Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monito...Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management.展开更多
BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery...BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery speed and quality of life.Effective prevention of anxiety and depression in elderly patients has become an urgent problem.AIM To investigate the trajectory of anxiety and depression levels in elderly patients after LIF,and the influencing factors.METHODS Random sampling was used to select 239 elderly patients who underwent LIF from January 2020 to December 2024 in Shenzhen Pingle Orthopedic Hospital.General information and surgery-related indices were recorded,and participants completed measures of psychological status,lumbar spine dysfunction,and quality of life.A latent class growth model was used to analyze the post-LIF trajectory of anxiety and depression levels,and unordered multi-categorical logistic regression was used to analyze the influencing factors.RESULTS Three trajectories of change in anxiety level were identified:Increasing anxiety(n=26,10.88%),decreasing anxiety(n=27,11.30%),and stable anxiety(n=186,77.82%).Likewise,three trajectories of change in depression level were identified:Increasing depression(n=30,12.55%),decreasing depression(n=26,10.88%),and stable depression(n=183,76.57%).Regression analysis showed that having no partner,female sex,elevated Oswestry dysfunction index(ODI)scores,and reduced 36-Item Short Form Health Survey scores all contributed to increased anxiety levels,whereas female sex,postoperative opioid use,and elevated ODI scores all contributed to increased depression levels.CONCLUSION During clinical observation,combining factors to predict anxiety and depression in post-LIF elderly patients enables timely intervention,quickens recovery,and enhances quality of life.展开更多
This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis...This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis,and Sen's slope estimation methods,historical climate trends(1980-2100)were analyzed,while land cover changes represented human impacts.Future projections were simulated using the MIROC model with Shared Socioeconomic Pathways(SSPs)and the Tank model.Results show that during the past 40 years,air temperature significantly increased(Z=3.93^(***)),while precipitation(Z=-1.54^(*))and river flow(Z=-1.73^(*))both declined.The Khyargas Lake water level dropped markedly(Z=-5.57***).Land cover analysis reveals expanded cropland and impervious areas due to human activity.Under the SSP1.26 scenario,which assumes minimal climate change,air temperature is projected to rise by 2.0℃,precipitation by 21.8 mm,and river discharge by 1.61 m^(3)/s between 2000 and 2100.These findings indicate that both global warming and intensified land use have substantially altered hydrological and climatic processes in the basin,highlighting the vulnerability of western Mongolia's water resources to combined climatic and anthropogenic influence.展开更多
Using more than 14 years of GRACE(Gravity Recovery and Climate Experiment) satellite gravimetry observations, we estimate the ice loss rate for the Patagonia Ice Field(PIF) of South America. After correcting the effec...Using more than 14 years of GRACE(Gravity Recovery and Climate Experiment) satellite gravimetry observations, we estimate the ice loss rate for the Patagonia Ice Field(PIF) of South America. After correcting the effects of glacier isostatic adjustment(GIA) and hydrological variations, the ice loss rate is -23.5 ± 8.1 Giga ton per year(Gt/yr) during the period April 2002 through December 2016, equivalent to an average ice thickness change of-1.3 m/yr if evenly distributed over PIF. The PIF ice mass change series also show obvious inter-annual variations during the entire period. For the time spans April 2002 to December 2007, January 2008 to December 2012 and January 2013 to December 2016, the ice loss rates are -26.4,-9.0 and -25.0 Gt/yr, respectively, indicating that the ice melting experienced significant slowing down and accelerating again in the past decade. Comparison with time series from temperature and precipitation data over PIF suggests that the inter-annual ice losses might not be directly correlated with the temperature changes and precipitation anomalies, and thus their interrelation is intricate. However, the dramatic ice loss acceleration in 2016(with more than 100 Gt within the first half of the year) appears closely related with the evident temperature increase and severe precipitation shortage over 2016, which are likely correlated with the strong E1 Nino event around 2016. Moreover, we compare the GRACE spherical harmonic(SH) and mass concentration(Mascon) solutions in estimating the PIF ice loss rate, and find that the Mascon result has larger uncertainty in leakage error correction,while the SH solutions can better correct leakage errors based on a constrained forward modeling iterative method. Thus the GRACE SH solutions with constrained forward modeling recovery are recommended to evaluating the ice mass change of PIF or other glacier regions with relatively smaller spatial scales.展开更多
Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what exten...Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what extent CO_(2)fertilization affects vegetation changes in such regions remains unclear.In this study,we investigated the degree to which CO_(2)fertilization influences vegetation changes,along with their spatial and temporal differences,in the subtropical humid karst region using time-lag effect analysis,a random forest model,and multiple regression analysis.Results showed that CO_(2)fertilization plays an important role in vegetation changes,exhibiting clear spatial variations across different geomorphological zones,with its degree of influence ranging mainly between 11%and 25%.The highest contribution of CO_(2)fertilization was observed in the karst basin and non-karstic region,whereas the lowest contribution was found in the karst plateau region.Previous studies have primarily attributed vegetation changes in subtropical humid karst region to ecological engineering,leading to an overestimation of its contribution to these changes.The findings of this study enhance the understanding of the mechanism of vegetation changes in humid karst region and provide theoretical and practical insights for ecological and environmental protection in these regions.展开更多
The toxicity of PM_(2.5)does not necessarily change synchronously with its mass concentration.In this study,the chemical composition(carbonaceous species,water-soluble ions,and metals)and oxidative potential(dithiothr...The toxicity of PM_(2.5)does not necessarily change synchronously with its mass concentration.In this study,the chemical composition(carbonaceous species,water-soluble ions,and metals)and oxidative potential(dithiothreitol assay,DTT)of PM_(2.5)were investigated in 2017/2018 and 2022 in Xiamen,China.The decrease rate of volume-normalized DTT(DTTv)(38%)was lower than that of PM_(2.5)(55%)between the two sampling periods.However,the mass-normalized DTT(DTTm)increased by 44%.Clear seasonal patterns with higher levels in winter were found for PM_(2.5),most chemical constituents and DTTv but not for DTTm.The large decrease in DTT activity(84%−92%)after the addition of EDTA suggested that watersoluble metals were the main contributors to DTT in Xiamen.The increased gap between the reconstructed and measured DTTv and the stronger correlations between the reconstructed/measured DTT ratio and carbonaceous species in 2022were observed.The decrease rates of the hazard index(32.5%)and lifetime cancer risk(9.1%)differed from those of PM_(2.5)and DTTv due to their different main contributors.The PMF-MLR model showed that the contributions(nmol/(min·m^(3)))of vehicle emission,coal+biomass burning,ship emission and secondary aerosol to DTTv in 2022 decreased by 63.0%,65.2%,66.5%,and 22.2%,respectively,compared to those in 2017/2018,which was consistent with the emission reduction of vehicle exhaust and coal consumption,the adoption of low-sulfur fuel oil used on board ships and the reduced production of WSOC.However,the contributions of dust+sea salt and industrial emission increased.展开更多
BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic im...BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.展开更多
Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sw...Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity.展开更多
There is growing interest in introducing ecological risks(ERs)and ecosystem services(ESs)into environmental policies and practices.However,the integration of ESs and ERs into actual decision-making remains insufficien...There is growing interest in introducing ecological risks(ERs)and ecosystem services(ESs)into environmental policies and practices.However,the integration of ESs and ERs into actual decision-making remains insufficient.We simulated the spatiotemporal dynamics of ESs(e.g.,carbon storage,water yield,habitat quality,and soil conservation)and ERs in the upper reach of the Yellow River(URYR)from 2000 to 2100.Additionally,we explored their relationships by combining the InVEST model and a landscape ecological risk model with CMIP6 data.Our main findings showed that regional ERs change in response to land use and environmental dynamics.Specifically,the ER area decreased by 27,673 m^(2)during 2000-2020,but it is projected to increase by 13,273,438,and 68 m^(2)under the SSP1-2.6,SSP2-4.5,and SSP5-8.5 scenarios,respectively.We also observed remarkable spatial differences in ESs and ERs between past and future scenarios.For instance,the source area of the URYR exhibited high ESs and low ERs(P<0.001),while the ESs and ERs are declining and increasing,respectively,in the northeastern URYR(P<0.05).Finally,we proposed a spatial optimization framework to improve ESs and reduce ERs,which will support regional sustainable development.展开更多
Climate change and anthropogenic activities have driven significant terrestrial water storage changes(TWSC)in the Three Rivers Source Region(TRSR),exerting profound impacts on freshwater availability across China and ...Climate change and anthropogenic activities have driven significant terrestrial water storage changes(TWSC)in the Three Rivers Source Region(TRSR),exerting profound impacts on freshwater availability across China and broader Asia.However,long-term TWSC characterization remains challenging due to limited observational data in this alpine region.Here,we integrate GRACE observations(2002-2020),ERA5-Land reanalysis,and GLDAS data to reconstruct TWSC using two methods:(1)the water balance method(PER)and(2)the component summation method(SS),applied to three input datasets(ERA5-Land,GLDAS,and their average,GLER).Comparative analysis reveals that the SS method applied to GL-ER yields the highest consistency with GRACE-derived TWSC.Using this optimal approach,we extend the analysis to 1951~2020,uncovering spatiotemporal TWSC patterns.Although annual TWSC trends appear negligible due to strong seasonality,we introduce the intra-year TWSC fluctuation(TWSCF)index to quantify cumulative variability.A significant(p<0.05)transition occurred in 1980,with TWSCF shifting from a declining trend(-0.39 mm/yr)to an increasing trend(0.56 mm/yr),primarily driven by soil moisture changes.However,Hurst exponent analysis suggests this upward trend may not persist.Drought and vegetation assessments indicate concurrent wetting and greening in the TRSR.TWSC correlates strongly with meteorological drought,acting as a reliable drought indicator while its linkage with vegetation dynamics suggests a potential contribution to greening.Our findings provide a robust framework for understanding long-term TWSC evolution and its hydrological-ecological interactions under climate change.展开更多
BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.AIM To investigate the link between longitudinal changes ...BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.AIM To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive population.METHODS Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of 2018.Longitudinal changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal group.To examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%CI.RESULTS The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the sample.Over the course of a mean follow-up of 4.8 years,143 ischemic strokes happened.When normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et al.Dyslipidemia changed and ischemic stroke WJCC https://www.wjgnet.com 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),respectively.CONCLUSION In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.展开更多
The Pearl River Delta(PRD)region has been identified as a significant hotspot of wet ammonium deposition.However,the absence of long-term monitoring data in the area hinders the comprehension of the historical trends ...The Pearl River Delta(PRD)region has been identified as a significant hotspot of wet ammonium deposition.However,the absence of long-term monitoring data in the area hinders the comprehension of the historical trends and changes in wet NH_(4)^(+)-N deposition in response to emissions,which interferes with the ability to make effective decisions.This study has analyzed the long-term trends of wet NH_(4)^(+)-N deposition flux and has quantified the effect of anthropogenic emissions and meteorological factors at a typical urban site and a typical forest site in the PRD region from 2009 to 2020.It revealed a significant decreasing trend in wet NH_(4)^(+)-N flux in both the typical urban and forest areas of the PRD region,at-6.2%/year(p<0.001)and-3.3%/year(p<0.001),respectively.Anthropogenic emissions are thought to have contributed 47%–57%of the wet NH_(4)^(+)-N deposition trend over the past 12 years compared to meteorological factors.Meteorological conditions dominated the interannual fluctuations in wet NH_(4)^(+)-N deposition with an absolute contribution of 46%–52%,while anthropogenic emissions change alone explained 10%–31%.NH_(3)emissions have the greatest impact on the urban area among anthropogenic emission factors,while SO_(2)emissions have the greatest impact on the forest area.Additionally,precipitation was identified as the primary meteorological driver for both sites.Our findings also imply that the benefits of NH_(3)emissions reductions might not immediately emerge due to interference from weather-related factors.展开更多
On September 5, 2022, an earthquake of magnitude M_(S)6.8 occurred in Luding County, Sichuan Province.This earthquake occurred at the key part of the southeast-clockwise extrusion of material on the eastern margin of ...On September 5, 2022, an earthquake of magnitude M_(S)6.8 occurred in Luding County, Sichuan Province.This earthquake occurred at the key part of the southeast-clockwise extrusion of material on the eastern margin of the Qinghai Plateau, the Y-shaped confluence of the Xianshuihe, Longmenshan and Anninghe fault zones. In this study, the three-dimensional dynamic crustal density changes in the earthquake area are obtained by the typical gravity change data from 2019 to 2022 before the earthquake and gravity inversion by growing bodies. The results indicate that gravity changes presented an obvious fourquadrant and gradient belt distribution in the Luding area before the earthquake. The threedimensional density horizontal slices show that small density changes occurred at the epicenter in the mid-to-upper crust between 2019.9-2020.9 and 2019.9-2021.9. At the same time, the surrounding areas exhibited a positive and negative quadrant distribution. These observations indicate that the source region was likely in a stable locked state, with locking-in shear forces oriented in the NW and NE directions. From 2021.9 to 2022.8, the epicentral region showed negative density changes, indicating that the source region was in the expansion stage, approaching a near-seismic state. The three-dimensional density vertical slices reveal a southeastward migration of positive and negative densities near the epicenter and on the western of the Xianshuihe Fault Zone, indicating that the material is flowing out to the southeast. The observed local negative density changes at the epicenter along the Longmenshan Fault Zone are likely associated with the NE-oriented extensional stress shown by the seismic source mechanism. The above results can provide a basis for interpreting pre-earthquake gravity and density changes,thereby contributing to the advancement of earthquake precursor theory.展开更多
This study aims to construct a large-scale hydrological Variable Infiltration Capacity(VIC)model based on temperature and precipitation at high altitudes,while elucidating the applicability of the model for hydrologic...This study aims to construct a large-scale hydrological Variable Infiltration Capacity(VIC)model based on temperature and precipitation at high altitudes,while elucidating the applicability of the model for hydrological simulation and analyzing the factors affecting runoff volume.Runoff volume and runoff depth were simulated using the VIC model and its performance was evaluated.Meanwhile,the factors affecting runoff volume were analyzed using Spearman correlation.The following model sensitivity parameters were obtained based on the China Natural Runoff Grid Point Dataset(CNRD v1.0):The variable infiltration curve parameter was 0.3,the Dsmax fraction where non-linear baseflow begins was 0.02,the maximum baseflow velocity was 15 mm/d,the maximum soil moisture where non-linear baseflow occurred was 0.7,the second soil moisture layer thickness was 0.3,and the thickness of the third soil moisture layer was 1.5.The surface runoff values in the Nyang River basin were similar in the first and fourth quarters(1.05–2.27 mm and 2.38–4.77 mm,respectively),and the surface runoff values were similar in the second and third quarters when the surface runoff was greater(23.46–52.20 mm and 60.59–85.63 mm,respectively).Watershed area,temperature,and precipitation significantly influenced the amount of runoff from the Nyang River.The applicability of the model to the Nyang River basin was confirmed using two different rate models.In some areas,precipitation and temperature did not have a dominating influence on runoff.Although the VIC model has significant advantages in runoff simulation,it requires a wealth of meteorological,soil,and hydrological data that may be difficult to obtain in some areas.展开更多
Previous works were mainly concentrated on long-term average runoff alterations,and extreme temperatures and watershed conditions are little analyzed.In this study,we collected gauged river flow and meteorological dat...Previous works were mainly concentrated on long-term average runoff alterations,and extreme temperatures and watershed conditions are little analyzed.In this study,we collected gauged river flow and meteorological data time series from 1916 to 2015 and 1941 to 2015 across the contiguous United States(CONUS)for 188 catchments to investigate the temporal trends and spatial features of runoff changes at multi-time scales.We also analyzed the relationships between runoff changes and climatic factors.Median descriptive statistics and Budyko coupled climate elasticity methods were used to calculate runoff elasticity in each time scale.The original Mann-Kendall trend test was used to test their trend significance in four time-scale(11,20,40,and 60 a),respectively.The results show that the trend of runoff changes is more significant in high time scales;total changes are heterogeneous over CONUS.After the 1970s,increases of up to 27%decade-1 were mainly concentrated in the mid-northern regions.Maximum temperature and catchment characteristics are vital factors for runoff alteration;runoff changes are independent of rainfall,and wet regions tend to have lower changes.These findings could help develop better regional water resource planning and management.展开更多
Climate warming and humidification trends have significantly influenced vegetation growth patterns in Chinese semi-arid areas.Exploring vegetation dynamics is crucial for understanding regional ecosystem structure and...Climate warming and humidification trends have significantly influenced vegetation growth patterns in Chinese semi-arid areas.Exploring vegetation dynamics is crucial for understanding regional ecosystem structure and improving the efforts of ecosystem restoration.However,the applicability of various vegetation indices(VIs)in these arid areas remains uncertain.Evaluating the applicability of multiple VIs for vegetation monitoring can elucidate the variability of VIs performance at regional scale.Therefore,this study selected the Zuli River Basin(ZLRB),a typical loess hilly watershed in the semi-arid areas of China.Using Landsat data,we calculated the Normalized Difference Vegetation Index(NDVI),Enhanced Vegetation Index(EVI),and kernel NDVI(kNDVI)for the ZLRB from 1990 to 2020.We analyzed the spatiotemporal variations of these VIs using trend analysis and the Mann-Kendall test,and quantified the contributions of climate change(considering time-lag effects)and human activities to VIs changes through wavelet and residual analyses.Results indicated that VIs generally exhibited an upward trend in the ZLRB,with significant improvements observed in 54.91% of the area for NDVI,31.69% for EVI,and 33.71% for kNDVI.Among them,NDVI outperformed EVI and kNDVI in capturing vegetation changes in the semi-arid area.VIs responded to precipitation with 1-month time lag and no time lag to temperature during growing season.Moreover,precipitation had a stronger positive correlation with VIs than temperature.Climate change was identified as the dominant driver of vegetation dynamics in the ZLRB,accounting for 93.12% of NDVI variation,while human activities contributed only 6.88%.Comparative analysis of VIs suggests that NDVI was more suitable for describing vegetation changes in the typical arid area of the ZLRB.Our findings underscore the importance of selecting appropriate VIs for targeted ecological restoration and sustainable land management.展开更多
Renewable energy,especially solar power,is vital for mitigating global warming,while climate change also impacts solar photovoltaic potential(PVpot).This study analyzes historical(1985–2014)and future(2015–2100)clim...Renewable energy,especially solar power,is vital for mitigating global warming,while climate change also impacts solar photovoltaic potential(PVpot).This study analyzes historical(1985–2014)and future(2015–2100)climate effects on PVpot,and quantifies contributions from changed radiation,temperature,and wind speed.Historically,global PVpot increased by 0.42‰,with notable rises in eastern China(+7.1‰)and southern Europe(+3.5‰).By the end of the century,increased radiation-induced PVpot(+1.27‰)offsets temperatureinduced PVpot loss(−0.54‰)under SSP1-2.6,yielding a net PVpot increase(+0.74‰).Under SSP2-4.5,the temperature-induced PVpot decline(−1.50‰)drives the final PVpot reduction(−1.15‰).Under SSP3-7.0 and SSP5-8.5,combined radiation-induced(−1.94‰and−1.99‰)and temperature-induced PVpot changes(−2.67‰and−3.41‰)result in significant PVpot declines(−4.57‰and−5.31‰).Regional analysis reveals that eastern China(+0.7‰to+8.6‰),southern Europe(+0.3‰to+2.5‰),and Northwest South America(+0.6‰to+2.1‰)retain positive changes in future PVpot across all climate scenarios,which may be due to reduced aerosols and cloud cover,suggesting these areas can remain suitable for photovoltaic installations despite climate changes.In contrast,temperature-driven PVpot declines over the Qinghai-Tibet Plateau(−9.1‰to−4.3‰)and northern Africa(−9.3‰to−4.9‰)under future high-emission scenarios indicate that these historically advantageous regions will become less suitable for solar energy deployment.The findings underscore that climate changes driven by sustainable development pathways will generate more PVpot in the future for better global warming mitigation.展开更多
Dear Editor,Post-traumatic stress disorder(PTSD)is a chronic neuropsychiatric disorder triggered by severe traumatic events,characterized by persistent intrusive memories,emotional dysregulation,hyperarousal,and avoid...Dear Editor,Post-traumatic stress disorder(PTSD)is a chronic neuropsychiatric disorder triggered by severe traumatic events,characterized by persistent intrusive memories,emotional dysregulation,hyperarousal,and avoidance behaviors[1,2].PTSD is associated with significant gene expression changes in key brain regions,including the ventral tegmental area(VTA),which may underlie dysregulation of dopaminergic signaling and stress-related behaviors[3].展开更多
Background Cardiovascular disease(CVD)and frailty are interrelated conditions prevalent in aging populations,yet their dynamic temporal relationship remains underexplored.This study investigates longitudinal changes i...Background Cardiovascular disease(CVD)and frailty are interrelated conditions prevalent in aging populations,yet their dynamic temporal relationship remains underexplored.This study investigates longitudinal changes in frailty trajectories before and after incident CVD across diverse cohorts.Methods Utilizing data from four longitudinal,multinational cohorts(ELSA,HRS,CHARLS,SHARE;n=66,537),we constructed the frailty index(FI)based on age-related health deficits,using 40,40,42,and 44 items from ELSA,HRS,CHARLS and SHARE,respectively.Linear mixed models assessed FI changes pre-and post-CVD,adjusting for demographics,lifestyle,and baseline FI.Sensitivity analyses excluded hypertension,diabetes,and arthritis to mitigate confounding.Results Frailty increased steadily before CVD onset(pre-CVD slope:ELSAβ=0.005,HRSβ=0.005,CHARLSβ=0.012,SHAREβ=0.007;all P<0.001),with an acute FI spike at diagnosis(post-CVD acute change:ELSAβ=0.024,HRSβ=0.031,CHARLSβ=0.046,SHAREβ=0.038;all P<0.001).Post-CVD,frailty progression further accelerated(ELSAβ=0.008,HRSβ=0.005,CHARLSβ=0.017,SHAREβ=0.010;all P<0.001).Sensitivity analyses confirmed robustness across age strata and FI definitions.Conclusions This first multinational study demonstrates bidirectional acceleration of frailty around CVD onset,highlighting their close temporal interplay.These findings suggest that incorporating frailty assessment into CVD management may help identify high-risk individuals and support timely,multidimensional care in aging populations.展开更多
Vertebrate limbs have undergone profound morphological diversification,enabling adaptations to a broad spectrum of ecological niches.In marine mammals,the evolution of highly specialized flipper-like forelimbs represe...Vertebrate limbs have undergone profound morphological diversification,enabling adaptations to a broad spectrum of ecological niches.In marine mammals,the evolution of highly specialized flipper-like forelimbs represents a profound structural transformation associated with aquatic habitats.This adaptation has been hypothesized to result,in part,from the inhibition of interphalangeal cell apoptosis during limb development,although the underlying genetic mechanism remains poorly understood.This study investigated the evolutionary dynamics and functional consequences of three key bone morphogenetic protein genes,BMP2,BMP4,and BMP7,which regulate apoptosis in interphalangeal mesenchymal stromal cells during embryonic limb development to ensure proper differentiation of interphalangeal tissues.Comparative genomic analysis revealed significantly accelerated evolution for BMP4 and BMP7 in the cetacean ancestral lineage,with two positively selected sites(V79I and H247R)involved in cetacean-specific amino acid substitutions located in the TGF-βpropeptide functional domain in BMP4.In vitro assays confirmed that cetacean-specific BMP4 mutations significantly disrupted normal cell apoptosis and proliferation and altered the transcription and protein expression of downstream apoptosis-related factors,including cytochrome c(Cyt c),BCL2 associated X,and B-cell lymphoma 2,within the BMP signaling pathway.The significant influence of BMP4 mutations on apoptotic inhibition highlights a potential role in the development of limb bud mesenchymal tissue and the emergence of the flipper forelimb phenotype in cetaceans.展开更多
基金supported by the National Key R&D Plan“Inter-governmental International Science&Technology Innovation Cooperation”Key Specialized Program,China(2025YFE0102800)the Program of the State Key Laboratory of Cryospheric Science and Frozen Soil Engineering,Chinese Academy of Sciences(CSFSE-ZZ-2403).
文摘Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management.
基金Supported by the Scientific Research Projects of the Health System in Pingshan District,No.2023122.
文摘BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery speed and quality of life.Effective prevention of anxiety and depression in elderly patients has become an urgent problem.AIM To investigate the trajectory of anxiety and depression levels in elderly patients after LIF,and the influencing factors.METHODS Random sampling was used to select 239 elderly patients who underwent LIF from January 2020 to December 2024 in Shenzhen Pingle Orthopedic Hospital.General information and surgery-related indices were recorded,and participants completed measures of psychological status,lumbar spine dysfunction,and quality of life.A latent class growth model was used to analyze the post-LIF trajectory of anxiety and depression levels,and unordered multi-categorical logistic regression was used to analyze the influencing factors.RESULTS Three trajectories of change in anxiety level were identified:Increasing anxiety(n=26,10.88%),decreasing anxiety(n=27,11.30%),and stable anxiety(n=186,77.82%).Likewise,three trajectories of change in depression level were identified:Increasing depression(n=30,12.55%),decreasing depression(n=26,10.88%),and stable depression(n=183,76.57%).Regression analysis showed that having no partner,female sex,elevated Oswestry dysfunction index(ODI)scores,and reduced 36-Item Short Form Health Survey scores all contributed to increased anxiety levels,whereas female sex,postoperative opioid use,and elevated ODI scores all contributed to increased depression levels.CONCLUSION During clinical observation,combining factors to predict anxiety and depression in post-LIF elderly patients enables timely intervention,quickens recovery,and enhances quality of life.
基金The National University of Mongolia,No.P2024-4814The Mongolian Science and Technology Foundation,No.CHN-2022/274The‘Chey Institute for Advanced Studies’International Scholar Exchange Fellowship for the Academic Year of 2025-2026。
文摘This study investigates climate-and human-induced hydrological changes in the Zavkhan River-Khyargas Lake Basin,a highly sensitive arid and semi-arid region of Central Asia.Using Mann-Kendall,innovative trend analysis,and Sen's slope estimation methods,historical climate trends(1980-2100)were analyzed,while land cover changes represented human impacts.Future projections were simulated using the MIROC model with Shared Socioeconomic Pathways(SSPs)and the Tank model.Results show that during the past 40 years,air temperature significantly increased(Z=3.93^(***)),while precipitation(Z=-1.54^(*))and river flow(Z=-1.73^(*))both declined.The Khyargas Lake water level dropped markedly(Z=-5.57***).Land cover analysis reveals expanded cropland and impervious areas due to human activity.Under the SSP1.26 scenario,which assumes minimal climate change,air temperature is projected to rise by 2.0℃,precipitation by 21.8 mm,and river discharge by 1.61 m^(3)/s between 2000 and 2100.These findings indicate that both global warming and intensified land use have substantially altered hydrological and climatic processes in the basin,highlighting the vulnerability of western Mongolia's water resources to combined climatic and anthropogenic influence.
基金supported by the Natural Science Foundation of Shanghai (17ZR1435600)the Open Fund of Key Laboratory of Geospace Environment and Geodesy, Ministry of Education, Wuhan University (16-01-05)the National Key Research and Development Program of China (2016YFB0501405)
文摘Using more than 14 years of GRACE(Gravity Recovery and Climate Experiment) satellite gravimetry observations, we estimate the ice loss rate for the Patagonia Ice Field(PIF) of South America. After correcting the effects of glacier isostatic adjustment(GIA) and hydrological variations, the ice loss rate is -23.5 ± 8.1 Giga ton per year(Gt/yr) during the period April 2002 through December 2016, equivalent to an average ice thickness change of-1.3 m/yr if evenly distributed over PIF. The PIF ice mass change series also show obvious inter-annual variations during the entire period. For the time spans April 2002 to December 2007, January 2008 to December 2012 and January 2013 to December 2016, the ice loss rates are -26.4,-9.0 and -25.0 Gt/yr, respectively, indicating that the ice melting experienced significant slowing down and accelerating again in the past decade. Comparison with time series from temperature and precipitation data over PIF suggests that the inter-annual ice losses might not be directly correlated with the temperature changes and precipitation anomalies, and thus their interrelation is intricate. However, the dramatic ice loss acceleration in 2016(with more than 100 Gt within the first half of the year) appears closely related with the evident temperature increase and severe precipitation shortage over 2016, which are likely correlated with the strong E1 Nino event around 2016. Moreover, we compare the GRACE spherical harmonic(SH) and mass concentration(Mascon) solutions in estimating the PIF ice loss rate, and find that the Mascon result has larger uncertainty in leakage error correction,while the SH solutions can better correct leakage errors based on a constrained forward modeling iterative method. Thus the GRACE SH solutions with constrained forward modeling recovery are recommended to evaluating the ice mass change of PIF or other glacier regions with relatively smaller spatial scales.
基金National Natural Science Foundation of China,No.41761003The Karst Science Research Center of Guizhou Province,No.U1812401。
文摘Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what extent CO_(2)fertilization affects vegetation changes in such regions remains unclear.In this study,we investigated the degree to which CO_(2)fertilization influences vegetation changes,along with their spatial and temporal differences,in the subtropical humid karst region using time-lag effect analysis,a random forest model,and multiple regression analysis.Results showed that CO_(2)fertilization plays an important role in vegetation changes,exhibiting clear spatial variations across different geomorphological zones,with its degree of influence ranging mainly between 11%and 25%.The highest contribution of CO_(2)fertilization was observed in the karst basin and non-karstic region,whereas the lowest contribution was found in the karst plateau region.Previous studies have primarily attributed vegetation changes in subtropical humid karst region to ecological engineering,leading to an overestimation of its contribution to these changes.The findings of this study enhance the understanding of the mechanism of vegetation changes in humid karst region and provide theoretical and practical insights for ecological and environmental protection in these regions.
基金supported by the Science and Technology Program of Fujian Province,China(No.2023R1014002)the National Natural Science Foundation of China(No.41471390).
文摘The toxicity of PM_(2.5)does not necessarily change synchronously with its mass concentration.In this study,the chemical composition(carbonaceous species,water-soluble ions,and metals)and oxidative potential(dithiothreitol assay,DTT)of PM_(2.5)were investigated in 2017/2018 and 2022 in Xiamen,China.The decrease rate of volume-normalized DTT(DTTv)(38%)was lower than that of PM_(2.5)(55%)between the two sampling periods.However,the mass-normalized DTT(DTTm)increased by 44%.Clear seasonal patterns with higher levels in winter were found for PM_(2.5),most chemical constituents and DTTv but not for DTTm.The large decrease in DTT activity(84%−92%)after the addition of EDTA suggested that watersoluble metals were the main contributors to DTT in Xiamen.The increased gap between the reconstructed and measured DTTv and the stronger correlations between the reconstructed/measured DTT ratio and carbonaceous species in 2022were observed.The decrease rates of the hazard index(32.5%)and lifetime cancer risk(9.1%)differed from those of PM_(2.5)and DTTv due to their different main contributors.The PMF-MLR model showed that the contributions(nmol/(min·m^(3)))of vehicle emission,coal+biomass burning,ship emission and secondary aerosol to DTTv in 2022 decreased by 63.0%,65.2%,66.5%,and 22.2%,respectively,compared to those in 2017/2018,which was consistent with the emission reduction of vehicle exhaust and coal consumption,the adoption of low-sulfur fuel oil used on board ships and the reduced production of WSOC.However,the contributions of dust+sea salt and industrial emission increased.
文摘BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.
文摘Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity.
基金supported by the Ecological Conservation and High-Quality Development of the Yellow River Basin Program,China(2022-YRUC-010102)the Second Tibetan Plateau Scientific Expedition and Research Program,China(20190ZKK0405)the Basic Research Fund Project of Innovation Team of Novel Forage Germplasm and Sustainable Utilization of Grassland Resources,China(BR22-12-07)。
文摘There is growing interest in introducing ecological risks(ERs)and ecosystem services(ESs)into environmental policies and practices.However,the integration of ESs and ERs into actual decision-making remains insufficient.We simulated the spatiotemporal dynamics of ESs(e.g.,carbon storage,water yield,habitat quality,and soil conservation)and ERs in the upper reach of the Yellow River(URYR)from 2000 to 2100.Additionally,we explored their relationships by combining the InVEST model and a landscape ecological risk model with CMIP6 data.Our main findings showed that regional ERs change in response to land use and environmental dynamics.Specifically,the ER area decreased by 27,673 m^(2)during 2000-2020,but it is projected to increase by 13,273,438,and 68 m^(2)under the SSP1-2.6,SSP2-4.5,and SSP5-8.5 scenarios,respectively.We also observed remarkable spatial differences in ESs and ERs between past and future scenarios.For instance,the source area of the URYR exhibited high ESs and low ERs(P<0.001),while the ESs and ERs are declining and increasing,respectively,in the northeastern URYR(P<0.05).Finally,we proposed a spatial optimization framework to improve ESs and reduce ERs,which will support regional sustainable development.
基金funded by the Postdoctoral Research Startup Foundation of University of Jinan(Grant No.100389917).
文摘Climate change and anthropogenic activities have driven significant terrestrial water storage changes(TWSC)in the Three Rivers Source Region(TRSR),exerting profound impacts on freshwater availability across China and broader Asia.However,long-term TWSC characterization remains challenging due to limited observational data in this alpine region.Here,we integrate GRACE observations(2002-2020),ERA5-Land reanalysis,and GLDAS data to reconstruct TWSC using two methods:(1)the water balance method(PER)and(2)the component summation method(SS),applied to three input datasets(ERA5-Land,GLDAS,and their average,GLER).Comparative analysis reveals that the SS method applied to GL-ER yields the highest consistency with GRACE-derived TWSC.Using this optimal approach,we extend the analysis to 1951~2020,uncovering spatiotemporal TWSC patterns.Although annual TWSC trends appear negligible due to strong seasonality,we introduce the intra-year TWSC fluctuation(TWSCF)index to quantify cumulative variability.A significant(p<0.05)transition occurred in 1980,with TWSCF shifting from a declining trend(-0.39 mm/yr)to an increasing trend(0.56 mm/yr),primarily driven by soil moisture changes.However,Hurst exponent analysis suggests this upward trend may not persist.Drought and vegetation assessments indicate concurrent wetting and greening in the TRSR.TWSC correlates strongly with meteorological drought,acting as a reliable drought indicator while its linkage with vegetation dynamics suggests a potential contribution to greening.Our findings provide a robust framework for understanding long-term TWSC evolution and its hydrological-ecological interactions under climate change.
文摘BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.AIM To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive population.METHODS Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of 2018.Longitudinal changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal group.To examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%CI.RESULTS The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the sample.Over the course of a mean follow-up of 4.8 years,143 ischemic strokes happened.When normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et al.Dyslipidemia changed and ischemic stroke WJCC https://www.wjgnet.com 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),respectively.CONCLUSION In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.
基金supported by the National Natural Science Foundation(Nos.42275107,42121004,and 42375109)the National Key Research and Development Plan(No.2023YFC3706202)+1 种基金the Foundational and Applied Basic Research in Guangzhou in 2023(No.2023A04J0251)the Special Fund Project for Science and Technology Innovation Strategy of Guangdong Province(No.2019B121205004).
文摘The Pearl River Delta(PRD)region has been identified as a significant hotspot of wet ammonium deposition.However,the absence of long-term monitoring data in the area hinders the comprehension of the historical trends and changes in wet NH_(4)^(+)-N deposition in response to emissions,which interferes with the ability to make effective decisions.This study has analyzed the long-term trends of wet NH_(4)^(+)-N deposition flux and has quantified the effect of anthropogenic emissions and meteorological factors at a typical urban site and a typical forest site in the PRD region from 2009 to 2020.It revealed a significant decreasing trend in wet NH_(4)^(+)-N flux in both the typical urban and forest areas of the PRD region,at-6.2%/year(p<0.001)and-3.3%/year(p<0.001),respectively.Anthropogenic emissions are thought to have contributed 47%–57%of the wet NH_(4)^(+)-N deposition trend over the past 12 years compared to meteorological factors.Meteorological conditions dominated the interannual fluctuations in wet NH_(4)^(+)-N deposition with an absolute contribution of 46%–52%,while anthropogenic emissions change alone explained 10%–31%.NH_(3)emissions have the greatest impact on the urban area among anthropogenic emission factors,while SO_(2)emissions have the greatest impact on the forest area.Additionally,precipitation was identified as the primary meteorological driver for both sites.Our findings also imply that the benefits of NH_(3)emissions reductions might not immediately emerge due to interference from weather-related factors.
基金the National Natural Science Foundation of China(Grant No.42374105,42204089,42174104)Scientific Research Fund of Institute of Seismology,China Earthquake Administration(Grant No.IS202326341,IS202336350).
文摘On September 5, 2022, an earthquake of magnitude M_(S)6.8 occurred in Luding County, Sichuan Province.This earthquake occurred at the key part of the southeast-clockwise extrusion of material on the eastern margin of the Qinghai Plateau, the Y-shaped confluence of the Xianshuihe, Longmenshan and Anninghe fault zones. In this study, the three-dimensional dynamic crustal density changes in the earthquake area are obtained by the typical gravity change data from 2019 to 2022 before the earthquake and gravity inversion by growing bodies. The results indicate that gravity changes presented an obvious fourquadrant and gradient belt distribution in the Luding area before the earthquake. The threedimensional density horizontal slices show that small density changes occurred at the epicenter in the mid-to-upper crust between 2019.9-2020.9 and 2019.9-2021.9. At the same time, the surrounding areas exhibited a positive and negative quadrant distribution. These observations indicate that the source region was likely in a stable locked state, with locking-in shear forces oriented in the NW and NE directions. From 2021.9 to 2022.8, the epicentral region showed negative density changes, indicating that the source region was in the expansion stage, approaching a near-seismic state. The three-dimensional density vertical slices reveal a southeastward migration of positive and negative densities near the epicenter and on the western of the Xianshuihe Fault Zone, indicating that the material is flowing out to the southeast. The observed local negative density changes at the epicenter along the Longmenshan Fault Zone are likely associated with the NE-oriented extensional stress shown by the seismic source mechanism. The above results can provide a basis for interpreting pre-earthquake gravity and density changes,thereby contributing to the advancement of earthquake precursor theory.
基金supported by the Key R&D Project of Science and Technology Program of Tibet Autonomous Region(XZ202301ZY0006G)the Graduate High-level Talent Training Program of Xizang University(2022-GSP-B007)+1 种基金Nagqu City Science and Technology Program Key R&D Projects(NQKJ-2023-15)Central Financial Support for Local Universities to Construct Wetland Station in Mitika and Collaborative Innovation Center for Ecological Civilization of the Qinghai-Tibetan Plateau([2024]NO.01).
文摘This study aims to construct a large-scale hydrological Variable Infiltration Capacity(VIC)model based on temperature and precipitation at high altitudes,while elucidating the applicability of the model for hydrological simulation and analyzing the factors affecting runoff volume.Runoff volume and runoff depth were simulated using the VIC model and its performance was evaluated.Meanwhile,the factors affecting runoff volume were analyzed using Spearman correlation.The following model sensitivity parameters were obtained based on the China Natural Runoff Grid Point Dataset(CNRD v1.0):The variable infiltration curve parameter was 0.3,the Dsmax fraction where non-linear baseflow begins was 0.02,the maximum baseflow velocity was 15 mm/d,the maximum soil moisture where non-linear baseflow occurred was 0.7,the second soil moisture layer thickness was 0.3,and the thickness of the third soil moisture layer was 1.5.The surface runoff values in the Nyang River basin were similar in the first and fourth quarters(1.05–2.27 mm and 2.38–4.77 mm,respectively),and the surface runoff values were similar in the second and third quarters when the surface runoff was greater(23.46–52.20 mm and 60.59–85.63 mm,respectively).Watershed area,temperature,and precipitation significantly influenced the amount of runoff from the Nyang River.The applicability of the model to the Nyang River basin was confirmed using two different rate models.In some areas,precipitation and temperature did not have a dominating influence on runoff.Although the VIC model has significant advantages in runoff simulation,it requires a wealth of meteorological,soil,and hydrological data that may be difficult to obtain in some areas.
基金supported by National Key R&D Program of China(No.2018YFC0407303)“Young Talents”Project of Northeast Agricultural University(No.20QC13)the Natural Science Foundation of Heilongjiang Province of China(No.E2017009)。
文摘Previous works were mainly concentrated on long-term average runoff alterations,and extreme temperatures and watershed conditions are little analyzed.In this study,we collected gauged river flow and meteorological data time series from 1916 to 2015 and 1941 to 2015 across the contiguous United States(CONUS)for 188 catchments to investigate the temporal trends and spatial features of runoff changes at multi-time scales.We also analyzed the relationships between runoff changes and climatic factors.Median descriptive statistics and Budyko coupled climate elasticity methods were used to calculate runoff elasticity in each time scale.The original Mann-Kendall trend test was used to test their trend significance in four time-scale(11,20,40,and 60 a),respectively.The results show that the trend of runoff changes is more significant in high time scales;total changes are heterogeneous over CONUS.After the 1970s,increases of up to 27%decade-1 were mainly concentrated in the mid-northern regions.Maximum temperature and catchment characteristics are vital factors for runoff alteration;runoff changes are independent of rainfall,and wet regions tend to have lower changes.These findings could help develop better regional water resource planning and management.
基金funded by the National Natural Science Foundation of China(U21A2011).
文摘Climate warming and humidification trends have significantly influenced vegetation growth patterns in Chinese semi-arid areas.Exploring vegetation dynamics is crucial for understanding regional ecosystem structure and improving the efforts of ecosystem restoration.However,the applicability of various vegetation indices(VIs)in these arid areas remains uncertain.Evaluating the applicability of multiple VIs for vegetation monitoring can elucidate the variability of VIs performance at regional scale.Therefore,this study selected the Zuli River Basin(ZLRB),a typical loess hilly watershed in the semi-arid areas of China.Using Landsat data,we calculated the Normalized Difference Vegetation Index(NDVI),Enhanced Vegetation Index(EVI),and kernel NDVI(kNDVI)for the ZLRB from 1990 to 2020.We analyzed the spatiotemporal variations of these VIs using trend analysis and the Mann-Kendall test,and quantified the contributions of climate change(considering time-lag effects)and human activities to VIs changes through wavelet and residual analyses.Results indicated that VIs generally exhibited an upward trend in the ZLRB,with significant improvements observed in 54.91% of the area for NDVI,31.69% for EVI,and 33.71% for kNDVI.Among them,NDVI outperformed EVI and kNDVI in capturing vegetation changes in the semi-arid area.VIs responded to precipitation with 1-month time lag and no time lag to temperature during growing season.Moreover,precipitation had a stronger positive correlation with VIs than temperature.Climate change was identified as the dominant driver of vegetation dynamics in the ZLRB,accounting for 93.12% of NDVI variation,while human activities contributed only 6.88%.Comparative analysis of VIs suggests that NDVI was more suitable for describing vegetation changes in the typical arid area of the ZLRB.Our findings underscore the importance of selecting appropriate VIs for targeted ecological restoration and sustainable land management.
基金supported by the Natural Science Foundation of Jiangsu Province[grant number BK20220031]the National Natural Science Foundation of China[grant number 42007195].
文摘Renewable energy,especially solar power,is vital for mitigating global warming,while climate change also impacts solar photovoltaic potential(PVpot).This study analyzes historical(1985–2014)and future(2015–2100)climate effects on PVpot,and quantifies contributions from changed radiation,temperature,and wind speed.Historically,global PVpot increased by 0.42‰,with notable rises in eastern China(+7.1‰)and southern Europe(+3.5‰).By the end of the century,increased radiation-induced PVpot(+1.27‰)offsets temperatureinduced PVpot loss(−0.54‰)under SSP1-2.6,yielding a net PVpot increase(+0.74‰).Under SSP2-4.5,the temperature-induced PVpot decline(−1.50‰)drives the final PVpot reduction(−1.15‰).Under SSP3-7.0 and SSP5-8.5,combined radiation-induced(−1.94‰and−1.99‰)and temperature-induced PVpot changes(−2.67‰and−3.41‰)result in significant PVpot declines(−4.57‰and−5.31‰).Regional analysis reveals that eastern China(+0.7‰to+8.6‰),southern Europe(+0.3‰to+2.5‰),and Northwest South America(+0.6‰to+2.1‰)retain positive changes in future PVpot across all climate scenarios,which may be due to reduced aerosols and cloud cover,suggesting these areas can remain suitable for photovoltaic installations despite climate changes.In contrast,temperature-driven PVpot declines over the Qinghai-Tibet Plateau(−9.1‰to−4.3‰)and northern Africa(−9.3‰to−4.9‰)under future high-emission scenarios indicate that these historically advantageous regions will become less suitable for solar energy deployment.The findings underscore that climate changes driven by sustainable development pathways will generate more PVpot in the future for better global warming mitigation.
基金supported by grants from the National Natural Science Foundation of China(81871062)Guangdong Basic and Applied Basic Research Foundation(2024A1515012913)+1 种基金the Key Research Foundation of Guangdong Provincial Education Bureau(2023ZDZX2037)the Special Fund of Science and Technology Innovation Cultivation of Guangdong University Students(pdjh2024a238,pdjh2025ak133)。
文摘Dear Editor,Post-traumatic stress disorder(PTSD)is a chronic neuropsychiatric disorder triggered by severe traumatic events,characterized by persistent intrusive memories,emotional dysregulation,hyperarousal,and avoidance behaviors[1,2].PTSD is associated with significant gene expression changes in key brain regions,including the ventral tegmental area(VTA),which may underlie dysregulation of dopaminergic signaling and stress-related behaviors[3].
基金Natural Science Foundation of Shandong Province(Grant No.ZR2021QH176)。
文摘Background Cardiovascular disease(CVD)and frailty are interrelated conditions prevalent in aging populations,yet their dynamic temporal relationship remains underexplored.This study investigates longitudinal changes in frailty trajectories before and after incident CVD across diverse cohorts.Methods Utilizing data from four longitudinal,multinational cohorts(ELSA,HRS,CHARLS,SHARE;n=66,537),we constructed the frailty index(FI)based on age-related health deficits,using 40,40,42,and 44 items from ELSA,HRS,CHARLS and SHARE,respectively.Linear mixed models assessed FI changes pre-and post-CVD,adjusting for demographics,lifestyle,and baseline FI.Sensitivity analyses excluded hypertension,diabetes,and arthritis to mitigate confounding.Results Frailty increased steadily before CVD onset(pre-CVD slope:ELSAβ=0.005,HRSβ=0.005,CHARLSβ=0.012,SHAREβ=0.007;all P<0.001),with an acute FI spike at diagnosis(post-CVD acute change:ELSAβ=0.024,HRSβ=0.031,CHARLSβ=0.046,SHAREβ=0.038;all P<0.001).Post-CVD,frailty progression further accelerated(ELSAβ=0.008,HRSβ=0.005,CHARLSβ=0.017,SHAREβ=0.010;all P<0.001).Sensitivity analyses confirmed robustness across age strata and FI definitions.Conclusions This first multinational study demonstrates bidirectional acceleration of frailty around CVD onset,highlighting their close temporal interplay.These findings suggest that incorporating frailty assessment into CVD management may help identify high-risk individuals and support timely,multidimensional care in aging populations.
基金supported by the National Key Programme of Research and Development,Ministry of Science and Technology of China(2022YFF1301600)National Natural Science Foundation of China(32030011,U24A20362,32070409)+2 种基金PI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2021 GD0805)Qing Lan Project of Jiangsu ProvincePriority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Vertebrate limbs have undergone profound morphological diversification,enabling adaptations to a broad spectrum of ecological niches.In marine mammals,the evolution of highly specialized flipper-like forelimbs represents a profound structural transformation associated with aquatic habitats.This adaptation has been hypothesized to result,in part,from the inhibition of interphalangeal cell apoptosis during limb development,although the underlying genetic mechanism remains poorly understood.This study investigated the evolutionary dynamics and functional consequences of three key bone morphogenetic protein genes,BMP2,BMP4,and BMP7,which regulate apoptosis in interphalangeal mesenchymal stromal cells during embryonic limb development to ensure proper differentiation of interphalangeal tissues.Comparative genomic analysis revealed significantly accelerated evolution for BMP4 and BMP7 in the cetacean ancestral lineage,with two positively selected sites(V79I and H247R)involved in cetacean-specific amino acid substitutions located in the TGF-βpropeptide functional domain in BMP4.In vitro assays confirmed that cetacean-specific BMP4 mutations significantly disrupted normal cell apoptosis and proliferation and altered the transcription and protein expression of downstream apoptosis-related factors,including cytochrome c(Cyt c),BCL2 associated X,and B-cell lymphoma 2,within the BMP signaling pathway.The significant influence of BMP4 mutations on apoptotic inhibition highlights a potential role in the development of limb bud mesenchymal tissue and the emergence of the flipper forelimb phenotype in cetaceans.
