Functional magnetic resonance imaging（fMRI）is an in-vivo non-invasive technique for measuring brain activity with excellent spatial and good temporal resolution.Without performing explicit tasks,resting-state fMRI（...Functional magnetic resonance imaging（fMRI）is an in-vivo non-invasive technique for measuring brain activity with excellent spatial and good temporal resolution.Without performing explicit tasks,resting-state fMRI（rfMRI）is widely used to map the functional connectivity network（FCN）,which refers to a large-scale network of interdependent or functionally connected brain regions and it could be detected by using different algorithms（Zuo and Xing, 2014）.ciation CAS （2016084）, Guangxi Bagui Scholarship, the Natural Science Foundation of China （81471740, 81220108014）, the Major Project of National Social Science Foundation of China （14ZDB161）, Beijing Municipal Science and Tech Commission （Z161100002616023, Z161100000216152） and the National R＆D Infrastructure and Facility Development Program ＂Fundamental Science Data Sharing Platform＂ （DKA2017-12-02-21）.展开更多
Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to inve...Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome （IBS）. We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions： resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range： bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu （ST 25） manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain.展开更多
Background:The guiding principle of functional brain mapping is that the cortex exhibits a spatial pattern of response reflecting its underlying functional organization.We know that large-scale patterns are common acr...Background:The guiding principle of functional brain mapping is that the cortex exhibits a spatial pattern of response reflecting its underlying functional organization.We know that large-scale patterns are common across individuals-everyone roughly has the same visual areas for example,but we do not know about small patterns,like the distribution of ocular dominance and orientation columns.Studies investigating the temporal aspect of brain-to-brain similarity have shown that a large portion of the brain is temporally synchronized across subjects(Hasson et al.,2004),but spatial pattern similarity has been scarcely studied,let alone at a fine scale.In the current study,we investigated fine-scale spatial pattern similarity between subjects during movie viewing and generated a map of prototypical patterns spanning the visual system.Characteristics of the map,such as spatial pattern size and distribution,reveal properties of the underlying structure and organisation of the visual cortex.These results will guide future brain mapping studies in decoding the informative spatial patterns of the visual cortex and increasing the resolution of current brain maps.Methods:We had 56 subjects watch two movie clips from“Under the Sea 3D:IMAX”during an fMRI scan.Each clip was 5 minutes in length and was presented in 2D and 3D,in random order.We calculated the intersubject correlation of the spatial pattern inside predefined searchlights of diameter 3,5,7,9 and 11 mm,covering the entire brain.A single threshold permutations test was used to test for significance:we generated 1,000 permutations made from scrambling the spatial patterns inside each searchlight of every subject,pooled these permutations together to generate a large distribution and used the 95th percentile to threshold the actual measurements.We compared these spatial pattern correlations to convexity variance between subjects to determine whether spatial pattern correlation could be explained by differing degrees of alignment across the cortex.We also compared spatial pattern correlation during 2D and 3D movie presentation.Results:We found significant correlations in spatial pattern between subjects in the majority of early visual cortex,as well as higher visual areas.We found that mean spatial pattern similarity in a visual area tended to decrease as we move up the visual hierarchy.Spatial pattern correlation showed significant positive correlation with convexity variance for most visual areas,meaning that as anatomical misalignment increased,patterns became more similar.Spatial pattern correlation therefore cannot be explained by anatomical misalignment.Lastly,spatial pattern correlations tended to be higher for 3D movie presentation compared to 2D.Conclusions:Our results suggest that many processes in early visual areas and even higher visual areas process visual information the same way in different individuals.Our results expand past studies by exploring spatial patterns instead of temporal patterns and studying at a fine-scale.This is the first study,to our knowledge,exploring fine-scale spatial patterns across the visual system.Our results show that fine-scale structures underlying activation patterns may be highly similar across subjects,pointing to a more ingrained organisation of the visual system than previously believed.This map we termed the“protoSPACE map”,may one day result in the detection of more subtle abnormalities that arise only during realistic vision in situations such as schizophrenia or mild traumatic brain injury,where traditional anatomical MRI scans report no changes.展开更多
Background Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying...Background Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying language processing between normal subjects and aphasics.Methods Functional magnetic resonance imaging (fMRI) was used to map the language network in 6 normal subjects and 3 patients with aphasia who were in the stage of recovery from acute stroke. The participants performed a word generation task during multi-slice functional scanning for the measurement of signal change associated with regional neural activity induced by the task. Results In normal subjects, a distributed language network was activated. Activations were present in the frontal, temporal, parietal and occipital regions. In the patient group, however, no activation was detected in the left inferior frontal gyrus whether the patient had a lesion in the left frontal lobe or not. Two patients showed activations in some right hemisphere regions where no activation appeared in normal subjects. Conclusions fMRI with word generation task is feasible for evaluating language function in aphasic patients. Remote effect of focal lesion and functional redistribution or reorganisation can be found in aphasic patients.展开更多
基金supported by the National Basic Research Program(2015CB351702)the Youth Innovation Promotion Association CAS(2016084)+3 种基金Guangxi Bagui Scholarship,the Natural Science Foundation of China(81471740,81220108014)the Major Project of National Social Science Foundation of China(14ZDB161)Beijing Municipal Science and Tech Commission(Z161100002616023,Z161100000216152)the National R&D Infrastructure and Facility Development Program“Fundamental Science Data Sharing Platform”(DKA2017-12-02-21)
文摘Functional magnetic resonance imaging（fMRI）is an in-vivo non-invasive technique for measuring brain activity with excellent spatial and good temporal resolution.Without performing explicit tasks,resting-state fMRI（rfMRI）is widely used to map the functional connectivity network（FCN）,which refers to a large-scale network of interdependent or functionally connected brain regions and it could be detected by using different algorithms（Zuo and Xing, 2014）.ciation CAS （2016084）, Guangxi Bagui Scholarship, the Natural Science Foundation of China （81471740, 81220108014）, the Major Project of National Social Science Foundation of China （14ZDB161）, Beijing Municipal Science and Tech Commission （Z161100002616023, Z161100000216152） and the National R＆D Infrastructure and Facility Development Program ＂Fundamental Science Data Sharing Platform＂ （DKA2017-12-02-21）.
基金the National Basic Research Program of China (973 Program),No.2009CB522900the Leading Talents of Medical Science in Shanghai,No.LJ06019the Shanghai Leading Academic Discipline Project,No.S30304
文摘Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome （IBS）. We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions： resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range： bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu （ST 25） manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain.
文摘Background:The guiding principle of functional brain mapping is that the cortex exhibits a spatial pattern of response reflecting its underlying functional organization.We know that large-scale patterns are common across individuals-everyone roughly has the same visual areas for example,but we do not know about small patterns,like the distribution of ocular dominance and orientation columns.Studies investigating the temporal aspect of brain-to-brain similarity have shown that a large portion of the brain is temporally synchronized across subjects(Hasson et al.,2004),but spatial pattern similarity has been scarcely studied,let alone at a fine scale.In the current study,we investigated fine-scale spatial pattern similarity between subjects during movie viewing and generated a map of prototypical patterns spanning the visual system.Characteristics of the map,such as spatial pattern size and distribution,reveal properties of the underlying structure and organisation of the visual cortex.These results will guide future brain mapping studies in decoding the informative spatial patterns of the visual cortex and increasing the resolution of current brain maps.Methods:We had 56 subjects watch two movie clips from“Under the Sea 3D:IMAX”during an fMRI scan.Each clip was 5 minutes in length and was presented in 2D and 3D,in random order.We calculated the intersubject correlation of the spatial pattern inside predefined searchlights of diameter 3,5,7,9 and 11 mm,covering the entire brain.A single threshold permutations test was used to test for significance:we generated 1,000 permutations made from scrambling the spatial patterns inside each searchlight of every subject,pooled these permutations together to generate a large distribution and used the 95th percentile to threshold the actual measurements.We compared these spatial pattern correlations to convexity variance between subjects to determine whether spatial pattern correlation could be explained by differing degrees of alignment across the cortex.We also compared spatial pattern correlation during 2D and 3D movie presentation.Results:We found significant correlations in spatial pattern between subjects in the majority of early visual cortex,as well as higher visual areas.We found that mean spatial pattern similarity in a visual area tended to decrease as we move up the visual hierarchy.Spatial pattern correlation showed significant positive correlation with convexity variance for most visual areas,meaning that as anatomical misalignment increased,patterns became more similar.Spatial pattern correlation therefore cannot be explained by anatomical misalignment.Lastly,spatial pattern correlations tended to be higher for 3D movie presentation compared to 2D.Conclusions:Our results suggest that many processes in early visual areas and even higher visual areas process visual information the same way in different individuals.Our results expand past studies by exploring spatial patterns instead of temporal patterns and studying at a fine-scale.This is the first study,to our knowledge,exploring fine-scale spatial patterns across the visual system.Our results show that fine-scale structures underlying activation patterns may be highly similar across subjects,pointing to a more ingrained organisation of the visual system than previously believed.This map we termed the“protoSPACE map”,may one day result in the detection of more subtle abnormalities that arise only during realistic vision in situations such as schizophrenia or mild traumatic brain injury,where traditional anatomical MRI scans report no changes.
文摘Background Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying language processing between normal subjects and aphasics.Methods Functional magnetic resonance imaging (fMRI) was used to map the language network in 6 normal subjects and 3 patients with aphasia who were in the stage of recovery from acute stroke. The participants performed a word generation task during multi-slice functional scanning for the measurement of signal change associated with regional neural activity induced by the task. Results In normal subjects, a distributed language network was activated. Activations were present in the frontal, temporal, parietal and occipital regions. In the patient group, however, no activation was detected in the left inferior frontal gyrus whether the patient had a lesion in the left frontal lobe or not. Two patients showed activations in some right hemisphere regions where no activation appeared in normal subjects. Conclusions fMRI with word generation task is feasible for evaluating language function in aphasic patients. Remote effect of focal lesion and functional redistribution or reorganisation can be found in aphasic patients.
