With the actuality and characteristic and requirement of rural power enterprise distribution network management, this article introduced the function of geographic information system on the framework of distribution n...With the actuality and characteristic and requirement of rural power enterprise distribution network management, this article introduced the function of geographic information system on the framework of distribution network, in order to develop rural distribution network.展开更多
The cutting properties of the functionally gradient ceramic cutting tools relate closely to the gradient distribution. A cutting model of the functionally gradient ceramic tool is firstly designed in the present paper...The cutting properties of the functionally gradient ceramic cutting tools relate closely to the gradient distribution. A cutting model of the functionally gradient ceramic tool is firstly designed in the present paper. The optimum of gradient distribution is obtained by way of the FEM analyses.展开更多
The structure and stability of the compounds MRg^(+)and MRg F(Rg=Ar,Kr,and Xe;M=Co,Rh,and Ir)were investigated using the B3 LYP,MP2,MP4(SDQ)and CCSD(T)methods.We reported the geometry,vibrational frequencies and therm...The structure and stability of the compounds MRg^(+)and MRg F(Rg=Ar,Kr,and Xe;M=Co,Rh,and Ir)were investigated using the B3 LYP,MP2,MP4(SDQ)and CCSD(T)methods.We reported the geometry,vibrational frequencies and thermodynamics properties of these compounds.A series of theoretical methods on the basis of wavefunction analysis,including natural bond orbitals,atoms in molecules,electron localization function,and energy decomposition analysis,were performed to explore bonding nature of the M-Rg and Rg-F bonds.These bonds are mainly noncovalent,the metal weakly interacts with Rg in MRg^(+),but their interaction is much stronger in MRg F.The neutral molecule MRg F can be well described by the Lewis structure[MRg]^(+)F^(-).展开更多
Stathmin 1(stmn1)gene,which is involved in the control of cell cycle progression,cell proliferation,differentiation and motility,is a crucial relay in the signal transduction of multiple signaling pathways.Reports on ...Stathmin 1(stmn1)gene,which is involved in the control of cell cycle progression,cell proliferation,differentiation and motility,is a crucial relay in the signal transduction of multiple signaling pathways.Reports on the function of stmn1 in fish are scarce.In this study,the characterization and function of stmn1a gene were explored in an important food fish,namely bighead carp(Hypophthalmichthys nobilis).The bighead carp stmn1a(Hynstmn1a)genomic sequence,which has 2995 bp with an ORF of 447 bp,is evolutionarily conserved in teleost fish.The highest level of expression of Hynstmn1a is in the un-fertilized eggs and spleen of adult bighead carp.The overexpression of Hynstmn1a facilitates cell cycle progression and suppresses apoptosis in EPC cells.In an siRNA assay,disruption of stmn1a in EPC cells resulted in the inhibition of cell cycle progression and promotion of apoptosis.Analysis of promoter activity indicated that an upstream transcription factor(foxo4)regulates Hynstmn1a.Zebrafish mutants with stmn1a knockout by CRISPR/Cas9 exhibited a significant retardation of body length(p<0.05).There was no significant difference in body weight between stmn1a-mutant zebrafish and wildtype(p=0.053).A 22-bp Indel in the promoter region of Hynstmn1a with an observed heterozygosity(Ho)of 0.136 in a bighead carp population(n=191).The polymorphism of this 22-bp Indel genotype is significantly associated with body length(BL),head length(HL)(p<0.05),body weight(BW),head height(HH),and head width(HW)(p<0.01),showing its genetic effects on growth promotion.This study sheds light on the function of stmn1a in fish and demonstrates the potential of the 22-bp Indel of Hynstmn1a as a gene marker when selecting breeding individuals for faster growth and a bigger head of bighead carp in aquaculture.展开更多
基金Science and Technology Research Instruction Project of Heilongjiang Province Education Department (9553032)
文摘With the actuality and characteristic and requirement of rural power enterprise distribution network management, this article introduced the function of geographic information system on the framework of distribution network, in order to develop rural distribution network.
基金supported by the National Natural Science Foundation of China(59875091)
文摘The cutting properties of the functionally gradient ceramic cutting tools relate closely to the gradient distribution. A cutting model of the functionally gradient ceramic tool is firstly designed in the present paper. The optimum of gradient distribution is obtained by way of the FEM analyses.
文摘The structure and stability of the compounds MRg^(+)and MRg F(Rg=Ar,Kr,and Xe;M=Co,Rh,and Ir)were investigated using the B3 LYP,MP2,MP4(SDQ)and CCSD(T)methods.We reported the geometry,vibrational frequencies and thermodynamics properties of these compounds.A series of theoretical methods on the basis of wavefunction analysis,including natural bond orbitals,atoms in molecules,electron localization function,and energy decomposition analysis,were performed to explore bonding nature of the M-Rg and Rg-F bonds.These bonds are mainly noncovalent,the metal weakly interacts with Rg in MRg^(+),but their interaction is much stronger in MRg F.The neutral molecule MRg F can be well described by the Lewis structure[MRg]^(+)F^(-).
基金supported by the grants from National Natural Science Foundation of China(32072973)Special Fund for Strategic Pilot Technology of the Chinese Academy of Sciences(XDA24030505).
文摘Stathmin 1(stmn1)gene,which is involved in the control of cell cycle progression,cell proliferation,differentiation and motility,is a crucial relay in the signal transduction of multiple signaling pathways.Reports on the function of stmn1 in fish are scarce.In this study,the characterization and function of stmn1a gene were explored in an important food fish,namely bighead carp(Hypophthalmichthys nobilis).The bighead carp stmn1a(Hynstmn1a)genomic sequence,which has 2995 bp with an ORF of 447 bp,is evolutionarily conserved in teleost fish.The highest level of expression of Hynstmn1a is in the un-fertilized eggs and spleen of adult bighead carp.The overexpression of Hynstmn1a facilitates cell cycle progression and suppresses apoptosis in EPC cells.In an siRNA assay,disruption of stmn1a in EPC cells resulted in the inhibition of cell cycle progression and promotion of apoptosis.Analysis of promoter activity indicated that an upstream transcription factor(foxo4)regulates Hynstmn1a.Zebrafish mutants with stmn1a knockout by CRISPR/Cas9 exhibited a significant retardation of body length(p<0.05).There was no significant difference in body weight between stmn1a-mutant zebrafish and wildtype(p=0.053).A 22-bp Indel in the promoter region of Hynstmn1a with an observed heterozygosity(Ho)of 0.136 in a bighead carp population(n=191).The polymorphism of this 22-bp Indel genotype is significantly associated with body length(BL),head length(HL)(p<0.05),body weight(BW),head height(HH),and head width(HW)(p<0.01),showing its genetic effects on growth promotion.This study sheds light on the function of stmn1a in fish and demonstrates the potential of the 22-bp Indel of Hynstmn1a as a gene marker when selecting breeding individuals for faster growth and a bigger head of bighead carp in aquaculture.
