Objective:To analyze the significance of high-frequency ultrasound in differentiating benign and malignant breast micronodules.Methods:Eighty-five patients with breast micronodules admitted for diagnosis between Octob...Objective:To analyze the significance of high-frequency ultrasound in differentiating benign and malignant breast micronodules.Methods:Eighty-five patients with breast micronodules admitted for diagnosis between October 2022 and October 2024 were selected for high-frequency ultrasound diagnosis.The diagnostic efficacy of high-frequency ultrasound was evaluated by comparing it with the results of surgical pathology.Results:High-frequency ultrasound detected 50 benign nodules,primarily breast fibroadenomas,and 35 malignant nodules,mainly breast ductal carcinoma in situ.Based on surgical pathology results,the diagnostic accuracy of high-frequency ultrasound was 96.47%,specificity was 97.96%,and sensitivity was 94.44%.In high-frequency ultrasound diagnosis,the proportion of grade III and IV blood flow in malignant nodules was higher than that in benign nodules,while the proportion of regular shape and clear margins was lower.The proportion of microcalcifications and posterior echo attenuation was higher in malignant nodules,and the resistance index(RI)and peak blood flow velocity were lower than those in benign nodules(P<0.05).Conclusion:High-frequency ultrasound can effectively differentiate benign and malignant breast micronodules,determine specific nodule types,and exhibits high diagnostic accuracy and sensitivity.Additionally,benign and malignant nodules can be differentiated based on the grading of blood flow signals,sonographic features,and blood flow velocity,providing reasonable guidance for subsequent treatment plans.展开更多
Objective:To analyze the therapeutic effect of high-frequency electrosurgical knife surgery guided by painless digestive endoscopy(PDE)in elderly patients with gastrointestinal polyps(GP).Methods:A total of 100 elderl...Objective:To analyze the therapeutic effect of high-frequency electrosurgical knife surgery guided by painless digestive endoscopy(PDE)in elderly patients with gastrointestinal polyps(GP).Methods:A total of 100 elderly GP patients admitted between June 2021 and December 2022 were selected.Patients were randomly divided into two groups:the painless group(50 cases)underwent high-frequency electrosurgical knife surgery guided by PDE,while the conventional group(50 cases)underwent the same surgery guided by traditional digestive endoscopy(DE).The total treatment efficacy,perioperative indicators,gastrointestinal hormone levels,oxidative stress(OS)markers,and complication rates were compared between the two groups.Results:The total treatment efficacy in the painless group was higher than that in the conventional group,and perioperative indicators were superior in the painless group(P<0.05).One week after treatment,the gastrointestinal hormone levels and OS-related markers in the painless group were better than those in the conventional group(P<0.05).The complication rate in the painless group was lower than in the conventional group(P<0.05).Conclusion:High-frequency electrosurgical knife surgery guided by PDE improves the effectiveness of polyp removal in elderly GP patients and accelerates postoperative recovery.It also protects gastrointestinal function,reduces postoperative OS,and ensures higher surgical safety.展开更多
Low-frequency signals have been proven valuable in the fields of target detection and geological exploration.Nevertheless,the practical implementation of these signals is hindered by large antenna diameters,limiting t...Low-frequency signals have been proven valuable in the fields of target detection and geological exploration.Nevertheless,the practical implementation of these signals is hindered by large antenna diameters,limiting their potential applications.Therefore,it is imperative to study the creation of lowfrequency signals using antennas with suitable dimensions.In contrast to conventional mechanical antenna techniques,our study generates low-frequency signals in the spatial domain utilizing the principle of the Doppler effect.We also defines the antenna array architecture,the timing sequency,and the radiating element signal waveform,and provides experimental prototypes including 8/64 antennas based on earlier research.In the conducted experiments,121 MHz,40 MHz,and 10 kHz composite signals are generated by 156 MHz radiating element signals.The composite signal spectrum matches the simulations,proving our low-frequency signal generating method works.This holds significant implications for research on generating low-frequency signals with small-sized antennas.展开更多
High-frequency spinal cord stimulation(HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat ne...High-frequency spinal cord stimulation(HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat neuropathic pain was induced by spinal nerve ligation. Two days after modeling, the rats were subjected to 4 hours of HF-SCS(motor threshold 50%, frequency 10,000 Hz, and pulse width 0.024 ms) in the dorsal horn of the spinal cord. The results revealed that the tactile allodynia of spinal nerve-injured rats was markedly alleviated by HFSCS, and the effects were sustained for 3 hours after the stimulation had ceased. HF-SCS restored lysosomal function, increased the levels of lysosome-associated membrane protein 2(LAMP2) and the mature form of cathepsin D(matu-CTSD), and alleviated the abnormally elevated levels of microtubule-associated protein 1 A/B-light chain 3(LC3)-II and sequestosome 1(P62) in spinal nerve-injured rats. HF-SCS also mostly restored the immunoreactivity of LAMP2, which was localized in neurons in the superficial layers of the spinal dorsal horn in spinal nerve-injured rats. In addition, intraperitoneal administration of 15 mg/kg chloroquine for 60 minutes reversed the expression of the aforementioned proteins and shortened the timing of the analgesic effects of HF-SCS. These findings suggest that HF-SCS may exhibit longlasting analgesic effects on neuropathic pain in rats through improving lysosomal dysfunction and alleviating autophagic flux. This study was approved by the Laboratory Animal Ethics Committee of China Medical University, Shenyang, China(approval No. 2017 PS196 K) on March 1, 2017.展开更多
Objective: To observe the curative effect of high-frequency electric sparkle and point-injection therapy (HESPT) on knee osteoarthritis (KOA). Methods: Two hundred and five patients were randomly divided into a warmin...Objective: To observe the curative effect of high-frequency electric sparkle and point-injection therapy (HESPT) on knee osteoarthritis (KOA). Methods: Two hundred and five patients were randomly divided into a warming needle moxibustion group (68 cases), a HESPT group (68 cases) and a point-injection group (69 cases). In the warming needle moxibustion group, the main points of Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5), Dubi (ST 35), Zusanli (ST 36) and Yanglingquan (GB 34), and the adjunct points of Yinlingquan (SP 9) and Sanyinjiao (SP 6), on the affected side, were chosen for stimulation. In the HESPT group, tenderness points, the main points of Liangqiu (ST 34), Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5) and Zusanli (ST 36), and the adjunct points of Yinlingquan (SP 9), Weizhong (BL 40) and Chengshan (BL 57), were chosen. After proper manipulation, Corydalis decumbens Pers. liquid was injected into the points and a high-frequency electric sparkle was applied to stimulate the needles for 30 seconds. In the point-injection group, point injection was performed with the same method, but the patients did not receive electric stimulation. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC), the Lysholm Knee Score Scale (LKSS) and the ROM (Range of Motion) scale were used to evaluate the severity of KOA and the function of knee joints before treatment and 4 weeks after treatment. Finally, the Nimodipine method was used to assess the total curative effect. Results: After HESPT treatment, the scores for pain, morning stiffness and swelling were significantly lower (P<0.01) and LKSS index and ROM were much higher (P<0.01 and P<0.05 respectively) compared to the two other groups. The obviously effective rate and total effective rate were also significantly higher in the HESPT group than in the two other groups (P<0.01 or P<0.05). Conclusion: HESPT can improve joint function in KOA patients, and the curative effect is better than for warming needle moxibustion or point-injection only.展开更多
BACKGROUND： Deep-brain stimulation has proven to be beneficial in the treatment of Parkinson＇s disease （PD） patients. OBJECTIVE： To investigate the effects of high-frequency stimulation （HFS） to the subthalamic...BACKGROUND： Deep-brain stimulation has proven to be beneficial in the treatment of Parkinson＇s disease （PD） patients. OBJECTIVE： To investigate the effects of high-frequency stimulation （HFS） to the subthalamic nucleus （STN） on neuronal apoptosis and apoptosis-related gene expression in the substantia nigra pars compacta, and to analyze the neuroprotective effect of HFS-STN. DESIGN, TIME AND SETTING： Neuronal morphology experiments were performed in the Beijing Neurosurgical Institute from May to December in 2005. MATERIALS： Forty healthy, adult, Sprague Dawley rats were used to establish a PD model with a unilateral microinjection of 6-hydroxydopamine into two target areas of the right medial forebrain bundle. 6-hydroxydopamine was purchased from Sigma （USA）; high-frequency electrical stimulator was produced by World Precision Instruments （USA）; Terminal deoxynucleotidyl transferase dUTP nick end labeling （TUNEL） kit was a product of Nanjing Jiancheng Technology Co., Ltd. （China）; and Bcl-2 and Bax protein assay kit were purchased from Wuhan Boster Bioengineering Co., Ltd. （China）. METHODS： Forty rats were randomly divided into three groups. The stimulation group （n = 15） received HFS-STN on the day of PD modeling. The PD model group （n = 15） was used to establish the PD model. The control group （n = 10） was injected with normal saline containing 0.2 g/L ascorbic acid into two areas of the right medial forebrain bundle. MAIN OUTCOME MEASURES： Survival of dopaminergic neurons in the substantia nigra pars compacta was determined using Nissl staining. Apoptosis of dopaminergic neurons was detected using TUNEL techniques. Expression of anti-apoptotic protein, Bcl-2, and pro-apoptotic protein, Bax, were assayed by immunohistochemistry. RESULTS： Following 6-hydroxydopamine injection, the number of substantia nigra pars compacta neurons was reduced in the stimulation and PD model groups, compared to the control group. At 2 and 4 weeks post-surgery, the grey value of Nissl stained images was significantly less in the PD model and stimulation groups （P 〈 0.05）, and the stimulation group exhibited greater grey values compared to the model group （P 〈 0.05）. At 2 and 4 weeks post-surgery, the number of apoptotic neurons was significantly less in the stimulation group compared to the model group （P 〈 0.05）. In addition, Bcl-2 and Bax expression, as well as the Bcl-2/Bax ratio, was much higher in the stimulation group compared to the model group （P 〈 0.05）. CONCLUSION： HFS-STN has a neuroprotective effect on dopaminergic neurons in the substantia nigra pars compacta of PD rats by promoting Bcl-2 expression, inhibiting Bax expression, and reducing the number of apoptotic dopaminergic neurons.展开更多
The oil-based mud(OBM) borehole measurement environment presents significant limitations on the application of existing electrical logging instruments in high-resistance formations. In this paper, we propose a novel l...The oil-based mud(OBM) borehole measurement environment presents significant limitations on the application of existing electrical logging instruments in high-resistance formations. In this paper, we propose a novel logging method for detection of high-resistance formations in OBM using highfrequency electrodes. The method addresses the issue of shallow depth of investigation(DOI) in existing electrical logging instruments, while simultaneously ensuring the vertical resolution. Based on the principle of current continuity, the total impedance of the loop is obtained by equating the measurement loop to the series form of a capacitively coupled circuit. and its validity is verified in a homogeneous formation model and a radial two-layer formation model with a mud standoff. Then, the instrument operating frequency and electrode system parameters were preferentially determined by numerical simulation, and the effect of mud gap on impedance measurement was investigated. Subsequently, the DOI of the instrument was investigated utilizing the pseudo-geometric factor defined by the real part of impedance. It was determined that the detection depth of the instrument is 8.74 cm, while the effective vertical resolution was not less than 2 cm. Finally, a focused high-frequency electrode-type instrument was designed by introducing a pair of focused electrodes, which effectively enhanced the DOI of the instrument and was successfully deployed in the Oklahoma formation model. The simulation results demonstrate that the novel method can achieve a detection depth of 17.40 cm in highly-resistive formations drilling with OBM, which is approximately twice the depth of detection of the existing oil-based mud microimager instruments. Furthermore, its effective vertical resolution remains at or above 2 cm,which is comparable to the resolution of the existing OBM electrical logging instrument.展开更多
China has a long history of coal mining,among which open-pit coal mines have a large number of small coal mine goafs underground.The distribution,shape,structure and other characteristics of goafs are isolated and dis...China has a long history of coal mining,among which open-pit coal mines have a large number of small coal mine goafs underground.The distribution,shape,structure and other characteristics of goafs are isolated and discontinuous,and there is no definite geological law to follow,which seriously threatens the safety of coal mine production and personnel life.Conventional ground geophysical methods have low accuracy in detecting goaf areas affected by mechanical interference from open-pit mines,especially for waterless goaf areas,which cannot be detected by existing methods.This article proposes the use of high-frequency electromagnetic waves for goaf detection.The feasibility of using drilling radar to detect goaf was theoretically analyzed,and a goaf detection model was established.The response characteristics of different fillers in the goaf under different frequencies of high-frequency electromagnetic waves were simulated and analyzed.In a certain open-pit mine in Inner Mongolia,100MHz high-frequency electromagnetic waves were used to detect the goaf through directional drilling on the ground.After detection,excavation verification was carried out,and the location of one goaf detected was verified.The results of engineering practice show that the application of high-frequency electromagnetic waves in goaf detection expands the detection radius of boreholes,has the advantages of high efficiency and accuracy,and has important theoretical and practical significance.展开更多
New electric power systems characterized by a high proportion of renewable energy and power electronics equipment face significant challenges due to high-frequency(HF)electromagnetic interference from the high-speed s...New electric power systems characterized by a high proportion of renewable energy and power electronics equipment face significant challenges due to high-frequency(HF)electromagnetic interference from the high-speed switching of power converters.To address this situation,this paper offers an in-depth review of HF interference problems and challenges originating from power electronic devices.First,the root cause of HF electromagnetic interference,i.e.,the resonant response of the parasitic parameters of the system to high-speed switching transients,is analyzed,and various scenarios of HF interference in power systems are highlighted.Next,the types of HF interference are summarized,with a focus on common-mode interference in grounding systems.This paper thoroughly reviews and compares various suppression methods for conducted HF interference.Finally,the challenges involved and suggestions for addressing emerging HF interference problems from the perspective of both power electronics equipment and power systems are discussed.This review aims to offer a structured understanding of HF interference problems and their suppression techniques for researchers and practitioners.展开更多
Dielectric barrier discharge(DBD)plasma excited by a high-frequency alternating-current(AC)power supply is widely employed for the degradation of volatile organic compounds(VOCs).However,the thermal effect generated d...Dielectric barrier discharge(DBD)plasma excited by a high-frequency alternating-current(AC)power supply is widely employed for the degradation of volatile organic compounds(VOCs).However,the thermal effect generated during the discharge process leads to energy waste and low energy utilization efficiency.In this work,an innovative DBD thermally-conducted catalysis(DBD-TCC)system,integrating high-frequency AC-DBD plasma and its generated thermal effects to activate the Co/SBA-15 catalyst,was employed for toluene removal.Specifically,Co/SBA-15 catalysts are closely positioned to the ground electrode of the plasma zone and can be heated and activated by the thermal effect when the voltage exceeds 10 k V.At12.4 k V,the temperature in the catalyst zone reached 261℃ in the DBD-TCC system,resulting in an increase in toluene degradation efficiency of 17%,CO_(2)selectivity of 21.2%,and energy efficiency of 27%,respectively,compared to the DBD system alone.In contrast,the DBD thermally-unconducted catalysis(DBD-TUC)system fails to enhance toluene degradation due to insufficient heat absorption and catalytic activation,highlighting the crucial role of AC-DBD generated heat in the activation of the catalyst.Furthermore,the degradation pathway and mechanism of toluene in the DBD-TCC system were hypothesized.This work is expected to provide an energy-efficient approach for high-frequency AC-DBD plasma removal of VOCs.展开更多
Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the ra...Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the random code(Rcode)used in traditional UCI will lead to low-frequency noise covering high-frequency information due to its uneven sampling interval,which is a great challenge in the fidelity of large-frame reconstruction.Here,a high-frequency enhanced compressed active photography(H-CAP)is proposed.By uniformizing the sampling interval of R-code,H-CAP capture the ultrafast process with a random uniform sampling mode.This sampling mode makes the high-frequency sampling energy dominant,which greatly suppresses the low-frequency noise blurring caused by R-code and achieves high-frequency information of image enhanced.The superior dynamic performance and large-frame reconstruction ability of H-CAP are verified by imaging optical self-focusing effect and static object,respectively.We applied H-CAP to the spatial-temporal characterization of double-pulse induced silicon surface ablation dynamics,which is performed within 220 frames in a single-shot of 300 ps.H-CAP provides a high-fidelity imaging method for observing ultrafast unrepeatable dynamic processes with large frames.展开更多
Soft magnetic composites made from metallic magnetic particles with an easy magnetization plane(referred to as easy-plane metallic soft magnetic composites(SMC))are considered ideal materials for the next generation o...Soft magnetic composites made from metallic magnetic particles with an easy magnetization plane(referred to as easy-plane metallic soft magnetic composites(SMC))are considered ideal materials for the next generation of power electronic devices.This advantage is attributed to their ability to maintain high permeability at elevated frequencies.Despite these advantages,a definitive mathematical model that connects the high-frequency magnetic properties(e.g.,effective permeability)of easy-plane metallic SMCs to the intrinsic properties of the particles is still lacking.In this work,a theoretical calculation model for the effective permeability of easy-plane metallic SMCs was formulated.This model was derived from a skin effect-corrected Landau-Lifshitz-Gilbert(LLG)equation and integrated with effective medium theory incorporating inter-particle interaction.To validate the model,we prepared samples of easy-plane Y_(2)Co_(17)particle/PU SMCs with varying particle sizes and volume fractions.The experimental results showed a strong agreement with the calculated values.This research offers critical theoretical backing for the design and optimization of soft magnetic materials intended for high-frequency applications.展开更多
With the evolution of DC distribution networks from traditional radial topologies to more complex multi-branch structures,the number of measurement points supporting synchronous communication remains relatively limite...With the evolution of DC distribution networks from traditional radial topologies to more complex multi-branch structures,the number of measurement points supporting synchronous communication remains relatively limited.This poses challenges for conventional fault distance estimation methods,which are often tailored to simple topologies and are thus difficult to apply to large-scale,multi-node DC networks.To address this,a fault distance estimation method based on sparse measurement of high-frequency electrical quantities is proposed in this paper.First,a preliminary fault line identification model based on compressed sensing is constructed to effectively narrow the fault search range and improve localization efficiency.Then,leveraging the high-frequency impedance characteristics and the voltage-current relationship of electrical quantities,a fault distance estimation approach based on high-frequency measurements from both ends of a line is designed.This enables accurate distance estimation even when the measurement devices are not directly placed at both ends of the faulted line,overcoming the dependence on specific sensor placement inherent in traditional methods.Finally,to further enhance accuracy,an optimization model based on minimizing the high-frequency voltage error at the fault point is introduced to reduce estimation error.Simulation results demonstrate that the proposed method achieves a fault distance estimation error of less than 1%under normal conditions,and maintains good performance even under adverse scenarios.展开更多
The internal hotspot temperature rise prediction in nanocrystalline high-frequency transformers(nanoHFTs) is essential to ensure reliable operation. This paper presents a three-dimensional thermal network(3DTN) model ...The internal hotspot temperature rise prediction in nanocrystalline high-frequency transformers(nanoHFTs) is essential to ensure reliable operation. This paper presents a three-dimensional thermal network(3DTN) model for epoxy resin encapsulated nano HFTs, which aims to precisely predict the temperature distribution inside the transformer in combination with the finite element method(FEM). A magnetothermal bidirectional coupling 3DTN model is established by analyzing the thermal conduction between the core, windings, and epoxy resin, while also considering the convection and radiation heat transfer mechanisms on the surface of the epoxy resin. The model considers the impact of loss distribution in the core and windings on the temperature field and adopts a simplified 1/2 thermal network model to reduce computational complexity. Furthermore, the results of FEM are compared with experimental results to verify the accuracy of the 3DTN model in predicting the temperature rise of nano HFT. The results show that the 3DTN model reduces errors by an average of 5.25% over the traditional two-dimensional thermal network(2DTN) model, particularly for temperature distributions in the windings and core. This paper provides a temperature rise prediction method for the thermal design and offers a theoretical basis and engineering guidance for the optimization of their thermal management systems.展开更多
BACKGROUND Superimposed high-frequency jet ventilation(SHFJV)is suitable for respiratory motion reduction and essential for effective lung tumor ablation.Fluid filling of the target lung wing one-lung flooding(OLF)is ...BACKGROUND Superimposed high-frequency jet ventilation(SHFJV)is suitable for respiratory motion reduction and essential for effective lung tumor ablation.Fluid filling of the target lung wing one-lung flooding(OLF)is necessary for therapeutic ultrasound applications.However,whether unilateral SHFJV allows adequate hemodynamics and gas exchange is unclear.AIM To compared SHFJV with pressure-controlled ventilation(PCV)during OLF by assessing hemodynamics and gas exchange in different animal positions.METHODS SHFJV or PCV was used alternatingly to ventilate the non-flooded lungs of the 12 anesthetized pigs during OLF.The animal positions were changed from left lateral position to supine position(SP)to right lateral position(RLP)every 30 min.In each position,ventilation was maintained for 15 min in both modalities.Hemodynamic variables and arterial blood gas levels were repeatedly measured.RESULTS Unilateral SHFJV led to lower carbon dioxide removal than PCV without abnormally elevated carbon dioxide levels.SHFJV slightly decreased oxygenation in SP and RLP compared with PCV;the lowest values of PaO_(2) and PaO_(2)/FiO_(2) ratio were found in SP[13.0;interquartile range(IQR):12.6-5.6 and 32.5(IQR:31.5-38.9)kPa].Conversely,during SHFJV,the shunt fraction was higher in all animal positions(highest in the RLP:0.30).CONCLUSION In porcine model,unilateral SHFJV may provide adequate ventilation in different animal positions during OLF.Lower oxygenation and CO_(2) removal rates compared to PCV did not lead to hypoxia or hypercapnia.SHFJV can be safely used for lung tumor ablation to minimize ventilation-induced lung motion.展开更多
Objective: to explore the detection effect and value of high-frequency ultrasound in the diagnosis of mammary gland malignant tumor. Methods: a total of 80 patients with mammary gland malignant tumor in the hospital w...Objective: to explore the detection effect and value of high-frequency ultrasound in the diagnosis of mammary gland malignant tumor. Methods: a total of 80 patients with mammary gland malignant tumor in the hospital were selected as the objects of tumor diagnosis study. All patients were treated with high-frequency color Doppler ultrasound images to detect the tumor and determine its type. At the same time, the detection results were compared with pathological diagnosis results of clinical operation, so as to determine whether the high-frequency ultrasound diagnosis technology has high diagnostic accuracy. Results: the diagnosis accuracy rate reached 96.25% (77/80) after the high-frequency ultrasound diagnosis and the comparison of the diagnosis results with the pathological diagnosis results of clinical operation in 80 patients with mammary gland malignant tumor. Conclusion: the application of high-frequency ultrasound in the diagnosis of mammary gland malignant tumor has high diagnostic accuracy, which can be used as an important basis for clinical diagnosis and treatment. And ensure that patients get treatment in time.展开更多
In this paper, we present an improved high-frequency equivalent circuit for SiGe heterojunction bipolar transistors（HBTs） with a CBE layout, where we consider the distributed effects along the base region. The actua...In this paper, we present an improved high-frequency equivalent circuit for SiGe heterojunction bipolar transistors（HBTs） with a CBE layout, where we consider the distributed effects along the base region. The actual device structure is divided into three parts： a link base region under a spacer oxide, an intrinsic transistor region under the emitter window,and an extrinsic base region. Each region is considered as a two-port network, and is composed of a distributed resistance and capacitance. We solve the admittance parameters by solving the transmission-line equation. Then, we obtain the smallsignal equivalent circuit depending on the reasonable approximations. Unlike previous compact models, in our proposed model, we introduce an additional internal base node, and the intrinsic base resistance is shifted into this internal base node,which can theoretically explain the anomalous change in the intrinsic bias-dependent collector resistance in the conventional compact model.展开更多
Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electro...Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.展开更多
Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based met...Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.展开更多
Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative patho...Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.展开更多
文摘Objective:To analyze the significance of high-frequency ultrasound in differentiating benign and malignant breast micronodules.Methods:Eighty-five patients with breast micronodules admitted for diagnosis between October 2022 and October 2024 were selected for high-frequency ultrasound diagnosis.The diagnostic efficacy of high-frequency ultrasound was evaluated by comparing it with the results of surgical pathology.Results:High-frequency ultrasound detected 50 benign nodules,primarily breast fibroadenomas,and 35 malignant nodules,mainly breast ductal carcinoma in situ.Based on surgical pathology results,the diagnostic accuracy of high-frequency ultrasound was 96.47%,specificity was 97.96%,and sensitivity was 94.44%.In high-frequency ultrasound diagnosis,the proportion of grade III and IV blood flow in malignant nodules was higher than that in benign nodules,while the proportion of regular shape and clear margins was lower.The proportion of microcalcifications and posterior echo attenuation was higher in malignant nodules,and the resistance index(RI)and peak blood flow velocity were lower than those in benign nodules(P<0.05).Conclusion:High-frequency ultrasound can effectively differentiate benign and malignant breast micronodules,determine specific nodule types,and exhibits high diagnostic accuracy and sensitivity.Additionally,benign and malignant nodules can be differentiated based on the grading of blood flow signals,sonographic features,and blood flow velocity,providing reasonable guidance for subsequent treatment plans.
文摘Objective:To analyze the therapeutic effect of high-frequency electrosurgical knife surgery guided by painless digestive endoscopy(PDE)in elderly patients with gastrointestinal polyps(GP).Methods:A total of 100 elderly GP patients admitted between June 2021 and December 2022 were selected.Patients were randomly divided into two groups:the painless group(50 cases)underwent high-frequency electrosurgical knife surgery guided by PDE,while the conventional group(50 cases)underwent the same surgery guided by traditional digestive endoscopy(DE).The total treatment efficacy,perioperative indicators,gastrointestinal hormone levels,oxidative stress(OS)markers,and complication rates were compared between the two groups.Results:The total treatment efficacy in the painless group was higher than that in the conventional group,and perioperative indicators were superior in the painless group(P<0.05).One week after treatment,the gastrointestinal hormone levels and OS-related markers in the painless group were better than those in the conventional group(P<0.05).The complication rate in the painless group was lower than in the conventional group(P<0.05).Conclusion:High-frequency electrosurgical knife surgery guided by PDE improves the effectiveness of polyp removal in elderly GP patients and accelerates postoperative recovery.It also protects gastrointestinal function,reduces postoperative OS,and ensures higher surgical safety.
基金Science and Technology Project of Aerospace Information Research Institute,Chinese Academy of Sciences(Y910340Z2F)Science and Technology Project of BBEF(E3E2010201)。
文摘Low-frequency signals have been proven valuable in the fields of target detection and geological exploration.Nevertheless,the practical implementation of these signals is hindered by large antenna diameters,limiting their potential applications.Therefore,it is imperative to study the creation of lowfrequency signals using antennas with suitable dimensions.In contrast to conventional mechanical antenna techniques,our study generates low-frequency signals in the spatial domain utilizing the principle of the Doppler effect.We also defines the antenna array architecture,the timing sequency,and the radiating element signal waveform,and provides experimental prototypes including 8/64 antennas based on earlier research.In the conducted experiments,121 MHz,40 MHz,and 10 kHz composite signals are generated by 156 MHz radiating element signals.The composite signal spectrum matches the simulations,proving our low-frequency signal generating method works.This holds significant implications for research on generating low-frequency signals with small-sized antennas.
基金supported by the National Nature Science Foundation of China,No.81870838Liaoning Province Distinguished Professor Support Program of China,No.XLYC1802096+1 种基金Shenyang Clinical Medicine Research Center of Anesthesiology of China,Nos.19-110-4-24,20-204-4-44the Outstanding Scientific Foundation of Shengjing Hospital of China,No.201708(all to PZ)。
文摘High-frequency spinal cord stimulation(HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat neuropathic pain was induced by spinal nerve ligation. Two days after modeling, the rats were subjected to 4 hours of HF-SCS(motor threshold 50%, frequency 10,000 Hz, and pulse width 0.024 ms) in the dorsal horn of the spinal cord. The results revealed that the tactile allodynia of spinal nerve-injured rats was markedly alleviated by HFSCS, and the effects were sustained for 3 hours after the stimulation had ceased. HF-SCS restored lysosomal function, increased the levels of lysosome-associated membrane protein 2(LAMP2) and the mature form of cathepsin D(matu-CTSD), and alleviated the abnormally elevated levels of microtubule-associated protein 1 A/B-light chain 3(LC3)-II and sequestosome 1(P62) in spinal nerve-injured rats. HF-SCS also mostly restored the immunoreactivity of LAMP2, which was localized in neurons in the superficial layers of the spinal dorsal horn in spinal nerve-injured rats. In addition, intraperitoneal administration of 15 mg/kg chloroquine for 60 minutes reversed the expression of the aforementioned proteins and shortened the timing of the analgesic effects of HF-SCS. These findings suggest that HF-SCS may exhibit longlasting analgesic effects on neuropathic pain in rats through improving lysosomal dysfunction and alleviating autophagic flux. This study was approved by the Laboratory Animal Ethics Committee of China Medical University, Shenyang, China(approval No. 2017 PS196 K) on March 1, 2017.
基金supported by Talents Startup Project of China Three Gorges University (No.0620070106)
文摘Objective: To observe the curative effect of high-frequency electric sparkle and point-injection therapy (HESPT) on knee osteoarthritis (KOA). Methods: Two hundred and five patients were randomly divided into a warming needle moxibustion group (68 cases), a HESPT group (68 cases) and a point-injection group (69 cases). In the warming needle moxibustion group, the main points of Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5), Dubi (ST 35), Zusanli (ST 36) and Yanglingquan (GB 34), and the adjunct points of Yinlingquan (SP 9) and Sanyinjiao (SP 6), on the affected side, were chosen for stimulation. In the HESPT group, tenderness points, the main points of Liangqiu (ST 34), Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5) and Zusanli (ST 36), and the adjunct points of Yinlingquan (SP 9), Weizhong (BL 40) and Chengshan (BL 57), were chosen. After proper manipulation, Corydalis decumbens Pers. liquid was injected into the points and a high-frequency electric sparkle was applied to stimulate the needles for 30 seconds. In the point-injection group, point injection was performed with the same method, but the patients did not receive electric stimulation. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC), the Lysholm Knee Score Scale (LKSS) and the ROM (Range of Motion) scale were used to evaluate the severity of KOA and the function of knee joints before treatment and 4 weeks after treatment. Finally, the Nimodipine method was used to assess the total curative effect. Results: After HESPT treatment, the scores for pain, morning stiffness and swelling were significantly lower (P<0.01) and LKSS index and ROM were much higher (P<0.01 and P<0.05 respectively) compared to the two other groups. The obviously effective rate and total effective rate were also significantly higher in the HESPT group than in the two other groups (P<0.01 or P<0.05). Conclusion: HESPT can improve joint function in KOA patients, and the curative effect is better than for warming needle moxibustion or point-injection only.
基金Postdoctoral Science Foundation of China, No. 20070420399
文摘BACKGROUND： Deep-brain stimulation has proven to be beneficial in the treatment of Parkinson＇s disease （PD） patients. OBJECTIVE： To investigate the effects of high-frequency stimulation （HFS） to the subthalamic nucleus （STN） on neuronal apoptosis and apoptosis-related gene expression in the substantia nigra pars compacta, and to analyze the neuroprotective effect of HFS-STN. DESIGN, TIME AND SETTING： Neuronal morphology experiments were performed in the Beijing Neurosurgical Institute from May to December in 2005. MATERIALS： Forty healthy, adult, Sprague Dawley rats were used to establish a PD model with a unilateral microinjection of 6-hydroxydopamine into two target areas of the right medial forebrain bundle. 6-hydroxydopamine was purchased from Sigma （USA）; high-frequency electrical stimulator was produced by World Precision Instruments （USA）; Terminal deoxynucleotidyl transferase dUTP nick end labeling （TUNEL） kit was a product of Nanjing Jiancheng Technology Co., Ltd. （China）; and Bcl-2 and Bax protein assay kit were purchased from Wuhan Boster Bioengineering Co., Ltd. （China）. METHODS： Forty rats were randomly divided into three groups. The stimulation group （n = 15） received HFS-STN on the day of PD modeling. The PD model group （n = 15） was used to establish the PD model. The control group （n = 10） was injected with normal saline containing 0.2 g/L ascorbic acid into two areas of the right medial forebrain bundle. MAIN OUTCOME MEASURES： Survival of dopaminergic neurons in the substantia nigra pars compacta was determined using Nissl staining. Apoptosis of dopaminergic neurons was detected using TUNEL techniques. Expression of anti-apoptotic protein, Bcl-2, and pro-apoptotic protein, Bax, were assayed by immunohistochemistry. RESULTS： Following 6-hydroxydopamine injection, the number of substantia nigra pars compacta neurons was reduced in the stimulation and PD model groups, compared to the control group. At 2 and 4 weeks post-surgery, the grey value of Nissl stained images was significantly less in the PD model and stimulation groups （P 〈 0.05）, and the stimulation group exhibited greater grey values compared to the model group （P 〈 0.05）. At 2 and 4 weeks post-surgery, the number of apoptotic neurons was significantly less in the stimulation group compared to the model group （P 〈 0.05）. In addition, Bcl-2 and Bax expression, as well as the Bcl-2/Bax ratio, was much higher in the stimulation group compared to the model group （P 〈 0.05）. CONCLUSION： HFS-STN has a neuroprotective effect on dopaminergic neurons in the substantia nigra pars compacta of PD rats by promoting Bcl-2 expression, inhibiting Bax expression, and reducing the number of apoptotic dopaminergic neurons.
基金the National Natural Science Foundation of China(42074134,42474152,42374150)CNPC Innovation Found(2024DQ02-0152).
文摘The oil-based mud(OBM) borehole measurement environment presents significant limitations on the application of existing electrical logging instruments in high-resistance formations. In this paper, we propose a novel logging method for detection of high-resistance formations in OBM using highfrequency electrodes. The method addresses the issue of shallow depth of investigation(DOI) in existing electrical logging instruments, while simultaneously ensuring the vertical resolution. Based on the principle of current continuity, the total impedance of the loop is obtained by equating the measurement loop to the series form of a capacitively coupled circuit. and its validity is verified in a homogeneous formation model and a radial two-layer formation model with a mud standoff. Then, the instrument operating frequency and electrode system parameters were preferentially determined by numerical simulation, and the effect of mud gap on impedance measurement was investigated. Subsequently, the DOI of the instrument was investigated utilizing the pseudo-geometric factor defined by the real part of impedance. It was determined that the detection depth of the instrument is 8.74 cm, while the effective vertical resolution was not less than 2 cm. Finally, a focused high-frequency electrode-type instrument was designed by introducing a pair of focused electrodes, which effectively enhanced the DOI of the instrument and was successfully deployed in the Oklahoma formation model. The simulation results demonstrate that the novel method can achieve a detection depth of 17.40 cm in highly-resistive formations drilling with OBM, which is approximately twice the depth of detection of the existing oil-based mud microimager instruments. Furthermore, its effective vertical resolution remains at or above 2 cm,which is comparable to the resolution of the existing OBM electrical logging instrument.
文摘China has a long history of coal mining,among which open-pit coal mines have a large number of small coal mine goafs underground.The distribution,shape,structure and other characteristics of goafs are isolated and discontinuous,and there is no definite geological law to follow,which seriously threatens the safety of coal mine production and personnel life.Conventional ground geophysical methods have low accuracy in detecting goaf areas affected by mechanical interference from open-pit mines,especially for waterless goaf areas,which cannot be detected by existing methods.This article proposes the use of high-frequency electromagnetic waves for goaf detection.The feasibility of using drilling radar to detect goaf was theoretically analyzed,and a goaf detection model was established.The response characteristics of different fillers in the goaf under different frequencies of high-frequency electromagnetic waves were simulated and analyzed.In a certain open-pit mine in Inner Mongolia,100MHz high-frequency electromagnetic waves were used to detect the goaf through directional drilling on the ground.After detection,excavation verification was carried out,and the location of one goaf detected was verified.The results of engineering practice show that the application of high-frequency electromagnetic waves in goaf detection expands the detection radius of boreholes,has the advantages of high efficiency and accuracy,and has important theoretical and practical significance.
基金supported by the science and technology project of State Grid Shanghai Municipal Electric Power Company(No.52094023003L).
文摘New electric power systems characterized by a high proportion of renewable energy and power electronics equipment face significant challenges due to high-frequency(HF)electromagnetic interference from the high-speed switching of power converters.To address this situation,this paper offers an in-depth review of HF interference problems and challenges originating from power electronic devices.First,the root cause of HF electromagnetic interference,i.e.,the resonant response of the parasitic parameters of the system to high-speed switching transients,is analyzed,and various scenarios of HF interference in power systems are highlighted.Next,the types of HF interference are summarized,with a focus on common-mode interference in grounding systems.This paper thoroughly reviews and compares various suppression methods for conducted HF interference.Finally,the challenges involved and suggestions for addressing emerging HF interference problems from the perspective of both power electronics equipment and power systems are discussed.This review aims to offer a structured understanding of HF interference problems and their suppression techniques for researchers and practitioners.
基金supported by National Natural Science Foundation of China(No.52177130)the Key Projects for Industrial Prospects and Core Technology Research in Suzhou City(No.SYC2022029)。
文摘Dielectric barrier discharge(DBD)plasma excited by a high-frequency alternating-current(AC)power supply is widely employed for the degradation of volatile organic compounds(VOCs).However,the thermal effect generated during the discharge process leads to energy waste and low energy utilization efficiency.In this work,an innovative DBD thermally-conducted catalysis(DBD-TCC)system,integrating high-frequency AC-DBD plasma and its generated thermal effects to activate the Co/SBA-15 catalyst,was employed for toluene removal.Specifically,Co/SBA-15 catalysts are closely positioned to the ground electrode of the plasma zone and can be heated and activated by the thermal effect when the voltage exceeds 10 k V.At12.4 k V,the temperature in the catalyst zone reached 261℃ in the DBD-TCC system,resulting in an increase in toluene degradation efficiency of 17%,CO_(2)selectivity of 21.2%,and energy efficiency of 27%,respectively,compared to the DBD system alone.In contrast,the DBD thermally-unconducted catalysis(DBD-TUC)system fails to enhance toluene degradation due to insufficient heat absorption and catalytic activation,highlighting the crucial role of AC-DBD generated heat in the activation of the catalyst.Furthermore,the degradation pathway and mechanism of toluene in the DBD-TCC system were hypothesized.This work is expected to provide an energy-efficient approach for high-frequency AC-DBD plasma removal of VOCs.
基金supported by the National Science Foundation of China(No.12127806,No.62175195 and No.12304382)the International Joint Research Laboratory for Micro/Nano Manufacturing and Measurement Technologies.
文摘Single-shot ultrafast compressed imaging(UCI)is an effective tool for studying ultrafast dynamics in physics,chemistry,or material science because of its excellent high frame rate and large frame number.However,the random code(Rcode)used in traditional UCI will lead to low-frequency noise covering high-frequency information due to its uneven sampling interval,which is a great challenge in the fidelity of large-frame reconstruction.Here,a high-frequency enhanced compressed active photography(H-CAP)is proposed.By uniformizing the sampling interval of R-code,H-CAP capture the ultrafast process with a random uniform sampling mode.This sampling mode makes the high-frequency sampling energy dominant,which greatly suppresses the low-frequency noise blurring caused by R-code and achieves high-frequency information of image enhanced.The superior dynamic performance and large-frame reconstruction ability of H-CAP are verified by imaging optical self-focusing effect and static object,respectively.We applied H-CAP to the spatial-temporal characterization of double-pulse induced silicon surface ablation dynamics,which is performed within 220 frames in a single-shot of 300 ps.H-CAP provides a high-fidelity imaging method for observing ultrafast unrepeatable dynamic processes with large frames.
基金supported by the National Key R&D Program of China(Grant No.2021YFB3501300)the 9th Research Institute of China Electronics Technology Group Corporation’s open projects(Grant No.2024SK-002-01)the Science and Technology Project of Gansu Province(Grant No.22YF7GA001).
文摘Soft magnetic composites made from metallic magnetic particles with an easy magnetization plane(referred to as easy-plane metallic soft magnetic composites(SMC))are considered ideal materials for the next generation of power electronic devices.This advantage is attributed to their ability to maintain high permeability at elevated frequencies.Despite these advantages,a definitive mathematical model that connects the high-frequency magnetic properties(e.g.,effective permeability)of easy-plane metallic SMCs to the intrinsic properties of the particles is still lacking.In this work,a theoretical calculation model for the effective permeability of easy-plane metallic SMCs was formulated.This model was derived from a skin effect-corrected Landau-Lifshitz-Gilbert(LLG)equation and integrated with effective medium theory incorporating inter-particle interaction.To validate the model,we prepared samples of easy-plane Y_(2)Co_(17)particle/PU SMCs with varying particle sizes and volume fractions.The experimental results showed a strong agreement with the calculated values.This research offers critical theoretical backing for the design and optimization of soft magnetic materials intended for high-frequency applications.
基金National Natural Science Foundation of China, grant number 52177074.
文摘With the evolution of DC distribution networks from traditional radial topologies to more complex multi-branch structures,the number of measurement points supporting synchronous communication remains relatively limited.This poses challenges for conventional fault distance estimation methods,which are often tailored to simple topologies and are thus difficult to apply to large-scale,multi-node DC networks.To address this,a fault distance estimation method based on sparse measurement of high-frequency electrical quantities is proposed in this paper.First,a preliminary fault line identification model based on compressed sensing is constructed to effectively narrow the fault search range and improve localization efficiency.Then,leveraging the high-frequency impedance characteristics and the voltage-current relationship of electrical quantities,a fault distance estimation approach based on high-frequency measurements from both ends of a line is designed.This enables accurate distance estimation even when the measurement devices are not directly placed at both ends of the faulted line,overcoming the dependence on specific sensor placement inherent in traditional methods.Finally,to further enhance accuracy,an optimization model based on minimizing the high-frequency voltage error at the fault point is introduced to reduce estimation error.Simulation results demonstrate that the proposed method achieves a fault distance estimation error of less than 1%under normal conditions,and maintains good performance even under adverse scenarios.
基金supported by the Project of the National Key Research and Development Program of China under Grant 2022YFB2404100。
文摘The internal hotspot temperature rise prediction in nanocrystalline high-frequency transformers(nanoHFTs) is essential to ensure reliable operation. This paper presents a three-dimensional thermal network(3DTN) model for epoxy resin encapsulated nano HFTs, which aims to precisely predict the temperature distribution inside the transformer in combination with the finite element method(FEM). A magnetothermal bidirectional coupling 3DTN model is established by analyzing the thermal conduction between the core, windings, and epoxy resin, while also considering the convection and radiation heat transfer mechanisms on the surface of the epoxy resin. The model considers the impact of loss distribution in the core and windings on the temperature field and adopts a simplified 1/2 thermal network model to reduce computational complexity. Furthermore, the results of FEM are compared with experimental results to verify the accuracy of the 3DTN model in predicting the temperature rise of nano HFT. The results show that the 3DTN model reduces errors by an average of 5.25% over the traditional two-dimensional thermal network(2DTN) model, particularly for temperature distributions in the windings and core. This paper provides a temperature rise prediction method for the thermal design and offers a theoretical basis and engineering guidance for the optimization of their thermal management systems.
文摘BACKGROUND Superimposed high-frequency jet ventilation(SHFJV)is suitable for respiratory motion reduction and essential for effective lung tumor ablation.Fluid filling of the target lung wing one-lung flooding(OLF)is necessary for therapeutic ultrasound applications.However,whether unilateral SHFJV allows adequate hemodynamics and gas exchange is unclear.AIM To compared SHFJV with pressure-controlled ventilation(PCV)during OLF by assessing hemodynamics and gas exchange in different animal positions.METHODS SHFJV or PCV was used alternatingly to ventilate the non-flooded lungs of the 12 anesthetized pigs during OLF.The animal positions were changed from left lateral position to supine position(SP)to right lateral position(RLP)every 30 min.In each position,ventilation was maintained for 15 min in both modalities.Hemodynamic variables and arterial blood gas levels were repeatedly measured.RESULTS Unilateral SHFJV led to lower carbon dioxide removal than PCV without abnormally elevated carbon dioxide levels.SHFJV slightly decreased oxygenation in SP and RLP compared with PCV;the lowest values of PaO_(2) and PaO_(2)/FiO_(2) ratio were found in SP[13.0;interquartile range(IQR):12.6-5.6 and 32.5(IQR:31.5-38.9)kPa].Conversely,during SHFJV,the shunt fraction was higher in all animal positions(highest in the RLP:0.30).CONCLUSION In porcine model,unilateral SHFJV may provide adequate ventilation in different animal positions during OLF.Lower oxygenation and CO_(2) removal rates compared to PCV did not lead to hypoxia or hypercapnia.SHFJV can be safely used for lung tumor ablation to minimize ventilation-induced lung motion.
文摘Objective: to explore the detection effect and value of high-frequency ultrasound in the diagnosis of mammary gland malignant tumor. Methods: a total of 80 patients with mammary gland malignant tumor in the hospital were selected as the objects of tumor diagnosis study. All patients were treated with high-frequency color Doppler ultrasound images to detect the tumor and determine its type. At the same time, the detection results were compared with pathological diagnosis results of clinical operation, so as to determine whether the high-frequency ultrasound diagnosis technology has high diagnostic accuracy. Results: the diagnosis accuracy rate reached 96.25% (77/80) after the high-frequency ultrasound diagnosis and the comparison of the diagnosis results with the pathological diagnosis results of clinical operation in 80 patients with mammary gland malignant tumor. Conclusion: the application of high-frequency ultrasound in the diagnosis of mammary gland malignant tumor has high diagnostic accuracy, which can be used as an important basis for clinical diagnosis and treatment. And ensure that patients get treatment in time.
基金Project supported by the National Natural Science Funds of China(Grant Nos.61574056 and 61504156)the Natural Science Foundation of Shanghai,China(Grant No.14ZR1412000)+1 种基金Shanghai Sailing Program,China(Grant No.17YF1404700)the Science and Technology Commission of Shanghai Municipality,China(Grant No.14DZ2260800)
文摘In this paper, we present an improved high-frequency equivalent circuit for SiGe heterojunction bipolar transistors（HBTs） with a CBE layout, where we consider the distributed effects along the base region. The actual device structure is divided into three parts： a link base region under a spacer oxide, an intrinsic transistor region under the emitter window,and an extrinsic base region. Each region is considered as a two-port network, and is composed of a distributed resistance and capacitance. We solve the admittance parameters by solving the transmission-line equation. Then, we obtain the smallsignal equivalent circuit depending on the reasonable approximations. Unlike previous compact models, in our proposed model, we introduce an additional internal base node, and the intrinsic base resistance is shifted into this internal base node,which can theoretically explain the anomalous change in the intrinsic bias-dependent collector resistance in the conventional compact model.
基金supported by the National Natural Science Foundation of China(No.62464010)Spring City Plan-Special Program for Young Talents(K202005007)+2 种基金Yunnan Talents Support Plan for Young Talents(XDYC-QNRC-2022-0482)Yunnan Local Colleges Applied Basic Research Projects(202101BA070001-138)Frontier Research Team of Kunming University 2023.
文摘Rechargeable Zn/Sn-air batteries have received considerable attention as promising energy storage devices.However,the electrochemical performance of these batteries is significantly constrained by the sluggish electrocatalytic reaction kinetics at the cathode.The integration of light energy into Zn/Sn-air batteries is a promising strategy for enhancing their performance.However,the photothermal and photoelectric effects generate heat in the battery under prolonged solar irradiation,leading to air cathode instability.This paper presents the first design and synthesis of Ni_(2)-1,5-diamino-4,8-dihydroxyanthraquinone(Ni_(2)DDA),an electronically conductiveπ-d conjugated metal-organic framework(MOF).Ni_(2)DDA exhibits both photoelectric and photothermal effects,with an optical band gap of~1.14 eV.Under illumination,Ni_(2)DDA achieves excellent oxygen evolution reaction performance(with an overpotential of 245 mV vs.reversible hydrogen electrode at 10 mA cm^(−2))and photothermal stability.These properties result from the synergy between the photoelectric and photothermal effects of Ni_(2)DDA.Upon integration into Zn/Sn-air batteries,Ni_(2)DDA ensures excellent cycling stability under light and exhibits remarkable performance in high-temperature environments up to 80℃.This study experimentally confirms the stable operation of photo-assisted Zn/Sn-air batteries under high-temperature conditions for the first time and provides novel insights into the application of electronically conductive MOFs in photoelectrocatalysis and photothermal catalysis.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT)(No.RS-2022-00143178)the Ministry of Education(MOE)(Nos.2022R1A6A3A13053896 and 2022R1F1A1074616),Republic of Korea.
文摘Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.
基金supported by the National Natural Science Foundation of China(No.32170121).
文摘Benzalkonium chloride(BAC)is widely employed as a broad-spectrum biocide and has emerged as a significant environmental pollutant.Polymyxin B(PB)serves as the last-line defense for the treatment of Gram-negative pathogens.Previous studies reported that BAC-adapted Pseudomonas aeruginosa increased the tolerance to PB.Herein,we present the novel finding that the combination of BAC and PB exhibited synergistic antibacterial effects against P.aeruginosa.Time-killing assay demonstrated a significant reduction in bacterial cell viability.Scanning electron microscopy,zeta potential analysis,hydrophobicity measurements,and fluorescence probe analyses collectively revealed severe disruption of the cell envelope and membrane potential induced by the combination of BAC and PB.Transcriptomic analysis revealed that the BAC-PB combination notably downreg-ulated the expression of genes involved in lipid A modification and cell envelope production,including phoPQ,pmrAB,bamABCDE,lptABCDEG,lolB,yidC,and murJ.Additionally,the combination group exhibited augmented production of reactive oxygen species and diminished ATP synthesis.The expression of the genes associated with substance metabolism and energy generation was significantly impeded.This study provides significant implica-tions for the interactions of biocides and antibiotics on Gram-negative pathogens,while also addressing antibiotic resistance and developing the external treatment strategy for Pseudomonas-infected wounds and burns.
