Objective Tumors with accelerated growth or high malignancy are thought to undergo active angio- genesis. Whereas by far, there is few study concerning the combination of MIB-1 proliferation index (MIB-1 PI) and tumor...Objective Tumors with accelerated growth or high malignancy are thought to undergo active angio- genesis. Whereas by far, there is few study concerning the combination of MIB-1 proliferation index (MIB-1 PI) and tumor angiogenesis in carcinomas to show their significance in relate to clinicopathological parameters. In the present study, we evaluated the significance or MIB-1 PI and angiogenesis in early stage of gastric cancer. Our focus was es- pecially on the combination of MIB-1 PI and angiogenesis in relate to lymph node metastasis. Method Specimens from 95 patients with early gastric cancer were studied by means or immunohistochemistry using monoclonal MIB-1 and factor Ⅷ related antigen antibodies. Results The mean MIB-1 PI and microvessel count were 22.9% and 34.7, respectively. The MIB-1 PI did not correlate with microvessel count. Both correlated with depth of tumor invasion, lymphatic vessel invasion and lymph node metastasis. Multivarlate analysis showed that combined high MIB-1 PI/hy- pervascularity, as well as lymphatic vessel invasion and tumor size were independent factors that impact on lymph node metastasis. Conclusion A combination of the high MIB-1 PI/hypervascularity is a factor that related to lymph node metastasis in early gastric cancer.展开更多
Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metast...Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metastasis in breast cancer. Methods: We identified 343 invasive breast cancer patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The association between SLN status and clinicopathological features, molecular subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was detected in 79 patients (23.0%). SLN metastasis was significantly associated with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001). Ki-67 labeling index of primary tumor was significantly lower in SLN positive patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of Ki-67 labeling index, in addition to progression of clinical T-stage and presence of LVI, is significantly associated with SLN metastasis, and it seems to be useful to consider Ki-67 labeling index for SLN metastasis prediction.展开更多
文摘Objective Tumors with accelerated growth or high malignancy are thought to undergo active angio- genesis. Whereas by far, there is few study concerning the combination of MIB-1 proliferation index (MIB-1 PI) and tumor angiogenesis in carcinomas to show their significance in relate to clinicopathological parameters. In the present study, we evaluated the significance or MIB-1 PI and angiogenesis in early stage of gastric cancer. Our focus was es- pecially on the combination of MIB-1 PI and angiogenesis in relate to lymph node metastasis. Method Specimens from 95 patients with early gastric cancer were studied by means or immunohistochemistry using monoclonal MIB-1 and factor Ⅷ related antigen antibodies. Results The mean MIB-1 PI and microvessel count were 22.9% and 34.7, respectively. The MIB-1 PI did not correlate with microvessel count. Both correlated with depth of tumor invasion, lymphatic vessel invasion and lymph node metastasis. Multivarlate analysis showed that combined high MIB-1 PI/hy- pervascularity, as well as lymphatic vessel invasion and tumor size were independent factors that impact on lymph node metastasis. Conclusion A combination of the high MIB-1 PI/hypervascularity is a factor that related to lymph node metastasis in early gastric cancer.
文摘Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metastasis in breast cancer. Methods: We identified 343 invasive breast cancer patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The association between SLN status and clinicopathological features, molecular subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was detected in 79 patients (23.0%). SLN metastasis was significantly associated with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001). Ki-67 labeling index of primary tumor was significantly lower in SLN positive patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of Ki-67 labeling index, in addition to progression of clinical T-stage and presence of LVI, is significantly associated with SLN metastasis, and it seems to be useful to consider Ki-67 labeling index for SLN metastasis prediction.
文摘目的探讨全身性炎症标志物与甲状腺癌及淋巴结转移之间的关系,并评估其在调整肿瘤大小及年龄后的预测价值。方法回顾性分析2020年8月至2023年8月山东第一医科大学第二附属医院甲状腺外科收治的甲状腺结节(thyroid nodules,TNS)患者,根据术后病理结果将患者分为良性组和恶性组,根据是否存在淋巴结转移将恶性组分为淋巴结阳性组和淋巴结阴性组,收集各组患者年龄、性别、体质量指数(body mass index,BMI)等一般临床资料,白细胞计数(white blood cell count,WBC)、血小板计数(platelet count,PLT)、中性粒细胞计数(neutrophil count,NEUT)、淋巴细胞计数(lymphocyte count,LYMPH)、单核细胞计数(monocyte count,MONO)、血小板淋巴细胞计数比(platelet to lymphocyte ratio,PLR)、中性粒细胞淋巴细胞计数比(neutrophil to lymphocyte ratio,NLR)、淋巴细胞单核细胞计数比(lymphocyte to monocyte ratio,LMR)、全身免疫炎症指数(systemic immune inflammatory index,SII)等炎症指标以及肿瘤最长径、淋巴结转移等临床病理资料进行分析。结果570例接受TNS切除手术的患者被纳入研究,其中良性TNS患者215例(37.72%),TC患者355例(62.28%)。在570例TNS患者中,良性组的女性占比、年龄和肿瘤最长径明显高于恶性组,BMI小于恶性组,差异均具有统计学意义(P均<0.05)。在355例TC患者中,淋巴结阳性组男性占比、BMI和肿瘤最长径高于淋巴结阴性组,年龄小于淋巴结阴性组,差异均具有统计学意义(P均<0.05)。调整肿瘤大小后,NLR是肿瘤最长径>2 cm TNS患者发生TC的独立危险因素(OR=2.646,95%CI:1.242~5.638,P=0.012);调整年龄后,PLR是年龄≥55岁TC患者发生淋巴结转移的独立危险因素(OR=1.009,95%CI:1.001~1.017,P=0.035)。结论TNS的最长径>2cm时,NLR是发生TC的独立危险因素,且侧颈区淋巴结转移阳性患者的NLR显著高于阴性患者;PLR是年龄≥55岁TC患者发生淋巴结转移的独立危险因素。
