A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,...A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.展开更多
Without applying any stable element techniques in the mixed methods, two simple generalized mixed element(GME) formulations were derived by combining the minimum potential energy principle and Hellinger–Reissner(H–R...Without applying any stable element techniques in the mixed methods, two simple generalized mixed element(GME) formulations were derived by combining the minimum potential energy principle and Hellinger–Reissner(H–R) variational principle. The main features of the GME formulations are that the common C0-continuous polynomial shape functions for displacement methods are used to express both displacement and stress variables, and the coefficient matrix of these formulations is not only automatically symmetric but also invertible. Hence, the numerical results of the generalized mixed methods based on the GME formulations are stable. Displacement as well as stress results can be obtained directly from the algebraic system for finite element analysis after introducing stress and displacement boundary conditions simultaneously. Numerical examples show that displacement and stress results retain the same accuracy. The results of the noncompatible generalized mixed method proposed herein are more accurate than those of the standard noncompatible displacement method. The noncompatible generalized mixed element is less sensitive to element geometric distortions.展开更多
The new notions of H-metric spaces and generalized H-KKM mappings were introduced. Some generalized H-KKM type theorems for generalized H-K-KM mappings with finitely metrically compactly closed values and finitely met...The new notions of H-metric spaces and generalized H-KKM mappings were introduced. Some generalized H-KKM type theorems for generalized H-K-KM mappings with finitely metrically compactly closed values and finitely metrically compactly open values were established in H-metric spaces. These theorems generalize recent results of Khamsi and Yuan. As applications, some Ky Fan type matching theorems for finitely metrically compactly open covers and finitely metrically compactly closed covers, fixed point theorems and minimax inequality are obtained in H-metric spaces. These results generalize a number of known results in recent literature.展开更多
The flow near a wall suddenly set in motion for a viscoelastic fluid with the generalized Oldroyd-B model is studied. The fractional calculus approach is used in the constitutive relationship of fluid model. Exact ana...The flow near a wall suddenly set in motion for a viscoelastic fluid with the generalized Oldroyd-B model is studied. The fractional calculus approach is used in the constitutive relationship of fluid model. Exact analytical solutions of velocity and stress are obtained by using the discrete Laplace transform of the sequential fractional derivative and the Fox H-function. The obtained results indicate that some well known solutions for the Newtonian fluid, the generalized second grade fluid as well as the ordinary Oldroyd-B fluid, as limiting cases, are included in our solutions.展开更多
By using a continuous transition method of a matrix and the estimate for spectral radius of a sub-matrix etc., decision methods for a generalized H-matrix under positive definite matrix conditions are researched. Some...By using a continuous transition method of a matrix and the estimate for spectral radius of a sub-matrix etc., decision methods for a generalized H-matrix under positive definite matrix conditions are researched. Some new sufficient conditions for generalized H-matrices are obtained. When a block matrix degenerates a point matrix, these conditions namely become sufficient conditions of H-matrix.展开更多
Let R0,n be the real Clifford algebra generated by e1, e2,... , en satisfying eiej＋ejei=-2δij,i,j=1,2…,ne0 is the unit element.Let Ω be an open set. A function f is called left generalized analytic in ft if f sati...Let R0,n be the real Clifford algebra generated by e1, e2,... , en satisfying eiej＋ejei=-2δij,i,j=1,2…,ne0 is the unit element.Let Ω be an open set. A function f is called left generalized analytic in ft if f satisfies the equation Lf=0,where ……qi 〉0, i =-, 1, - ……, n. In this article, we first give the kernel function for the generalized analytic function. Further, the Hilbert boundary value problem for generalized analytic functions in Rn＋1 will be investigated.展开更多
We extend a previous model of the author which generalizes Bell local hidden variable models to the case of entangled photon pairs assuming that the standard Bell correlation functions depend on a hidden vacuum index....We extend a previous model of the author which generalizes Bell local hidden variable models to the case of entangled photon pairs assuming that the standard Bell correlation functions depend on a hidden vacuum index. We deduce a generalization of Bell theorem assuming that classical observables are not dichotomic and that photon pair emission and detection is not a stationary stochastic process. We derive a photon imperfect polarization correlation functions due to rotational invariance breaking induced by hidden vacuum spin currents. We implement formally this approach deducing a generalization of C.H.S.H. inequalities which asymptotically converges to the standard one and which might be competitive with standard quantum mechanics predictions. We suggest to test this inequalities conceiving new E.P.R.-Bell like tests with time dependent detector efficiency and photon flux. Finally, we suggest to apply these generalized inequalities to the correlation functions of entangled classical spinning waves realized recently with metamaterials.展开更多
In this paper, a new notion of a generalized H-η-accretive operator is introduced and studied, which provides a unifying framework for the generalized m-accretive operator and the H-η-monotone operator in Banach spa...In this paper, a new notion of a generalized H-η-accretive operator is introduced and studied, which provides a unifying framework for the generalized m-accretive operator and the H-η-monotone operator in Banach spaces. A resolvent operator associated with the generalized H-η-accretive operator is defined, and its Lipschitz continuity is shown. As an application, the solvability for a class of variational inclusions involving the generalized H-η-accretive operators in Banach spaces is considered. By using the technique of the resolvent mapping, an iterative algorithm for solving the variational inclusion in Banach spaces is constructed. Under some suitable conditions, it is proven that the solution for the variational inclusion and the convergence of the iterative sequence generated by the algorithm exist.展开更多
In this paper, we generalize H(.,.) accretive operator introduced by Zou and Huang [1] and we call it H(.,.)- φ - η - accretive operator. We define the resolvent operator associated with H(.,.)- φ - η - accretive ...In this paper, we generalize H(.,.) accretive operator introduced by Zou and Huang [1] and we call it H(.,.)- φ - η - accretive operator. We define the resolvent operator associated with H(.,.)- φ - η - accretive operator and prove its Lipschitz continuity. By using these concepts an iterative algorithm is suggested to solve a generalized variational-like inclusion problem. Some examples are given to justify the definition of H(.,.)- φ - η - accretive operator.展开更多
A new system of set-valued variational inclusions involving generalized H（·, ·）-accretive mapping in real q-uniformly smooth Banach spaces is introduced, and then based on the generalized resolvent operato...A new system of set-valued variational inclusions involving generalized H（·, ·）-accretive mapping in real q-uniformly smooth Banach spaces is introduced, and then based on the generalized resolvent operator technique associated with H（·, ·）-accretivity, the existence and approximation solvability of solutions using an iterative algorithm is investigated.展开更多
A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fra...A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fractional inequalities involving generalized midpoint type,trapezoid type and Simpson type are derived as consequences.Furthermore,as some applications,special means inequalities and numerical quadratures for local fractional integrals are discussed.展开更多
In this paper, we introduce and study a new system of generalized vari- ational inclusions involving H-η-monotone operators in uniformly smooth Banach spaces. Using the resolvent operator technique associated with H-...In this paper, we introduce and study a new system of generalized vari- ational inclusions involving H-η-monotone operators in uniformly smooth Banach spaces. Using the resolvent operator technique associated with H-η-monotone opera- tors, we prove the approximation solvability of solutions using an iterative algorithm. The results in this paper extend and improve some known results from the literature.展开更多
The object of this article is to study and develop the generalized fractional calcu- lus operators given by Saigo and Maeda in 1996. We establish generalized fractional calculus formulas involving the product of R-fun...The object of this article is to study and develop the generalized fractional calcu- lus operators given by Saigo and Maeda in 1996. We establish generalized fractional calculus formulas involving the product of R-function, Appell function F3 and a general class of poly- nomials. The results obtained provide unification and extension of the results given by Saxena et al. [13], Srivastava and Grag [17], Srivastava et al. [20], and etc. The results are obtained in compact form and are useful in preparing some tables of operators of fractional calculus. On account of the general nature of the Saigo-Maeda operators, R-function, and a general class of polynomials a large number of new and known results involving Saigo fractional calculus operators and several special functions notably H-function, /-function, Mittag-Leffier function, generalized Wright hypergeometric function, generalized Bessel-Maitland function follow as special cases of our main findings.展开更多
目前网约车拼车服务存在响应不及时、乘客舒适度低等现象,亟需对拼车路线及求解算法进行优化。本文首先考虑路网条件及时间窗阈值影响,以网约车运行成本与乘客出行成本最小化为目标,构建基于双向线路的网约车拼车优化模型("one-to-...目前网约车拼车服务存在响应不及时、乘客舒适度低等现象,亟需对拼车路线及求解算法进行优化。本文首先考虑路网条件及时间窗阈值影响,以网约车运行成本与乘客出行成本最小化为目标,构建基于双向线路的网约车拼车优化模型("one-to-many"online car-hailing carpooling model under multiple constraints)。其次以遗传算法为基础,结合模拟退火温度调控机制,改进适应度评价和接受准则,提出混合遗传-模拟退火算法(hybrid genetic-simulated annealing algorithm,H-GASA)。最后以呼和浩特东站及其周围交通网络为例进行实例验证。实验结果表明,与其他算法相比,H-GASA算法在多种时间窗下均能有效降低乘客出行时间和车辆运营成本。此外,H-GASA算法得到的网约车拼车服务问题求解方案更优,收敛曲线更平缓,效率更高,验证了H-GASA在克服遗传算法过快收敛问题上的有效性。展开更多
基金supported by the National Natural Science Foundation of China(32273037 and 32102636)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030007)+4 种基金Laboratory of Lingnan Modern Agriculture Project(NT2021007)the Guangdong Science and Technology Innovation Leading Talent Program(2019TX05N098)the 111 Center(D20008)the double first-class discipline promotion project(2023B10564003)the Department of Education of Guangdong Province(2019KZDXM004 and 2019KCXTD001).
文摘A switch from avian-typeα-2,3 to human-typeα-2,6 receptors is an essential element for the initiation of a pandemic from an avian influenza virus.Some H9N2 viruses exhibit a preference for binding to human-typeα-2,6 receptors.This identifies their potential threat to public health.However,our understanding of the molecular basis for the switch of receptor preference is still limited.In this study,we employed the random forest algorithm to identify the potentially key amino acid sites within hemagglutinin(HA),which are associated with the receptor binding ability of H9N2 avian influenza virus(AIV).Subsequently,these sites were further verified by receptor binding assays.A total of 12 substitutions in the HA protein(N158D,N158S,A160 N,A160D,A160T,T163I,T163V,V190T,V190A,D193 N,D193G,and N231D)were predicted to prefer binding toα-2,6 receptors.Except for the V190T substitution,the other substitutions were demonstrated to display an affinity for preferential binding toα-2,6 receptors by receptor binding assays.Especially,the A160T substitution caused a significant upregulation of immune-response genes and an increased mortality rate in mice.Our findings provide novel insights into understanding the genetic basis of receptor preference of the H9N2 AIV.
基金supported by the National Natural Science Foundation of China (Grant 11502286)
文摘Without applying any stable element techniques in the mixed methods, two simple generalized mixed element(GME) formulations were derived by combining the minimum potential energy principle and Hellinger–Reissner(H–R) variational principle. The main features of the GME formulations are that the common C0-continuous polynomial shape functions for displacement methods are used to express both displacement and stress variables, and the coefficient matrix of these formulations is not only automatically symmetric but also invertible. Hence, the numerical results of the generalized mixed methods based on the GME formulations are stable. Displacement as well as stress results can be obtained directly from the algebraic system for finite element analysis after introducing stress and displacement boundary conditions simultaneously. Numerical examples show that displacement and stress results retain the same accuracy. The results of the noncompatible generalized mixed method proposed herein are more accurate than those of the standard noncompatible displacement method. The noncompatible generalized mixed element is less sensitive to element geometric distortions.
文摘The new notions of H-metric spaces and generalized H-KKM mappings were introduced. Some generalized H-KKM type theorems for generalized H-K-KM mappings with finitely metrically compactly closed values and finitely metrically compactly open values were established in H-metric spaces. These theorems generalize recent results of Khamsi and Yuan. As applications, some Ky Fan type matching theorems for finitely metrically compactly open covers and finitely metrically compactly closed covers, fixed point theorems and minimax inequality are obtained in H-metric spaces. These results generalize a number of known results in recent literature.
基金The project supported by the National Natural Science Foundation of China(10272067)the Doctoral Program Foundation of the Education Ministry of China(20030422046)+1 种基金the Natural Science Foundation of Shandong Province,China(Y2006A 14)the Research Foundation of Shandong University at Weihai.
文摘The flow near a wall suddenly set in motion for a viscoelastic fluid with the generalized Oldroyd-B model is studied. The fractional calculus approach is used in the constitutive relationship of fluid model. Exact analytical solutions of velocity and stress are obtained by using the discrete Laplace transform of the sequential fractional derivative and the Fox H-function. The obtained results indicate that some well known solutions for the Newtonian fluid, the generalized second grade fluid as well as the ordinary Oldroyd-B fluid, as limiting cases, are included in our solutions.
基金Project supported by the National Natural Science Foundation of China (No.10671164)Hunan Provice Key Laboratory for Computation and Simulation in Science and Engineering
文摘By using a continuous transition method of a matrix and the estimate for spectral radius of a sub-matrix etc., decision methods for a generalized H-matrix under positive definite matrix conditions are researched. Some new sufficient conditions for generalized H-matrices are obtained. When a block matrix degenerates a point matrix, these conditions namely become sufficient conditions of H-matrix.
基金supported by NNSF of China (11171260)RFDP of Higher Education of China (20100141110054)Scientific Research Fund of Leshan Normal University (Z1265)
文摘Let R0,n be the real Clifford algebra generated by e1, e2,... , en satisfying eiej＋ejei=-2δij,i,j=1,2…,ne0 is the unit element.Let Ω be an open set. A function f is called left generalized analytic in ft if f satisfies the equation Lf=0,where ……qi 〉0, i =-, 1, - ……, n. In this article, we first give the kernel function for the generalized analytic function. Further, the Hilbert boundary value problem for generalized analytic functions in Rn＋1 will be investigated.
文摘We extend a previous model of the author which generalizes Bell local hidden variable models to the case of entangled photon pairs assuming that the standard Bell correlation functions depend on a hidden vacuum index. We deduce a generalization of Bell theorem assuming that classical observables are not dichotomic and that photon pair emission and detection is not a stationary stochastic process. We derive a photon imperfect polarization correlation functions due to rotational invariance breaking induced by hidden vacuum spin currents. We implement formally this approach deducing a generalization of C.H.S.H. inequalities which asymptotically converges to the standard one and which might be competitive with standard quantum mechanics predictions. We suggest to test this inequalities conceiving new E.P.R.-Bell like tests with time dependent detector efficiency and photon flux. Finally, we suggest to apply these generalized inequalities to the correlation functions of entangled classical spinning waves realized recently with metamaterials.
基金Project supported by the National Natural Science Foundation of China (No. 10671135)the Key Program of the National Natural Science Foundation of China (No. 70831005)the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20060610005)
文摘In this paper, a new notion of a generalized H-η-accretive operator is introduced and studied, which provides a unifying framework for the generalized m-accretive operator and the H-η-monotone operator in Banach spaces. A resolvent operator associated with the generalized H-η-accretive operator is defined, and its Lipschitz continuity is shown. As an application, the solvability for a class of variational inclusions involving the generalized H-η-accretive operators in Banach spaces is considered. By using the technique of the resolvent mapping, an iterative algorithm for solving the variational inclusion in Banach spaces is constructed. Under some suitable conditions, it is proven that the solution for the variational inclusion and the convergence of the iterative sequence generated by the algorithm exist.
文摘In this paper, we generalize H(.,.) accretive operator introduced by Zou and Huang [1] and we call it H(.,.)- φ - η - accretive operator. We define the resolvent operator associated with H(.,.)- φ - η - accretive operator and prove its Lipschitz continuity. By using these concepts an iterative algorithm is suggested to solve a generalized variational-like inclusion problem. Some examples are given to justify the definition of H(.,.)- φ - η - accretive operator.
基金Supported by the National Natural Science Foundation of China(Grant No.11371015)the Key Project of Chinese Ministry of Education(Grant No.211163)+3 种基金Sichuan Youth Science and Technology Foundation(GrantNo.2012JQ0032)the Foundation of China West Normal University(Grant No.11A028,11A029)the Fundamental Research Funds of China West Normal University(Grant No.13D016)the Natural Science Foundation ofSichuan Provincial Education Department(Grant No.14ZB0142)
文摘A new system of set-valued variational inclusions involving generalized H（·, ·）-accretive mapping in real q-uniformly smooth Banach spaces is introduced, and then based on the generalized resolvent operator technique associated with H（·, ·）-accretivity, the existence and approximation solvability of solutions using an iterative algorithm is investigated.
基金Supported by the National Natural Science Foundation of China(Grant No.11801342)the Natural Science Foundation of Shaanxi Province(Grant No.2023-JC-YB-043).
文摘A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fractional inequalities involving generalized midpoint type,trapezoid type and Simpson type are derived as consequences.Furthermore,as some applications,special means inequalities and numerical quadratures for local fractional integrals are discussed.
基金The NSF(60804065)of Chinathe Foundation(11A028)of China West Normal University
文摘In this paper, we introduce and study a new system of generalized vari- ational inclusions involving H-η-monotone operators in uniformly smooth Banach spaces. Using the resolvent operator technique associated with H-η-monotone opera- tors, we prove the approximation solvability of solutions using an iterative algorithm. The results in this paper extend and improve some known results from the literature.
基金NBHM Department of Atomic Energy,Government of India,Mumbai for the finanicai assistance under PDF sanction no.2/40(37)/2014/R&D-II/14131
文摘The object of this article is to study and develop the generalized fractional calcu- lus operators given by Saigo and Maeda in 1996. We establish generalized fractional calculus formulas involving the product of R-function, Appell function F3 and a general class of poly- nomials. The results obtained provide unification and extension of the results given by Saxena et al. [13], Srivastava and Grag [17], Srivastava et al. [20], and etc. The results are obtained in compact form and are useful in preparing some tables of operators of fractional calculus. On account of the general nature of the Saigo-Maeda operators, R-function, and a general class of polynomials a large number of new and known results involving Saigo fractional calculus operators and several special functions notably H-function, /-function, Mittag-Leffier function, generalized Wright hypergeometric function, generalized Bessel-Maitland function follow as special cases of our main findings.
文摘目前网约车拼车服务存在响应不及时、乘客舒适度低等现象,亟需对拼车路线及求解算法进行优化。本文首先考虑路网条件及时间窗阈值影响,以网约车运行成本与乘客出行成本最小化为目标,构建基于双向线路的网约车拼车优化模型("one-to-many"online car-hailing carpooling model under multiple constraints)。其次以遗传算法为基础,结合模拟退火温度调控机制,改进适应度评价和接受准则,提出混合遗传-模拟退火算法(hybrid genetic-simulated annealing algorithm,H-GASA)。最后以呼和浩特东站及其周围交通网络为例进行实例验证。实验结果表明,与其他算法相比,H-GASA算法在多种时间窗下均能有效降低乘客出行时间和车辆运营成本。此外,H-GASA算法得到的网约车拼车服务问题求解方案更优,收敛曲线更平缓,效率更高,验证了H-GASA在克服遗传算法过快收敛问题上的有效性。
