Industrial operators need reliable communication in high-noise,safety-critical environments where speech or touch input is often impractical.Existing gesture systems either miss real-time deadlines on resourceconstrai...Industrial operators need reliable communication in high-noise,safety-critical environments where speech or touch input is often impractical.Existing gesture systems either miss real-time deadlines on resourceconstrained hardware or lose accuracy under occlusion,vibration,and lighting changes.We introduce Industrial EdgeSign,a dual-path framework that combines hardware-aware neural architecture search(NAS)with large multimodalmodel(LMM)guided semantics to deliver robust,low-latency gesture recognition on edge devices.The searched model uses a truncated ResNet50 front end,a dimensional-reduction network that preserves spatiotemporal structure for tubelet-based attention,and localized Transformer layers tuned for on-device inference.To reduce reliance on gloss annotations and mitigate domain shift,we distill semantics from factory-tuned vision-language models and pre-train with masked language modeling and video-text contrastive objectives,aligning visual features with a shared text space.OnML2HP and SHREC’17,theNAS-derived architecture attains 94.7% accuracywith 86ms inference latency and about 5.9W power on Jetson Nano.Under occlusion,lighting shifts,andmotion blur,accuracy remains above 82%.For safetycritical commands,the emergency-stop gesture achieves 72 ms 99th percentile latency with 99.7% fail-safe triggering.Ablation studies confirm the contribution of the spatiotemporal tubelet extractor and text-side pre-training,and we observe gains in translation quality(BLEU-422.33).These results show that Industrial EdgeSign provides accurate,resource-aware,and safety-aligned gesture recognition suitable for deployment in smart factory settings.展开更多
Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nai...Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.展开更多
This work was carried out to investigate the efficacy of sensory integration therapy in improving gross motor coordination and grip control in Down syndrome children. Thirty children were enrolled in this study and ra...This work was carried out to investigate the efficacy of sensory integration therapy in improving gross motor coordination and grip control in Down syndrome children. Thirty children were enrolled in this study and randomly assigned into two groups: group A received (sensory integration therapy program plus specific physiotherapy training) and group B received (specific physiotherapy training program only). Motor coordination test measures (Balancing backward, Hopping, Jumping from side to side and Transferring boxes) to test and follow gross motor coordination, handheld dynamometer to test and follow grip control ability and kinesthesia test to test and follow awareness of joint position and movement. These measurements were taken before initial treatment and after 12 weeks of treatment. The children parents in both groups A and B were instructed to complete 3 hours of the home routine program. Data analysis was available on the 30 Down syndrome children participating in the study. The difference between pre- and post-treatment results was more significant in Motor coordination test measures in the study group than the control group. Grip control ability and kinesthesia test demonstrate representative improvement in the study groups (p = 0.0001) while insignificant in the kinesthesia control group and significant in a grip control group. The addition of sensory integration therapy program to specific physiotherapy training is recommended in improving gross motor coordination and grip control abilities in Down syndrome, so this suggested approach may be used as a selective choice for improving posture control and hand functions in Down syndrome children.展开更多
It has been proved by the ancient and modemacupuncture practices that needling techniques are ofvital importance in the acupuncture treatment ofdiseases.At present,much has been reported aboutthe researches on acupunc...It has been proved by the ancient and modemacupuncture practices that needling techniques are ofvital importance in the acupuncture treatment ofdiseases.At present,much has been reported aboutthe researches on acupuncture techniques,which canbe roughly divided into the following three types:reinforcing,reducing,and even methods.Throughlong years of study and clinical practice,Dr.展开更多
The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally le...The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interaction partners, and the physiological and pathophysiological role of the NECAB family.展开更多
Objective To assess health equity in the Yangtze River region to improve understanding of the correlation between hand, foot, and mouth disease(HFMD) and socioeconomic factors.Methods From 2014–2016, data on HFMD inc...Objective To assess health equity in the Yangtze River region to improve understanding of the correlation between hand, foot, and mouth disease(HFMD) and socioeconomic factors.Methods From 2014–2016, data on HFMD incidence, population statistics, economic indicators, and meteorology from 26 cities along the Yangtze River were analyzed. A multi-city random-effects metaanalysis was performed to study the relationship between temperature and HFMD transmission, and health equity was assessed with respect to socio-economic impact.Results Over the study period, 919,458 HFMD cases were reported, with Shanghai(162,303) having the highest incidence and Tongling(5,513) having the lowest. Males were more commonly affected(male-to-female ratio, 1.49:1). The exposure-response relationship had an M-shaped curve, with two HFMD peaks occurring at 4 ℃ and 26 ℃. The relative risk had two peaks at 1.30 ℃(1.834, 95% CI:1.204–2.794) and 31.4 ℃(1.143, 95% CI: 0.901–1.451), forming an M shape, with the first peak higher than the second. The most significant impact of temperature on HFMD was observed between –2 ℃ and18.1 ℃. The concentration index(0.2463) indicated moderate concentration differences, whereas the Theil index(0.0418) showed low inequality in distribution.Conclusion The incidence of HFMD varied across cities, particularly with changes in temperature.Economically prosperous areas showed higher risks, indicating disparities. Targeted interventions in these areas are crucial for mitigating the risk of HFMD.展开更多
在体育比赛的某些时刻,运动员的表现会优于平均水平,出现“火力全开”甚至“百发百中”的情况,这种状态或现象被称为“热手效应”(hot hand effect)或“热手现象”“热手状态”等;反之,则称为“冷手”(cold hand)。与“热手效应”类似...在体育比赛的某些时刻,运动员的表现会优于平均水平,出现“火力全开”甚至“百发百中”的情况,这种状态或现象被称为“热手效应”(hot hand effect)或“热手现象”“热手状态”等;反之,则称为“冷手”(cold hand)。与“热手效应”类似的概念还有连胜(steak)、势头(momentum)等。一直以来,运动科学领域对“热手效应”是否存在有巨大分歧,集中表现为3个议题:①该效应是否存在?②如何在统计学上证明其存在?③如果存在,其影响大小如何?1985年,Gilovich等人首次提出了“是否有热手效应”这一经典命题,其研究结果声称并未发现存在“热手效应”,并认为这种过度反应的现象源于人们对随机序列的认知偏差,即“热手谬误”(hot hand fallacy)。展开更多
Eton Systems-a member of TMAS,the Swedish Textile Machinery Association-is taking part in the current Microfactories System Innovation project which is working on the development of a fully automated workflow for seco...Eton Systems-a member of TMAS,the Swedish Textile Machinery Association-is taking part in the current Microfactories System Innovation project which is working on the development of a fully automated workflow for second hand garments.Eton is contributing its well-proven transport system for material handling to the project,which also involves spe-cialists at the Swedish School of Textiles in Boras,the Au-tomation Region innovation cluster at Mälardalen University and the national collaboration platform iHubs Sweden.展开更多
Background:Healthcare-associated infections continue to pose a significant threat to patient safety,and hand hygiene practices remain an effective preventive measure.Despite global campaigns,nurse compliance often rem...Background:Healthcare-associated infections continue to pose a significant threat to patient safety,and hand hygiene practices remain an effective preventive measure.Despite global campaigns,nurse compliance often remains substandard.Previous research has focused on technical and environmental factors;however,the influence of internal psychological aspects,such as self-leadership,has been rarely studied,particularly in Indonesia.Increasing compliance depends not only on external interventions but also on empowering nurses’motivation and self-regulation.Objective:This study aims to determine the relationship between self-leadership and hand hygiene compliance among inpatient nurses.Materials and Methods:A quantitative correlational design with a total sample of 88 nurses was used.Self-leadership was measured using the Abbreviated Self-Leadership Questionnaire,and compliance was assessed through direct observation based on the World Health Organization“5 Moments for Hand Hygiene”guidelines.Data analysis was conducted descriptively and using the Chi-square test.Results:The results showed that 54.5%of nurses had high self-leadership,but only 29.5%were compliant with hand hygiene procedures.The Chi-square test showed a significant relationship between self-leadership and compliance(χ^(2)=7.453;P=0.006).Conclusion:Higher self-leadership correlates with better compliance;however,low overall compliance indicates an intention-behaviour gap.Therefore,integrating self-leadership training with organisational support is necessary to strengthen the patient safety culture.展开更多
Youth With an International Perspective The Final Show of the Public Benefit International Challenge for Youth(PBIC)2025 concluded successfully in Beijing on 3 August.After three months of competition across three sta...Youth With an International Perspective The Final Show of the Public Benefit International Challenge for Youth(PBIC)2025 concluded successfully in Beijing on 3 August.After three months of competition across three stages,eight teams emerged from over 200 participants to compete in the finals.Ultimately,top honours were given to three groups,the Hand in Hand team,Green Wings team,and Legend Silk Road team,recognising their excellence in innovation,social responsibility,and global perspective.展开更多
BACKGROUND Osteochondroma of the hand and phalanges is rare.Although rare,solitary phalangeal osteochondromas can result in pain,cosmetic deformity,compression of nearby neurovascular structures and tendons,or functio...BACKGROUND Osteochondroma of the hand and phalanges is rare.Although rare,solitary phalangeal osteochondromas can result in pain,cosmetic deformity,compression of nearby neurovascular structures and tendons,or functional limitation of adjacent joints that warrant surgical correction when symptomatic.At times,involvement of the growth plate by juxtaepiphyseal exostosis can cause angulation deformity,necessitating corrective osteotomy.CASE SUMMARY We reported a case of a 3-year-old female with a right-sided painless deformity of the index finger along with swelling over the base of the index finger and its management.CONCLUSION This case report focused on the natural history of phalangeal exostosis and its association with angular deformities of the fingers.We demonstrated that the timely excision of the juxtaepiphyseal exostosis would allow the surgeon to achieve acute correction of the angular deformity with full functional recovery without recurrence at the 2-year follow-up.Significant delay of excision until skeletal maturity might necessitate corrective osteotomy of the finger deformity and tendon release for intrinsic tightness.展开更多
Frailty has emerged as a pivotal determinant of post-liver transplant(LT)outcomes,yet its integration into clinical practice remains inconsistent.Defined by functional impairments and reduced physiologic reserve,frail...Frailty has emerged as a pivotal determinant of post-liver transplant(LT)outcomes,yet its integration into clinical practice remains inconsistent.Defined by functional impairments and reduced physiologic reserve,frailty transcends traditional metrics like the model for end-stage liver disease(MELD)score,demonstrating increasing predictive value for mortality beyond the immediate postoperative period.Recent findings suggest that frail recipients experience significantly higher mortality within the first 12 months following transplantation—a period when traditional monitoring often wanes.This raises critical questions about the adequacy of current assessment and follow-up protocols.The observed dissociation between MELD scores and long-term survival underscores the limitations of existing selection criteria.Frailty,as a dynamic and modifiable condition,represents an opportunity for targeted intervention.Prehabilitation programs focusing on nutritional optimization,physical rehabilitation,and psychosocial support could enhance resilience in transplant candidates,reducing their risk profile and improving post-transplant outcomes.Furthermore,these findings call for an expanded approach to post-transplant monitoring.Extending surveillance for frail recipients beyond standard timelines may facilitate early detection of complications,mitigating their impact on survival.Incorporating frailty into both pre-and post-transplant protocols could redefine how transplant centers evaluate and manage risk.This editorial advocates for a paradigm shift:Frailty must no longer be viewed as a secondary consideration but as a core element in LT care.By addressing frailty comprehensively,we can move toward more personalized,effective strategies that improve survival and quality of life for LT recipients.展开更多
As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok...As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”展开更多
The rapid evolution of virtual reality(VR)and augmented reality(AR)technologies has significantly transformed human-computer interaction,with applications spanning entertainment,education,healthcare,industry,and remot...The rapid evolution of virtual reality(VR)and augmented reality(AR)technologies has significantly transformed human-computer interaction,with applications spanning entertainment,education,healthcare,industry,and remote collaboration.A central challenge in these immersive systems lies in enabling intuitive,efficient,and natural interactions.Hand gesture recognition offers a compelling solution by leveraging the expressiveness of human hands to facilitate seamless control without relying on traditional input devices such as controllers or keyboards,which can limit immersion.However,achieving robust gesture recognition requires overcoming challenges related to accurate hand tracking,complex environmental conditions,and minimizing system latency.This study proposes an artificial intelligence(AI)-driven framework for recognizing both static and dynamic hand gestures in VR and AR environments using skeleton-based tracking compliant with the OpenXR standard.Our approach employs a lightweight neural network architecture capable of real-time classification within approximately 1.3mswhilemaintaining average accuracy of 95%.We also introduce a novel dataset generation method to support training robust models and demonstrate consistent classification of diverse gestures across widespread commercial VR devices.This work represents one of the first studies to implement and validate dynamic hand gesture recognition in real time using standardized VR hardware,laying the groundwork for more immersive,accessible,and user-friendly interaction systems.By advancing AI-driven gesture interfaces,this research has the potential to broaden the adoption of VR and AR across diverse domains and enhance the overall user experience.展开更多
On August 20,the Xi Jinping Thought on Diplomacy Studies Center held a book launch event“Hand in Hand,Heart to Heart-Toward a Shared Future”for Stories of the SCO in the New Era in Beijing.China's Assistant Mini...On August 20,the Xi Jinping Thought on Diplomacy Studies Center held a book launch event“Hand in Hand,Heart to Heart-Toward a Shared Future”for Stories of the SCO in the New Era in Beijing.China's Assistant Minister of Foreign Affairs Liu Bin and Deputy Secretary-General of the Shanghai Cooperation Organization(SCO)Ahmad Saidmurodzoda delivered speeches at the event,which was also attended by Zhang Deguang,China's former Vice Foreign Minister and the SCO's inaugural Secretary-General.展开更多
Background:Muscular strength is a powerful marker of current health status and robust predictor of age-related disease and disability.Handgrip strength(HGS)using isometric dynamometry is a convenient,feasible,and wide...Background:Muscular strength is a powerful marker of current health status and robust predictor of age-related disease and disability.Handgrip strength(HGS)using isometric dynamometry is a convenient,feasible,and widely used method of assessing muscular strength among people of all ages.While adult HGS norms have been published for many countries,no study has yet synthesized available data to produce international norms.The objective of this study was to generate international sex-and age-specific norms for absolute and body size-normalized HGS across the adult lifespan.Methods:Systematic searches were conducted in 6 databases/web search engines(MEDLINE,SPORTDiscus,Embase,Web of Science,CINAHL,and Google Scholar)up to December 1,2023.We included full-text peer-reviewed observational studies that reported normative HGS data for adults aged ≥20 years by sex and age.Pseudo data were generated using Monte Carlo simulation following harmonization for methodo-logical variation.Population-weighted Generalized Additive Models for Location,Scale,and Shape were used to develop sex-and age-specific norms for absolute HGS(kg)and HGS normalized by height(Ht,m)squared(i.e.,HGS/Ht^(2)in kg/m^(2)).Norms were tabulated as percentile values(5th to 95th)and visualized as smoothed percentile curves.Results:We included data from 100 unique observational studies representing 2,405,863 adults(51.9%female)aged 20 to 100+years from 69 countries and regions tested from the year 2000 onward.On average,absolute and normalized HGS values negligibly improved throughout early adulthood,peaked from age 3039 years(at 49.7 kg(males)and 29.7 kg(females)for absolute HGS or 16.3 kg/m^(2)(males)and 11.3 kg/m^(2)(females)for HGS/Ht^(2)),and declined afterwards.The age-related decline in HGS accelerated from middle to late adulthood and was slightly larger for males than for females during middle adulthood.Conclusion:This study provides the world’s largest and most geographically comprehensive international norms for adult HGS by sex and age.These norms have utility for global peer-comparisons,health screening,and surveillance.展开更多
Objective:While albumin and the weight-standardized hand grip strength(HGS/W)serve as valuable prognostic indicators for cancer patients,their correlation with the prognosis in frail cancer patients remains inadequate...Objective:While albumin and the weight-standardized hand grip strength(HGS/W)serve as valuable prognostic indicators for cancer patients,their correlation with the prognosis in frail cancer patients remains inadequately explored.This study aimed to investigate the prognostic importance of the albumin level and HGS/W in cancer patients with frailty and to further investigate their combined prognostic value.Moreover,this comprehensive evaluation aimed to facilitate timely intervention and treatment for frail patients.Methods:The research enrolled 5,794 cancer patients identified with frailty from a multicenter research database.The diagnosis of frailty was based on the FRAIL scale.An Albumin-HGS/W score was constructed by combining the albumin and HGS/W values.Cox proportional hazard regression was utilized to examine the association between the albumin level and HGS/W and patient outcomes.Results:Among these patients,2,543 were females and 3,251 were males,with a median age of 60.0 years.Optimal stratification based on patient survival revealed the ideal threshold for HGS/W to be 0.48 for males and 0.39 for females,and for albumin to be 38 for both sexes.The fully adjusted model revealed that higher Albumin-HGS/W scores were correlated with a poorer patient prognosis.Notably,an Albumin-HGS/W score of 2 was associated with a higher risk of mortality compared with a score of 0 in the total population(HR:1.813,95%CI:1.580-2.080,P<0.001).Conclusions:Low albumin or HGS/W values are associated with low survival in cancer patients with frailty.Elevated Albumin-HGS/W scores were linked to decreased survival rates in cancer patients with frailty.展开更多
Perhaps the greatest compliment that an attending surgeon can bestow on a resident in training,is to comment,“He/she has good hands.”However,what defines good hands?What parameters are used to make that judgment?As ...Perhaps the greatest compliment that an attending surgeon can bestow on a resident in training,is to comment,“He/she has good hands.”However,what defines good hands?What parameters are used to make that judgment?As an academic urologist,I had the opportunity to observe urology and general surgery residents in the operating room over several decades.展开更多
文摘Industrial operators need reliable communication in high-noise,safety-critical environments where speech or touch input is often impractical.Existing gesture systems either miss real-time deadlines on resourceconstrained hardware or lose accuracy under occlusion,vibration,and lighting changes.We introduce Industrial EdgeSign,a dual-path framework that combines hardware-aware neural architecture search(NAS)with large multimodalmodel(LMM)guided semantics to deliver robust,low-latency gesture recognition on edge devices.The searched model uses a truncated ResNet50 front end,a dimensional-reduction network that preserves spatiotemporal structure for tubelet-based attention,and localized Transformer layers tuned for on-device inference.To reduce reliance on gloss annotations and mitigate domain shift,we distill semantics from factory-tuned vision-language models and pre-train with masked language modeling and video-text contrastive objectives,aligning visual features with a shared text space.OnML2HP and SHREC’17,theNAS-derived architecture attains 94.7% accuracywith 86ms inference latency and about 5.9W power on Jetson Nano.Under occlusion,lighting shifts,andmotion blur,accuracy remains above 82%.For safetycritical commands,the emergency-stop gesture achieves 72 ms 99th percentile latency with 99.7% fail-safe triggering.Ablation studies confirm the contribution of the spatiotemporal tubelet extractor and text-side pre-training,and we observe gains in translation quality(BLEU-422.33).These results show that Industrial EdgeSign provides accurate,resource-aware,and safety-aligned gesture recognition suitable for deployment in smart factory settings.
文摘Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.
文摘This work was carried out to investigate the efficacy of sensory integration therapy in improving gross motor coordination and grip control in Down syndrome children. Thirty children were enrolled in this study and randomly assigned into two groups: group A received (sensory integration therapy program plus specific physiotherapy training) and group B received (specific physiotherapy training program only). Motor coordination test measures (Balancing backward, Hopping, Jumping from side to side and Transferring boxes) to test and follow gross motor coordination, handheld dynamometer to test and follow grip control ability and kinesthesia test to test and follow awareness of joint position and movement. These measurements were taken before initial treatment and after 12 weeks of treatment. The children parents in both groups A and B were instructed to complete 3 hours of the home routine program. Data analysis was available on the 30 Down syndrome children participating in the study. The difference between pre- and post-treatment results was more significant in Motor coordination test measures in the study group than the control group. Grip control ability and kinesthesia test demonstrate representative improvement in the study groups (p = 0.0001) while insignificant in the kinesthesia control group and significant in a grip control group. The addition of sensory integration therapy program to specific physiotherapy training is recommended in improving gross motor coordination and grip control abilities in Down syndrome, so this suggested approach may be used as a selective choice for improving posture control and hand functions in Down syndrome children.
文摘It has been proved by the ancient and modemacupuncture practices that needling techniques are ofvital importance in the acupuncture treatment ofdiseases.At present,much has been reported aboutthe researches on acupuncture techniques,which canbe roughly divided into the following three types:reinforcing,reducing,and even methods.Throughlong years of study and clinical practice,Dr.
基金supported by the Deutsche Forschungsgemeinschaft (ME1922/14-1) to AM。
文摘The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interaction partners, and the physiological and pathophysiological role of the NECAB family.
基金The funding of this study was of the 2021 Shandong Province Higher Education“Young Innovative Talent Introduction and Training Program”(Public Health Safety Risk Assessment and Response Innovation Team)the annual education and teaching reform and research project at the school level of Shandong Second Medical University(No.2023YBD006)+1 种基金the Public Health Standards Research and Development Project of the National Disease Control and Prevention Bureau(No.233007)the Public Health Standards Revision and Supervision Support Project of the National Disease Control and Prevention Bureau (No.242401).
文摘Objective To assess health equity in the Yangtze River region to improve understanding of the correlation between hand, foot, and mouth disease(HFMD) and socioeconomic factors.Methods From 2014–2016, data on HFMD incidence, population statistics, economic indicators, and meteorology from 26 cities along the Yangtze River were analyzed. A multi-city random-effects metaanalysis was performed to study the relationship between temperature and HFMD transmission, and health equity was assessed with respect to socio-economic impact.Results Over the study period, 919,458 HFMD cases were reported, with Shanghai(162,303) having the highest incidence and Tongling(5,513) having the lowest. Males were more commonly affected(male-to-female ratio, 1.49:1). The exposure-response relationship had an M-shaped curve, with two HFMD peaks occurring at 4 ℃ and 26 ℃. The relative risk had two peaks at 1.30 ℃(1.834, 95% CI:1.204–2.794) and 31.4 ℃(1.143, 95% CI: 0.901–1.451), forming an M shape, with the first peak higher than the second. The most significant impact of temperature on HFMD was observed between –2 ℃ and18.1 ℃. The concentration index(0.2463) indicated moderate concentration differences, whereas the Theil index(0.0418) showed low inequality in distribution.Conclusion The incidence of HFMD varied across cities, particularly with changes in temperature.Economically prosperous areas showed higher risks, indicating disparities. Targeted interventions in these areas are crucial for mitigating the risk of HFMD.
文摘在体育比赛的某些时刻,运动员的表现会优于平均水平,出现“火力全开”甚至“百发百中”的情况,这种状态或现象被称为“热手效应”(hot hand effect)或“热手现象”“热手状态”等;反之,则称为“冷手”(cold hand)。与“热手效应”类似的概念还有连胜(steak)、势头(momentum)等。一直以来,运动科学领域对“热手效应”是否存在有巨大分歧,集中表现为3个议题:①该效应是否存在?②如何在统计学上证明其存在?③如果存在,其影响大小如何?1985年,Gilovich等人首次提出了“是否有热手效应”这一经典命题,其研究结果声称并未发现存在“热手效应”,并认为这种过度反应的现象源于人们对随机序列的认知偏差,即“热手谬误”(hot hand fallacy)。
文摘Eton Systems-a member of TMAS,the Swedish Textile Machinery Association-is taking part in the current Microfactories System Innovation project which is working on the development of a fully automated workflow for second hand garments.Eton is contributing its well-proven transport system for material handling to the project,which also involves spe-cialists at the Swedish School of Textiles in Boras,the Au-tomation Region innovation cluster at Mälardalen University and the national collaboration platform iHubs Sweden.
文摘Background:Healthcare-associated infections continue to pose a significant threat to patient safety,and hand hygiene practices remain an effective preventive measure.Despite global campaigns,nurse compliance often remains substandard.Previous research has focused on technical and environmental factors;however,the influence of internal psychological aspects,such as self-leadership,has been rarely studied,particularly in Indonesia.Increasing compliance depends not only on external interventions but also on empowering nurses’motivation and self-regulation.Objective:This study aims to determine the relationship between self-leadership and hand hygiene compliance among inpatient nurses.Materials and Methods:A quantitative correlational design with a total sample of 88 nurses was used.Self-leadership was measured using the Abbreviated Self-Leadership Questionnaire,and compliance was assessed through direct observation based on the World Health Organization“5 Moments for Hand Hygiene”guidelines.Data analysis was conducted descriptively and using the Chi-square test.Results:The results showed that 54.5%of nurses had high self-leadership,but only 29.5%were compliant with hand hygiene procedures.The Chi-square test showed a significant relationship between self-leadership and compliance(χ^(2)=7.453;P=0.006).Conclusion:Higher self-leadership correlates with better compliance;however,low overall compliance indicates an intention-behaviour gap.Therefore,integrating self-leadership training with organisational support is necessary to strengthen the patient safety culture.
文摘Youth With an International Perspective The Final Show of the Public Benefit International Challenge for Youth(PBIC)2025 concluded successfully in Beijing on 3 August.After three months of competition across three stages,eight teams emerged from over 200 participants to compete in the finals.Ultimately,top honours were given to three groups,the Hand in Hand team,Green Wings team,and Legend Silk Road team,recognising their excellence in innovation,social responsibility,and global perspective.
文摘BACKGROUND Osteochondroma of the hand and phalanges is rare.Although rare,solitary phalangeal osteochondromas can result in pain,cosmetic deformity,compression of nearby neurovascular structures and tendons,or functional limitation of adjacent joints that warrant surgical correction when symptomatic.At times,involvement of the growth plate by juxtaepiphyseal exostosis can cause angulation deformity,necessitating corrective osteotomy.CASE SUMMARY We reported a case of a 3-year-old female with a right-sided painless deformity of the index finger along with swelling over the base of the index finger and its management.CONCLUSION This case report focused on the natural history of phalangeal exostosis and its association with angular deformities of the fingers.We demonstrated that the timely excision of the juxtaepiphyseal exostosis would allow the surgeon to achieve acute correction of the angular deformity with full functional recovery without recurrence at the 2-year follow-up.Significant delay of excision until skeletal maturity might necessitate corrective osteotomy of the finger deformity and tendon release for intrinsic tightness.
文摘Frailty has emerged as a pivotal determinant of post-liver transplant(LT)outcomes,yet its integration into clinical practice remains inconsistent.Defined by functional impairments and reduced physiologic reserve,frailty transcends traditional metrics like the model for end-stage liver disease(MELD)score,demonstrating increasing predictive value for mortality beyond the immediate postoperative period.Recent findings suggest that frail recipients experience significantly higher mortality within the first 12 months following transplantation—a period when traditional monitoring often wanes.This raises critical questions about the adequacy of current assessment and follow-up protocols.The observed dissociation between MELD scores and long-term survival underscores the limitations of existing selection criteria.Frailty,as a dynamic and modifiable condition,represents an opportunity for targeted intervention.Prehabilitation programs focusing on nutritional optimization,physical rehabilitation,and psychosocial support could enhance resilience in transplant candidates,reducing their risk profile and improving post-transplant outcomes.Furthermore,these findings call for an expanded approach to post-transplant monitoring.Extending surveillance for frail recipients beyond standard timelines may facilitate early detection of complications,mitigating their impact on survival.Incorporating frailty into both pre-and post-transplant protocols could redefine how transplant centers evaluate and manage risk.This editorial advocates for a paradigm shift:Frailty must no longer be viewed as a secondary consideration but as a core element in LT care.By addressing frailty comprehensively,we can move toward more personalized,effective strategies that improve survival and quality of life for LT recipients.
文摘As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”
基金supported by research fund from Chosun University,2024.
文摘The rapid evolution of virtual reality(VR)and augmented reality(AR)technologies has significantly transformed human-computer interaction,with applications spanning entertainment,education,healthcare,industry,and remote collaboration.A central challenge in these immersive systems lies in enabling intuitive,efficient,and natural interactions.Hand gesture recognition offers a compelling solution by leveraging the expressiveness of human hands to facilitate seamless control without relying on traditional input devices such as controllers or keyboards,which can limit immersion.However,achieving robust gesture recognition requires overcoming challenges related to accurate hand tracking,complex environmental conditions,and minimizing system latency.This study proposes an artificial intelligence(AI)-driven framework for recognizing both static and dynamic hand gestures in VR and AR environments using skeleton-based tracking compliant with the OpenXR standard.Our approach employs a lightweight neural network architecture capable of real-time classification within approximately 1.3mswhilemaintaining average accuracy of 95%.We also introduce a novel dataset generation method to support training robust models and demonstrate consistent classification of diverse gestures across widespread commercial VR devices.This work represents one of the first studies to implement and validate dynamic hand gesture recognition in real time using standardized VR hardware,laying the groundwork for more immersive,accessible,and user-friendly interaction systems.By advancing AI-driven gesture interfaces,this research has the potential to broaden the adoption of VR and AR across diverse domains and enhance the overall user experience.
文摘On August 20,the Xi Jinping Thought on Diplomacy Studies Center held a book launch event“Hand in Hand,Heart to Heart-Toward a Shared Future”for Stories of the SCO in the New Era in Beijing.China's Assistant Minister of Foreign Affairs Liu Bin and Deputy Secretary-General of the Shanghai Cooperation Organization(SCO)Ahmad Saidmurodzoda delivered speeches at the event,which was also attended by Zhang Deguang,China's former Vice Foreign Minister and the SCO's inaugural Secretary-General.
基金supported by European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska Curie grant agreement(No.101028929)BJFis supported by National Heart Foundation of Australia Postdoc-toral Fellowship(No.106588)+1 种基金BG is supported by Australian Government Research Training Program ScholarshipDPLis supported by Clive Kearon Award,McMaster University.Additional funding information can be found in Supplemen-tary Funding.
文摘Background:Muscular strength is a powerful marker of current health status and robust predictor of age-related disease and disability.Handgrip strength(HGS)using isometric dynamometry is a convenient,feasible,and widely used method of assessing muscular strength among people of all ages.While adult HGS norms have been published for many countries,no study has yet synthesized available data to produce international norms.The objective of this study was to generate international sex-and age-specific norms for absolute and body size-normalized HGS across the adult lifespan.Methods:Systematic searches were conducted in 6 databases/web search engines(MEDLINE,SPORTDiscus,Embase,Web of Science,CINAHL,and Google Scholar)up to December 1,2023.We included full-text peer-reviewed observational studies that reported normative HGS data for adults aged ≥20 years by sex and age.Pseudo data were generated using Monte Carlo simulation following harmonization for methodo-logical variation.Population-weighted Generalized Additive Models for Location,Scale,and Shape were used to develop sex-and age-specific norms for absolute HGS(kg)and HGS normalized by height(Ht,m)squared(i.e.,HGS/Ht^(2)in kg/m^(2)).Norms were tabulated as percentile values(5th to 95th)and visualized as smoothed percentile curves.Results:We included data from 100 unique observational studies representing 2,405,863 adults(51.9%female)aged 20 to 100+years from 69 countries and regions tested from the year 2000 onward.On average,absolute and normalized HGS values negligibly improved throughout early adulthood,peaked from age 3039 years(at 49.7 kg(males)and 29.7 kg(females)for absolute HGS or 16.3 kg/m^(2)(males)and 11.3 kg/m^(2)(females)for HGS/Ht^(2)),and declined afterwards.The age-related decline in HGS accelerated from middle to late adulthood and was slightly larger for males than for females during middle adulthood.Conclusion:This study provides the world’s largest and most geographically comprehensive international norms for adult HGS by sex and age.These norms have utility for global peer-comparisons,health screening,and surveillance.
基金supported by a Henan Province Science and Technology Research Project(No.252102311033)the National Key Research and Development Program(No.2022YFC2009600 and No.2022YFC2009601).
文摘Objective:While albumin and the weight-standardized hand grip strength(HGS/W)serve as valuable prognostic indicators for cancer patients,their correlation with the prognosis in frail cancer patients remains inadequately explored.This study aimed to investigate the prognostic importance of the albumin level and HGS/W in cancer patients with frailty and to further investigate their combined prognostic value.Moreover,this comprehensive evaluation aimed to facilitate timely intervention and treatment for frail patients.Methods:The research enrolled 5,794 cancer patients identified with frailty from a multicenter research database.The diagnosis of frailty was based on the FRAIL scale.An Albumin-HGS/W score was constructed by combining the albumin and HGS/W values.Cox proportional hazard regression was utilized to examine the association between the albumin level and HGS/W and patient outcomes.Results:Among these patients,2,543 were females and 3,251 were males,with a median age of 60.0 years.Optimal stratification based on patient survival revealed the ideal threshold for HGS/W to be 0.48 for males and 0.39 for females,and for albumin to be 38 for both sexes.The fully adjusted model revealed that higher Albumin-HGS/W scores were correlated with a poorer patient prognosis.Notably,an Albumin-HGS/W score of 2 was associated with a higher risk of mortality compared with a score of 0 in the total population(HR:1.813,95%CI:1.580-2.080,P<0.001).Conclusions:Low albumin or HGS/W values are associated with low survival in cancer patients with frailty.Elevated Albumin-HGS/W scores were linked to decreased survival rates in cancer patients with frailty.
文摘Perhaps the greatest compliment that an attending surgeon can bestow on a resident in training,is to comment,“He/she has good hands.”However,what defines good hands?What parameters are used to make that judgment?As an academic urologist,I had the opportunity to observe urology and general surgery residents in the operating room over several decades.
