Objective:This study compared the long-term outcomes between rotational atherectomy(RA)for specific indications and on-label use of RA for severely calcified coronary lesions.Methods:Data for patients who underwent RA...Objective:This study compared the long-term outcomes between rotational atherectomy(RA)for specific indications and on-label use of RA for severely calcified coronary lesions.Methods:Data for patients who underwent RA between 2015 and 2020 in a single-center registry were analyzed.The specific indication group included patients with ostial lesions,unprotected left main coronary artery stenosis,chronic total occlusions,stent ablation,angulated lesions,and cardiac dysfunction,whereas patients with none of the above-mentioned characteristics were included in the on-label group.The primary endpoint was compared between groups.Results:A total of 176 patients in the on-label group and 125 patients in the specific indication group were included.Patient clinical characteristics were comparable between groups.The incidence of complications during the procedure was higher in the specific indication group than in the on-label group(20.0%vs.10.8%,P=0.018).No significant dif-ference was observed in in-hospital MACCE between groups(12.5%vs 9.7%,P=0.392).During 35(10–57)months of follow-up,MACCE occurred in 46 patients(15.3%).The incidence of MACCE was much higher in the specific indication group than the on-label group(25.6%vs 13.6%,P=0.034).Conclusions:RA for specific indications,compared with on-label use,had a higher incidence of complications dur-ing the procedure and poorer long-term clinical outcomes.展开更多
Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BM...Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BMD’s heritability is more than 60%(Arden et al.,1996).A number of candidate loci for BMD have been previously identified by Genome Wide Association Studies(GWAS)(Xiong et al.,2009;Karasik et al.,2010;Zhang et al.,2013).Nevertheless,many significant signals based on GWAS are展开更多
基金This study was supported by the National Natural Science Foundation of China(grant No.81800316).
文摘Objective:This study compared the long-term outcomes between rotational atherectomy(RA)for specific indications and on-label use of RA for severely calcified coronary lesions.Methods:Data for patients who underwent RA between 2015 and 2020 in a single-center registry were analyzed.The specific indication group included patients with ostial lesions,unprotected left main coronary artery stenosis,chronic total occlusions,stent ablation,angulated lesions,and cardiac dysfunction,whereas patients with none of the above-mentioned characteristics were included in the on-label group.The primary endpoint was compared between groups.Results:A total of 176 patients in the on-label group and 125 patients in the specific indication group were included.Patient clinical characteristics were comparable between groups.The incidence of complications during the procedure was higher in the specific indication group than in the on-label group(20.0%vs.10.8%,P=0.018).No significant dif-ference was observed in in-hospital MACCE between groups(12.5%vs 9.7%,P=0.392).During 35(10–57)months of follow-up,MACCE occurred in 46 patients(15.3%).The incidence of MACCE was much higher in the specific indication group than the on-label group(25.6%vs 13.6%,P=0.034).Conclusions:RA for specific indications,compared with on-label use,had a higher incidence of complications dur-ing the procedure and poorer long-term clinical outcomes.
基金partially supported by or benefited from grants from NIH (P50AR055081,R01AG026564,R01AR050496,R01AR059781,D43TW009107,P20GM109036,R01GM109068,R01MH104680,R01MH107354,R01AR057049,and R03TW008221)
文摘Low hip bone mineral density(BMD)is an important index for osteoporosis and is associated with hip fracture,which leads to more cases of disability and mortality than all other kinds of fractures(Kanis et al.,2007).BMD’s heritability is more than 60%(Arden et al.,1996).A number of candidate loci for BMD have been previously identified by Genome Wide Association Studies(GWAS)(Xiong et al.,2009;Karasik et al.,2010;Zhang et al.,2013).Nevertheless,many significant signals based on GWAS are
