Slip-form system constitutes the latest technology for the erection of elevated concrete pylons. This paper investigates the design of slip-form system applying BIM technology for the efficient development of the slip...Slip-form system constitutes the latest technology for the erection of elevated concrete pylons. This paper investigates the design of slip-form system applying BIM technology for the efficient development of the slip-form system. The considered pylon has a height of 10 m and presents the rectangular hollow section generally adopted in cable-supported bridges. The slip-form was thus designed to accommodate the tapered cross-section and changing thickness considering the continuous placing of concrete. In addition, the safety of the system was examined with regard to the various loads applied on the slip form along the construction. The design results could be verified visually through BIM and the applicability of the designed slip-form was validated in advance through virtual assembly and construction.展开更多
Most material distribution-based topology optimization methods work on a relaxed form of the optimization problem and then push the solution toward the binary limits.However,when benchmarking these methods,researchers...Most material distribution-based topology optimization methods work on a relaxed form of the optimization problem and then push the solution toward the binary limits.However,when benchmarking these methods,researchers use known solutions to only a single form of benchmark problem.This paper proposes a comparison platform for systematic benchmarking of topology optimization methods using both binary and relaxed forms.A greyness measure is implemented to evaluate how far a solution is from the desired binary form.The well-known ZhouRozvany(ZR)problem is selected as the benchmarking problem here,making use of available global solutions for both its relaxed and binary forms.The recently developed non-penalization Smooth-edged Material Distribution for Optimizing Topology(SEMDOT),well-established Solid Isotropic Material with Penalization(SIMP),and continuation methods are studied on this platform.Interestingly,in most cases,the grayscale solutions obtained by SEMDOT demonstrate better performance in dealing with the ZR problem than SIMP.The reasons are investigated and attributed to the usage of two different regularization techniques,namely,the Heaviside smooth function in SEMDOT and the power-law penalty in SIMP.More importantly,a simple-to-use benchmarking graph is proposed for evaluating newly developed topology optimization methods.展开更多
Tailings produced by mining and ore smelting are a major source of soil pollution.Understanding the speciation of heavy metals(HMs)in tailings is essential for soil remediation and sustainable development.Given the co...Tailings produced by mining and ore smelting are a major source of soil pollution.Understanding the speciation of heavy metals(HMs)in tailings is essential for soil remediation and sustainable development.Given the complex and time-consuming nature of traditional sequential laboratory extraction methods for determining the forms of HMs in tailings,a rapid and precise identification approach is urgently required.To address this issue,a general empirical prediction method for HM occurrence was developed using machine learning(ML).The compositional information of the tailings,properties of the HMs,and sequential extraction steps were used as inputs to calculate the percentages of the seven forms of HMs.After the models were tuned and compared,extreme gradient boosting,gradient boosting decision tree,and categorical boosting methods were found to be the top three performing ML models,with the coefficient of determination(R^(2))values on the testing set exceeding 0.859.Feature importance analysis for these three optimal models indicated that electronegativity was the most important factor affecting the occurrence of HMs,with an average feature importance of 0.4522.The subsequent use of stacking as a model integration method enabled the ability of the ML models to predict HM occurrence forms to be further improved,and resulting in an increase of R^(2) to 0.879.Overall,this study developed a robust technique for predicting the occurrence forms in tailings and provides an important reference for the environmental assessment and recycling of tailings.展开更多
Theoretical education and practical education are very important in clinical laboratory teaching.The teaching evaluation system is one of the important means to test the quality of course teaching.The traditional summ...Theoretical education and practical education are very important in clinical laboratory teaching.The teaching evaluation system is one of the important means to test the quality of course teaching.The traditional summative evaluation needs to be improved in terms of scientificity and impartiality,and its guiding effect on teaching reform is limited.Therefore,this paper proposes to apply formative evaluation to clinical laboratory teaching to remobilize students'learning enthusiasm and provide valuable guidance for the subsequent teaching reform,hoping to achieve the purpose of improving the quality of laboratory teaching.展开更多
Economic globalization is a process of forming a global market under the conditions of technological progress and national opening-up.Influenced by factors such as national policies,the international environment and g...Economic globalization is a process of forming a global market under the conditions of technological progress and national opening-up.Influenced by factors such as national policies,the international environment and geopolitics,the values,concepts and choices of the participants of globalization will change accordingly,thus affecting the mode,scale and speed of globalization.展开更多
In this paper,we studyλ-biharmonic hypersurfaces M_(r)^(5) of 6-dimensional pseudo Riemannian space form N_(p)^(6)(c)with the indexs 0≤p≤6,r=p−1 or p,and constant curvature c.It was proved that if the shape operato...In this paper,we studyλ-biharmonic hypersurfaces M_(r)^(5) of 6-dimensional pseudo Riemannian space form N_(p)^(6)(c)with the indexs 0≤p≤6,r=p−1 or p,and constant curvature c.It was proved that if the shape operator of M_(r)^(5) is diagonalizable,then the mean curvature is a constant.As an application,we find some types of biharmonic hypersurfaces of N_(p)^(6)(c)are minimal.展开更多
To study a form invariance of Lagrange system, the form invariance of Lagrange equations under the infinitesimal transformations was used. The definition and criterion for the form invariance are given. The relati...To study a form invariance of Lagrange system, the form invariance of Lagrange equations under the infinitesimal transformations was used. The definition and criterion for the form invariance are given. The relation between the form invariance and the Noether symmetry was established.展开更多
The form invariance of Birkhoffian systems is a kind of invariance of the Birkhoffian equations under the infinitesimal transformations. The definition and criteria of the form invariance are given, and the relation b...The form invariance of Birkhoffian systems is a kind of invariance of the Birkhoffian equations under the infinitesimal transformations. The definition and criteria of the form invariance are given, and the relation between the form invariance and the Noether symmetry is studied.展开更多
A formula was proposed to calculate the distribution of metal ions quantitatively in chemical reaction system forming hydroxide where precipitation and complex are formed together. The effects of some factors on forma...A formula was proposed to calculate the distribution of metal ions quantitatively in chemical reaction system forming hydroxide where precipitation and complex are formed together. The effects of some factors on formation of precipitation and complex were investigated, and the corresponding precipitation rates of zinc, iron （III）, aluminum, copper and magnesium were calculated. As a result, it shows that the proposed formula is reliable. By the proposed formula, the existence state of metal ions in hydroxides reaction system with any metal ions can be well described and the effects of some factors on the distribution of metal ions were determined.展开更多
An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, clo...An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.展开更多
Changes of soil organic nitrogen forms and soil nitrogen supply under continuous rice cropping system were investigated in a long-term fertilization experiment in Jinhua, Zhejiang Province, China. The fertilizer treat...Changes of soil organic nitrogen forms and soil nitrogen supply under continuous rice cropping system were investigated in a long-term fertilization experiment in Jinhua, Zhejiang Province, China. The fertilizer treatments included combination of P-K, N-K, N-P, and N-P-K as well as the control. After six years of continuous double-rice cropping, total soil N and hydrolysable N contents remained stable in plots with N treatments, while the hydrolysable N contents were substantially reduced in those plots without N application. Compared to the unbalanced fertilization treatments, P and K increased the percentage of hydrolysable ammonium N in the total soil N with the balanced application of N, and also maintained higher rice grain yields and nitrogen uptake. Grain yield was positively correlated with total N uptake (r = 0.875**), hydrolysable N (r = 0.608**), hydrolysable ammonium N (r = 0.560**) and the hydrolysable unknown N (r = 0.417**). Total N uptake was positively correlated with hydrolysable N (r = 0.608**), hydrolysable ammonium N (r = 0.440**) and hydrolysable unknown N (r = 0.431**). Soil nutrient depletion and/or unbalanced fertilization to rice crop reduced N content in soil microbial biomass, and therefore increased C/N ratio, suggesting a negative effect on the total microbial biomass in the soil.展开更多
In this article, the Killing form of a Lie supertriple system （LSTS） and that of its imbedding Lie superalgebra （LSA） are investigated, and a unique decomposition theorem for a quasiclassical LSTS with trivial cen...In this article, the Killing form of a Lie supertriple system （LSTS） and that of its imbedding Lie superalgebra （LSA） are investigated, and a unique decomposition theorem for a quasiclassical LSTS with trivial center is established by means of the parallel decomposition theorem for a quasiclassical LSA.展开更多
Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the ...Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the patient to the treatment regimen as well as the system’s ability to adhere to skin during the therapy so as to promote drug penetration through the skin barrier.Conventional formulations for topical and dermatological administration of drugs have certain limitations like poor adherence to skin, poor permeability and compromised patient compliance.For the treatment of diseases of body tissues and wounds, the drug has to be maintained at the site of treatment for an effective period of time. Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action. The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance.In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery. Further the various types of film forming systems (sprays/solutions, gels and emulsions) along with their evaluation parameters have also been reviewed.展开更多
The present study was conducted in the alpine pastures of Tungnath （30° 14＇ N and 79° 13＇ E） to observe life-form and growth-form patterns of alpine plant species under grazed and ungrazed conditions and...The present study was conducted in the alpine pastures of Tungnath （30° 14＇ N and 79° 13＇ E） to observe life-form and growth-form patterns of alpine plant species under grazed and ungrazed conditions and to work out the plant life form spectrum. Species were categorized as plant habit, height and length of growth-cycle and life-form classes according to Raunkiaer＇s system. The results show that in total of 68 species at grazed site, hemicryptophytes （He） accounted for 50.00% species, followed by cryptophytes （26.47%）, chamaephytes （16.18%）, phanemphytes （4.41%） and therophytes （2.94%）. At the ungrazed site in 65 plant species, hemicryptophytes （He） accounted fo＇r 49.23% species, cryptophytes （26.15%）, chamaephytes （15.38%）, phanerophytes （6.15%） and ther6phytes （3.08 % species）. In general, hemicrptophyte are dominant^in both sites i.e. graged and ungrazed. Growth form categories were classified as forbs, shrubs, grasses and sedges＇and undershrubs, according to plant habit and height. On the basis of length of the growth cycle, species were categorized as plant species of short growth cycle, intermediate growth cycle and long growth cycle. The short forbs of plant habit and height, had the highest emergence, and grasses and sedges had the lowest emergence in representative species. Percentage of species with long growth cycle was highest in both sites.展开更多
The aim of this work is to simulate thermal deformation of tool system and investigate the influence of cutting parameters on it in single-point diamond turning(SPDT) of aluminum alloy. The experiments with various cu...The aim of this work is to simulate thermal deformation of tool system and investigate the influence of cutting parameters on it in single-point diamond turning(SPDT) of aluminum alloy. The experiments with various cutting parameters were conducted. Cutting temperature was measured by FLIR A315 infrared thermal imager. Tool wear was measured by scanning electron microscope(SEM). The numerical model of heat flux considering tool wear generated in cutting zone was established. Then two-step finite element method(FEM) simulations matching the experimental conditions were carried out to simulate the thermal deformation. In addition, the tests of deformation of tool system were performed to verify previous simulation results. And then the influence of cutting parameters on thermal deformation was investigated. The results show that the temperature and thermal deformation from simulations agree well with the results from experiments in the same conditions. The maximum thermal deformation of tool reaches to 7 μm. The average flank wear width and cutting speed are the dominant factors affecting thermal deformation, and the effective way to decrease the thermal deformation of tool is to control the tool wear and the cutting speed.展开更多
A method based on the semi-empirical Miedema model and a geometrical model was used to study the glass forming abili-ties （GFA） and the amorphous forming ranges of Al-Fe-Nd-Zr system and its constituent ternary syst...A method based on the semi-empirical Miedema model and a geometrical model was used to study the glass forming abili-ties （GFA） and the amorphous forming ranges of Al-Fe-Nd-Zr system and its constituent ternary systems. The amorphous forming composition ranges were analyzed based on different criteria such asΔGam-ss and PHSS （PHSS=ΔHchem （ΔSC/R）（ΔSσ/R）） for Al-Fe-Nd system. The predicted amorphous forming range was in good agreement with the experimental results. The results showed that the criterion ofΔGam-ss was more accurate, and agreed well with the experiment results. The Gibbs free energy differenceΔGam-ss and pa-rameter PHSS were then used to predict the amorphous forming composition range for the rest of the constitutive ternary systems of Al-Fe-Nd-Zr. In addition, the amorphous forming composition ranges of the （Al-Fe-Zr）100-xNdx （x=50, 60, 70） systems were predicted byΔGam-ss and the modified parameter PHSS. The Gibbs free energy of Al10（Fe1-xZrx）30Nd60 were also calculated. The GFA parameter PHSS indicated that the composition with the highest GFA was Al33.5Fe13.5Zr3Nd50 for the （Al-Fe-Zr）50Nd50 system, Al28.8Fe10Zr1.2Nd60 for the （Al-Fe-Zr）40Nd60 system and Al22.8Fe6.9Zr0.3Nd70 for the （Al-Fe-Zr）30Nd70 system, and the results suggested that those alloys with high content of Al had higher GFA. The appropriate content of neodymium and zirconium resulted in the lower value of PHSS and increased the GFA obviously.展开更多
A form invariance and a conserved quantity of the generalised Birkhoffian system are studied. First, a definition and a criterion of the form invariance are given. Secondly, through the form invariance, a new conserve...A form invariance and a conserved quantity of the generalised Birkhoffian system are studied. First, a definition and a criterion of the form invariance are given. Secondly, through the form invariance, a new conserved quantity can be deduced. Finally, an example is given to illustrate the application of the result.展开更多
Ballistic impact tests were carried out with examined projectiles of the Ti-6Al-4V titanium alloy to investigate the impact response of the 2618 aluminum plates at a nominal velocity of 210 m/s. The influence of proje...Ballistic impact tests were carried out with examined projectiles of the Ti-6Al-4V titanium alloy to investigate the impact response of the 2618 aluminum plates at a nominal velocity of 210 m/s. The influence of projectile forms and oblique angles on damage formation was particularly discussed by applying different loading conditions such as multiple projectile forms and oblique angles. Additionally, the numerical simulation method was employed to provide further insight into the characteristics of damage and target responses. The Johnson-Cook(J-C)constitutive model with revised failure parameters was used to support the simulations to assess target responses and characteristics of the damage created from different impact conditions. Results show that there is a significant transition in the deformation mode as changes of the projectile form are applied. Moreover, the cracks on the back of the 2618 aluminum alloy plates impacted by the solid plate projectile and the hollow blade projectile tend to locate at different positions, which are supposed to be influenced by local bending and stretching. The work in this paper may provide guidance for the design of fan blade containment systems.展开更多
Under the infinitesimal transformations of groups, a form invariance of rotational relativistic Birkhoffsystems is studied and the definition and criteria are given. In view of the invariance of rotational relativisti...Under the infinitesimal transformations of groups, a form invariance of rotational relativistic Birkhoffsystems is studied and the definition and criteria are given. In view of the invariance of rotational relativistic PfaffBirkhoff D'Alcmbert principle under the infinitesimal transformations of groups, the theory of Noether symmetries ofrotational relativistic Birkhoff systems are constructed. The relation between the form invariance and the Noethersymmetries is studied, and the conserved quantities of rotational relativistic Birkhoff systems are obtained.展开更多
The form invariance and the conserved quantity for a weakly nonholonomic system （WNS） are studied. The WNS is a nonholonomic system （NS） whose constraint equations contain a small parameter. The differential equat...The form invariance and the conserved quantity for a weakly nonholonomic system （WNS） are studied. The WNS is a nonholonomic system （NS） whose constraint equations contain a small parameter. The differential equations of motion of the system are established. The definition and the criterion of form invariance of the system are given. The conserved quantity deduced from the form invariance is obtained. Finally, an illustrative example is shown.展开更多
文摘Slip-form system constitutes the latest technology for the erection of elevated concrete pylons. This paper investigates the design of slip-form system applying BIM technology for the efficient development of the slip-form system. The considered pylon has a height of 10 m and presents the rectangular hollow section generally adopted in cable-supported bridges. The slip-form was thus designed to accommodate the tapered cross-section and changing thickness considering the continuous placing of concrete. In addition, the safety of the system was examined with regard to the various loads applied on the slip form along the construction. The design results could be verified visually through BIM and the applicability of the designed slip-form was validated in advance through virtual assembly and construction.
文摘Most material distribution-based topology optimization methods work on a relaxed form of the optimization problem and then push the solution toward the binary limits.However,when benchmarking these methods,researchers use known solutions to only a single form of benchmark problem.This paper proposes a comparison platform for systematic benchmarking of topology optimization methods using both binary and relaxed forms.A greyness measure is implemented to evaluate how far a solution is from the desired binary form.The well-known ZhouRozvany(ZR)problem is selected as the benchmarking problem here,making use of available global solutions for both its relaxed and binary forms.The recently developed non-penalization Smooth-edged Material Distribution for Optimizing Topology(SEMDOT),well-established Solid Isotropic Material with Penalization(SIMP),and continuation methods are studied on this platform.Interestingly,in most cases,the grayscale solutions obtained by SEMDOT demonstrate better performance in dealing with the ZR problem than SIMP.The reasons are investigated and attributed to the usage of two different regularization techniques,namely,the Heaviside smooth function in SEMDOT and the power-law penalty in SIMP.More importantly,a simple-to-use benchmarking graph is proposed for evaluating newly developed topology optimization methods.
基金financially supported by the Natural Science Foundation of Hunan Province,China(No.2024JJ2074)the National Natural Science Foundation of China(No.22376221)the Young Elite Scientists Sponsorship Program by CAST,China(No.2023QNRC001).
文摘Tailings produced by mining and ore smelting are a major source of soil pollution.Understanding the speciation of heavy metals(HMs)in tailings is essential for soil remediation and sustainable development.Given the complex and time-consuming nature of traditional sequential laboratory extraction methods for determining the forms of HMs in tailings,a rapid and precise identification approach is urgently required.To address this issue,a general empirical prediction method for HM occurrence was developed using machine learning(ML).The compositional information of the tailings,properties of the HMs,and sequential extraction steps were used as inputs to calculate the percentages of the seven forms of HMs.After the models were tuned and compared,extreme gradient boosting,gradient boosting decision tree,and categorical boosting methods were found to be the top three performing ML models,with the coefficient of determination(R^(2))values on the testing set exceeding 0.859.Feature importance analysis for these three optimal models indicated that electronegativity was the most important factor affecting the occurrence of HMs,with an average feature importance of 0.4522.The subsequent use of stacking as a model integration method enabled the ability of the ML models to predict HM occurrence forms to be further improved,and resulting in an increase of R^(2) to 0.879.Overall,this study developed a robust technique for predicting the occurrence forms in tailings and provides an important reference for the environmental assessment and recycling of tailings.
文摘Theoretical education and practical education are very important in clinical laboratory teaching.The teaching evaluation system is one of the important means to test the quality of course teaching.The traditional summative evaluation needs to be improved in terms of scientificity and impartiality,and its guiding effect on teaching reform is limited.Therefore,this paper proposes to apply formative evaluation to clinical laboratory teaching to remobilize students'learning enthusiasm and provide valuable guidance for the subsequent teaching reform,hoping to achieve the purpose of improving the quality of laboratory teaching.
文摘Economic globalization is a process of forming a global market under the conditions of technological progress and national opening-up.Influenced by factors such as national policies,the international environment and geopolitics,the values,concepts and choices of the participants of globalization will change accordingly,thus affecting the mode,scale and speed of globalization.
基金Supported by National Natural Science Foundation of China(12161078)Foundation for Innovative Fundamental Research Group Project of Gansu Province(24JRRA778)Project of Northwest Normal University(20240010)。
文摘In this paper,we studyλ-biharmonic hypersurfaces M_(r)^(5) of 6-dimensional pseudo Riemannian space form N_(p)^(6)(c)with the indexs 0≤p≤6,r=p−1 or p,and constant curvature c.It was proved that if the shape operator of M_(r)^(5) is diagonalizable,then the mean curvature is a constant.As an application,we find some types of biharmonic hypersurfaces of N_(p)^(6)(c)are minimal.
文摘To study a form invariance of Lagrange system, the form invariance of Lagrange equations under the infinitesimal transformations was used. The definition and criterion for the form invariance are given. The relation between the form invariance and the Noether symmetry was established.
文摘The form invariance of Birkhoffian systems is a kind of invariance of the Birkhoffian equations under the infinitesimal transformations. The definition and criteria of the form invariance are given, and the relation between the form invariance and the Noether symmetry is studied.
基金Project (51304047) supported by the National Natural Science Foundation of ChinaProject (20131037) supported by Science and Technology Foundation of Liaoning Province,China
文摘A formula was proposed to calculate the distribution of metal ions quantitatively in chemical reaction system forming hydroxide where precipitation and complex are formed together. The effects of some factors on formation of precipitation and complex were investigated, and the corresponding precipitation rates of zinc, iron （III）, aluminum, copper and magnesium were calculated. As a result, it shows that the proposed formula is reliable. By the proposed formula, the existence state of metal ions in hydroxides reaction system with any metal ions can be well described and the effects of some factors on the distribution of metal ions were determined.
基金Project(51274250)supported by the National Natural Science Foundation of ChinaProject(2012BAK09B02-05)supported by the National Key Technology R&D Program during the 12th Five-year Plan of China
文摘An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.
基金Project supported by the International Fertilizer Industry Association (IFI), Francethe Potast & Phosphate Institute (PPI), USA and Canadathe International Potassium Institute (IPI), Switzerland
文摘Changes of soil organic nitrogen forms and soil nitrogen supply under continuous rice cropping system were investigated in a long-term fertilization experiment in Jinhua, Zhejiang Province, China. The fertilizer treatments included combination of P-K, N-K, N-P, and N-P-K as well as the control. After six years of continuous double-rice cropping, total soil N and hydrolysable N contents remained stable in plots with N treatments, while the hydrolysable N contents were substantially reduced in those plots without N application. Compared to the unbalanced fertilization treatments, P and K increased the percentage of hydrolysable ammonium N in the total soil N with the balanced application of N, and also maintained higher rice grain yields and nitrogen uptake. Grain yield was positively correlated with total N uptake (r = 0.875**), hydrolysable N (r = 0.608**), hydrolysable ammonium N (r = 0.560**) and the hydrolysable unknown N (r = 0.417**). Total N uptake was positively correlated with hydrolysable N (r = 0.608**), hydrolysable ammonium N (r = 0.440**) and hydrolysable unknown N (r = 0.431**). Soil nutrient depletion and/or unbalanced fertilization to rice crop reduced N content in soil microbial biomass, and therefore increased C/N ratio, suggesting a negative effect on the total microbial biomass in the soil.
基金Supported by the Natural Science Foundation of Hebei Province of China(A2005000088)
文摘In this article, the Killing form of a Lie supertriple system （LSTS） and that of its imbedding Lie superalgebra （LSA） are investigated, and a unique decomposition theorem for a quasiclassical LSTS with trivial center is established by means of the parallel decomposition theorem for a quasiclassical LSA.
基金Vivekanand Education Society’s College of Pharmacy, Chembur, Mumbai, for their support and encouragement
文摘Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the patient to the treatment regimen as well as the system’s ability to adhere to skin during the therapy so as to promote drug penetration through the skin barrier.Conventional formulations for topical and dermatological administration of drugs have certain limitations like poor adherence to skin, poor permeability and compromised patient compliance.For the treatment of diseases of body tissues and wounds, the drug has to be maintained at the site of treatment for an effective period of time. Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action. The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance.In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery. Further the various types of film forming systems (sprays/solutions, gels and emulsions) along with their evaluation parameters have also been reviewed.
文摘The present study was conducted in the alpine pastures of Tungnath （30° 14＇ N and 79° 13＇ E） to observe life-form and growth-form patterns of alpine plant species under grazed and ungrazed conditions and to work out the plant life form spectrum. Species were categorized as plant habit, height and length of growth-cycle and life-form classes according to Raunkiaer＇s system. The results show that in total of 68 species at grazed site, hemicryptophytes （He） accounted for 50.00% species, followed by cryptophytes （26.47%）, chamaephytes （16.18%）, phanemphytes （4.41%） and therophytes （2.94%）. At the ungrazed site in 65 plant species, hemicryptophytes （He） accounted fo＇r 49.23% species, cryptophytes （26.15%）, chamaephytes （15.38%）, phanerophytes （6.15%） and ther6phytes （3.08 % species）. In general, hemicrptophyte are dominant^in both sites i.e. graged and ungrazed. Growth form categories were classified as forbs, shrubs, grasses and sedges＇and undershrubs, according to plant habit and height. On the basis of length of the growth cycle, species were categorized as plant species of short growth cycle, intermediate growth cycle and long growth cycle. The short forbs of plant habit and height, had the highest emergence, and grasses and sedges had the lowest emergence in representative species. Percentage of species with long growth cycle was highest in both sites.
基金Project(51175122)supported by the National Natural Science Foundation of China
文摘The aim of this work is to simulate thermal deformation of tool system and investigate the influence of cutting parameters on it in single-point diamond turning(SPDT) of aluminum alloy. The experiments with various cutting parameters were conducted. Cutting temperature was measured by FLIR A315 infrared thermal imager. Tool wear was measured by scanning electron microscope(SEM). The numerical model of heat flux considering tool wear generated in cutting zone was established. Then two-step finite element method(FEM) simulations matching the experimental conditions were carried out to simulate the thermal deformation. In addition, the tests of deformation of tool system were performed to verify previous simulation results. And then the influence of cutting parameters on thermal deformation was investigated. The results show that the temperature and thermal deformation from simulations agree well with the results from experiments in the same conditions. The maximum thermal deformation of tool reaches to 7 μm. The average flank wear width and cutting speed are the dominant factors affecting thermal deformation, and the effective way to decrease the thermal deformation of tool is to control the tool wear and the cutting speed.
基金Project supported by the National Natural Science Foundation of China(51061004)Science Foundation of Guangxi Education Department(2013YB377)
文摘A method based on the semi-empirical Miedema model and a geometrical model was used to study the glass forming abili-ties （GFA） and the amorphous forming ranges of Al-Fe-Nd-Zr system and its constituent ternary systems. The amorphous forming composition ranges were analyzed based on different criteria such asΔGam-ss and PHSS （PHSS=ΔHchem （ΔSC/R）（ΔSσ/R）） for Al-Fe-Nd system. The predicted amorphous forming range was in good agreement with the experimental results. The results showed that the criterion ofΔGam-ss was more accurate, and agreed well with the experiment results. The Gibbs free energy differenceΔGam-ss and pa-rameter PHSS were then used to predict the amorphous forming composition range for the rest of the constitutive ternary systems of Al-Fe-Nd-Zr. In addition, the amorphous forming composition ranges of the （Al-Fe-Zr）100-xNdx （x=50, 60, 70） systems were predicted byΔGam-ss and the modified parameter PHSS. The Gibbs free energy of Al10（Fe1-xZrx）30Nd60 were also calculated. The GFA parameter PHSS indicated that the composition with the highest GFA was Al33.5Fe13.5Zr3Nd50 for the （Al-Fe-Zr）50Nd50 system, Al28.8Fe10Zr1.2Nd60 for the （Al-Fe-Zr）40Nd60 system and Al22.8Fe6.9Zr0.3Nd70 for the （Al-Fe-Zr）30Nd70 system, and the results suggested that those alloys with high content of Al had higher GFA. The appropriate content of neodymium and zirconium resulted in the lower value of PHSS and increased the GFA obviously.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 10772025,10932002)the Beijing Municipal Key Disciplines Fund for General Mechanics and Foundation of Mechanics
文摘A form invariance and a conserved quantity of the generalised Birkhoffian system are studied. First, a definition and a criterion of the form invariance are given. Secondly, through the form invariance, a new conserved quantity can be deduced. Finally, an example is given to illustrate the application of the result.
基金financial support from the National Natural Science Foundation of China (No. 11772268, 11522220, 11627901 and 11527803)
文摘Ballistic impact tests were carried out with examined projectiles of the Ti-6Al-4V titanium alloy to investigate the impact response of the 2618 aluminum plates at a nominal velocity of 210 m/s. The influence of projectile forms and oblique angles on damage formation was particularly discussed by applying different loading conditions such as multiple projectile forms and oblique angles. Additionally, the numerical simulation method was employed to provide further insight into the characteristics of damage and target responses. The Johnson-Cook(J-C)constitutive model with revised failure parameters was used to support the simulations to assess target responses and characteristics of the damage created from different impact conditions. Results show that there is a significant transition in the deformation mode as changes of the projectile form are applied. Moreover, the cracks on the back of the 2618 aluminum alloy plates impacted by the solid plate projectile and the hollow blade projectile tend to locate at different positions, which are supposed to be influenced by local bending and stretching. The work in this paper may provide guidance for the design of fan blade containment systems.
基金The project supported by National Natural Science Foundation of China under Grant No. 19972010, and Natural Science Foundation of Henan Province under Grant Nos. 984053100 and 998040080
文摘Under the infinitesimal transformations of groups, a form invariance of rotational relativistic Birkhoffsystems is studied and the definition and criteria are given. In view of the invariance of rotational relativistic PfaffBirkhoff D'Alcmbert principle under the infinitesimal transformations of groups, the theory of Noether symmetries ofrotational relativistic Birkhoff systems are constructed. The relation between the form invariance and the Noethersymmetries is studied, and the conserved quantities of rotational relativistic Birkhoff systems are obtained.
基金supported by the National Natural Science Foundation of China(Nos.10932002,10972031,and 11272050)
文摘The form invariance and the conserved quantity for a weakly nonholonomic system （WNS） are studied. The WNS is a nonholonomic system （NS） whose constraint equations contain a small parameter. The differential equations of motion of the system are established. The definition and the criterion of form invariance of the system are given. The conserved quantity deduced from the form invariance is obtained. Finally, an illustrative example is shown.
