Thermodynamic properties and electrochemical behaviors of gold and its associated elements, such as silver, copper, nickel and iron, in various complex agent solutions were studied. Within CS（NH2）2, S2O2-3 and SCN- ...Thermodynamic properties and electrochemical behaviors of gold and its associated elements, such as silver, copper, nickel and iron, in various complex agent solutions were studied. Within CS（NH2）2, S2O2-3 and SCN- systems, alkaline thiourea is the optimal nontoxic lixiviating agent substituting cyanide from the viewpoint of thermodynamics. The electrochemical study indicates that the anodic dissolution current densities of gold are 2.616, （1.805,） 1.267, 1.088, 0.556, and 0.145 mA·cm-2 respectively in the solutions of cyanide, alkaline thiourea containing Na2SiO3, SCN-, acidic thiourea, alkaline thiourea and thiosulfate at the potential of 0.500 V. Comparing various lixiviating agents, the alkaline thiourea solution containing Na2SiO3 is of prominent selectivity in leaching gold, in the potential range from 0.500 to 0.600 V, which is most efficient for leaching gold selectively instead of cyanide. The effect on leaching gold is similar to that in the cyanide system.展开更多
Numerical simulation of meso-β-scale convective cloud systems associated with a PRE-STORM MCC case has been carried out using a 2-D version of the CSU Regional Atmospheric Modeling System (RAMS) nonhydrostatic model ...Numerical simulation of meso-β-scale convective cloud systems associated with a PRE-STORM MCC case has been carried out using a 2-D version of the CSU Regional Atmospheric Modeling System (RAMS) nonhydrostatic model with parameterized microphysics. It is found that the predicted meso-r-scale convective phenomena arc basically unsteady under the situation of strong shear at low-levels, while the meso-β-scale convective system is maintained up to 3 hours or more. The meso -β- scale cloud system exhibits characteristics of a multi-celled convective storm in which the meso-r-scale convective cells have lifetime of about 30 min. Pressure perturbation depicts a meso-low after a half hour in the low levels. As the cloud system evolves, the meso-low intensifies and extends to the upshear side and covers the entire domain in the mid-lower levels with the peak values of 5-8 hPa. Temperature perturbation depicts a warm region in the middle levels through the entire simulation period. The meso-r-scale warm cores with peak values of 4-8 ℃ are associated with strong convective cells. The cloud top evaporation causes a stronger cold layer around the cloud top levels.Simulation of microphysics exhibits that graupel is primarily concentrated in the strong convective cells forming the main source of convective rainfall after one hour of simulation time. Aggregates are mainly located in the stratiform region and decaying convective cells which produce the stratiform rainfall. Riming of the ice crystals is the predominant precipitation formation mechanism in the convection region, whereas aggregation of ice crystals is the predominant one in the stratiform region, which is consistent with observations. Sensitivity experiments of ice-phase mierophysical processes show that the microphysical structures of the convective cloud system can be simulated better with the diagnosed aggregation collection efficiencies.展开更多
The research on dyke swarms is very important,for it can not only shed light on within-plate geological processes of some regions but also contribute to our understanding on evolution of a specific orogenic belt.The Y...The research on dyke swarms is very important,for it can not only shed light on within-plate geological processes of some regions but also contribute to our understanding on evolution of a specific orogenic belt.The Yangtze Block,展开更多
Objective To explore the diagnosis and treatment features of tuberous sclerosis complex associated renal cell carcinoma. Methods A 22-year-old boy with a childhood history of epilepsy and mental retardation pres-
Worldwide,metastasis is the leading cause of more than 90%of cancer-related deaths.Currently,no specific therapies effectively impede metastasis.Metastatic processes are controlled by complex regulatory networks and t...Worldwide,metastasis is the leading cause of more than 90%of cancer-related deaths.Currently,no specific therapies effectively impede metastasis.Metastatic processes are controlled by complex regulatory networks and transcriptional hierarchy.Corepressor metastasis-associated protein 3(MTA3)has been confirmed as a novel component of nucleosome remodeling and histone deacetylation(NuRD).Increasing evidence supports the theory that,in the recruitment of transcription factors,coregulators function as master regulators rather than passive passengers.As a master regulator,MTA3 governs the target selection for Nu RD and functions as a transcriptional repressor.MTA3dysregulation is associated with tumor progression,invasion,and metastasis in various cancers.MTA3 is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal transition.Elucidating the functions of MTA3 might help to find additional therapeutic approaches for targeting components of NuRD.展开更多
Aim： To investigate the stage-specific localization of metastasis-associated protein 1 （MTA1） during spermatogenesis in adult human and mouse testis. Methods： The immunolocalization of MTA1 was studied by immunohi...Aim： To investigate the stage-specific localization of metastasis-associated protein 1 （MTA1） during spermatogenesis in adult human and mouse testis. Methods： The immunolocalization of MTA1 was studied by immunohistochemistry and Western blot analysis. The distribution pattern of MTA1 in mouse testis was confirmed by using quantitative analysis of purified spermatogenic cells. Results： The specificity of polyclonal antibody was confirmed by Western blot analysis. MTA1 was found expressed in the nucleus of germ cells, except elongate spermatids, and in the cytoplasm of Sertoli cells; Leydig cells did not show any specific reactivity. MTA1 possessed different distribution patterns in the two species： in humans, the most intensive staining was found in the nucleus of round spermatids and of primary spermatocytes while in mice, the most intense MTA 1 staining was in the nucleus of leptotene, zygotene and pachytene spermatocytes. In both species the staining exhibited a cyclic pattern. Conclusion： The present communication initially provides new evidence for the potential role of MTA1 in mature testis. In addition, its distinctive expression in germ cells suggests a regulatory role of the peptide during spermatogenesis.展开更多
AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.M...AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.METHODS The English language medical literature on gut-or gastrointestinal-associated lymphoid tissue(GALT) or "dome" carcinoma of the colon was searched and appraised.RESULTS GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque-or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence.CONCLUSION Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.展开更多
In this paper, a novel design procedure is proposed for synthesizing high-capacity auto-associative memories based on complex-valued neural networks with real-imaginary-type activation functions and constant delays. S...In this paper, a novel design procedure is proposed for synthesizing high-capacity auto-associative memories based on complex-valued neural networks with real-imaginary-type activation functions and constant delays. Stability criteria dependent on external inputs of neural networks are derived. The designed networks can retrieve the stored patterns by external inputs rather than initial conditions. The derivation can memorize the desired patterns with lower-dimensional neural networks than real-valued neural networks, and eliminate spurious equilibria of complex-valued neural networks. One numerical example is provided to show the effectiveness and superiority of the presented results.展开更多
Integrated Sensing and Communication(ISAC)is envisioned as a promising technology for Sixth-Generation(6G)wireless communications,which enables simultaneous high-rate communication and high-precision target localizati...Integrated Sensing and Communication(ISAC)is envisioned as a promising technology for Sixth-Generation(6G)wireless communications,which enables simultaneous high-rate communication and high-precision target localization.Compared to independent sensing and communication modules,dual-function ISAC could leverage the strengths of both communication and sensing in order to achieve cooperative gains.When considering the communication core network,ISAC system facilitates multiple communication devices to collaborate for networked sensing.This paper investigates such kind of cooperative ISAC systems with distributed transmitters and receivers to support non-connected and multi-target localization.Specifically,we introduce a Time of Arrival(TOA)based multi-target localization scheme,which leverages the bi-static range measurements between the transmitter,target,and receiver channels in order to achieve elliptical localization.To obtain the low-complexity localization,a two-stage search-refine localization methodology is proposed.In the first stage,we propose a Successive Greedy Grid-Search(SGGS)algorithm and a Successive-Cancellation-List Grid-Search(SCLGS)algorithm to address the Measurement-to-Target Association(MTA)problem with relatively low computational complexity.In the second stage,a linear approximation refinement algorithm is derived to facilitate high-precision localization.Simulation results are presented to validate the effectiveness and superiority of our proposed multi-target localization method.展开更多
Luminescent Fe(Ⅲ) complexes have received increasing attention in recent years.However,upconversion luminescence from Fe(Ⅲ) complexes has not been explored yet,due to the low photoluminescence quantum yields(PLQYs)o...Luminescent Fe(Ⅲ) complexes have received increasing attention in recent years.However,upconversion luminescence from Fe(Ⅲ) complexes has not been explored yet,due to the low photoluminescence quantum yields(PLQYs)of Fe(Ⅲ) complexes,as well as a significant challenge in combining a proper sensitizer and Fe(Ⅲ) activator.In this work,a novel ion-paired Fe(Ⅲ)-Yb(Ⅲ) complex[Fe(phtmeimb)_(2)][Yb(ND)_(4)]was designed and synthesized,where the cation[Fe(phtmeimb)_(2)]^(+)(phtmeimb=phenyl[tris(3-methylimidazol-1-ylidene)]borate)arming the highest PLQY among Fe(Ⅲ) complexes so far was employed as activator,and the anion[Yb(ND)_(4)]^(-)(ND=3-cyano-2-methyl-1,5-naphthyridin-4-olate)featuring a large absorption cross-section at 980 nm was constructed as sensitizer.Upon the excitation of 980 nm,red doublet ligand-to-metal charge transfer(^(2)LMCT)emission of[Fe(phtmeimb)_(2)]^(+)was realized both in solution and doped film through a cooperative sensitization upconversion process.This is the first time to achieve Fe(Ⅲ) complex-based emission using the near-infrared light excitation,demonstrating the great potential of luminescent Fe(Ⅲ) complexes as activators in the upconversion luminescence field and promoting the development of fundamental research on the iron-based optical functional materials.展开更多
Genome-wide association studies （GWASs） have identified thousands of genes and genetic variants （mainly SNPs） that contribute to complex diseases in humans. Functional characterization and mechanistic elucidation ...Genome-wide association studies （GWASs） have identified thousands of genes and genetic variants （mainly SNPs） that contribute to complex diseases in humans. Functional characterization and mechanistic elucidation of these SNPs and genes action are the next major challenge. It has been well established that SNPs altering the amino acids of protein-coding genes can drastically impact protein function, and play an important role in molecular pathogenesis. Functions of regulatory SNPs can be complex and elusive, and involve gene expression regulation through the effect on RNA splicing, transcription factor binding, DNA metbylation and miRNA recruitment. In the present review, we summarize the recent progress in our understanding of functional consequences of GWAS-associated non-coding regulatory SNPs, and discuss the application of systems genetics and network biology in the interpretation of GWAS findings.展开更多
Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and pheno...Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and phenotype for 60 leaf samples at four developmental stages, from three plant architectural positions and for three cultivars that were grown in two locations. Association mapping was conducted to detect genetic variants at quantitative trait SNP(QTS) loci, quantitative trait transcript(QTT) differences,quantitative trait protein(QTP) variability, and quantitative trait metabolite(QTM) changes,which can be summarized as QTX locus variation. The total heritabilities of the four-omics loci for both traits tested were 23.60% for epistasis and 15.26% for treatment interaction.Epistasis and environment × treatment interaction had important impacts on complex traits at all-omics levels. For decreasing chromium content and increasing total sugar in tobacco leaf, six methylated loci can be directly used for marker-assisted selection, and expression of ten QTTs, seven QTPs and six QTMs can be modified by selection or cultivation.展开更多
Neuromyelitis optica（NMO） and multiple sclerosis（ M S） a r e b o t h a u t o i m m u n e i n f l a m m a t o r y a n d demyelinating disorders of the central nervous system. Recently, more than 50 MS-susceptibilit...Neuromyelitis optica（NMO） and multiple sclerosis（ M S） a r e b o t h a u t o i m m u n e i n f l a m m a t o r y a n d demyelinating disorders of the central nervous system. Recently, more than 50 MS-susceptibility single-nucleotide polymorphisms（SNPs） have been detected outside the major histocompatibility complex（MHC） region. In this study, we aimed to evaluate the association of these identified non-MHC MS risk loci with Chinese patients with NMO. Thirtyfive non-MHC SNPs were selected and genotyped by matrix-assisted laser desorption/ionization timeof-fl ight mass spectrometry（MALDI-TOF MS） in 110 NMO patients and 332 controls from southeastern China. Among the 35 SNPs, only one, rs1800693 in the TNFRSF1 A locus, was nominally associated with NMO（P = 0.045, OR = 1.550, 95% CI = 1.007 – 2.384）. However, none of the 35 SNPs was associated with NMO after Bonferroni correction. Our results showed no association between these identified non-MHC MS risk loci and NMO, suggesting there are genetic differences in the etiology of NMO and MS.展开更多
A group tracking algorithm for split maneuvering based on complex domain topological descriptions is proposed for the tracking of members in a maneuvering group. According to the split characteristics of a group targe...A group tracking algorithm for split maneuvering based on complex domain topological descriptions is proposed for the tracking of members in a maneuvering group. According to the split characteristics of a group target, split models of group targets are established based on a sliding window feedback mechanism to determine the occurrence and classification of split maneuvering, which makes the tracked objects focus by group members effectively. The track of an outlier single target is reconstructed by the sequential least square method. At the same time, the relationship between the group members is expressed by the complex domain topological description method, which solves the problem of point-track association between the members. The Singer method is then used to update the tracks. Compared with classical multi-target tracking algorithms based on Multiple Hypothesis Tracking （MHT） and the Different Structure Joint Probabilistic Data Association （DS-JPDA） algorithm, the proposed algorithm has better tracking accuracy and stability, is robust against environmental clutter and has stable time-consumption under both classical radar conditions and partly resolvable conditions.展开更多
Association analysis provides an opportunity to find genetic variants underlying complex traits. A principal components regression （PCR）-based approach was shown to outperform some competing approaches. However, a l...Association analysis provides an opportunity to find genetic variants underlying complex traits. A principal components regression （PCR）-based approach was shown to outperform some competing approaches. However, a limitation of this method is that the principal components （PCs） selected from single nucleotide polyrnorphisms （SNPs） may be unrelated to the phenotype. In this article, we investigate the theoretical properties of such a method in more detail. We first derive the exact power function of the test based on PCR, and hence clarify the relationship between the test power and the degrees of freedom （DF）. Next, we extend the PCR test to a general weighted PCs test, which provides a unified framework for understanding the properties of some related statistics. We then compare the performance of these tests. We also introduce several data-driven adaptive alternatives to overcome difficulties in the PCR approach. Finally, we illustrate our results using simulations based on real genotype data. Simulation study shows the risk of using the unsupervised rule to determine the number of PCs, and demonstrates that there is no single uniformly powerful method for detecting genetic variants.展开更多
We investigate the solution self-assembly of a mixture of positively charged homopolymers and AB diblock copolymers,in which the A blocks are negatively charged,and the B blocks are neutral.The electrostatic complexat...We investigate the solution self-assembly of a mixture of positively charged homopolymers and AB diblock copolymers,in which the A blocks are negatively charged,and the B blocks are neutral.The electrostatic complexation between oppositely charged polymers drives the formation of many ordered phases.The microstructures and phase diagrams are calculated using self-consistent field theory(SCFT)based on an ion-pair model with an equilibrium constant K to characterize the strength of binding between positively and negatively charged monomers.The effects of the charge ratio,representing the ratio of charges from the homopolymer over all charges from polymers in the system,on the ordered structure are systematically studied,both for hydrophobic and hydrophilic A blocks.The charge ratio plays an important role in determining the phase boundaries in the phase diagram of salt concentration versus polymer concentration.We also provide information about the varying tendency of the domain spacing and core size of the spherical phase when the charge ratio is changed,and the results are in good agreement with experiments.These studies provide a deep understanding of the self-assembled microstructures of oppositely charged diblock copolymer-homopolymer systems.展开更多
An equation for determining the equilibrium association constant (KA) of cyclodextrin inclusion complex with fluorescence anisotropy is derived and used to determine KA of pyrene-B-cyclodextrin inclusion complex. The ...An equation for determining the equilibrium association constant (KA) of cyclodextrin inclusion complex with fluorescence anisotropy is derived and used to determine KA of pyrene-B-cyclodextrin inclusion complex. The existing forms of cyclodextrin inclusion complex in solution, the interaction type of host with vip, and the possibility of application of B-cyclodextrin in the analysis of metal ions using naphthalene derivative as a ligand are discussed based on the equation derived along with the curve of fluorescence anisotropy versus cyclodextrin concentration of vip/cyclodextrin system.展开更多
文摘Thermodynamic properties and electrochemical behaviors of gold and its associated elements, such as silver, copper, nickel and iron, in various complex agent solutions were studied. Within CS（NH2）2, S2O2-3 and SCN- systems, alkaline thiourea is the optimal nontoxic lixiviating agent substituting cyanide from the viewpoint of thermodynamics. The electrochemical study indicates that the anodic dissolution current densities of gold are 2.616, （1.805,） 1.267, 1.088, 0.556, and 0.145 mA·cm-2 respectively in the solutions of cyanide, alkaline thiourea containing Na2SiO3, SCN-, acidic thiourea, alkaline thiourea and thiosulfate at the potential of 0.500 V. Comparing various lixiviating agents, the alkaline thiourea solution containing Na2SiO3 is of prominent selectivity in leaching gold, in the potential range from 0.500 to 0.600 V, which is most efficient for leaching gold selectively instead of cyanide. The effect on leaching gold is similar to that in the cyanide system.
文摘Numerical simulation of meso-β-scale convective cloud systems associated with a PRE-STORM MCC case has been carried out using a 2-D version of the CSU Regional Atmospheric Modeling System (RAMS) nonhydrostatic model with parameterized microphysics. It is found that the predicted meso-r-scale convective phenomena arc basically unsteady under the situation of strong shear at low-levels, while the meso-β-scale convective system is maintained up to 3 hours or more. The meso -β- scale cloud system exhibits characteristics of a multi-celled convective storm in which the meso-r-scale convective cells have lifetime of about 30 min. Pressure perturbation depicts a meso-low after a half hour in the low levels. As the cloud system evolves, the meso-low intensifies and extends to the upshear side and covers the entire domain in the mid-lower levels with the peak values of 5-8 hPa. Temperature perturbation depicts a warm region in the middle levels through the entire simulation period. The meso-r-scale warm cores with peak values of 4-8 ℃ are associated with strong convective cells. The cloud top evaporation causes a stronger cold layer around the cloud top levels.Simulation of microphysics exhibits that graupel is primarily concentrated in the strong convective cells forming the main source of convective rainfall after one hour of simulation time. Aggregates are mainly located in the stratiform region and decaying convective cells which produce the stratiform rainfall. Riming of the ice crystals is the predominant precipitation formation mechanism in the convection region, whereas aggregation of ice crystals is the predominant one in the stratiform region, which is consistent with observations. Sensitivity experiments of ice-phase mierophysical processes show that the microphysical structures of the convective cloud system can be simulated better with the diagnosed aggregation collection efficiencies.
文摘The research on dyke swarms is very important,for it can not only shed light on within-plate geological processes of some regions but also contribute to our understanding on evolution of a specific orogenic belt.The Yangtze Block,
文摘Objective To explore the diagnosis and treatment features of tuberous sclerosis complex associated renal cell carcinoma. Methods A 22-year-old boy with a childhood history of epilepsy and mental retardation pres-
基金supported in part by the National Natural Science Foundation of China(Nos.81071736,30973508,and 81572876)the Clinical Research Enhancement Initiative of Shantou University Medical College(Nos.201412 and 201421)the Collaborative and Creative Center,Molecular Diagnosis and Personalized Medicine,Shantou University,Guangdong Province,and the Department of Education,Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases(Nos.2015072,2015065,2015020,and 2015077)
文摘Worldwide,metastasis is the leading cause of more than 90%of cancer-related deaths.Currently,no specific therapies effectively impede metastasis.Metastatic processes are controlled by complex regulatory networks and transcriptional hierarchy.Corepressor metastasis-associated protein 3(MTA3)has been confirmed as a novel component of nucleosome remodeling and histone deacetylation(NuRD).Increasing evidence supports the theory that,in the recruitment of transcription factors,coregulators function as master regulators rather than passive passengers.As a master regulator,MTA3 governs the target selection for Nu RD and functions as a transcriptional repressor.MTA3dysregulation is associated with tumor progression,invasion,and metastasis in various cancers.MTA3 is also a key regulator of E-cadherin expression and epithelial-to-mesenchymal transition.Elucidating the functions of MTA3 might help to find additional therapeutic approaches for targeting components of NuRD.
基金We are grateful to Prof. Rui-An Wang （Department of Molecular and Cellular 0ncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA） for his helpful advice and discussion regarding the pos- sible functions of MTA1. We also thank Miss Hui Wang for her careful assistance in English. This study was supported by the Natural Science Foundation of China （2006： No. 30570982 2003： No. 30370750 2003： No. 30371584）.
文摘Aim： To investigate the stage-specific localization of metastasis-associated protein 1 （MTA1） during spermatogenesis in adult human and mouse testis. Methods： The immunolocalization of MTA1 was studied by immunohistochemistry and Western blot analysis. The distribution pattern of MTA1 in mouse testis was confirmed by using quantitative analysis of purified spermatogenic cells. Results： The specificity of polyclonal antibody was confirmed by Western blot analysis. MTA1 was found expressed in the nucleus of germ cells, except elongate spermatids, and in the cytoplasm of Sertoli cells; Leydig cells did not show any specific reactivity. MTA1 possessed different distribution patterns in the two species： in humans, the most intensive staining was found in the nucleus of round spermatids and of primary spermatocytes while in mice, the most intense MTA 1 staining was in the nucleus of leptotene, zygotene and pachytene spermatocytes. In both species the staining exhibited a cyclic pattern. Conclusion： The present communication initially provides new evidence for the potential role of MTA1 in mature testis. In addition, its distinctive expression in germ cells suggests a regulatory role of the peptide during spermatogenesis.
文摘AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.METHODS The English language medical literature on gut-or gastrointestinal-associated lymphoid tissue(GALT) or "dome" carcinoma of the colon was searched and appraised.RESULTS GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque-or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence.CONCLUSION Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61503338,61573316,61374152,and 11302195)the Natural Science Foundation of Zhejiang Province,China(Grant No.LQ15F030005)
文摘In this paper, a novel design procedure is proposed for synthesizing high-capacity auto-associative memories based on complex-valued neural networks with real-imaginary-type activation functions and constant delays. Stability criteria dependent on external inputs of neural networks are derived. The designed networks can retrieve the stored patterns by external inputs rather than initial conditions. The derivation can memorize the desired patterns with lower-dimensional neural networks than real-valued neural networks, and eliminate spurious equilibria of complex-valued neural networks. One numerical example is provided to show the effectiveness and superiority of the presented results.
文摘Integrated Sensing and Communication(ISAC)is envisioned as a promising technology for Sixth-Generation(6G)wireless communications,which enables simultaneous high-rate communication and high-precision target localization.Compared to independent sensing and communication modules,dual-function ISAC could leverage the strengths of both communication and sensing in order to achieve cooperative gains.When considering the communication core network,ISAC system facilitates multiple communication devices to collaborate for networked sensing.This paper investigates such kind of cooperative ISAC systems with distributed transmitters and receivers to support non-connected and multi-target localization.Specifically,we introduce a Time of Arrival(TOA)based multi-target localization scheme,which leverages the bi-static range measurements between the transmitter,target,and receiver channels in order to achieve elliptical localization.To obtain the low-complexity localization,a two-stage search-refine localization methodology is proposed.In the first stage,we propose a Successive Greedy Grid-Search(SGGS)algorithm and a Successive-Cancellation-List Grid-Search(SCLGS)algorithm to address the Measurement-to-Target Association(MTA)problem with relatively low computational complexity.In the second stage,a linear approximation refinement algorithm is derived to facilitate high-precision localization.Simulation results are presented to validate the effectiveness and superiority of our proposed multi-target localization method.
基金supported by the National Key R&D Program of China(2021YFB3501800,2022YFB3503702,2023YFB3506901)the National Natural Science Foundation of China(U23A20593,22071003,92156016,21621061)。
文摘Luminescent Fe(Ⅲ) complexes have received increasing attention in recent years.However,upconversion luminescence from Fe(Ⅲ) complexes has not been explored yet,due to the low photoluminescence quantum yields(PLQYs)of Fe(Ⅲ) complexes,as well as a significant challenge in combining a proper sensitizer and Fe(Ⅲ) activator.In this work,a novel ion-paired Fe(Ⅲ)-Yb(Ⅲ) complex[Fe(phtmeimb)_(2)][Yb(ND)_(4)]was designed and synthesized,where the cation[Fe(phtmeimb)_(2)]^(+)(phtmeimb=phenyl[tris(3-methylimidazol-1-ylidene)]borate)arming the highest PLQY among Fe(Ⅲ) complexes so far was employed as activator,and the anion[Yb(ND)_(4)]^(-)(ND=3-cyano-2-methyl-1,5-naphthyridin-4-olate)featuring a large absorption cross-section at 980 nm was constructed as sensitizer.Upon the excitation of 980 nm,red doublet ligand-to-metal charge transfer(^(2)LMCT)emission of[Fe(phtmeimb)_(2)]^(+)was realized both in solution and doped film through a cooperative sensitization upconversion process.This is the first time to achieve Fe(Ⅲ) complex-based emission using the near-infrared light excitation,demonstrating the great potential of luminescent Fe(Ⅲ) complexes as activators in the upconversion luminescence field and promoting the development of fundamental research on the iron-based optical functional materials.
基金supported by the National Natural Science Foundation of China (Nos. 31371275 and 30971635)the National Basic Research Program of China (973 Program) (No. 2011CB504004)self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (No. CCNU14Z01003)
文摘Genome-wide association studies （GWASs） have identified thousands of genes and genetic variants （mainly SNPs） that contribute to complex diseases in humans. Functional characterization and mechanistic elucidation of these SNPs and genes action are the next major challenge. It has been well established that SNPs altering the amino acids of protein-coding genes can drastically impact protein function, and play an important role in molecular pathogenesis. Functions of regulatory SNPs can be complex and elusive, and involve gene expression regulation through the effect on RNA splicing, transcription factor binding, DNA metbylation and miRNA recruitment. In the present review, we summarize the recent progress in our understanding of functional consequences of GWAS-associated non-coding regulatory SNPs, and discuss the application of systems genetics and network biology in the interpretation of GWAS findings.
基金supported by the National Basic Research Program of China (2011CB109306 and 2009CB118404)the Program of Introducing Talents of Discipline to Universities of China ("111" Project, B06014)Research Programs (CNTC-D2011100, CNTC-[2012]146, NY-[2011]3047, QKHRZ [2013] 02)
文摘Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and phenotype for 60 leaf samples at four developmental stages, from three plant architectural positions and for three cultivars that were grown in two locations. Association mapping was conducted to detect genetic variants at quantitative trait SNP(QTS) loci, quantitative trait transcript(QTT) differences,quantitative trait protein(QTP) variability, and quantitative trait metabolite(QTM) changes,which can be summarized as QTX locus variation. The total heritabilities of the four-omics loci for both traits tested were 23.60% for epistasis and 15.26% for treatment interaction.Epistasis and environment × treatment interaction had important impacts on complex traits at all-omics levels. For decreasing chromium content and increasing total sugar in tobacco leaf, six methylated loci can be directly used for marker-assisted selection, and expression of ten QTTs, seven QTPs and six QTMs can be modified by selection or cultivation.
基金supported by the National Natural Science Foundation of China (81125009 and 3091110488)
文摘Neuromyelitis optica（NMO） and multiple sclerosis（ M S） a r e b o t h a u t o i m m u n e i n f l a m m a t o r y a n d demyelinating disorders of the central nervous system. Recently, more than 50 MS-susceptibility single-nucleotide polymorphisms（SNPs） have been detected outside the major histocompatibility complex（MHC） region. In this study, we aimed to evaluate the association of these identified non-MHC MS risk loci with Chinese patients with NMO. Thirtyfive non-MHC SNPs were selected and genotyped by matrix-assisted laser desorption/ionization timeof-fl ight mass spectrometry（MALDI-TOF MS） in 110 NMO patients and 332 controls from southeastern China. Among the 35 SNPs, only one, rs1800693 in the TNFRSF1 A locus, was nominally associated with NMO（P = 0.045, OR = 1.550, 95% CI = 1.007 – 2.384）. However, none of the 35 SNPs was associated with NMO after Bonferroni correction. Our results showed no association between these identified non-MHC MS risk loci and NMO, suggesting there are genetic differences in the etiology of NMO and MS.
基金co-supported by the National Natural Science Foundation of China(Nos.61471383,61531020,61471379 and 61102166)
文摘A group tracking algorithm for split maneuvering based on complex domain topological descriptions is proposed for the tracking of members in a maneuvering group. According to the split characteristics of a group target, split models of group targets are established based on a sliding window feedback mechanism to determine the occurrence and classification of split maneuvering, which makes the tracked objects focus by group members effectively. The track of an outlier single target is reconstructed by the sequential least square method. At the same time, the relationship between the group members is expressed by the complex domain topological description method, which solves the problem of point-track association between the members. The Singer method is then used to update the tracks. Compared with classical multi-target tracking algorithms based on Multiple Hypothesis Tracking （MHT） and the Different Structure Joint Probabilistic Data Association （DS-JPDA） algorithm, the proposed algorithm has better tracking accuracy and stability, is robust against environmental clutter and has stable time-consumption under both classical radar conditions and partly resolvable conditions.
基金supported by the National Basic Research Program (973) of China (No. 2004CB117306)the Hi-Tech Research and Development Program (863) of China (No. 2006AA10A102)
文摘Association analysis provides an opportunity to find genetic variants underlying complex traits. A principal components regression （PCR）-based approach was shown to outperform some competing approaches. However, a limitation of this method is that the principal components （PCs） selected from single nucleotide polyrnorphisms （SNPs） may be unrelated to the phenotype. In this article, we investigate the theoretical properties of such a method in more detail. We first derive the exact power function of the test based on PCR, and hence clarify the relationship between the test power and the degrees of freedom （DF）. Next, we extend the PCR test to a general weighted PCs test, which provides a unified framework for understanding the properties of some related statistics. We then compare the performance of these tests. We also introduce several data-driven adaptive alternatives to overcome difficulties in the PCR approach. Finally, we illustrate our results using simulations based on real genotype data. Simulation study shows the risk of using the unsupervised rule to determine the number of PCs, and demonstrates that there is no single uniformly powerful method for detecting genetic variants.
基金supported by the National Natural Science Foundation of China(NSFC)(Nos.22073002,51921002 and 22373008).
文摘We investigate the solution self-assembly of a mixture of positively charged homopolymers and AB diblock copolymers,in which the A blocks are negatively charged,and the B blocks are neutral.The electrostatic complexation between oppositely charged polymers drives the formation of many ordered phases.The microstructures and phase diagrams are calculated using self-consistent field theory(SCFT)based on an ion-pair model with an equilibrium constant K to characterize the strength of binding between positively and negatively charged monomers.The effects of the charge ratio,representing the ratio of charges from the homopolymer over all charges from polymers in the system,on the ordered structure are systematically studied,both for hydrophobic and hydrophilic A blocks.The charge ratio plays an important role in determining the phase boundaries in the phase diagram of salt concentration versus polymer concentration.We also provide information about the varying tendency of the domain spacing and core size of the spherical phase when the charge ratio is changed,and the results are in good agreement with experiments.These studies provide a deep understanding of the self-assembled microstructures of oppositely charged diblock copolymer-homopolymer systems.
文摘An equation for determining the equilibrium association constant (KA) of cyclodextrin inclusion complex with fluorescence anisotropy is derived and used to determine KA of pyrene-B-cyclodextrin inclusion complex. The existing forms of cyclodextrin inclusion complex in solution, the interaction type of host with vip, and the possibility of application of B-cyclodextrin in the analysis of metal ions using naphthalene derivative as a ligand are discussed based on the equation derived along with the curve of fluorescence anisotropy versus cyclodextrin concentration of vip/cyclodextrin system.
