Understanding the cellular and molecular mechanisms underlying human neurological disorders is hindered by both the complexity of the disorders and the lack of suitable experimental models recapitulating key pathologi...Understanding the cellular and molecular mechanisms underlying human neurological disorders is hindered by both the complexity of the disorders and the lack of suitable experimental models recapitulating key pathological features of the disease.This is a crucial issue since a limited understanding of pathogenic mechanisms precludes the development of drugs counteracting the progression of the disease.Among neurological disorders,展开更多
The analysis of ancient genomics provides opportunities to explore human population history across both temporal and geographic dimensions(Haak et al.,2015;Wang et al.,2021,2024)to enhance the accessibility and utilit...The analysis of ancient genomics provides opportunities to explore human population history across both temporal and geographic dimensions(Haak et al.,2015;Wang et al.,2021,2024)to enhance the accessibility and utility of these ancient genomic datasets,a range of databases and advanced statistical models have been developed,including the Allen Ancient DNA Resource(AADR)(Mallick et al.,2024)and AdmixTools(Patterson et al.,2012).While upstream processes such as sequencing and raw data processing have been streamlined by resources like the AADR,the downstream analysis of these datasets-encompassing population genetics inference and spatiotemporal interpretation-remains a significant challenge.The AADR provides a unified collection of published ancient DNA(aDNA)data,yet its file-based format and reliance on command-line tools,such as those in Admix-Tools(Patterson et al.,2012),require advanced computational expertise for effective exploration and analysis.These requirements can present significant challenges forresearchers lackingadvanced computational expertise,limiting the accessibility and broader application of these valuable genomic resources.展开更多
Wuthering Heights is an extraordinary novel of love and revenge.It describes the tragic love story of Catherine and Heathcliff and the happy ending of Cathy and Hareton’s love story.These two love stories are combine...Wuthering Heights is an extraordinary novel of love and revenge.It describes the tragic love story of Catherine and Heathcliff and the happy ending of Cathy and Hareton’s love story.These two love stories are combined together,from which Emily the writer discloses the motif of the novel is the everlasting hope to the reviving of humanity.展开更多
Human Mars exploration has significant values in terms of exploring extraterrestrial life,interplanetary immigration,promoting science and technology development,and the progress of human society.This paper summarizes...Human Mars exploration has significant values in terms of exploring extraterrestrial life,interplanetary immigration,promoting science and technology development,and the progress of human society.This paper summarizes the research progress on human Mars exploration and the corresponding proposed space transportation systems in the world,and analyzes the development trends.A preliminary scheme including the human Mars exploration mission architecture and corresponding space transportation system is then proposed,and the related key technologies are identified.The results can be a reference for future further research.展开更多
The Communist Party of China （CPC） ascended the stage of history holding high the banner of human rights. From themoment of its establishment, the Party has inscribed manifestly on its banner the principle of strivi...The Communist Party of China （CPC） ascended the stage of history holding high the banner of human rights. From themoment of its establishment, the Party has inscribed manifestly on its banner the principle of striving for human rights for the public.展开更多
文摘Understanding the cellular and molecular mechanisms underlying human neurological disorders is hindered by both the complexity of the disorders and the lack of suitable experimental models recapitulating key pathological features of the disease.This is a crucial issue since a limited understanding of pathogenic mechanisms precludes the development of drugs counteracting the progression of the disease.Among neurological disorders,
基金by the National Key Research and Development Program of China(2023YFC3303701-02 and 2024YFC3306701)the National Natural Science Foundation of China(T2425014 and 32270667)+3 种基金the Natural Science Foundation of Fujian Province of China(2023J06013)the Major Project of the National Social Science Foundation of China granted to Chuan-Chao Wang(21&ZD285)Open Research Fund of State Key Laboratory of Genetic Engineering at Fudan University(SKLGE-2310)Open Research Fund of Forensic Genetics Key Laboratory of the Ministry of Public Security(2023FGKFKT07).
文摘The analysis of ancient genomics provides opportunities to explore human population history across both temporal and geographic dimensions(Haak et al.,2015;Wang et al.,2021,2024)to enhance the accessibility and utility of these ancient genomic datasets,a range of databases and advanced statistical models have been developed,including the Allen Ancient DNA Resource(AADR)(Mallick et al.,2024)and AdmixTools(Patterson et al.,2012).While upstream processes such as sequencing and raw data processing have been streamlined by resources like the AADR,the downstream analysis of these datasets-encompassing population genetics inference and spatiotemporal interpretation-remains a significant challenge.The AADR provides a unified collection of published ancient DNA(aDNA)data,yet its file-based format and reliance on command-line tools,such as those in Admix-Tools(Patterson et al.,2012),require advanced computational expertise for effective exploration and analysis.These requirements can present significant challenges forresearchers lackingadvanced computational expertise,limiting the accessibility and broader application of these valuable genomic resources.
文摘Wuthering Heights is an extraordinary novel of love and revenge.It describes the tragic love story of Catherine and Heathcliff and the happy ending of Cathy and Hareton’s love story.These two love stories are combined together,from which Emily the writer discloses the motif of the novel is the everlasting hope to the reviving of humanity.
文摘Human Mars exploration has significant values in terms of exploring extraterrestrial life,interplanetary immigration,promoting science and technology development,and the progress of human society.This paper summarizes the research progress on human Mars exploration and the corresponding proposed space transportation systems in the world,and analyzes the development trends.A preliminary scheme including the human Mars exploration mission architecture and corresponding space transportation system is then proposed,and the related key technologies are identified.The results can be a reference for future further research.
文摘The Communist Party of China （CPC） ascended the stage of history holding high the banner of human rights. From themoment of its establishment, the Party has inscribed manifestly on its banner the principle of striving for human rights for the public.
