BACKGROUND: Virological clearance, delayed progression to cirrhosis or liver cancer, and increased survival are the long-term goals of antiviral therapy in chronic hepatitis B patients. Identification of host factors ...BACKGROUND: Virological clearance, delayed progression to cirrhosis or liver cancer, and increased survival are the long-term goals of antiviral therapy in chronic hepatitis B patients. Identification of host factors correlated with therapeutic response may contribute greatly to individual treatment. This study aimed at investigating whether T29C genotype polymorphism of estrogen receptor alpha (ESR1) is associated with the initial response to interferon-alpha (IFN-alpha) therapy in chronic hepatitis B patients. METHODS: The initial responses of 100 patients to IFN-alpha therapy were evaluated and compared by classifying them into three groups according to T29C genotype polymorphism of ESR1: T/T, TIC, and C/C genotype groups. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze the genotype polymorphism in T29C. RESULTS: The frequency of initially combined response was markedly higher in both the T/T and TIC groups than in the C/C group (Z=10.326, P=0.006 and Z=26.247, P=0.000, respectively). In addition, the initial virological response was higher in the T/T and T/C groups than the C/C group (chi(2)=5.674, P=0.017 and chi(2)=4.980, P=0.026, respectively). In 78 initially HBeAg-positive patients, however, the frequency of initial e-antigen disappearance or seroconversion among the T/T, T/C, and C/C genotype groups was 34.15%, 27.78% and 15.79%, respectively, which were not significantly different. CONCLUSION. The T29C genotype polymorphism of ESR1 is associated with the initial response to IFN-alpha in patients with chronic hepatitis B, and might be a significant marker for predicting the initial response to IFN-alpha, at least in this study population. (Hepatobiliary Pancreat Dis Int 2010; 9: 275-279)展开更多
In this paper,we consider the dynamic response of a pre-stressed sandwich plate-strip with a piezoelectric core and elastic layers under the action of a time-harmonic force resting on a rigid foundation.The investigat...In this paper,we consider the dynamic response of a pre-stressed sandwich plate-strip with a piezoelectric core and elastic layers under the action of a time-harmonic force resting on a rigid foundation.The investigation is carried out within the framework of the piecewise homogeneous body model by utilizing the exact equations of motion and relations of the linear theory of electro-elasticity.It is assumed that there is a shear-spring-type imperfect contact between the layers,but a complete contact between the plate-strip and the rigid foundation.A mathematical model of the problem is constructed,and the governing equations of motion are solved by employing the finite element method（FEM）.Numerical results illustrating the influence of a change in the value of the shear-spring parameter on the dynamic response of the plate-strip are then presented.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.30771907)the Foundation of Pre-973 Program Projects(No.2009CB526411)
文摘BACKGROUND: Virological clearance, delayed progression to cirrhosis or liver cancer, and increased survival are the long-term goals of antiviral therapy in chronic hepatitis B patients. Identification of host factors correlated with therapeutic response may contribute greatly to individual treatment. This study aimed at investigating whether T29C genotype polymorphism of estrogen receptor alpha (ESR1) is associated with the initial response to interferon-alpha (IFN-alpha) therapy in chronic hepatitis B patients. METHODS: The initial responses of 100 patients to IFN-alpha therapy were evaluated and compared by classifying them into three groups according to T29C genotype polymorphism of ESR1: T/T, TIC, and C/C genotype groups. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze the genotype polymorphism in T29C. RESULTS: The frequency of initially combined response was markedly higher in both the T/T and TIC groups than in the C/C group (Z=10.326, P=0.006 and Z=26.247, P=0.000, respectively). In addition, the initial virological response was higher in the T/T and T/C groups than the C/C group (chi(2)=5.674, P=0.017 and chi(2)=4.980, P=0.026, respectively). In 78 initially HBeAg-positive patients, however, the frequency of initial e-antigen disappearance or seroconversion among the T/T, T/C, and C/C genotype groups was 34.15%, 27.78% and 15.79%, respectively, which were not significantly different. CONCLUSION. The T29C genotype polymorphism of ESR1 is associated with the initial response to IFN-alpha in patients with chronic hepatitis B, and might be a significant marker for predicting the initial response to IFN-alpha, at least in this study population. (Hepatobiliary Pancreat Dis Int 2010; 9: 275-279)
基金a member of a research project supported by the Research Fund of Kastamonu University via project num-ber Kü-BAP01/2016-4
文摘In this paper,we consider the dynamic response of a pre-stressed sandwich plate-strip with a piezoelectric core and elastic layers under the action of a time-harmonic force resting on a rigid foundation.The investigation is carried out within the framework of the piecewise homogeneous body model by utilizing the exact equations of motion and relations of the linear theory of electro-elasticity.It is assumed that there is a shear-spring-type imperfect contact between the layers,but a complete contact between the plate-strip and the rigid foundation.A mathematical model of the problem is constructed,and the governing equations of motion are solved by employing the finite element method（FEM）.Numerical results illustrating the influence of a change in the value of the shear-spring parameter on the dynamic response of the plate-strip are then presented.
