A series of controllable amphiphilic block copolymers composed of poly(ethylene oxide)(PEO) as the hydrophilic block and poly(ε-caprolactone)(PCL) as the hydrophobic block with the amino terminal group at the end of ...A series of controllable amphiphilic block copolymers composed of poly(ethylene oxide)(PEO) as the hydrophilic block and poly(ε-caprolactone)(PCL) as the hydrophobic block with the amino terminal group at the end of the PEO chain(PCL-b-PEO-NH2) were synthesized.Based on the further reaction of reactive amino groups,diblock copolymers with functional carboxyl groups(PCL-b-PEO-COOH) and functional compounds RGD(PCL-b-PEO-RGD) as well as the triblock copolymers with thermosensitive PNIPAAm blocks(PCL-b-PEO-b-PNIPAAM) were synthesized.The well-controlled structures of these copolymers with functional groups and blocks were characterized by gel permeation chromatography(GPC) and 1H NMR spectroscopy.These copolymers with functionalized hydrophilic blocks were fabricated into microspheres for the examination of biofunctions via cell culture experiments and in vitro drug release.The results indicated the significance of introducing functional groups(e.g.,NH2,COOH and RGD) into the end of the hydrophilic block of amphiphilic block copolymers for biomedical potentials in tissue engineering and controlled drug release.展开更多
目的超声引导下髋关节囊周围神经(PENG)阻滞联合硬膜外麻醉对股骨头置换术老年患者麻醉效果、术后认知功能及免疫功能的影响。方法选取2021年6月至2024年7月成都市中西医结合医院收治的120例行股骨头置换术的老年患者,采用随机数字表法...目的超声引导下髋关节囊周围神经(PENG)阻滞联合硬膜外麻醉对股骨头置换术老年患者麻醉效果、术后认知功能及免疫功能的影响。方法选取2021年6月至2024年7月成都市中西医结合医院收治的120例行股骨头置换术的老年患者,采用随机数字表法将患者分为对照组(n=60)和研究组(n=60),年龄>60岁,美国麻醉医师协会(ASA)分级Ⅰ或Ⅱ级,研究组接受超声引导下PENG阻滞联合硬膜外麻醉,对照组仅行硬膜外麻醉。比较两组患者的血流动力学指标(心率、平均动脉压)、免疫功能[CD4^(+)、CD4^(+)/CD8^(+)、调节性T细胞(CD4^(+)CD25^(+))]、简易智力状态检查评分(MMSE)、术后认知功能障碍(POCD)发生率、视觉模拟评分法(VAS)。结果研究组麻醉后心率、平均动脉压波动低于对照组(P<0.05);研究组术后6、24、72 h的CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD4^(+)CD25^(+)低于对照组(P<0.05);研究组术后6 h、术后24 h、术后48 h MMSE评分明显高于对照组(P<0.05);与对照组比较,研究组术后6、24 h POCD发生率明显降低(P<0.05);研究组术后30 min、2 h VAS评分低于对照组(P<0.05);术后24 h两组VAS评分差异无统计学意义(P>0.05)。结论超声引导下PENG阻滞联合硬膜外麻醉效果更佳,镇痛效果好,有利于降低对血流动力学和免疫功能的影响,更快恢复认知,降低POCD发生率。展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos 50873109 and 50830103)Chinese Academy of Sciences
文摘A series of controllable amphiphilic block copolymers composed of poly(ethylene oxide)(PEO) as the hydrophilic block and poly(ε-caprolactone)(PCL) as the hydrophobic block with the amino terminal group at the end of the PEO chain(PCL-b-PEO-NH2) were synthesized.Based on the further reaction of reactive amino groups,diblock copolymers with functional carboxyl groups(PCL-b-PEO-COOH) and functional compounds RGD(PCL-b-PEO-RGD) as well as the triblock copolymers with thermosensitive PNIPAAm blocks(PCL-b-PEO-b-PNIPAAM) were synthesized.The well-controlled structures of these copolymers with functional groups and blocks were characterized by gel permeation chromatography(GPC) and 1H NMR spectroscopy.These copolymers with functionalized hydrophilic blocks were fabricated into microspheres for the examination of biofunctions via cell culture experiments and in vitro drug release.The results indicated the significance of introducing functional groups(e.g.,NH2,COOH and RGD) into the end of the hydrophilic block of amphiphilic block copolymers for biomedical potentials in tissue engineering and controlled drug release.
文摘目的超声引导下髋关节囊周围神经(PENG)阻滞联合硬膜外麻醉对股骨头置换术老年患者麻醉效果、术后认知功能及免疫功能的影响。方法选取2021年6月至2024年7月成都市中西医结合医院收治的120例行股骨头置换术的老年患者,采用随机数字表法将患者分为对照组(n=60)和研究组(n=60),年龄>60岁,美国麻醉医师协会(ASA)分级Ⅰ或Ⅱ级,研究组接受超声引导下PENG阻滞联合硬膜外麻醉,对照组仅行硬膜外麻醉。比较两组患者的血流动力学指标(心率、平均动脉压)、免疫功能[CD4^(+)、CD4^(+)/CD8^(+)、调节性T细胞(CD4^(+)CD25^(+))]、简易智力状态检查评分(MMSE)、术后认知功能障碍(POCD)发生率、视觉模拟评分法(VAS)。结果研究组麻醉后心率、平均动脉压波动低于对照组(P<0.05);研究组术后6、24、72 h的CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD4^(+)CD25^(+)低于对照组(P<0.05);研究组术后6 h、术后24 h、术后48 h MMSE评分明显高于对照组(P<0.05);与对照组比较,研究组术后6、24 h POCD发生率明显降低(P<0.05);研究组术后30 min、2 h VAS评分低于对照组(P<0.05);术后24 h两组VAS评分差异无统计学意义(P>0.05)。结论超声引导下PENG阻滞联合硬膜外麻醉效果更佳,镇痛效果好,有利于降低对血流动力学和免疫功能的影响,更快恢复认知,降低POCD发生率。
