AIM:To evaluate the therapeutic effects of itopride vs other drugs(placebo,domperidone,mosapride) for functional dyspepsia(FD).METHODS:Randomized controlled trials(RCTs) of itopride for FD were retrieved from database...AIM:To evaluate the therapeutic effects of itopride vs other drugs(placebo,domperidone,mosapride) for functional dyspepsia(FD).METHODS:Randomized controlled trials(RCTs) of itopride for FD were retrieved from databases.Relevant information was extracted and analyzed,using the relative risk(RR) and weighted mean deviation,as appropriate.A random or fixed effect model was used,based on the heterogeneity of the included articles,and visual inspection of funnel plots was used to evaluate publication bias.RESULTS:Nine RCTs enrolling 2620 FD cases were included;1372 cases received itopride treatment and 1248 cases received placebo or other drugs(control groups).Compared with control groups,itopride had superior RR values of 1.11 [95%CI:(1.03,1.19),P = 0.006],1.21 [95%CI:(1.03,1.44),P = 0.02],and1.24 [95%CI:(1.01,1.53),P = 0.04] for global patient assessment,postprandial fullness,and early satiety,respectively.For the Leeds Dyspepsia Questionnaire score,the weighted mean deviation was-1.38 [95%CI:(-1.75,-1.01),P < 0.01].The incidence of adverse effects was similar in the itopride and control groups.The funnel plots for all indicators showed no evidence of publication bias.CONCLUSION:Itopride has good efficacy in terms of global patients assessment,postprandial fullness,and early satiety in the treatment of patients with FD and shows a low rate of adverse reactions.Itopride can greatly improve FD syndromes-score.展开更多
Objective To further evaluate the effect of hypertension on renal graft function, and the relationship between hypertension, hyperlipoidemia and ischemic heart disease. Methods 102 renal transplant recipients with a f...Objective To further evaluate the effect of hypertension on renal graft function, and the relationship between hypertension, hyperlipoidemia and ischemic heart disease. Methods 102 renal transplant recipients with a functioning renal graft for more than 1 year were enrolled in this study. Renal function was followed for the further 24 months. Results The overall prevalence of hypertension was 89.2%(91/102) and 36.2%(33/91) hypertensive patients had uncontrolled blood pressure. After 24 months those with high blood pressure had significantly higher Scr levels than normotensive patients (P<0.05). The number of different antihypertensive classes required was related to Scr (P<0.05). Plasma cholesterol levels in hypertension patients especially in blood pressure uncontrolled group were significantly elevated (P<0.01). Ischemic heart disease was more common in hypertensive patients (P<0.05). Cyclosporine A was associated with hypertension more frequently than azathioprine and FK506, whereas low-dose prednisolone did not appear to influence blood pressure. Conclusion The data further confirmed that hypertension was associated with hyperlipidemia and ischemic heart disease, and emerged as a predictor of renal graft dysfunction. Whether cyclosporine A should be converted to new immunosuppressive agents and which class of antihypertensive medication is more effective in this population remain open questions.展开更多
Objective To assess retrospectively the clinical characteristics and cell immune function of infections caused by Flavimonas oryzihabitans (F oryzihabitans) Methods We indentified 11 cases of F oryzih...Objective To assess retrospectively the clinical characteristics and cell immune function of infections caused by Flavimonas oryzihabitans (F oryzihabitans) Methods We indentified 11 cases of F oryzihabitans positive cultures from all microbial cultures collected in our hospital from November 1994 to December 1998 Relevant clinical information was collected, including demographic data, underlying disease, and clinical manifestations of the F. oryzihabitans infections Minimal inhibitory concentrations (MICs) of 15 antimicrobial agents against the 11 F oryzihabitans isolates were determined Cell immune function tests were determined by flow cytometry including T lymphocyte subsets (CD3, CD4, CD8 and ratio CD4/CD8) and NK cells (CD16+56) from peripheral blood Results Six of these patients with infections caused by F oryzihabitans were male, 5 were female and the mean age was 47 64 years (range, 5 to 69 years) All but 1 patients had severe underlying diseases 9 (81 8%) of these patients developed infection while hospitalization and 2 (18 2%) before hospitalization (Cases 2 and 5) 8 (72 7%) of these patients manifested primary F oryzihabitans bacteremia and one each (9 1%) had pleurisy, soft tissue infection and peritonitis All these isolates were susceptible to amikacin, gentamicin and ciprofloxacin, but resistance to cefazolin, nitrofurantoin, penicillin and piperacillin CD3, CD4, CD4/CD8 and CD16+56 value (±s) of these patients were significatly lower than normal values ( P <0 01) The mean time of body temperature fell ≤37℃ after antibiotic treatment in these patients was 3 5 days (range, 1 to 6 days) All clinical symptom caused F oryzihabitans after antibiotic treatment disappeared and all patients recovered Conclusions Infections caused by F oryzihabitans was very few clinically, and relative to underlying diseases and the presence of foreign material Immune function abnormality was among mostly factor for the F oryzihabitans infections展开更多
基金Supported by The Natural Science Foundation of Zhejiang Province of China,No. LY12H29002Traditional Chinese Medicine Science Foundation of Zhejiang Province of China,No. 2011ZB032
文摘AIM:To evaluate the therapeutic effects of itopride vs other drugs(placebo,domperidone,mosapride) for functional dyspepsia(FD).METHODS:Randomized controlled trials(RCTs) of itopride for FD were retrieved from databases.Relevant information was extracted and analyzed,using the relative risk(RR) and weighted mean deviation,as appropriate.A random or fixed effect model was used,based on the heterogeneity of the included articles,and visual inspection of funnel plots was used to evaluate publication bias.RESULTS:Nine RCTs enrolling 2620 FD cases were included;1372 cases received itopride treatment and 1248 cases received placebo or other drugs(control groups).Compared with control groups,itopride had superior RR values of 1.11 [95%CI:(1.03,1.19),P = 0.006],1.21 [95%CI:(1.03,1.44),P = 0.02],and1.24 [95%CI:(1.01,1.53),P = 0.04] for global patient assessment,postprandial fullness,and early satiety,respectively.For the Leeds Dyspepsia Questionnaire score,the weighted mean deviation was-1.38 [95%CI:(-1.75,-1.01),P < 0.01].The incidence of adverse effects was similar in the itopride and control groups.The funnel plots for all indicators showed no evidence of publication bias.CONCLUSION:Itopride has good efficacy in terms of global patients assessment,postprandial fullness,and early satiety in the treatment of patients with FD and shows a low rate of adverse reactions.Itopride can greatly improve FD syndromes-score.
文摘Objective To further evaluate the effect of hypertension on renal graft function, and the relationship between hypertension, hyperlipoidemia and ischemic heart disease. Methods 102 renal transplant recipients with a functioning renal graft for more than 1 year were enrolled in this study. Renal function was followed for the further 24 months. Results The overall prevalence of hypertension was 89.2%(91/102) and 36.2%(33/91) hypertensive patients had uncontrolled blood pressure. After 24 months those with high blood pressure had significantly higher Scr levels than normotensive patients (P<0.05). The number of different antihypertensive classes required was related to Scr (P<0.05). Plasma cholesterol levels in hypertension patients especially in blood pressure uncontrolled group were significantly elevated (P<0.01). Ischemic heart disease was more common in hypertensive patients (P<0.05). Cyclosporine A was associated with hypertension more frequently than azathioprine and FK506, whereas low-dose prednisolone did not appear to influence blood pressure. Conclusion The data further confirmed that hypertension was associated with hyperlipidemia and ischemic heart disease, and emerged as a predictor of renal graft dysfunction. Whether cyclosporine A should be converted to new immunosuppressive agents and which class of antihypertensive medication is more effective in this population remain open questions.
文摘Objective To assess retrospectively the clinical characteristics and cell immune function of infections caused by Flavimonas oryzihabitans (F oryzihabitans) Methods We indentified 11 cases of F oryzihabitans positive cultures from all microbial cultures collected in our hospital from November 1994 to December 1998 Relevant clinical information was collected, including demographic data, underlying disease, and clinical manifestations of the F. oryzihabitans infections Minimal inhibitory concentrations (MICs) of 15 antimicrobial agents against the 11 F oryzihabitans isolates were determined Cell immune function tests were determined by flow cytometry including T lymphocyte subsets (CD3, CD4, CD8 and ratio CD4/CD8) and NK cells (CD16+56) from peripheral blood Results Six of these patients with infections caused by F oryzihabitans were male, 5 were female and the mean age was 47 64 years (range, 5 to 69 years) All but 1 patients had severe underlying diseases 9 (81 8%) of these patients developed infection while hospitalization and 2 (18 2%) before hospitalization (Cases 2 and 5) 8 (72 7%) of these patients manifested primary F oryzihabitans bacteremia and one each (9 1%) had pleurisy, soft tissue infection and peritonitis All these isolates were susceptible to amikacin, gentamicin and ciprofloxacin, but resistance to cefazolin, nitrofurantoin, penicillin and piperacillin CD3, CD4, CD4/CD8 and CD16+56 value (±s) of these patients were significatly lower than normal values ( P <0 01) The mean time of body temperature fell ≤37℃ after antibiotic treatment in these patients was 3 5 days (range, 1 to 6 days) All clinical symptom caused F oryzihabitans after antibiotic treatment disappeared and all patients recovered Conclusions Infections caused by F oryzihabitans was very few clinically, and relative to underlying diseases and the presence of foreign material Immune function abnormality was among mostly factor for the F oryzihabitans infections
