Digital in-line holographic microscopy(DIHM)is a non-invasive,real-time,label-free technique that captures three-dimensional(3D)positional,orientational,and morphological information from digital holographic images of...Digital in-line holographic microscopy(DIHM)is a non-invasive,real-time,label-free technique that captures three-dimensional(3D)positional,orientational,and morphological information from digital holographic images of living biological cells.Unlike conventional microscopies,the DIHM technique enables precise measurements of dynamic behaviors exhibited by living cells within a 3D volume.This review outlines the fundamental principles and comprehensive digital image processing procedures employed in DIHM-based cell tracking methods.In addition,recent applications of DIHM technique for label-free identification and digital tracking of various motile biological cells,including human blood cells,spermatozoa,diseased cells,and unicellular microorganisms,are thoroughly examined.Leveraging artificial intelligence has significantly enhanced both the speed and accuracy of digital image processing for cell tracking and identification.The quantitative data on cell morphology and dynamics captured by DIHM can effectively elucidate the underlying mechanisms governing various microbial behaviors and contribute to the accumulation of diagnostic databases and the development of clinical treatments.展开更多
A grain-oriented silicon steel was normalized with a novel high magnetic field using one-stage cooling process.The effect of high-magnetic-field normalizing on the microstructures and textures was studied with a hot-r...A grain-oriented silicon steel was normalized with a novel high magnetic field using one-stage cooling process.The effect of high-magnetic-field normalizing on the microstructures and textures was studied with a hot-rolled sheet as initial material.It was found that recrystallization and the grain growth were enhanced owing to the external magnetic field driving force.The angle between Goss orientation and magnetic field direction was small,resulting in a high nucleation rate of Goss grains,and hence,the intensity of Goss texture was increased and the deviation angle of Goss grains was reduced after high-magnetic-field normalizing.Furthermore,the migration of dislocation was promoted with an external magnetic field driving force and the density of dislocation decreased,reducing the proportion of low-angle grain boundaries around the Goss grains.The enhancement of recrystallization process and grain growth increased the proportion of high-energy grain boundaries and high-angle grain boundaries,providing a favorable condition for the growth of Goss grains.展开更多
Deep learning has emerged as a powerful tool for predicting the remaining useful life(RUL)of batteries,contingent upon access to ample data.However,the inherent limitations of data availability from traditional or acc...Deep learning has emerged as a powerful tool for predicting the remaining useful life(RUL)of batteries,contingent upon access to ample data.However,the inherent limitations of data availability from traditional or accelerated life testing pose significant challenges.To mitigate the prediction accuracy issues arising from small sample sizes in existing intelligent methods,we introduce a novel data augmentation framework for RUL prediction.This framework harnesses the inherent high coincidence of degradation patterns exhibited by lithium-ion batteries to pinpoint the knee point,a critical juncture marking a significant shift in the degradation trajectory.By focusing on this critical knee point,we leverage the power of normalizing flow models to generate virtual data,effectively augmenting the training sample size.Additionally,we integrate a Bayesian Long Short-Term Memory network,optimized with Box-Cox transformation,to address the inherent uncertainty associated with predictions based on augmented data.This integration allows for a more nuanced understanding of RUL prediction uncertainties,offering valuable confidence intervals.The efficacy and superiority of the proposed framework are validated through extensive experiments on the CS2 dataset from the University of Maryland and the CrFeMnNiCo dataset from our laboratory.The results clearly demonstrate a substantial improvement in the confidence interval of RUL predictions compared to pre-optimization,highlighting the ability of the framework to achieve high-precision RUL predictions even with limited data.展开更多
DDoS attacks represent one of the most pervasive and evolving threats in cybersecurity,capable of crippling critical infrastructures and disrupting services globally.As networks continue to expand and threats become m...DDoS attacks represent one of the most pervasive and evolving threats in cybersecurity,capable of crippling critical infrastructures and disrupting services globally.As networks continue to expand and threats become more sophisticated,there is an urgent need for Intrusion Detection Systems(IDS)capable of handling these challenges effectively.Traditional IDS models frequently have difficulties in detecting new or changing attack patterns since they heavily depend on existing characteristics.This paper presents a novel approach for detecting unknown Distributed Denial of Service(DDoS)attacks by integrating Sliced Iterative Normalizing Flows(SINF)into IDS.SINF utilizes the Sliced Wasserstein distance to repeatedly modify probability distributions,enabling better management of high-dimensional data when there are only a few samples available.The unique architecture of SINF ensures efficient density estimation and robust sample generation,enabling IDS to adapt dynamically to emerging threats without relying heavily on predefined signatures or extensive retraining.By incorporating Open-Set Recognition(OSR)techniques,this method improves the system’s ability to detect both known and unknown attacks while maintaining high detection performance.The experimental evaluation on CICIDS2017 and CICDDoS2019 datasets demonstrates that the proposed system achieves an accuracy of 99.85%for known attacks and an F1 score of 99.99%after incremental learning for unknown attacks.The results clearly demonstrate the system’s strong generalization capability across unseen attacks while maintaining the computational efficiency required for real-world deployment.展开更多
Microstructure, precipitate and magnetic characteristic of fmal products with different normalizing cooling processes for Fe-3.2%Si low-temperature hot-rolled grain-oriented silicon steel were analyzed and compared wi...Microstructure, precipitate and magnetic characteristic of fmal products with different normalizing cooling processes for Fe-3.2%Si low-temperature hot-rolled grain-oriented silicon steel were analyzed and compared with the hot-rolled plate by optical microscopy （OM）, transmission electron microscopy （TEM）, and energy dispersive spectrometry （EDS）. The results show that, the surface microstructure is uniform, the proportion of recrystallization in matrix increases, and the banding textures are narrowed; the precipitates, whose quantity in normalized plate is more than that in hot-rolled plate greatly, are mainly A1N, MnS, composite precipitates （Cu,Mn）S and so on. Normalizing technology with a temperature of 1120 ℃, holding for 3 min, and a two-stage cooling is a most advantaged method to obtain oriented silicon steel with sharper Goss texture and higher magnetic properties, owing to the uniform surface microstructures and the obvious inhomogeneity of microstructures along the thickness. The normalizing technology with the two-stage cooling is the optimum process, which can generate more fine precipitates dispersed over the matrix, and be beneficial for finished products to get higher magnetic properties.展开更多
The grain-oriented silicon steel is a kind of important magnetic materials with low iron loss and high induc tion. Hot hand normalizing annealing is an important process which influences the microstructure and the dev...The grain-oriented silicon steel is a kind of important magnetic materials with low iron loss and high induc tion. Hot hand normalizing annealing is an important process which influences the microstructure and the development of the inhibitors. The effects of different annealing temperatures and cooling conditions on the inhibitors and microstructures of normalizing annealing band were investigated. The microstructure and different kinds of the inhibitors, i. e. , A1N, AIN＋Cu, S＋MnS, and TiN, were discovered. The result shows that a suitable cooling condition leads to more nano scale inhibitors and uniform microstructure of the normalizing annealing band and consequently results in better magnetic properties.展开更多
OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatom...OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatoma mice model.METHODS: Hepa1-6 hepatoma-bearing mice were treated with TanⅡA for 14 d. Distribution and anti-tumor efficacy of PLD, and the structure and function of the tumor vasculature were evaluated using various techniques.RESULTS: TanⅡ A significantly reduced the micro-vessel density(MVD). After Tan vascular walls were betteⅡr s A treatment,the tumor tructured, as the increased coverage of the pericytes and the promoted contact of the basement membrane and endothelial cell. Functional tests showed that tumor hypoxia was improved and the exudation amount of Evans blue in the parenchyma of the tumor decreased. In addition, mice treated with TanA had greater PLD penetration distance intratumoⅡrally. Furthermore, combined therapy of Tanibited tumor growth.ⅡA and PLD significantly inhCONCLUSION: This study suggests that Tanasculature andⅡ h A helps normalizing the tumor vas therapeutic potential in increasing the distribution of chemotherapy drug in the tumor.展开更多
In this work, we study the coupled cross-flow and in-line vortex-induced vibration （VIV） of a fixedly mounted flexible pipe, which is free to move in cross-flow （ Y- ） and in-line （ X- ） direction in a fluid flo...In this work, we study the coupled cross-flow and in-line vortex-induced vibration （VIV） of a fixedly mounted flexible pipe, which is free to move in cross-flow （ Y- ） and in-line （ X- ） direction in a fluid flow where the mass and natural frequencies are precisely the same in both X- and Y-direction. The fluid speed varies from low to high with the corresponding vortex shedding frequency varying from below the first natural frequency to above the second natural frequency of the flexible pipe. Particular emphasis was placed on the investigation of the relationship between in-line and cross-flow vibration. The experimental results analyzed by using these measurements exhibits several valuable features.展开更多
The in-line （IL） vortex-induced vibration （VIV） that occurs frequently in ocean engineering may cause severe fatigue damage in slender marine structures. To the best knowledge of the authors, in existing literatur...The in-line （IL） vortex-induced vibration （VIV） that occurs frequently in ocean engineering may cause severe fatigue damage in slender marine structures. To the best knowledge of the authors, in existing literatures, there is no efficient analytical model for predicting pure IL VIV. In this paper, a wake oscillator model capable of analyzing the IL VIV of slender marine structures has been developed. Two different kinds of van der Pol equations are used to describe the near wake dynamics related to the fluctuating nature of symmetric vortex shedding in the first excitation region and alternate vortex shedding in the second one. Some comparisons are carried out between the present model results and experimental data. It is found that many phenomena observed in experiments could be reproduced by the present wake oscillator model.展开更多
Experimental and theoretical analysis were made on the natural humic acid removal and the membrane fouling of ultrafiltration （UF） with in-line coagulation. The results showed dissolved organic carbon （DOC） and UV...Experimental and theoretical analysis were made on the natural humic acid removal and the membrane fouling of ultrafiltration （UF） with in-line coagulation. The results showed dissolved organic carbon （DOC） and UV254 removals by the UF with in-line coagulation at pH 7 were increased from 28% to 53% and 40% to 78% in comparison with direct UF treatment respectively. At the same time, the analysis of high performance liquid chromatography showed that UF with coagulation had significant improvement of removal of humic acid with molecular weights less than 6000 Da in particular. Compared to direct UF, the in-line coagulation UF also kept more constant permeate flux and very slight increase oftransmembrane pressure during a filtration circle. Two typical membrane fouling models were used by inducing two coefficients Kc and Kp corresponding to cake filtration model and pore narrowing model respectively. It was found that membrane fouling by pore-narrowing effect was effectively alleviated and that by cake-filtration was much decreased by in-line coagulation. Under the condition of coagulation prior to ultrafiltration at pH 7, the cake layer formed on the membrane surface became thicker, but the membrane filtration resistance was lower than that at pH 5 with the extension of operation time.展开更多
The precipitation behavior of V-N microalloyed steel during normalizing process was studied by physicochemical phase analysis and transmission electron microscopy（TEM）. The effect of precipitation behavior on mechan...The precipitation behavior of V-N microalloyed steel during normalizing process was studied by physicochemical phase analysis and transmission electron microscopy（TEM）. The effect of precipitation behavior on mechanical properties was investigated by theoretical calculations. The results showed that 32.9% of V（C,N） precipitates remained undissolved in the austenite during the soaking step of the normalizing process. These precipitates prevented the growth of the austenite grains. During the subsequent cooling process, the dissolved V（C,N） re-precipitated and played a role in precipitation strengthening. The undissolved V（C,N） induced intragranular ferrite nucleation and refined the ferrite grains. Consequently, compared with hot-rolled steel, the normalized steel exhibited increased grain-refining strengthening but diminished precipitation strengthening, leading to an improvement of the impact energy at the expense of about 40 MPa yield strength.展开更多
The in-line response of a vertical flexibly mounted cylinder in regular and random waves is reported. Both theoretical analyses and experimental measurements have been performed. The theoretical predictions are based ...The in-line response of a vertical flexibly mounted cylinder in regular and random waves is reported. Both theoretical analyses and experimental measurements have been performed. The theoretical predictions are based on the Morison equation which is solved by the incremental harmonic balance method. Experiments are then performed in a wave flume to determine the accuracy of the Morison equation in predicting the in-line response of the cylinder in regular and random waves. The interaction between waves and vibrating cylinders are investigated.展开更多
With the increase of pipelines, corrosion leakage accidents happen frequently. Therefore, nondestructive testing technology is important for ensuring the safe operation of the pipelines and energy mining. In this pape...With the increase of pipelines, corrosion leakage accidents happen frequently. Therefore, nondestructive testing technology is important for ensuring the safe operation of the pipelines and energy mining. In this paper, the structure and principle of magnetic flux leakage （MFL） in-line inspection system is introduced first. Besides, a mathematic model of the system according to the ampere circuit rule, flux continuity theorem, and column coordinate transform is built, and the magnetic flux density in every point of space is calculated based on the theory of finite element analysis. Then we analyze and design the disposition of measurement section probes and sensors combining both three-axis MFL in-line inspection and multi-sensor fusion technology. Its advantage is that the three-axis changes of magnetic flux leakage field are measured by the multi-probes at the same time, so we can determine various defects accurately. Finally, the theory of finite element analysis is used to build a finite element simulation model, and the relationship between defects and MFL inspection signals is studied. Simulation and experiment results verify that the method not only enhances the detection ability to different types of defects but also improves the precision and reliability of the inspection system.展开更多
The fluctuating furces of the fluid exerted on the top terrsioned riser （＇FIR） in the in-line and cross-flow directions are both modeled by van del Pol wake oscillator model and the nonlinear coupled dynamics of th...The fluctuating furces of the fluid exerted on the top terrsioned riser （＇FIR） in the in-line and cross-flow directions are both modeled by van del Pol wake oscillator model and the nonlinear coupled dynamics of the in-line and cross-flow vortex-induced vibrations （VIV） of the riser are analyzed in time domain in this papar. The numencal shnulation results of the riser＇s in-line and cross-flow displacements and curvatures are compared with experimental measurements and the comparison shows the validity of this method in modeling some main features of the riser＇s VIV. Finally, the effects of the riser＇s top tensions and internal flow velocities on the coupled vibrations of the riser are investigated.展开更多
In-line phase-contrast computed tomography（IL-PC-CT） imaging is a new physical and biochemical imaging method.IL-PC-CT has advantages compared to absorption CT when imaging soft tissues. In practical applications, r...In-line phase-contrast computed tomography（IL-PC-CT） imaging is a new physical and biochemical imaging method.IL-PC-CT has advantages compared to absorption CT when imaging soft tissues. In practical applications, ring artifacts which will reduce the image quality are commonly encountered in IL-PC-CT, and numerous correction methods exist to either pre-process the sinogram or post-process the reconstructed image. In this study, we develop an IL-PC-CT reconstruction method based on anisotropic total variation（TV） minimization. Using this method, the ring artifacts are corrected during the reconstruction process. This method is compared with two methods： a sinogram preprocessing correction technique based on wavelet-FFT filter and a reconstruction method based on isotropic TV. The correction results show that the proposed method can reduce visible ring artifacts while preserving the liver section details for real liver section synchrotron data.展开更多
Because of the mixed grain and coarse grain structure, the long heat treatment cycle and large energy conservation in the heavy cylinder heat treatment process, the up ladder type and terraced type normalizing heat tr...Because of the mixed grain and coarse grain structure, the long heat treatment cycle and large energy conservation in the heavy cylinder heat treatment process, the up ladder type and terraced type normalizing heat treatment of heavy cylinder after rolling were put forward. The microstructure and mechanical properties of 2.25Cr1Mo0.25 V steel after the up ladder type normalizing, terraced type normalizing and isothermal type normalizing were studied. Experimental results show that： 1） For the grain refinement, the twice terraced type normalizing is better than the up ladder type and isothermal type normalizing, and the average grain size is 18 μm; 2） The yield strength, tensile strength and-30℃ charpy impact energy after twice terraced type normalizing are 681 MPa, 768 MPa and 181 J, respectively, and the mechanical properties are better than those of the up ladder type and isothermal type normalizing; 3） Compared with the isothermal type normalizing, the holding time of terraced type normalizing can be shortened by 30%, which greatly reduces the energy consumption.展开更多
This study was carried out to investigate the effect of heat treatment (Normalizing and Hardening) on the mechanical properties of springs. The springs were made from mild steel rod having a diameter of 6 mm, a total ...This study was carried out to investigate the effect of heat treatment (Normalizing and Hardening) on the mechanical properties of springs. The springs were made from mild steel rod having a diameter of 6 mm, a total of 15 springs were made. The springs were then subjected to various heat treatment processes which included;normalizing, hardening and tempering. The heat treated springs were then subjected to various test in other to determine their mechanical properties, these included;impact toughness test, hardness test and tension test. The normalized spring had more strength, was harder and was much tougher than both the annealed and as received springs. The water quenched springs were the hardest of all the heat treated springs, were very brittle and had the lowest percentage elongation. Their strength was also lower than that of the normalized and as received springs. The water quenched and tempered springs had better mechanical properties required for spring making, they had the optimum combination of hardness, strength and toughness when compared with the other heat treated springs.展开更多
In this work, a novel hollow fiber membrane extractor was set up to extract inorganic anions from ethyl acetate using deionized water. Inorganic anions in slightly soluble organic solvents can be determined by the in-...In this work, a novel hollow fiber membrane extractor was set up to extract inorganic anions from ethyl acetate using deionized water. Inorganic anions in slightly soluble organic solvents can be determined by the in-line hollow fiber membrane extractor coupled with ion chromatography at first time. Different aspects of the extraction procedure such as magnetic stirring speed, extraction flow rate and extraction time were optimized to achieve high extraction efficiency and good separation results. Satisfactory linear range, limits of detection and good repeatability were obtained. The procedure was applied to analyze inorganic anions in two commercial ethyl acetate samples.展开更多
For the first time,we derive the compact forms of normalization factors for photon-added（-subtracted） two-mode squeezed thermal states by using the P-representation and the integration within an ordered product of o...For the first time,we derive the compact forms of normalization factors for photon-added（-subtracted） two-mode squeezed thermal states by using the P-representation and the integration within an ordered product of operators（IWOP） technique.It is found that these two factors are related to the Jacobi polynomials.In addition,some new relationships for Jacobi polynomials are presented.展开更多
Objective:As an important part of metabolomics analysis,untargeted metabolomics has become a powerful tool in the study of tumor mechanisms and the discovery of metabolic markers with high-throughput spectrometric dat...Objective:As an important part of metabolomics analysis,untargeted metabolomics has become a powerful tool in the study of tumor mechanisms and the discovery of metabolic markers with high-throughput spectrometric data which also poses great challenges to data analysis,from the extraction of raw data to the identification of differential metabolites.To date,a large number of analytical tools and processes have been developed and constructed to serve untargeted metabolomics research.The different selection of analytical tools and parameter settings lead to varied results of untargeted metabolomics data.Our goal is to establish an easily operated platform and obtain a repeatable analysis result.Methods:We used the R language basic environment to construct the preprocessing system of the original data and the LAMP(Linux+Apache+MySQL+PHP)architecture to build a cloud mass spectrum data analysis system.Results:An open-source analysis software for untargeted metabolomics data(openNAU)was constructed.It includes the extraction of raw mass data and quality control for the identification of differential metabolic ion peaks.A reference metabolomics database based on public databases was also constructed.Conclusions:A complete analysis system platform for untargeted metabolomics was established.This platform provides a complete template interface for the addition and updating of the analysis process,so we can finish complex analyses of untargeted metabolomics with simple human-computer interactions.The source code can be downloaded from https://github.com/zjuRong/openNAU.展开更多
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT,RS-2023-00218630).
文摘Digital in-line holographic microscopy(DIHM)is a non-invasive,real-time,label-free technique that captures three-dimensional(3D)positional,orientational,and morphological information from digital holographic images of living biological cells.Unlike conventional microscopies,the DIHM technique enables precise measurements of dynamic behaviors exhibited by living cells within a 3D volume.This review outlines the fundamental principles and comprehensive digital image processing procedures employed in DIHM-based cell tracking methods.In addition,recent applications of DIHM technique for label-free identification and digital tracking of various motile biological cells,including human blood cells,spermatozoa,diseased cells,and unicellular microorganisms,are thoroughly examined.Leveraging artificial intelligence has significantly enhanced both the speed and accuracy of digital image processing for cell tracking and identification.The quantitative data on cell morphology and dynamics captured by DIHM can effectively elucidate the underlying mechanisms governing various microbial behaviors and contribute to the accumulation of diagnostic databases and the development of clinical treatments.
基金supported by the National Natural Science Foundation of China(Nos.52274393,52074200 and 12102310)the Key R&D Program of Hubei Province(No.2023BAB141).
文摘A grain-oriented silicon steel was normalized with a novel high magnetic field using one-stage cooling process.The effect of high-magnetic-field normalizing on the microstructures and textures was studied with a hot-rolled sheet as initial material.It was found that recrystallization and the grain growth were enhanced owing to the external magnetic field driving force.The angle between Goss orientation and magnetic field direction was small,resulting in a high nucleation rate of Goss grains,and hence,the intensity of Goss texture was increased and the deviation angle of Goss grains was reduced after high-magnetic-field normalizing.Furthermore,the migration of dislocation was promoted with an external magnetic field driving force and the density of dislocation decreased,reducing the proportion of low-angle grain boundaries around the Goss grains.The enhancement of recrystallization process and grain growth increased the proportion of high-energy grain boundaries and high-angle grain boundaries,providing a favorable condition for the growth of Goss grains.
基金supported by the National Natural Science Foundation of China(Grant No.62227814,52205040,22279070,and U21A20170)the Natural Science Basic Research Program of Shaanxi(2023-JC-QN-0140)+3 种基金the Young Talent Fund of Xi’an Association for Science and Technology(Grant No.959202313096)the Key Projects of the Shaanxi Province Natural Science Foundation(Grant No.2025JC-QYXQ-038)the Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems(Grant No.GZKF-202430)the National Key Research and Development Program of China(Grant No.2024YFB3311204)。
文摘Deep learning has emerged as a powerful tool for predicting the remaining useful life(RUL)of batteries,contingent upon access to ample data.However,the inherent limitations of data availability from traditional or accelerated life testing pose significant challenges.To mitigate the prediction accuracy issues arising from small sample sizes in existing intelligent methods,we introduce a novel data augmentation framework for RUL prediction.This framework harnesses the inherent high coincidence of degradation patterns exhibited by lithium-ion batteries to pinpoint the knee point,a critical juncture marking a significant shift in the degradation trajectory.By focusing on this critical knee point,we leverage the power of normalizing flow models to generate virtual data,effectively augmenting the training sample size.Additionally,we integrate a Bayesian Long Short-Term Memory network,optimized with Box-Cox transformation,to address the inherent uncertainty associated with predictions based on augmented data.This integration allows for a more nuanced understanding of RUL prediction uncertainties,offering valuable confidence intervals.The efficacy and superiority of the proposed framework are validated through extensive experiments on the CS2 dataset from the University of Maryland and the CrFeMnNiCo dataset from our laboratory.The results clearly demonstrate a substantial improvement in the confidence interval of RUL predictions compared to pre-optimization,highlighting the ability of the framework to achieve high-precision RUL predictions even with limited data.
基金supported by the National Science and Technology Council,Taiwan with grant numbers NSTC 112-2221-E-992-045,112-2221-E-992-057-MY3,and 112-2622-8-992-009-TD1.
文摘DDoS attacks represent one of the most pervasive and evolving threats in cybersecurity,capable of crippling critical infrastructures and disrupting services globally.As networks continue to expand and threats become more sophisticated,there is an urgent need for Intrusion Detection Systems(IDS)capable of handling these challenges effectively.Traditional IDS models frequently have difficulties in detecting new or changing attack patterns since they heavily depend on existing characteristics.This paper presents a novel approach for detecting unknown Distributed Denial of Service(DDoS)attacks by integrating Sliced Iterative Normalizing Flows(SINF)into IDS.SINF utilizes the Sliced Wasserstein distance to repeatedly modify probability distributions,enabling better management of high-dimensional data when there are only a few samples available.The unique architecture of SINF ensures efficient density estimation and robust sample generation,enabling IDS to adapt dynamically to emerging threats without relying heavily on predefined signatures or extensive retraining.By incorporating Open-Set Recognition(OSR)techniques,this method improves the system’s ability to detect both known and unknown attacks while maintaining high detection performance.The experimental evaluation on CICIDS2017 and CICDDoS2019 datasets demonstrates that the proposed system achieves an accuracy of 99.85%for known attacks and an F1 score of 99.99%after incremental learning for unknown attacks.The results clearly demonstrate the system’s strong generalization capability across unseen attacks while maintaining the computational efficiency required for real-world deployment.
基金Projects(51274083,51074062)supported by the National Natural Science Foundation of China
文摘Microstructure, precipitate and magnetic characteristic of fmal products with different normalizing cooling processes for Fe-3.2%Si low-temperature hot-rolled grain-oriented silicon steel were analyzed and compared with the hot-rolled plate by optical microscopy （OM）, transmission electron microscopy （TEM）, and energy dispersive spectrometry （EDS）. The results show that, the surface microstructure is uniform, the proportion of recrystallization in matrix increases, and the banding textures are narrowed; the precipitates, whose quantity in normalized plate is more than that in hot-rolled plate greatly, are mainly A1N, MnS, composite precipitates （Cu,Mn）S and so on. Normalizing technology with a temperature of 1120 ℃, holding for 3 min, and a two-stage cooling is a most advantaged method to obtain oriented silicon steel with sharper Goss texture and higher magnetic properties, owing to the uniform surface microstructures and the obvious inhomogeneity of microstructures along the thickness. The normalizing technology with the two-stage cooling is the optimum process, which can generate more fine precipitates dispersed over the matrix, and be beneficial for finished products to get higher magnetic properties.
基金Item Sponsored by National Science Fund and Baosteel Joint Funding of China(50934009)
文摘The grain-oriented silicon steel is a kind of important magnetic materials with low iron loss and high induc tion. Hot hand normalizing annealing is an important process which influences the microstructure and the development of the inhibitors. The effects of different annealing temperatures and cooling conditions on the inhibitors and microstructures of normalizing annealing band were investigated. The microstructure and different kinds of the inhibitors, i. e. , A1N, AIN＋Cu, S＋MnS, and TiN, were discovered. The result shows that a suitable cooling condition leads to more nano scale inhibitors and uniform microstructure of the normalizing annealing band and consequently results in better magnetic properties.
基金Supported by National Natural Science Foundation of China(CN):Vascular Normalization by Huoxuehuayu medicine Induces decrease of the Interstitial Fluid and Improves Drug Penetration in Tumors(No.81202784)
文摘OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatoma mice model.METHODS: Hepa1-6 hepatoma-bearing mice were treated with TanⅡA for 14 d. Distribution and anti-tumor efficacy of PLD, and the structure and function of the tumor vasculature were evaluated using various techniques.RESULTS: TanⅡ A significantly reduced the micro-vessel density(MVD). After Tan vascular walls were betteⅡr s A treatment,the tumor tructured, as the increased coverage of the pericytes and the promoted contact of the basement membrane and endothelial cell. Functional tests showed that tumor hypoxia was improved and the exudation amount of Evans blue in the parenchyma of the tumor decreased. In addition, mice treated with TanA had greater PLD penetration distance intratumoⅡrally. Furthermore, combined therapy of Tanibited tumor growth.ⅡA and PLD significantly inhCONCLUSION: This study suggests that Tanasculature andⅡ h A helps normalizing the tumor vas therapeutic potential in increasing the distribution of chemotherapy drug in the tumor.
基金This project was financially supported by the High Technology Research and Developmant Programof China (GrantNo.2006AA09Z356) the National Natural Science Foundation of China (Grant No.503795)
文摘In this work, we study the coupled cross-flow and in-line vortex-induced vibration （VIV） of a fixedly mounted flexible pipe, which is free to move in cross-flow （ Y- ） and in-line （ X- ） direction in a fluid flow where the mass and natural frequencies are precisely the same in both X- and Y-direction. The fluid speed varies from low to high with the corresponding vortex shedding frequency varying from below the first natural frequency to above the second natural frequency of the flexible pipe. Particular emphasis was placed on the investigation of the relationship between in-line and cross-flow vibration. The experimental results analyzed by using these measurements exhibits several valuable features.
基金supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (SRFDP)(20100032120047)the Independent Innovation Fund of Tianjin University (2010XJ-0098)+2 种基金State Key Laboratory of Ocean Engineering (Shanghai Jiao Tong University) (1104)the National High Technology Research and Development Program of China(863 Program) ( 2012AA051705)the National Natural Science Foundation of China (51209161)
文摘The in-line （IL） vortex-induced vibration （VIV） that occurs frequently in ocean engineering may cause severe fatigue damage in slender marine structures. To the best knowledge of the authors, in existing literatures, there is no efficient analytical model for predicting pure IL VIV. In this paper, a wake oscillator model capable of analyzing the IL VIV of slender marine structures has been developed. Two different kinds of van der Pol equations are used to describe the near wake dynamics related to the fluctuating nature of symmetric vortex shedding in the first excitation region and alternate vortex shedding in the second one. Some comparisons are carried out between the present model results and experimental data. It is found that many phenomena observed in experiments could be reproduced by the present wake oscillator model.
基金The National Natural Science Foundation of China (No. 50138020)
文摘Experimental and theoretical analysis were made on the natural humic acid removal and the membrane fouling of ultrafiltration （UF） with in-line coagulation. The results showed dissolved organic carbon （DOC） and UV254 removals by the UF with in-line coagulation at pH 7 were increased from 28% to 53% and 40% to 78% in comparison with direct UF treatment respectively. At the same time, the analysis of high performance liquid chromatography showed that UF with coagulation had significant improvement of removal of humic acid with molecular weights less than 6000 Da in particular. Compared to direct UF, the in-line coagulation UF also kept more constant permeate flux and very slight increase oftransmembrane pressure during a filtration circle. Two typical membrane fouling models were used by inducing two coefficients Kc and Kp corresponding to cake filtration model and pore narrowing model respectively. It was found that membrane fouling by pore-narrowing effect was effectively alleviated and that by cake-filtration was much decreased by in-line coagulation. Under the condition of coagulation prior to ultrafiltration at pH 7, the cake layer formed on the membrane surface became thicker, but the membrane filtration resistance was lower than that at pH 5 with the extension of operation time.
基金Item Sponsored by National Science and Technology Pillar Program of China(2011BAE25B01)
文摘The precipitation behavior of V-N microalloyed steel during normalizing process was studied by physicochemical phase analysis and transmission electron microscopy（TEM）. The effect of precipitation behavior on mechanical properties was investigated by theoretical calculations. The results showed that 32.9% of V（C,N） precipitates remained undissolved in the austenite during the soaking step of the normalizing process. These precipitates prevented the growth of the austenite grains. During the subsequent cooling process, the dissolved V（C,N） re-precipitated and played a role in precipitation strengthening. The undissolved V（C,N） induced intragranular ferrite nucleation and refined the ferrite grains. Consequently, compared with hot-rolled steel, the normalized steel exhibited increased grain-refining strengthening but diminished precipitation strengthening, leading to an improvement of the impact energy at the expense of about 40 MPa yield strength.
基金The work was supported by the National Natural Science Foundation of China under contract No. 10272118 ；The Hong Kong Polytechnic University Research of China under contract No. A - PE28
文摘The in-line response of a vertical flexibly mounted cylinder in regular and random waves is reported. Both theoretical analyses and experimental measurements have been performed. The theoretical predictions are based on the Morison equation which is solved by the incremental harmonic balance method. Experiments are then performed in a wave flume to determine the accuracy of the Morison equation in predicting the in-line response of the cylinder in regular and random waves. The interaction between waves and vibrating cylinders are investigated.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 61273164 and 61034005)the National High Technology Research and Development Program of China (Grant No. 2012AA040104)the Fundamental Research Funds for the Central Universities, China (Grant No. N100104102)
文摘With the increase of pipelines, corrosion leakage accidents happen frequently. Therefore, nondestructive testing technology is important for ensuring the safe operation of the pipelines and energy mining. In this paper, the structure and principle of magnetic flux leakage （MFL） in-line inspection system is introduced first. Besides, a mathematic model of the system according to the ampere circuit rule, flux continuity theorem, and column coordinate transform is built, and the magnetic flux density in every point of space is calculated based on the theory of finite element analysis. Then we analyze and design the disposition of measurement section probes and sensors combining both three-axis MFL in-line inspection and multi-sensor fusion technology. Its advantage is that the three-axis changes of magnetic flux leakage field are measured by the multi-probes at the same time, so we can determine various defects accurately. Finally, the theory of finite element analysis is used to build a finite element simulation model, and the relationship between defects and MFL inspection signals is studied. Simulation and experiment results verify that the method not only enhances the detection ability to different types of defects but also improves the precision and reliability of the inspection system.
基金supported by the High Technology Research and Development Program of China (863 Pro-gram, Grant No.2010AA09Z303)the Key Project of National Natural Science Foundation of China (Grant No.50739004)
文摘The fluctuating furces of the fluid exerted on the top terrsioned riser （＇FIR） in the in-line and cross-flow directions are both modeled by van del Pol wake oscillator model and the nonlinear coupled dynamics of the in-line and cross-flow vortex-induced vibrations （VIV） of the riser are analyzed in time domain in this papar. The numencal shnulation results of the riser＇s in-line and cross-flow displacements and curvatures are compared with experimental measurements and the comparison shows the validity of this method in modeling some main features of the riser＇s VIV. Finally, the effects of the riser＇s top tensions and internal flow velocities on the coupled vibrations of the riser are investigated.
基金supported by the National Natural Science Foundation of China(Grant Nos.61671004,61271012,81371549,81671683,and 11501415)the Natural Science Foundation of Tianjin City,China(Grant No.16JCYBJC28600)+4 种基金the WBE Liver Fibrosis Foundation of China(Grant No.CFHPC20131033)the Instrument Developing Project of the Chinese Academy of Sciences(Grant No.YZ201410)the Foundation of Tianjin University of Technology and Education(Grant Nos.KJ11-22 and J10011060321)SRF for ROCS,SEMthe IHEP-CAS Scientific Research Foundation(Grant No.2013IHEPYJRC801)
文摘In-line phase-contrast computed tomography（IL-PC-CT） imaging is a new physical and biochemical imaging method.IL-PC-CT has advantages compared to absorption CT when imaging soft tissues. In practical applications, ring artifacts which will reduce the image quality are commonly encountered in IL-PC-CT, and numerous correction methods exist to either pre-process the sinogram or post-process the reconstructed image. In this study, we develop an IL-PC-CT reconstruction method based on anisotropic total variation（TV） minimization. Using this method, the ring artifacts are corrected during the reconstruction process. This method is compared with two methods： a sinogram preprocessing correction technique based on wavelet-FFT filter and a reconstruction method based on isotropic TV. The correction results show that the proposed method can reduce visible ring artifacts while preserving the liver section details for real liver section synchrotron data.
基金Project(51305388)supported by the National Natural Science Foundation of ChinaProject(BJ2014055)supported by the Youth Talent Projects of Colleges in Hebei Province,ChinaProject(2016M590211)supported by China Postdoctoral Science Foundation
文摘Because of the mixed grain and coarse grain structure, the long heat treatment cycle and large energy conservation in the heavy cylinder heat treatment process, the up ladder type and terraced type normalizing heat treatment of heavy cylinder after rolling were put forward. The microstructure and mechanical properties of 2.25Cr1Mo0.25 V steel after the up ladder type normalizing, terraced type normalizing and isothermal type normalizing were studied. Experimental results show that： 1） For the grain refinement, the twice terraced type normalizing is better than the up ladder type and isothermal type normalizing, and the average grain size is 18 μm; 2） The yield strength, tensile strength and-30℃ charpy impact energy after twice terraced type normalizing are 681 MPa, 768 MPa and 181 J, respectively, and the mechanical properties are better than those of the up ladder type and isothermal type normalizing; 3） Compared with the isothermal type normalizing, the holding time of terraced type normalizing can be shortened by 30%, which greatly reduces the energy consumption.
文摘This study was carried out to investigate the effect of heat treatment (Normalizing and Hardening) on the mechanical properties of springs. The springs were made from mild steel rod having a diameter of 6 mm, a total of 15 springs were made. The springs were then subjected to various heat treatment processes which included;normalizing, hardening and tempering. The heat treated springs were then subjected to various test in other to determine their mechanical properties, these included;impact toughness test, hardness test and tension test. The normalized spring had more strength, was harder and was much tougher than both the annealed and as received springs. The water quenched springs were the hardest of all the heat treated springs, were very brittle and had the lowest percentage elongation. Their strength was also lower than that of the normalized and as received springs. The water quenched and tempered springs had better mechanical properties required for spring making, they had the optimum combination of hardness, strength and toughness when compared with the other heat treated springs.
基金supported by National Natural Science Foundation of China(No.20775070)by Zhejiang Provincial Natural Science Foundation of China(No.R4080124)Zhejiang Qianjiang Project of Science and Technology for Competent People(No.2008R10028).
文摘In this work, a novel hollow fiber membrane extractor was set up to extract inorganic anions from ethyl acetate using deionized water. Inorganic anions in slightly soluble organic solvents can be determined by the in-line hollow fiber membrane extractor coupled with ion chromatography at first time. Different aspects of the extraction procedure such as magnetic stirring speed, extraction flow rate and extraction time were optimized to achieve high extraction efficiency and good separation results. Satisfactory linear range, limits of detection and good repeatability were obtained. The procedure was applied to analyze inorganic anions in two commercial ethyl acetate samples.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11264018 and 60978009)the Major Research Plan of the National Natural Science Foundation of China (Grant No. 91121023)+1 种基金the National Basic Research Project of China (Grant No. 2011CBA00200)the Young Talents Foundation of Jiangxi Normal University,China
文摘For the first time,we derive the compact forms of normalization factors for photon-added（-subtracted） two-mode squeezed thermal states by using the P-representation and the integration within an ordered product of operators（IWOP） technique.It is found that these two factors are related to the Jacobi polynomials.In addition,some new relationships for Jacobi polynomials are presented.
文摘Objective:As an important part of metabolomics analysis,untargeted metabolomics has become a powerful tool in the study of tumor mechanisms and the discovery of metabolic markers with high-throughput spectrometric data which also poses great challenges to data analysis,from the extraction of raw data to the identification of differential metabolites.To date,a large number of analytical tools and processes have been developed and constructed to serve untargeted metabolomics research.The different selection of analytical tools and parameter settings lead to varied results of untargeted metabolomics data.Our goal is to establish an easily operated platform and obtain a repeatable analysis result.Methods:We used the R language basic environment to construct the preprocessing system of the original data and the LAMP(Linux+Apache+MySQL+PHP)architecture to build a cloud mass spectrum data analysis system.Results:An open-source analysis software for untargeted metabolomics data(openNAU)was constructed.It includes the extraction of raw mass data and quality control for the identification of differential metabolic ion peaks.A reference metabolomics database based on public databases was also constructed.Conclusions:A complete analysis system platform for untargeted metabolomics was established.This platform provides a complete template interface for the addition and updating of the analysis process,so we can finish complex analyses of untargeted metabolomics with simple human-computer interactions.The source code can be downloaded from https://github.com/zjuRong/openNAU.
