Palladium-catalyzed asymmetric allylic C-H functionalization is an efficient method for the construction of enantiomerically enriched allylic derivatives.This includes asymmetric allylic amination reactions for the ef...Palladium-catalyzed asymmetric allylic C-H functionalization is an efficient method for the construction of enantiomerically enriched allylic derivatives.This includes asymmetric allylic amination reactions for the efficient construction of chiral amines.However,the asymmetric allylic C-H amination of alkenes by Lewis basic amines is a longstanding challenge.Herein,we present a highly efficient method for the palladium-catalyzed asymmetric intramolecular allylic C-H amination reaction.This method provides a means for synthesizing a range of biologically important enantioenriched isoindolines with high yields and excellent enantioselectivities(up to 98%yield and 98%ee).展开更多
基金support was provided by the State Key Laboratory of Pulp and Paper Engineering,China(grant no.2022PY01)the National Natural Science Foundation of China(grant nos.22231002 and 21871095)the KeyArea Research and Development Program of Guangdong Province,China(grant no.2020B010188001)。
文摘Palladium-catalyzed asymmetric allylic C-H functionalization is an efficient method for the construction of enantiomerically enriched allylic derivatives.This includes asymmetric allylic amination reactions for the efficient construction of chiral amines.However,the asymmetric allylic C-H amination of alkenes by Lewis basic amines is a longstanding challenge.Herein,we present a highly efficient method for the palladium-catalyzed asymmetric intramolecular allylic C-H amination reaction.This method provides a means for synthesizing a range of biologically important enantioenriched isoindolines with high yields and excellent enantioselectivities(up to 98%yield and 98%ee).
