Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects ...Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects of tTIS on the superior colliculus(SC),a region involved in eye movement control,in mice.Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation.In vivo experiments,including Ca^(2+)signal recordings and eye movement tracking,showed that tTIS effectively modulates SC neural activity and induces eye movements.A significant correlation was found between stimulation frequency and saccade frequency,suggesting direct tTIS-induced modulation of SC activity.These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements,highlighting its potential for neuroscientific research and therapeutic applications.展开更多
Temporal interference(TI)stimulation is a non-invasive technique for electrically stimulating neurons at depth.1 It leverages the low-pass filtering properties of neural membranes,which render neurons more sensitive t...Temporal interference(TI)stimulation is a non-invasive technique for electrically stimulating neurons at depth.1 It leverages the low-pass filtering properties of neural membranes,which render neurons more sensitive to low-frequency oscillating fields compared with high-frequency fields(e.g.,R1 kHz).This approach generates a low-frequency modulated electric field—termed envelope modulation—by superimposing high-frequency currents with slightly different frequencies,applied via scalp electrodes.The characteristics of the envelope modulation are determined by the vector sum of the applied field vectors at a given point.By adjusting electrode positions and current ratios,the amplitude of the envelope modulation can be maximized at a point distant from the scalp,potentially reaching deep brain regions.展开更多
The present study analyzed changes in the biochemical metabolites N-acetyl aspartate, choline, and creatine in a simple concussion rabbit model following quiet rest, hyperbaric oxygen therapy, or interference stimulat...The present study analyzed changes in the biochemical metabolites N-acetyl aspartate, choline, and creatine in a simple concussion rabbit model following quiet rest, hyperbaric oxygen therapy, or interference stimulation through the use of hydrogen proton magnetic resonance spectroscopy detection. Experimental findings showed that brain N-acetyl aspartate and choline peak values significantly decreased, while creatine peak values significantly increased following simple concussion. Following treatments, N-acetyl aspartate and choline peaks returned to normal levels in the quiet rest and hyperbaric oxygen therapy groups, but no changes were observed in the interference stimulation group. Results demonstrated abnormal changes in the brain biochemical metabolism environment following simple concussion. Quiet rest was shown to play an important role in restoration of biochemical metabolism following simple concussion.展开更多
基金supported by the National Natural Science Foundation of China(T2394533,32222036,82030038,and 62472206)the National Key Research and Development Program of China(2018YFA0701400)the Shenzhen Science and Technology Innovation Committee(2022410129,KJZD20230923115221044,and KCXFZ20201221173400001).
文摘Transcranial temporal interference stimulation(tTIS)is a novel non-invasive neuromodulation technique with the potential to precisely target deep brain structures.This study explores the neural and behavioral effects of tTIS on the superior colliculus(SC),a region involved in eye movement control,in mice.Computational modeling revealed that tTIS delivers more focused stimulation to the SC than traditional transcranial alternating current stimulation.In vivo experiments,including Ca^(2+)signal recordings and eye movement tracking,showed that tTIS effectively modulates SC neural activity and induces eye movements.A significant correlation was found between stimulation frequency and saccade frequency,suggesting direct tTIS-induced modulation of SC activity.These results demonstrate the precision of tTIS in targeting deep brain regions and regulating eye movements,highlighting its potential for neuroscientific research and therapeutic applications.
基金supported by the National Natural Science Foundation of China(32322035,32171078,and 82060315)Guangxi Key Research and Development Program(AB22080053)。
文摘Temporal interference(TI)stimulation is a non-invasive technique for electrically stimulating neurons at depth.1 It leverages the low-pass filtering properties of neural membranes,which render neurons more sensitive to low-frequency oscillating fields compared with high-frequency fields(e.g.,R1 kHz).This approach generates a low-frequency modulated electric field—termed envelope modulation—by superimposing high-frequency currents with slightly different frequencies,applied via scalp electrodes.The characteristics of the envelope modulation are determined by the vector sum of the applied field vectors at a given point.By adjusting electrode positions and current ratios,the amplitude of the envelope modulation can be maximized at a point distant from the scalp,potentially reaching deep brain regions.
基金Military Medical Science and Technology Research During the Eleventh Five-Year Plan,No. 06MA96
文摘The present study analyzed changes in the biochemical metabolites N-acetyl aspartate, choline, and creatine in a simple concussion rabbit model following quiet rest, hyperbaric oxygen therapy, or interference stimulation through the use of hydrogen proton magnetic resonance spectroscopy detection. Experimental findings showed that brain N-acetyl aspartate and choline peak values significantly decreased, while creatine peak values significantly increased following simple concussion. Following treatments, N-acetyl aspartate and choline peaks returned to normal levels in the quiet rest and hyperbaric oxygen therapy groups, but no changes were observed in the interference stimulation group. Results demonstrated abnormal changes in the brain biochemical metabolism environment following simple concussion. Quiet rest was shown to play an important role in restoration of biochemical metabolism following simple concussion.
