6页
The emission of microwave sulfur lamp is mainly composed of visible light. The sulfur lamp, producing little infrared radiation, has high efficiency, long duration of illumination and less energy consumption. In order... The emission of microwave sulfur lamp is mainly composed of visible light. The sulfur lamp, producing little infrared radiation, has high efficiency, long duration of illumination and less energy consumption. In order to probe the agricultural application of the lamp, experiments were carried out with wheat (cv. Yangmai 158) to emphatically study illuminating effects of xenon or sulfur lamp on tillering, jointing and net photosynthetic rate during tillering and jointing periods. Results indicated that there is almost no difference in net photosynthetic rate of wheat leaves growing under different lamps. Xenon lamp significantly advanced the time of jointing, decreased number of tillers, number of total leaves per plant and leaf size, as well as inhibited root growth. In contrast with xenon lamp, sulfur lamp evidently delays the time of heading and grain maturation, increased number of heads per plant, head length, total number of grains per plant, head weight and total grain weight per plant, 展开更多
关键词 sulfur LAMP XENON LAMP joint TILLER wheat.
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